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    CORTICAL RECORDING AND SIGNAL PROCESSING METHODS AND DEVICES
    13.
    发明公开
    CORTICAL RECORDING AND SIGNAL PROCESSING METHODS AND DEVICES 审中-公开

    公开(公告)号：US20240090817A1

    公开(公告)日：2024-03-21

    申请号：US18510470

    申请日：2023-11-15

    Applicant: Thomas Jefferson University

    Inventor： Shennan Aibel Weiss ,  Zachary Waldman ,  Michael Sperling

    IPC: A61B5/374 ,  A61B5/384 ,  A61N1/36

    CPC classification number: A61B5/374 ,  A61B5/384 ,  A61N1/36025 ,  A61N1/36171

    Abstract: A device and a signal processing method that can monitor human memory performance by recognizing and characterizing high-gamma (65-250 Hz) and beta (14-30 Hz) band oscillations in the left Brodmann Area 40 (BA40) of the brain that correspond with the strength of memory encoding or correct recall. The signal processing method detects high-gamma and beta band oscillations in the electrical signals recorded from left BA40, and quantifies the spectral content, power, duration, onset, and offset of the oscillations. The oscillation's properties are used to classify the subject's memory performance on the basis of a comparison with the subject's prior human memory performance and the properties of the corresponding oscillations. A report of the subject's current memory performance can be utilized in a closed loop brain stimulation device that serves the purpose of enhancing human memory performance.

    ACOUSTIC SENSOR AND VENTILATION MONITORING SYSTEM
    17.
    发明申请
    ACOUSTIC SENSOR AND VENTILATION MONITORING SYSTEM 有权

    公开(公告)号：US20230123995A1

    公开(公告)日：2023-04-20

    申请号：US18082022

    申请日：2022-12-15

    Applicant: Thomas Jefferson University ,  RTM Vital Signs LLC

    Inventor： Jeffrey I. JOSEPH ,  Noud Van HELMOND ,  Marc C. TORJMAN ,  Denise L. DEVINE ,  Nance K. DICCIANI ,  Channy LOEUM

    IPC: A61B5/113 ,  A61B5/00 ,  A61B5/022 ,  A61B5/08 ,  A61B7/00

    Abstract: A method of monitoring physiological conditions including an acoustic measurement device and a remote controller. The remove controller configured to measure physiological conditions; calculate absolute tidal volume, a direction of tidal volume, and a rate of change of tidal volume; correlate absolute tidal volume, a direction of tidal volume, and a rate of change of tidal volume to a risk score; calculate a direction trend and rate of change for each physiological condition; correlate the direction trend and rate of change for each physiological condition; detect predefined patterns in the direction trend and rate of change of the measured physiological condition at the predetermined interval; and generating at least one from the group consisting of an alert, an alarm, and a medical treatment if the risk score defined on the predefined scale exceeds a first predetermined risk score threshold and at least one predefined pattern is detected.

    Dumbbell-PCR: a method to quantify specific small RNA variants with a single nucleotide resolution at terminal sequences
    19.
    发明授权
    Dumbbell-PCR: a method to quantify specific small RNA variants with a single nucleotide resolution at terminal sequences 有权

    公开(公告)号：US11535888B2

    公开(公告)日：2022-12-27

    申请号：US15754194

    申请日：2016-08-22

    Applicant: THOMAS JEFFERSON UNIVERSITY

    Inventor： Yohei Kirino ,  Shozo Honda

    IPC: C12Q1/6853 ,  C12Q1/6851 ,  C12Q1/6811

    Abstract: A method for specifically and efficiently quantifying the expression of targeted RNA variants with specific terminal sequences suitable to identify multiple isoforms bearing complex heterogeneity in terminal sequences by hybridizing a 5′-Dbs-adapter to the 5′-end of target RNAs, wherein the 5′-Dbs-adapter has a stem-loop structure whose protruding 5′-end base-pairs with the 5′-end of target RNAs, and wherein the loop region of 5′-Dbs-adapter contains a base-lacking spacer which will terminate reverse transcription in a subsequent step; hybridizing a 3′Db-adapter to the 3′-end of target RNAs, wherein the 3′-Db-adapter has a stem-loop structure whose protruding 3′-end base-pairs with the 3′-end of target RNAs; ligating both adapters with target RNAs by RN12 ligation to form a “dumbbell-like” structure; and, amplifying and quantifying the ligation product by RT-PCR.

    METHOD OF VACCINATION AGAINST CANCER USING PLASMA TREATED CANCER CELLS
    20.
    发明申请
    METHOD OF VACCINATION AGAINST CANCER USING PLASMA TREATED CANCER CELLS 有权

    公开(公告)号：US20220256682A1

    公开(公告)日：2022-08-11

    申请号：US17567424

    申请日：2022-01-03

    Applicant: DREXEL UNIVERSITY ,  Thomas Jefferson University

    Inventor： Danil V. DOBRYNIN ,  Alexander FRIDMAN ,  Abraham LIN ,  Vandana MILLER ,  Adam Snook

    IPC: H05H1/24

    Abstract: Applications of dielectric barrier discharge (DBD) based atmospheric pressure plasma jets are often limited by the relatively small area of treatment due to their 1D configuration. This system generates 2D plasma jets permitting fast treatment of larger targets. DBD evolution starts with formation of transient anode glow, and continues with development of cathode-directed streamers. The anode glow can propagate as an ionization wave along the dielectric surface through and outside of the discharge gap. Plasma propagation is not limited to 1D geometry such as tubes, and can be organized in a form of a rectangular plasma jet, or other 2D or 3D shapes. Also described are a method for generating 2D plasma jets and use of the 2D plasma jets for cancer therapy.

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