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公开(公告)号：US20180149717A1
公开(公告)日：2018-05-31
申请号：US15576018
申请日：2015-05-22
Applicant: Universität Ulm
Inventor： Fedor JELEZKO , Martin PLENIO , Ilai SCHWARTZ , Qiong CHEN , Alex RETZKER
CPC classification number: G01R33/282 , G01N24/12 , G01R33/26 , G01R33/5601 , G01R33/62
Abstract: A method of hyperpolarisation of nuclear spins in one or more particle(s) moving relatively to a polarisation structure, wherein a polarisation of electron spins in the polarisation structure is transferred to the nuclear spins in the particle(s), wherein for one or more of the moving particle(s) within 20 nm from a surface of the polarisation structure, the correlation time of the interaction with the nearest polarisation structure electron spin due to the molecular motion is larger than the inverse of the nuclear Larmor frequency; the electron spins in the polarisation structure are polarised above thermal equilibrium; and the polarisation transfer is performed resonantly.
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公开(公告)号：US20160206699A1
公开(公告)日：2016-07-21
申请号：US15071163
申请日：2016-03-15
Applicant: Ruprecht-Karls-Universität Heidelberg , Universität Ulm
Inventor： Ziya KAYA , Hugo KATUS , Oliver ZIMMERMANN , Wolfgang ROTTBAUER , Jan TORZEWSKI
IPC: A61K38/20 , C12N5/0786 , A61K45/06
CPC classification number: C07K14/5428 , A61K35/15 , A61K38/2066 , A61K45/06 , C12N5/0645 , C12N2510/00
Abstract: The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.
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13.发明申请公开(公告)号：US20150265594A1
公开(公告)日：2015-09-24
申请号：US14434138
申请日：2013-10-08
Applicant: UNIVERSITÄT ULM
Inventor： Claudia Friesen , Erich Miltner
IPC: A61K31/485 , A61K31/445 , G01N33/50 , A61K45/06
CPC classification number: A61K31/485 , A61K31/137 , A61K31/445 , A61K31/4468 , A61K31/704 , A61K31/7048 , A61K31/7076 , A61K33/24 , A61K45/06 , G01N33/5011 , G01N33/5014 , G01N2500/04 , A61K2300/00
Abstract: The invention relates to novel strategies for the treatment of cancer patients based on a combination of an opioid receptor agonist and an anticancer compound.
Abstract translation: 本发明涉及基于阿片受体激动剂和抗癌化合物的组合治疗癌症患者的新策略。
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14.发明申请公开(公告)号：US20220214331A1
公开(公告)日：2022-07-07
申请号：US17270014
申请日：2019-08-20
Applicant: UNIVERSITÄT ULM
Inventor： Tobias NECKERNUSS , Daniel GEIGER , Othmar MARTI
Abstract: An apparatus for detecting a spatial elongation of at least one adherent biological cell is provided. The apparatus contains at least one biological cell, which is adhered to a substrate, a laser for irradiating the at least one biological cell for a spatial elongation of the cell in a direction parallel to the irradiation direction and a detector for detecting the spatial elongation of the cell in the direction parallel to the radiation direction. Further, a corresponding method for spatial elongation of an adherent biological cell is provided and the uses of the apparatus and of the method proposed. Using the apparatus and method, it is possible to ascertain, from parts of adherent cells to entire groups of adherent cells, the mechanical properties in the natural, adherent state of the cell(s) in spatially selective, temporally selective and contactless fashion.
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公开(公告)号：US20140255988A1
公开(公告)日：2014-09-11
申请号：US14164903
申请日：2014-01-27
Applicant: Universität Ulm
Inventor： Jörg Wiedenmann , Simone Kredel , Franz Oswald , Gerd Ulrich Nienhaus
IPC: C07K14/435 , G01N33/58
CPC classification number: C07K14/43504 , C07K14/43595 , G01N33/582
Abstract: DNA encoding a monomeric variant of red fluorescent protein eqFP611 comprising an amino acid sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 3 and SEQ ID No. 5. DNA comprising a nucleotide sequence selected from the group consisting of SEQ ID No. 2, SEQ ID No. 4 and SEQ ID No. 6.
Abstract translation: 编码红色荧光蛋白eqFP611的单体变体的DNA，其包含选自SEQ ID No.1，SEQ ID No.3和SEQ ID No.5的氨基酸序列。包含选自下组的核苷酸序列的DNA： SEQ ID No.2，SEQ ID No.4和SEQ ID No.6。
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Patent Agency Ranking
公开(公告)号：US20240190918A1
公开(公告)日：2024-06-13
申请号：US18553732
申请日：2022-03-29
Applicant: Universität Ulm
Inventor： Jan Münch , Desiree Schütz , Lena Rauch
CPC classification number: C07K7/06 , A61K48/0025 , A61K38/00
Abstract: The present invention relates to a fibril peptide consisting of a sequence of from 8 to 20 amino acids and wherein said fibril peptide comprises the amino acid sequence RTIFIISM or a sequence at least 75% identical thereto. The present invention further relates to a method of delivering a cargo comprised in a particle into a host cell, comprising a) contacting said host cell with said particle and with a fibril peptide according to any one of claims 1 to 8; and, thereby b) delivering said cargo into said host cell; and to uses, kits, and devices related thereto.
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公开(公告)号：US20230215535A1
公开(公告)日：2023-07-06
申请号：US17996457
申请日：2021-04-20
Applicant: UNIVERSITÄT ULM
Inventor： Marc-Eric HALATSCH
Abstract: The invention relates to a method for providing a medication combination, wherein at least one medication of the medication combination to be provided is selected on the basis of the result of a molecular in vitro characterization of tumor tissue of a glioblastoma of a patient. The selection is made on the basis of eliminating and not selecting medications from a list of non-oncological medications for which no benefit has been acknowledged for treating the patient on the basis of the result of the molecular in vitro characterization. The medication combination which can be provided using the method is inexpensive, exhibits a low degree of toxicity, and is characterized by an improved efficacy in comparison to known medication combinations. The invention additionally relates to a data carrier with software which can support or simplify the process of carrying out the method according to the invention.
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公开(公告)号：US20220380411A1
公开(公告)日：2022-12-01
申请号：US17769689
申请日：2020-10-20
Applicant: UNIVERSITÄT ULM
Inventor： Stefan KOCHANEK , Lea KRUTZKE , Robin STEINER , Olivia LÜBBERS
IPC: C07K14/005 , C12N15/86 , A61K35/28
Abstract: The invention discloses a human adenovirus species C having a capsid which comprises a modified adenovirus hexon protein, wherein the modified adenovirus hexon protein has a modified HVR1 region, wherein the modified HVR1 region has the sequence DEAATALEINLKKKKQAEQQ (SEQ ID NO.: 1). The invention further discloses the adenovirus of the disclosure for use in treating or preventing a human disease. The invention further discloses a nucleic acid encoding the modified adenovirus hexon protein. The invention further discloses the use of an adenovirus according to the disclosure for transducing mesenchymal stromal cells (MSCs) or tumor cells. The invention further discloses an in vitro method for transducing MSCs and a transduced MSC obtainable by the method. The invention further discloses the transduced MSC of the disclosure for use in treating a disease.
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公开(公告)号：US20220116113A1
公开(公告)日：2022-04-14
申请号：US17556944
申请日：2021-12-20
Inventor： Felix FREY , Johannes FISCHER , Robert FISCHER
IPC: H04B10/2575 , H04B10/69 , H04B10/50
Abstract: An apparatus for determining an interference in a transmission medium during a transmission of a data input signal according to an embodiment has a transform module configured to transform the data input signal from a time domain to a frequency domain comprising a plurality of frequency channels to obtain a frequency-domain data signal comprising a plurality of spectral coefficients, wherein each spectral coefficient is assigned to one of the frequency channels, an analysis module configured to determine the interference by determining one or more spectral interference coefficients, wherein each spectral interference coefficient is assigned to one frequency channel. The analysis module is configured to determine each spectral interference coefficient depending on the spectral coefficients, and depending on a transfer function, wherein the transfer function is configured to receive two or more argument values, wherein each of the argument values indicates one frequency channel, and wherein the transfer function is configured to return a return value depending on the argument values.
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公开(公告)号：US10649044B2
公开(公告)日：2020-05-12
申请号：US15576018
申请日：2015-05-22
Applicant: Universität Ulm
Inventor： Fedor Jelezko , Martin Plenio , Ilai Schwartz , Qiong Chen , Alex Retzker
Abstract: A method of hyperpolarisation of nuclear spins in one or more particle(s) moving relatively to a polarisation structure, wherein a polarisation of electron spins in the polarisation structure is transferred to the nuclear spins in the particle(s), wherein for one or more of the moving particle(s) within 20 nm from a surface of the polarisation structure, the correlation time of the interaction with the nearest polarisation structure electron spin due to the molecular motion is larger than the inverse of the nuclear Larmor frequency; the electron spins in the polarisation structure are polarised above thermal equilibrium; and the polarisation transfer is performed resonantly.
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