公开(公告)号：US20240058453A1

公开(公告)日：2024-02-22

申请号：US18364891

申请日：2023-08-03

Applicant: Virginia Commonwealth University ,  Johns Hopkins University

Inventor： Barbara D. Boyan ,  Zvi Schwartz ,  David J. Cohen ,  Jingyao Deng ,  David Scott Wilson

IPC: A61K47/32 ,  A61K9/06 ,  A61K38/17 ,  A61K38/14 ,  A61K31/7036 ,  A61K31/05 ,  A61K47/22 ,  A61K47/10

CPC classification number: A61K47/32 ,  A61K9/06 ,  A61K38/1774 ,  A61K38/14 ,  A61K31/7036 ,  A61K31/05 ,  A61K47/22 ,  A61K47/10

Abstract: Provided herein is a copper-free, non-toxic click hydrogel that exhibits minimal swelling. The hydrogel may be used as a sealant and/or as a delivery vehicle for local administration of substances of interest, such as therapeutic agents.

公开(公告)号：US20240001270A1

公开(公告)日：2024-01-04

申请号：US18251585

申请日：2021-10-25

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Weining Wang ,  Zan Zhu ,  Ping Xu

IPC: B01D39/16 ,  A01N33/12 ,  A01P1/00 ,  A01N25/08 ,  B01D39/20

CPC classification number: B01D39/1623 ,  A01N33/12 ,  A01P1/00 ,  A01N25/08 ,  B01D39/2027 ,  B01D2239/0478 ,  B01D2239/0631 ,  B01D2239/1225

Abstract: A filter having antibacterial activity is provided. The filter comprises at least one layer of polymer nanofibers and antibacterial particles positioned on or within the at least one layer of polymer nanofibers, wherein the antibacterial particles comprise a quaternary ammonium compound grafted onto a surface of a metal-organic framework. Methods of manufacturing the filter and decontaminating a fluid are also provided.

公开(公告)号：US20230407304A1

公开(公告)日：2023-12-21

申请号：US18253529

申请日：2021-11-19

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Zvi SCHWARTZ ,  Barbara D. BOYAN ,  Kayla M. SCOTT ,  Joshua D. COHEN

IPC: C12N15/113 ,  A61K31/7105 ,  A61P19/02

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61P19/02

Abstract: Inflammatory processes, particularly those arising from trauma or injury to the region of a bone joint, are causative of osteoarthritis (OA). A composition comprising microRNA-122, microRNA-122 mimic, and/or an inhibitor of microRNA-451 reduces or inhibits inflammatory mediators in articular chondrocytes and related cells. When administered to a subject at risk of developing OA, development of OA and/or progression of OA disease are inhibited, and cartilaginous structures are preserved in the joint. Since joint injury is associated with subsequent development of OA, the treatment is particularly suitable following an acute injury to a joint.

公开(公告)号：US20230197249A1

公开(公告)日：2023-06-22

申请号：US17925538

申请日：2021-04-28

Applicant: Virginia Commonwealth University

Inventor： Siyong Kim

IPC: G16H30/40 ,  G06N3/0464 ,  G06T11/60 ,  A61B5/055

CPC classification number: G16H30/40 ,  G06N3/0464 ,  G06T11/60 ,  A61B5/055 ,  G06T2210/41

Abstract: Disclosed are various approaches for generating synthetic computer tomography (CT) images using magnetic resonance imaging A patient body outline (PBO) of a patient is obtained. Then, a magnetic resonance image set in a limited field of view (MRI-in-LFOV) of the patient is converted into a synthetic computed tomography (CT) image set in limited field of view (syn-CT-in-LFOV) of the patient. Next, the syn-CT-in-LFOV is expanded to a synthetic CT image set in full field of view (syn-CT-in-FFOV) of the patient based at least in part on the PBO.

公开(公告)号：US11673913B2

公开(公告)日：2023-06-13

申请号：US16408711

申请日：2019-05-10

Applicant: Virginia Commonwealth University

Inventor： Heather R. Lucas ,  Ricardo D. Fernandez

IPC: C07K1/30 ,  C07K14/47 ,  C07K1/36 ,  G01N33/68 ,  C12N15/70

CPC classification number: C07K1/303 ,  C07K1/36 ,  C07K14/47 ,  C12N15/70 ,  G01N33/68 ,  G01N2800/2835

Abstract: Tetrameric N-terminally acetylated α-synuclein is prepared by transforming an expression system with an expression vector encoding α-synuclein, wherein the expression system expresses a native NatB acetylase complex or ortholog thereof and/or wherein an exogenous NatB acetylase complex or ortholog thereof is co-expressed in the expression system, inducing protein expression in the transformed expression system, lysing cells in the transformed expression system to produce a cell lysate, performing salt precipitation of the cell lysate, recovering tetrameric N-terminally acetylated α-synuclein by centrifugation, and purifying the tetrameric N-terminally acetylated α-synuclein. Compositions comprising the same and methods for identifying compounds that stabilize natively folded tetrameric α-synuclein are also provided.

公开(公告)号：US11661433B2

公开(公告)日：2023-05-30

申请号：US17053837

申请日：2019-05-09

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Matthew Hartman ,  Koushambi Mitra

IPC: C07F15/00 ,  A61K31/282 ,  A61K41/00

CPC classification number: C07F15/0093 ,  A61K31/282 ,  A61K41/0042 ,  A61K41/0057

Abstract: Near-infrared activatable fluorescent small molecules for the photodynamic treatment of cancer are provided. Methods of treatment include contacting a plurality of cells of the cancer with a near-infrared activatable fluorescent small molecule and directing a near-IR light to the molecule for an amount of time sufficient to induce release of the active platinum species and a reactive oxygen species.

公开(公告)号：US20230071308A1

公开(公告)日：2023-03-09

申请号：US17794875

申请日：2021-01-22

Applicant: Virginia Commonwealth University

Inventor： Worth LONGEST ,  Connor HOWE ,  Dale FARKAS ,  Sarah STRICKLER ,  Vijaya RANI ,  Ahmad EL-ACHWAY

IPC: A61M15/00 ,  A61M15/08

Abstract: Proposed devices operate on positive pressure with as little as 5-6 ml of air and can efficiently empty (emitted doses >80%) and deliver the aerosol to infant lungs (lung delivery efficiency of ˜60% of the loaded dose). Significant features include internal flow structure of the air-jet DPI, automatic gas sources, infant-specific interfaces, small diameter nasopharyngeal tubes, sealed nasal prongs, 3D rod array preceding patient interface, nasal CPAP rapid aerosol delivery system, nasal CPAP streamlined interface, multidose storage and delivery unit, and pressure sensing near the infant airways (at the nasal cannula interface).

公开(公告)号：US11531982B2

公开(公告)日：2022-12-20

申请号：US16910670

申请日：2020-06-24

Applicant: University of Florida Research Foundation, Inc. ,  Virginia Commonwealth University

Inventor： My T. Thai ,  Thang N. Dinh ,  Lan Nguyen ,  Truc Nguyen

IPC: G06Q20/36 ,  G06Q20/06 ,  H04L9/06 ,  H04L9/08

Abstract: An exemplary transaction sharding method comprises splitting a distributed ledger into a plurality of shards; and storing a shard across the subgroup of computer nodes associated with the shard. Such a method further comprises assigning a new transaction to one of the plurality of shards, wherein assigning the new transaction comprises iteratively choosing one of the plurality of shards; in each iteration, determining a transaction-to-shard score measuring a probability that a subgroup of computing nodes associated with the chosen shard for the current iteration would be involved in a same-shard transaction for the new transaction; in each iteration, determining a latency-to-shard score by estimating a confirmation latency of the new transaction under the chosen shard for the current iteration; and selecting the new transaction to be assigned to the shard based on a combination of the transaction-to-shard score and the latency-to-shard score.

公开(公告)号：US20220323634A1

公开(公告)日：2022-10-13

申请号：US17713803

申请日：2022-04-05

Applicant: The United States of America, as represented by the Secretary of Agriculture ,  H&H Medical Corporation ,  Virginia Commonwealth University

Inventor： Judson V. Edwards ,  Nicolette T. Prevost ,  Elena E. Graves ,  Joseph Dacorta ,  Dorne Yager

IPC: A61L15/44 ,  A61L15/40 ,  D06M10/06 ,  D06M10/10 ,  D06M15/03 ,  D06M11/77 ,  D06M11/45

Abstract: The invention relates to fabric compositions with improved hemostatic properties comprising attached a zeolite, a zeolite/pectin complex, or a mixture thereof, and methods of preparing such fabric compositions.

公开(公告)号：US11458144B1

公开(公告)日：2022-10-04

申请号：US17560795

申请日：2021-12-23

Applicant: King Abdulaziz University ,  The Children's Hospital of Philadelphia ,  Virginia Commonwealth University

Inventor： Moustafa E. El-Araby ,  Abdelsatter M. Omar ,  Osheiza Abdulmalik ,  Martin K. Safo

IPC: A61K31/5377 ,  A61K31/341 ,  A61K31/4155 ,  A61P7/06 ,  A61K31/496 ,  A61K31/351 ,  A61K31/4525

Abstract: Methods for administering compounds provide a rapid treatment for sickle cell disease (SCD) to inhibit or reverse red blood cell sickling. The compounds are a group of 5-hydroxymethylfurfural (5-HMF) analogs modified to increase water-solubility. The compounds can be formulated in an aqueous carrier and administered intravenously for immediate uptake into red blood cells (RBCs) within hours, rather than days or weeks. In vitro experiments demonstrated rapid uptake into RBCs and increased O2 affinity of HbS to an equilibrium point within 30 to 90 minutes. The compounds have a desired level of safety as well as a short half-life, both of which are compatible with acute usage. Thus, the methods of treatment rapidly achieve therapeutic steady-state drug levels, making it possible to deliver a treatment in critical emergency care situations to prevent, reverse and otherwise treat acute sickling or anemia.