公开(公告)号：US08503981B1

公开(公告)日：2013-08-06

申请号：US13289711

申请日：2011-11-04

Applicant: Wen Xue ,  Raymond E. Reeves ,  Ryan A. Wick

Inventor： Wen Xue ,  Raymond E. Reeves ,  Ryan A. Wick

IPC: H04M1/66 ,  H04L29/06 ,  G06F3/00 ,  G06F3/048 ,  G06F15/173

CPC classification number: H04L67/02 ,  H04L63/0876 ,  H04L63/101 ,  H04L63/18 ,  H04W4/12 ,  H04W12/08

Abstract: A method of providing network access notification is provided. The method can include receiving an identification for a wireless device at an access gateway and determining that the wireless device is not authorized to access a communication network based on the received identification. The method can further include sending a rejection notification to a messaging node indicating that the wireless device is not authorized to access the communication network and sending an access notification from the messaging node to an authorization device when the rejection notification is received at the messaging node. The access notification can include network access information to enable the wireless device to access the communication network. The authorization device is determined based on the identification. The method can also include receiving a response from the authorization device based on the network access information, and enabling access from the wireless device to the communication network.

Abstract translation: 提供了一种提供网络访问通知的方法。 该方法可以包括在接入网关处接收无线设备的标识，并且基于接收的标识确定无线设备不被授权接入通信网络。 该方法还可以包括：在消息收发节点处接收到拒绝通知时，向消息接发节点发送拒绝通知，指示无线设备未被授权访问通信网络，并且将消息收发节点的接入通知发送到授权设备。 访问通知可以包括网络访问信息以使得无线设备能够访问通信网络。 基于识别确定授权装置。 该方法还可以包括基于网络接入信息接收来自授权设备的响应，并且允许从无线设备到通信网络的接入。

公开(公告)号：US08185936B1

公开(公告)日：2012-05-22

申请号：US12502018

申请日：2009-07-13

Applicant: Raymond Emilio Reeves ,  Ryan Alan Wick ,  Wen Xue

Inventor： Raymond Emilio Reeves ,  Ryan Alan Wick ,  Wen Xue

IPC: H04L29/06 ,  H04L9/00

CPC classification number: H04W12/06 ,  H04L9/0891 ,  H04L9/321 ,  H04L63/102 ,  H04L2209/80 ,  H04W8/20 ,  H04W12/08

Abstract: A method and medium are provided for automatically updating user profiles based on authentication failures associated with network-access requests from mobile communications devices. A mobile communications device requests access to a mobile network and the access is rejected due to an authentication failure. Upon communicating a rejection message to the mobile communications device, the authentication server communicates a network-access rejection notification to a user-profile updating server that resets network-generated authentication credentials and provides updated profiles containing reset credentials to a provisioning server. Subsequent access requests from the mobile device are handled through a dedicated profile-provisioning home agent until the device is updated, at which time network access can be granted through a more conventional home agent.

Abstract translation: 提供了一种基于与来自移动通信设备的网络访问请求相关联的认证失败来自动更新用户简档的方法和介质。 移动通信设备请求对移动网络的访问，并且由于认证失败而拒绝访问。 在向移动通信设备传达拒绝消息时，认证服务器将网络访问拒绝通知传送到用户简档更新服务器，该用户简档更新服务器重置网络生成的认证凭证，并向配置服务器提供包含重置凭据的更新的配置文件。 来自移动设备的随后的访问请求通过专用简档配置归属代理来处理，直到设备被更新，此时可以通过更传统的归属代理授予网络访问。

公开(公告)号：US20110289410A1

公开(公告)日：2011-11-24

申请号：US12782472

申请日：2010-05-18

Applicant: Lyle Walter Paczkowski ,  Farni B. Weaver ,  Talat Jamshidi ,  Nicolas A. Nehme Antoun ,  Wen Xue

Inventor： Lyle Walter Paczkowski ,  Farni B. Weaver ,  Talat Jamshidi ,  Nicolas A. Nehme Antoun ,  Wen Xue

IPC: G06F17/00 ,  G06F3/01 ,  H04M3/42

CPC classification number: G10L21/06 ,  G11B27/034 ,  G11B27/34

Abstract: A wireless communication device comprises a wireless communication interface, a processing system, and a user interface. The wireless communication interface is configured to wirelessly receive a mixed media signal comprising a plurality of audio streams originating from different source devices. The processing system is configured to isolate the audio streams and generate graphical representations of each one of the audio streams. The user interface is configured to display the graphical representations of each one of the audio streams and receive audio stream modification instructions from a user. The processing system is configured to process the audio stream modification instructions to generate at least one modified audio stream based on the audio stream modification instructions. The user interface is configured to display a graphical representation of the modified audio stream and audibly output a modified mixed media signal comprising the modified audio stream.

Abstract translation: 无线通信设备包括无线通信接口，处理系统和用户接口。 无线通信接口被配置为无线地接收包括源自不同源设备的多个音频流的混合媒体信号。 处理系统被配置为隔离音频流并且生成每个音频流的图形表示。 用户界面被配置为显示每个音频流的图形表示，并从用户接收音频流修改指令。 处理系统被配置为处理音频流修改指令以基于音频流修改指令生成至少一个修改的音频流。 用户界面被配置为显示经修改的音频流的图形表示，并且可听地输出包括经修改的音频流的修改的混合媒体信号。

公开(公告)号：US08054754B1

公开(公告)日：2011-11-08

申请号：US12508510

申请日：2009-07-23

Applicant: Wen Xue ,  Raymond E. Reeves ,  Ryan A. Wick

Inventor： Wen Xue ,  Raymond E. Reeves ,  Ryan A. Wick

IPC: G01R31/08

CPC classification number: H04L65/1006 ,  H04L65/1083 ,  H04L65/80 ,  H04L69/40 ,  H04M7/0084

Abstract: Exemplary methods and systems may provide a soft-inactivity notification during a VoIP call, which according to an exemplary embodiment involves a SIP session and packet-data communications between participants in the VoIP call. The method comprises (a) detecting that packet-data communications in the VoIP call have been interrupted; (b) in response to determining that the packet-data communications have been interrupted, making a determination as to whether or not the SIP session is active; (c) if the SIP session is active, then initiating a soft-inactivity notification procedure; and (d) otherwise, if the SIP session is inactive, refraining from initiating the soft-inactivity notification procedure. The soft-inactivity notification thus notifies a user that while the call has been interrupted, the call may be re-established without requiring the user to reconnect.

Abstract translation: 示范性方法和系统可以在VoIP呼叫期间提供软不活动通知，其根据示例性实施例涉及VoIP会话中的参与者之间的SIP会话和分组数据通信。 该方法包括：（a）检测VoIP呼叫中的分组数据通信已被中断; （b）响应于确定分组数据通信已被中断，确定SIP会话是否活动; （c）如果SIP会话是活动的，则启动软休眠通知过程; 和（d）否则，如果SIP会话不活动，则不启动软休眠通知过程。 因此，软休息不通知通知用户在呼叫已被中断的情况下，可以重新建立呼叫，而不需要用户重新连接。

公开(公告)号：US20100273660A1

公开(公告)日：2010-10-28

申请号：US12617624

申请日：2009-11-12

Applicant: Lars Zender ,  Wen Xue ,  Scott Powers ,  Scott W. Lowe

Inventor： Lars Zender ,  Wen Xue ,  Scott Powers ,  Scott W. Lowe

IPC: C40B20/06 ,  C07K16/00 ,  C40B50/04 ,  C40B40/06 ,  C12N5/09 ,  C12Q1/68 ,  G01N33/574

CPC classification number: A01K67/0271 ,  A01K2217/058 ,  A01K2267/0331 ,  C07K14/4747 ,  C12N15/1079 ,  C12N15/8509 ,  C12N2510/04 ,  C12N2517/02 ,  C12N2799/027 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/178 ,  G01N33/5044 ,  G01N33/5067 ,  G01N33/5088 ,  G01N33/57415 ,  G01N33/57438 ,  G01N2500/00 ,  G01N2800/50 ,  G01N2800/52

Abstract: In some aspects, the invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver cancer, in understanding the genetic alterations that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model of this invention is made by altering hepatocytes to increase oncogene expression, to reduce tumor suppressor gene expression or both and by transplanting the resulting hepatocytes into a recipient non-human animal.The present invention also provides methods for identifying and validating tumor suppressor genes by screening pools of shRNAs that target genomic regions deleted in human cancers, such as human hepatocellular carcinomas. The present invention also provides validated tumor suppressor genes, and methods of inhibiting cell proliferation and/or tumor growth, for example by expression of such tumor suppressor genes.

Abstract translation: 在一些方面，本发明提供了用于肝细胞癌的遗传易处的非人动物模型。 该模型除其他外，有助于理解肝癌的分子机制，了解导致化学耐药性或预后不良的遗传改变，以及鉴定和评估针对肝细胞癌的新疗法。 本发明的肝癌模型通过改变肝细胞以增加癌基因表达，减少肿瘤抑制基因表达或两者并通过将所得肝细胞移植到受体非人动物中来制备。 本发明还提供了通过筛选靶向人类癌症中缺失的基因组区域（例如人肝细胞癌）的shRNA的鉴定和验证肿瘤抑制基因的方法。 本发明还提供了经过验证的肿瘤抑制基因，以及例如通过表达这种肿瘤抑制基因来抑制细胞增殖和/或肿瘤生长的方法。

公开(公告)号：US07031700B1

公开(公告)日：2006-04-18

申请号：US10716845

申请日：2003-11-19

Applicant: Farni Weaver ,  Piyush Jethwa ,  Jesse Grindeland ,  David Welch ,  Wen Xue ,  Mike McMullen ,  Edward Ross

Inventor： Farni Weaver ,  Piyush Jethwa ,  Jesse Grindeland ,  David Welch ,  Wen Xue ,  Mike McMullen ,  Edward Ross

IPC: H04Q7/20

CPC classification number: H04W4/06 ,  H04L12/1818 ,  H04L12/1845 ,  H04L12/189 ,  H04L65/00 ,  H04W4/021 ,  H04W4/023

Abstract: A method and system for location-based group conference initiation is provided. A server will receive a request from a user to initiate a media conference, and the server will then initiate a conference with members of a group who are located in a designated location. The request may indicate a group of users who are candidates to be invited to the conference, and the location at issue. Given the request, the server will determine which of the candidate users are currently located within the zone at issue. And the server will then invite each of those candidate users to participate in the conference.

Abstract translation: 提供了基于位置的组会议启动的方法和系统。 服务器将收到用户发起媒体会议的请求，然后服务器将启动与位于指定位置的组的成员进行会议。 该请求可以指示被邀请参加会议的候选人的一组用户以及所讨论的位置。 根据请求，服务器将确定当前所在的区域中哪些候选用户当前位于该区域。 然后，服务器将邀请每个候选用户参加会议。

公开(公告)号：US06741695B1

公开(公告)日：2004-05-25

申请号：US10115341

申请日：2002-04-03

Applicant: Von McConnell ,  Wen Xue ,  Baoquan Zhang ,  Jesse Money

Inventor： Von McConnell ,  Wen Xue ,  Baoquan Zhang ,  Jesse Money

IPC: H04M700

CPC classification number: H04L65/104 ,  H04L12/66 ,  H04L65/1006 ,  H04L65/103 ,  H04L65/1069 ,  H04M3/4228 ,  H04M7/1225 ,  H04M2207/203

Abstract: An interface engine that is communicatively connected to a packet-switched network and to a legacy circuit-switched network uses a call processing protocol, such as the session initiation protocol (SIP), for packet-switched network communications and uses a legacy signaling protocol, such as IS-41, for legacy circuit-switched communications. In response to a registration request initiated by a subscriber device on the packet-switched network, the interface engine obtains a service profile for the subscriber from a call processing system, such as a home location register (HLR), of the legacy circuit-switched network. Service parameters derived from the service profile and stored in a service database may be used to apply services on the packet-switched network for the subscriber device.

Abstract translation: 通信地连接到分组交换网络和传统电路交换网络的接口引擎使用诸如会话发起协议（SIP）的呼叫处理协议进行分组交换网络通信，并且使用传统信令协议， 例如IS-41，用于传统电路交换通信。 响应于分组交换网络上的用户设备发起的注册请求，接口引擎从诸如归属位置寄存器（HLR）的呼叫处理系统获得用于该用户的服务简档，该传统电路交换 网络。 可以使用从服务简档导出并存储在服务数据库中的服务参数来为用户设备在分组交换网络上应用服务。

公开(公告)号：US6114535A

公开(公告)日：2000-09-05

申请号：US479294

申请日：2000-01-06

Applicant: Wen-Xue Wu

Inventor： Wen-Xue Wu

IPC: C07D213/80 ,  C07D401/04 ,  C07D401/14

CPC classification number: C07D213/80 ,  C07D401/04 ,  Y02P20/582

Abstract: The present invention provides a process to prepare a pyridine-2,3-dicarboxylate derivative via the reaction of a dialkyl alkoxy(or alkylthio)oxalacetate with an appropriately substituted acrolein compound in the presence of an ammonia source and a solvent. The present invention also provides useful intermediate compounds of formula IV. ##STR1##

Abstract translation: 本发明提供了在氨源和溶剂的存在下，通过二烷基烷氧基（或烷硫基）草酸乙酯与适当取代的丙烯醛化合物的反应来制备吡啶-2,3-二羧酸酯衍生物的方法。 本发明还提供有用的式IV的中间体化合物。

公开(公告)号：US5925764A

公开(公告)日：1999-07-20

申请号：US097871

申请日：1998-06-15

Applicant: Wen-Xue Wu

Inventor： Wen-Xue Wu

IPC: C07D213/803 ,  C07C69/52 ,  C07C229/30 ,  C07C323/58 ,  C07D213/00 ,  C07D213/79 ,  C07D213/80 ,  C07D401/04

CPC classification number: C07D213/80 ,  C07C229/30 ,  Y02P20/582

Abstract: The present invention provides a process to prepare a pyridine-2,3-dicarboxylate derivative via the reaction of a dailkyl alkoxy(or alkylthio)oxalacetate with an appropriately substituted acrolein compound in the presence of an ammonia source and a solvent.The present invention also provides useful intermediate compounds of formula IV. ##STR1##

Abstract translation: 本发明提供了在氨源和溶剂的存在下，通过二烷基烷氧基（或烷硫基）草酸乙酯与适当取代的丙烯醛化合物的反应来制备吡啶-2,3-二羧酸酯衍生物的方法。 本发明还提供有用的式IV的中间体化合物。

公开(公告)号：US09907007B1

公开(公告)日：2018-02-27

申请号：US13558419

申请日：2012-07-26

Applicant: Wen Xue ,  Jay Cole

Inventor： Wen Xue ,  Jay Cole

IPC: H04W24/00 ,  H04W36/30 ,  H04W88/06

CPC classification number: H04W36/30 ,  H04W88/06 ,  Y02D70/00

Abstract: Methods and systems for selective scanning and connecting to a wireless network are described. In an example, a mobile device may be configured to scan for availability of a wireless network and measure, at the mobile device, signal strengths of a wireless signal from the wireless network. Also, the mobile device may be configured to determine a rate of signal strength change for the wireless signal from the wireless network based on the measured signal strengths; and compare the rate of signal strength change to a threshold value. If the rate of signal strength change is less than the threshold value, the mobile device may be configured to establish a connection with the wireless network; if not, the mobile device may be configured to stop scanning for the wireless network.