公开(公告)号：US20240058026A1

公开(公告)日：2024-02-22

申请号：US18498210

申请日：2023-10-31

Applicant: Temple University-Of The Commonwealth System of Higher Education ,  Thrombolex, Inc.

Inventor： Riyaz Bashir ,  Nicholas A. Green

IPC: A61B17/221 ,  A61B17/22 ,  A61B18/00 ,  A61M25/00 ,  A61M25/01

CPC classification number: A61B17/221 ,  A61B17/22 ,  A61B18/00 ,  A61M25/0043 ,  A61M25/007 ,  A61M25/0108 ,  A61B2017/22084 ,  A61B2017/2217 ,  A61B17/320725 ,  A61M25/0074 ,  A61M2205/0266

Abstract: An infusion catheter has an elongate flexible shaft including a wall and a lumen extending between a proximal end and a distal end. The catheter also has a sealing member within the shaft lumen including a wall and a lumen. The catheter also has a slidable, retractable elongate central axis member extending through the shaft and sealing member lumens connected to an end cap. The catheter also has a plurality of eluting arms extending radially around the central axis member, including lumens fluidly connected to the shaft lumen and the distal end cap. A method for treating a thrombus is also disclosed.

公开(公告)号：US11897942B2

公开(公告)日：2024-02-13

申请号：US17058575

申请日：2019-05-24

Applicant: Temple University—Of The Commonwealth System of Higher Education ,  LANKENAU INSTITUTE OF MEDICAL RESEARCH

Inventor： Cagla Tukel Wilson ,  Scott Dessain

IPC: C07K16/12 ,  A61P31/04

CPC classification number: C07K16/1235 ,  A61P31/04 ,  C07K16/1228 ,  C07K16/1232

Abstract: The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition.

公开(公告)号：US11896037B2

公开(公告)日：2024-02-13

申请号：US16323018

申请日：2017-08-03

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Gregory S. Smutzer ,  Kevin Lee ,  Dhruti Patel

IPC: A23L27/00 ,  A23P10/35 ,  A61K8/60 ,  A23G1/54 ,  A61K8/11 ,  A61Q11/00 ,  A61K8/42 ,  A23G4/20 ,  A61K8/92 ,  A23G1/00 ,  A23G9/48 ,  A61K8/36 ,  A61K9/50 ,  A61K9/00 ,  A23G3/54 ,  A23L27/30 ,  A01N25/00 ,  A01N25/28

CPC classification number: A23L27/72 ,  A01N25/002 ,  A01N25/28 ,  A23G1/00 ,  A23G1/54 ,  A23G3/54 ,  A23G4/20 ,  A23G9/48 ,  A23L27/30 ,  A23L27/79 ,  A23L27/86 ,  A23P10/35 ,  A61K8/11 ,  A61K8/361 ,  A61K8/42 ,  A61K8/60 ,  A61K8/922 ,  A61K9/0056 ,  A61K9/5015 ,  A61Q11/00 ,  A23V2002/00 ,  A61K2800/412 ,  A23V2002/00 ,  A23V2200/16 ,  A23V2200/224 ,  A23V2250/1886 ,  A23V2250/264

Abstract: The present invention relates to compositions and methods for masking the taste of an agent. In certain aspects, the invention comprises a microsphere and at least one sweetener therein. In another aspect, the invention comprises an edible material comprising at least one microsphere comprising an agent and at least one microsphere comprising a sweetener.

公开(公告)号：US20240009154A1

公开(公告)日：2024-01-11

申请号：US18040515

申请日：2021-08-04

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Mark Feitelson ,  Alla ARZUMANYAN ,  lra Spector

IPC: A61K31/19 ,  A61K47/38 ,  A61K45/06 ,  A61P37/06

CPC classification number: A61K31/19 ,  A61K47/38 ,  A61K45/06 ,  A61P37/06

Abstract: Disclosed herein are methods and pharmaceutical compositions to treat systemic inflammatory response syndrome. In some embodiments, a pharmaceutical composition disclosed herein comprises at least two short chain fatty acids or pharmaceutically-acceptable salts thereof in a ratio of at least 4:1. In some embodiments, administering a pharmaceutical composition of the disclosure reduces a level of a cytokine in the subject.

公开(公告)号：US20230417669A1

公开(公告)日：2023-12-28

申请号：US18252724

申请日：2021-11-12

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Hai-Lung Dai ,  Mohammad Sharifian ,  Michael Wilhelm

IPC: G01N21/63

CPC classification number: G01N21/636

Abstract: The present invention generally relates to improved methods for characterizing the cell wall complex composition of a bacterial specimen via differential transport kinetics of a small molecule. The present invention also relates to improved and automated methods for Gram differentiation of a bacterial specimen using nonlinear optical techniques.

公开(公告)号：US20230390367A1

公开(公告)日：2023-12-07

申请号：US18249569

申请日：2021-10-19

Applicant: Temple University - of the Commonwealth System of Higher Education

Inventor： Kamel Khalili ,  Rafal Kaminski ,  Shuren Liao

IPC: A61K38/46 ,  C12N15/113 ,  A61K45/06

CPC classification number: A61K38/465 ,  C12N15/1131 ,  A61K45/06 ,  C12N2310/20

Abstract: Compositions include gene editing agents, e.g. CRISPR that employ Cas13a for editing and inactivating sequences in the Coronavirus genome.

公开(公告)号：US11826065B2

公开(公告)日：2023-11-28

申请号：US17222588

申请日：2021-04-05

Applicant: Temple University—Of The Commonwealth System of Higher Education ,  THROMBOLEX, INC.

Inventor： Riyaz Bashir ,  Nicholas A. Green

IPC: A61M25/00 ,  A61B17/22 ,  A61B17/221 ,  A61B18/00 ,  A61M25/01 ,  A61B17/3207 ,  A61B17/00

CPC classification number: A61B17/221 ,  A61B17/22 ,  A61B18/00 ,  A61M25/007 ,  A61M25/0043 ,  A61M25/0108 ,  A61B17/320725 ,  A61B2017/00871 ,  A61B2017/2217 ,  A61B2017/22038 ,  A61B2017/22084 ,  A61M25/0074 ,  A61M2025/0057 ,  A61M2205/0266

Abstract: An infusion catheter has an elongate flexible shaft including a wall and a lumen extending between a proximal end and a distal end. The catheter also has a sealing member within the shaft lumen including a wall and a lumen. The catheter also has a slidable, retractable elongate central axis member extending through the shaft and sealing member lumens connected to an end cap. The catheter also has a plurality of eluting arms extending radially around the central axis member, including lumens fluidly connected to the shaft lumen and the distal end cap. A method for treating a thrombus is also disclosed.

公开(公告)号：US11807642B2

公开(公告)日：2023-11-07

申请号：US17541682

申请日：2021-12-03

Applicant: Temple University—Of the Commonwealth System of Higher Education

Inventor： Benjamin E. Blass ,  Daniel J. Canney ,  Kevin M. Blattner

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

公开(公告)号：US20230181698A1

公开(公告)日：2023-06-15

申请号：US17832457

申请日：2022-06-03

Applicant: Temple University-of The Commonwealth System of Higher Education

Inventor： Kamel Khalili ,  Wenhui Hu

IPC: A61K38/46 ,  C12N15/11 ,  A61K48/00 ,  A61K9/00 ,  A61K35/12 ,  A61K45/06 ,  C12N7/00 ,  C12N9/22

CPC classification number: A61K38/465 ,  C12N15/111 ,  A61K48/00 ,  A61K9/0034 ,  A61K35/12 ,  A61K45/06 ,  A61K48/005 ,  C12N7/00 ,  C12N9/22 ,  C12N2320/30 ,  C12N2310/20 ,  C12N2740/16063 ,  C12Y301/21

Abstract: A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-I proviral genome, eradicating the HIV-I proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.

公开(公告)号：US20230172886A1

公开(公告)日：2023-06-08

申请号：US17996830

申请日：2021-04-23

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Salim MERALI ,  Wayne E. CHILDERS ,  Carlos BARRERO ,  George C. MORTON ,  Mario Cesar RICO

IPC: A61K31/198 ,  A61P1/16 ,  A61K9/00

CPC classification number: A61K31/198 ,  A61P1/16 ,  A61K9/0056

Abstract: (S)-2-amino-6-((3-aminopropyl)amino)hexanoic acid (APL) for use in the treatment of non-alcoholic steatohepatitis (NASH), liver inflammation, hepatocellular ballooning, liver fibrosis and steatosis.