公开(公告)号：US07863446B2

公开(公告)日：2011-01-04

申请号：US12068668

申请日：2008-02-08

申请人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran

发明人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran

IPC分类号： C07D239/24 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  A61K31/505 ,  A61K31/506 ,  A61P11/06 ,  A61P17/04 ,  A61P19/02 ,  A61P1/00 ,  A61P25/00

CPC分类号： C07D213/30 ,  C07D239/30 ,  C07D239/32 ,  C07D239/34 ,  C07D239/42 ,  C07D239/52 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof are described. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell-damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors, and useful for treating PDE4 mediated diseases.

摘要翻译： 描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。 这些化合物可用于治疗免疫性疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 动脉粥样硬化 癌症; 恶病质 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症 脓毒症 败血性休克 中毒性休克综合征和发烧。 更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

公开(公告)号：US07786142B2

公开(公告)日：2010-08-31

申请号：US11546299

申请日：2006-10-12

申请人： Siripragada Mahender Rao ,  Akella Satya Surya Visweswara Srinvas ,  Shikha Rani ,  Gaddam Om Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Duddu Savaraiah Sharada ,  Rajagopalan Nirmala ,  Velaiah Sivasudar ,  Lakshmanan Manikandan ,  Ramachandran Balaji

发明人： Siripragada Mahender Rao ,  Akella Satya Surya Visweswara Srinvas ,  Shikha Rani ,  Gaddam Om Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Duddu Savaraiah Sharada ,  Rajagopalan Nirmala ,  Velaiah Sivasudar ,  Lakshmanan Manikandan ,  Ramachandran Balaji

IPC分类号： A61K31/4468 ,  A61K31/403 ,  C07D405/14 ,  C07D209/88

CPC分类号： C07D209/88 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12

摘要： The present invention relates to novel heterocyclic compounds of the general formula (I), as IL-6 inhibitors, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly provides novel heterocyclic compounds of the general formula (I). Also included is a method for treatment of cancer, cancer cachexia and inflammatory diseases including immunological diseases, particularly those mediated by cytokines such as IL-6, through pSTAT3 inhibition, in a mammal comprising administering an effective amount of a compound of formula (I) as described above

摘要翻译： 本发明涉及通式（I）的新型杂环化合物，作为IL-6抑制剂，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其水合物，其溶剂合物，其药学上可接受的盐和组合物 ，它们的代谢物和前药。 本发明更具体地提供了通式（I）的新型杂环化合物。 还包括在哺乳动物中治疗癌症，癌症恶病质和炎性疾病的方法，包括免疫疾病，特别是通过pSTAT3抑制的细胞因子如IL-6介导的疾病，包括给予有效量的式（I）化合物， 如上所述

公开(公告)号：US07687488B2

公开(公告)日：2010-03-30

申请号：US11822956

申请日：2007-07-11

申请人： Senthilkumar Udayampalayam Palanisamy ,  Andrew Gnanaprakasam ,  Panchapakesan Ganapathy ,  Mukut Gohain ,  Venkatasubramanian Hariharan ,  Sriram Rajagopal ,  Maneesh Paul-Satyaseela ,  Shakti Singh Solanki ,  Sathishkumar Devarajan

发明人： Senthilkumar Udayampalayam Palanisamy ,  Andrew Gnanaprakasam ,  Panchapakesan Ganapathy ,  Mukut Gohain ,  Venkatasubramanian Hariharan ,  Sriram Rajagopal ,  Maneesh Paul-Satyaseela ,  Shakti Singh Solanki ,  Sathishkumar Devarajan

IPC分类号： A61K31/43 ,  C07D499/00

CPC分类号： C07D499/86 ,  Y02P20/55

摘要： Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them; wherein A=C or N; Het is a three- to seven-membered heterocyclic ring; R1 represents carboxylate anion, or —COOR4 where R4 represents hydrogen, carboxylic acid protecting group or a pharmaceutically acceptable salt; R2 and R3 may be same or different and independently represent hydrogen, halogen, amino, alkyl, protected amino, optionally substituted alkyl, alkenyl, alkynyl and the like; R represents substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heterocyclylalkyl.

摘要翻译： 新的2-取代的甲基penam衍生物包括式（I），它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的溶剂合物，其药学上可接受的盐和含有它们的药物组合物; 其中A = C或N; Het是一个三至七元的杂环; R1表示羧酸根阴离子，或-COOR4，其中R4表示氢，羧酸保护基或药学上可接受的盐; R2和R3可以相同或不同，并且独立地表示氢，卤素，氨基，烷基，保护的氨基，任选取代的烷基，烯基，炔基等; R代表取代或未取代的烷基，烯基，芳基，芳烷基，环烷基，杂环基或杂环基烷基。

公开(公告)号：US20080221103A1

公开(公告)日：2008-09-11

申请号：US12073635

申请日：2008-03-07

申请人： Ganapavarapu V.R. Sharma ,  Gaddam O. Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Sukunath Narayanan ,  Nagalakshmi Pichika ,  Venkatesh Nemmara Viswanathan ,  Lavanya Andiappan ,  Saravanan Thirunavukkarasu

发明人： Ganapavarapu V.R. Sharma ,  Gaddam O. Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Sukunath Narayanan ,  Nagalakshmi Pichika ,  Venkatesh Nemmara Viswanathan ,  Lavanya Andiappan ,  Saravanan Thirunavukkarasu

IPC分类号： A61K31/5377 ,  C07D239/24 ,  C07D413/14 ,  A61K31/435 ,  A61P37/06

CPC分类号： C07D239/24 ,  C07D413/14

摘要： Provided herein are heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, wherein R1, R2, R3, R4 and R5 are as described herein. Further described herein in particular are heterocyclic compounds of the formula (I) for treating various diseases. and disorders by administering in a patient one or more TNF-α, Thromboxane synthase, 5-LOX, and PDE4 inhibitors. In particular described herein are methods for treating immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection and diseases mediated by HIV-1; HIV-2; HIV-3; cytomegalovirus (CMV); influenza; adenovirus; the herpes viruses (including HSV-1, HSV-2) and herpes zoster viruses in a mammal comprising administering an effective amount of a compound of formula (I).

摘要翻译： 本文提供了通式（I）的杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药，其中R 1， R 2，R 3，R 4和R 5如本文所述。 本文进一步描述的是用于治疗各种疾病的式（I）的杂环化合物。 以及通过在患者中施用一种或多种TNF-α，血栓烷合成酶，5-LOX和PDE4抑制剂的障碍。 本文特别描述的是用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎的方法; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 恶病质 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症 脓毒症 败血性休克 中毒性休克综合征; 发热和由于HIV-1介导的感染和疾病引起的肌痛; HIV-2; HIV-3; 巨细胞病毒（CMV）; 流感; 腺病毒 哺乳动物中的疱疹病毒（包括HSV-1，HSV-2）和带状疱疹病毒，包括施用有效量的式（I）化合物。

公开(公告)号：US20080015156A1

公开(公告)日：2008-01-17

申请号：US11822956

申请日：2007-07-11

申请人： Senthilkumar Udayampalayam Palanisamy ,  Andrew Gnanaprakasam ,  Panchapakesan Ganapathy ,  Mukut Gohain ,  Venkatasubramanian Hariharan ,  Sriram Rajagopal ,  Maneesh Paul-Satyaseela ,  Shakti Solanki ,  Sathishkumar Devarajan

发明人： Senthilkumar Udayampalayam Palanisamy ,  Andrew Gnanaprakasam ,  Panchapakesan Ganapathy ,  Mukut Gohain ,  Venkatasubramanian Hariharan ,  Sriram Rajagopal ,  Maneesh Paul-Satyaseela ,  Shakti Solanki ,  Sathishkumar Devarajan

IPC分类号： A61K31/431 ,  A61K31/7036 ,  A61P31/00 ,  C07D499/00

CPC分类号： C07D499/86 ,  Y02P20/55

摘要： Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them; wherein A=C or N; Het is a three- to seven-membered heterocyclic ring; R1 represents carboxylate anion, or —COOR4 where R4 represents hydrogen, carboxylic acid protecting group or a pharmaceutically acceptable salt; R2 and R3 may be same or different and independently represent hydrogen, halogen, amino, alkyl, protected amino, optionally substituted alkyl, alkenyl, alkynyl and the like; R represents substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heterocyclylalkyl.

摘要翻译： 新的2-取代的甲基penam衍生物包括式（I），它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的溶剂合物，其药学上可接受的盐和含有它们的药物组合物; 其中A = C或N; Het是一个三至七元的杂环; R 1表示羧酸根阴离子或-COOR 4，其中R 4表示氢，羧酸保护基或其药学上可接受的盐; R 2和R 3可以相同或不同，并且独立地表示氢，卤素，氨基，烷基，保护的氨基，任选取代的烷基，烯基，炔基等; R代表取代或未取代的烷基，烯基，芳基，芳烷基，环烷基，杂环基或杂环基烷基。

公开(公告)号：US06576662B2

公开(公告)日：2003-06-10

申请号：US09849584

申请日：2001-05-04

申请人： Srinivas Nanduri ,  Sriram Rajagopal ,  Venkateswarlu Akella

发明人： Srinivas Nanduri ,  Sriram Rajagopal ,  Venkateswarlu Akella

IPC分类号： A61K3134

CPC分类号： C07D405/06 ,  C07D307/58 ,  C07D405/08 ,  C07D405/12 ,  C07D417/12

摘要： The present invention relates to novel anticancer agents, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The present invention more particularly relates to novel derivatives of andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of andrographolide have the general formula (I).

公开(公告)号：US09008734B2

公开(公告)日：2015-04-14

申请号：US13309290

申请日：2011-12-01

申请人： Shashidhar Vummintala ,  Gowrisankar Somichetty ,  Sriram Rajagopal ,  Sindhu Verma ,  Manish Airy ,  Hariprasad Gangadharan ,  Ramasamy Palanisamy Pugazhanthi ,  Felix Varghese ,  Erik Stauffer

发明人： Shashidhar Vummintala ,  Gowrisankar Somichetty ,  Sriram Rajagopal ,  Sindhu Verma ,  Manish Airy ,  Hariprasad Gangadharan ,  Ramasamy Palanisamy Pugazhanthi ,  Felix Varghese ,  Erik Stauffer

IPC分类号： H04B1/00 ,  H04W4/00 ,  H04W52/02

CPC分类号： H04W52/0216 ,  H03D7/16 ,  H04L41/0803 ,  H04W28/0263 ,  Y02D70/00 ,  Y02D70/1262 ,  Y02D70/146 ,  Y02D70/164 ,  Y02D70/23 ,  Y02D70/24

摘要： A wireless communication device is disclosed that is capable of reduced power consumption. Uplink and downlink sub-frames in a WiMAX, 802.16m or LTE environment often include several vacant symbols during which power-hungry hardware and software components need not operate at full power. By analyzing a physical layer beacon and control information of a received signal, the specific locations of data bursts can be determined, as well as periods of needed operation of a receiver module to effectively decode those data bursts. The receiver module can otherwise be controlled to operate in a LOW power state during remaining periods of vacant time, thereby conserving power consumption and extending battery life.

摘要翻译： 公开了能够降低功耗的无线通信设备。 WiMAX，802.16m或LTE环境中的上行链路和下行链路子帧通常包括几个空闲符号，在此期间，功耗很大的硬件和软件组件不需要在全功率下运行。 通过分析接收信号的物理层信标和控制信息，可以确定数据突发的特定位置以及接收机模块有效解码这些数据脉冲串的所需操作周期。 否则，在空闲时间的剩余时间期间，接收器模块可以被控制为在低功率状态下操作，从而节省功耗并延长电池寿命。

公开(公告)号：US08675761B2

公开(公告)日：2014-03-18

申请号：US12815540

申请日：2010-06-15

申请人： Djordje Tujkovic ,  Vummintala Shashidhar ,  Erik Stauffer ,  Rishi Ranjan ,  Soumen Chakraborty ,  Bertrand Hochwald ,  Sriram Rajagopal ,  Sam Alex

发明人： Djordje Tujkovic ,  Vummintala Shashidhar ,  Erik Stauffer ,  Rishi Ranjan ,  Soumen Chakraborty ,  Bertrand Hochwald ,  Sriram Rajagopal ,  Sam Alex

IPC分类号： H04L1/02

CPC分类号： H04B7/0671 ,  H04B7/0691

摘要： Methods and apparatus of allocating antennas for cyclic delay diversity (CDD) transmission are disclosed. One method includes estimating a transmission channel of a transceiver having a plurality of antennas. A subset of a plurality of transceiver antennas is selected based on the estimated transmission channel. A single transceiver antenna of the subset is identified based on a channel quality of a transmission path of the single transceiver antenna. Cyclic delay diversity (CDD) signals are transmitted from the subset of the plurality of antennas, wherein a minimally delayed CDD signal is transmitted from the identified single transceiver antenna of the subset of the plurality of transceiver antennas.

摘要翻译： 公开了分配用于循环延迟分集（CDD）传输的天线的方法和装置。 一种方法包括估计具有多个天线的收发机的传输信道。 基于估计的传输信道来选择多个收发天线的子集。 基于单个收发器天线的传输路径的信道质量来识别该子集的单个收发天线。 从多个天线的子集中发送循环延迟分集（CDD）信号，其中从所述多个收发器天线的子集的所识别的单个收发器天线发送最小延迟的CDD信号。

公开(公告)号：US20130340165A1

公开(公告)日：2013-12-26

申请号：US14002787

申请日：2012-03-09

申请人： Shufang Dong ,  Terrance Joseph Nemenz ,  Patrick Cumpson ,  Jeremy David Pettinato ,  Sriram Rajagopal

发明人： Shufang Dong ,  Terrance Joseph Nemenz ,  Patrick Cumpson ,  Jeremy David Pettinato ,  Sriram Rajagopal

IPC分类号： A61B6/10

CPC分类号： A61B6/105 ,  A61B5/055 ,  A61B6/032 ,  A61B6/037 ,  A61B6/04 ,  A61B6/102 ,  A61B6/4441 ,  A61B6/547 ,  A61B6/586

摘要： A method includes receiving a subject support motion disable signal indicative of at least one of power removal of an imaging system, a collision of a horizontally moving tabletop of the imaging system, a decoupling of a horizontal motion drive system configured to horizontally drive the tabletop, or a collision of a vertically moving subject support of the imaging system, wherein a vertical motion drive system drives the subject support vertical motion, and disabling, in response to receiving the subject support motion disable signal, at least one of tabletop horizontal motion or subject support vertical motion.

摘要翻译： 一种方法包括：接收指示成像系统的功率去除，成像系统的水平移动台面的碰撞，被配置为水平驱动桌面的水平运动驱动系统的解耦的对象支持运动禁止信号， 或成像系统的垂直移动的被摄体支架的碰撞，其中垂直运动驱动系统驱动对象支架垂直运动，并且响应于接收到对象支持运动禁止信号而禁用桌面水平运动或被摄体中的至少一个 支持垂直运动。

公开(公告)号：US08476255B2

公开(公告)日：2013-07-02

申请号：US12734026

申请日：2008-10-08

申请人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Umamaheswari Mani ,  Suresh Rathinasamy ,  Praveen Rajendran ,  Kamaraj Mani ,  Balaji Ramachandran ,  Punthalir Narayanaswamy ,  Sriram Rajagopal

发明人： Sridharan Rajagopal ,  Virendra Kachhadia ,  Thanasekaran Ponpandian ,  Abdul Raheem Keeri ,  Umamaheswari Mani ,  Suresh Rathinasamy ,  Praveen Rajendran ,  Kamaraj Mani ,  Balaji Ramachandran ,  Punthalir Narayanaswamy ,  Sriram Rajagopal

IPC分类号： A01N43/00 ,  A61K31/33 ,  A61K31/16 ,  A01N37/18 ,  C07D215/38

CPC分类号： C07C237/42 ,  C07C237/22 ,  C07C259/06 ,  C07C259/10 ,  C07C271/22 ,  C07C275/50 ,  C07C2601/02 ,  C07D213/56 ,  C07D215/14 ,  C07D317/60 ,  C07D333/24 ,  C07D333/44

摘要： Provided herein are novel, stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds can inhibit HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.

摘要翻译： 本文提供了新颖的通式（I）的二苯乙烯类化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，代谢物，前药，溶剂合物，药学上可接受的盐和组合物。 这些化合物可以抑制HDAC，并且可用作涉及细胞生长的疾病如恶性肿瘤，自身免疫性疾病，皮肤病，感染，炎症等的治疗或改善剂。