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    ONCOGENOMICS-BASED RNAi SCREEN AND USE THEREOF TO IDENTIFY NOVEL TUMOR SUPPRESSORS
    1.
    发明申请
    ONCOGENOMICS-BASED RNAi SCREEN AND USE THEREOF TO IDENTIFY NOVEL TUMOR SUPPRESSORS 审中-公开
    基于ONCOGENOMICS的RNAi筛选及其用于鉴定新型肿瘤抑制剂

    公开(公告)号：US20100273660A1

    公开(公告)日：2010-10-28

    申请号：US12617624

    申请日：2009-11-12

    申请人： Lars Zender ,  Wen Xue ,  Scott Powers ,  Scott W. Lowe

    发明人： Lars Zender ,  Wen Xue ,  Scott Powers ,  Scott W. Lowe

    IPC分类号： C40B20/06 ,  C07K16/00 ,  C40B50/04 ,  C40B40/06 ,  C12N5/09 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： A01K67/0271 ,  A01K2217/058 ,  A01K2267/0331 ,  C07K14/4747 ,  C12N15/1079 ,  C12N15/8509 ,  C12N2510/04 ,  C12N2517/02 ,  C12N2799/027 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/178 ,  G01N33/5044 ,  G01N33/5067 ,  G01N33/5088 ,  G01N33/57415 ,  G01N33/57438 ,  G01N2500/00 ,  G01N2800/50 ,  G01N2800/52

    摘要： In some aspects, the invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver cancer, in understanding the genetic alterations that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model of this invention is made by altering hepatocytes to increase oncogene expression, to reduce tumor suppressor gene expression or both and by transplanting the resulting hepatocytes into a recipient non-human animal.The present invention also provides methods for identifying and validating tumor suppressor genes by screening pools of shRNAs that target genomic regions deleted in human cancers, such as human hepatocellular carcinomas. The present invention also provides validated tumor suppressor genes, and methods of inhibiting cell proliferation and/or tumor growth, for example by expression of such tumor suppressor genes.

    摘要翻译： 在一些方面，本发明提供了用于肝细胞癌的遗传易处的非人动物模型。 该模型除其他外，有助于理解肝癌的分子机制，了解导致化学耐药性或预后不良的遗传改变，以及鉴定和评估针对肝细胞癌的新疗法。 本发明的肝癌模型通过改变肝细胞以增加癌基因表达，减少肿瘤抑制基因表达或两者并通过将所得肝细胞移植到受体非人动物中来制备。 本发明还提供了通过筛选靶向人类癌症中缺失的基因组区域（例如人肝细胞癌）的shRNA的鉴定和验证肿瘤抑制基因的方法。 本发明还提供了经过验证的肿瘤抑制基因，以及例如通过表达这种肿瘤抑制基因来抑制细胞增殖和/或肿瘤生长的方法。

    Orthotopic, controllable, and genetically tractable non-human animal model for cancer
    3.
    发明申请
    Orthotopic, controllable, and genetically tractable non-human animal model for cancer 审中-公开
    原位，可控和可遗传的非人类动物模型

    公开(公告)号：US20090022685A1

    公开(公告)日：2009-01-22

    申请号：US11893611

    申请日：2007-08-15

    申请人： Scott W. Lowe ,  Gregory J. Hannon ,  Lars Zender ,  Wen Xue ,  Ross Dickins

    发明人： Scott W. Lowe ,  Gregory J. Hannon ,  Lars Zender ,  Wen Xue ,  Ross Dickins

    IPC分类号： A61K38/20 ,  A61K35/12 ,  A01K67/027 ,  G01N33/574 ,  A61P31/00 ,  C12Q1/02 ,  A61K31/7088 ,  A61K31/7105

    CPC分类号： A01K67/0271 ,  A01K2267/0331 ,  C07K14/82 ,  C12N15/1135 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/50 ,  C12N2799/027 ,  C12N2830/006

    摘要： This invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding the molecular mechanisms of liver cancer, in understanding the genetic alterations (e.g., in oncogenes and tumor suppressor genes) that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model of this invention is made by altering hepatocytes to increase oncogene expression, to reduce tumor suppressor gene expression or both, preferably by inducible, reversible, and/or tissue specific expression of double-stranded RNA molecules that interfere with the expression of a target gene, and by transplanting the resulting hepatocytes into a recipient non-human animal. The invention further provides a method to treat cancer involving cooperative interactions between a tumor cell senescence program and the innate immune system.

    摘要翻译： 本发明提供了用于肝细胞癌的遗传易处理的非人动物模型。 该模型特别有助于了解肝癌的分子机制，了解导致化疗耐药性或预后不良的遗传改变（例如，致癌基因和肿瘤抑制基因），以及鉴定和评估针对肝细胞癌的新疗法 。 本发明的肝癌模型通过改变肝细胞以增加癌基因表达，减少肿瘤抑制基因表达或两者，优选通过诱导的，可逆的和/或组织特异性表达的双链RNA分子来制备，所述双链RNA分子干扰表达 靶基因，并将所得肝细胞移植到受体非人动物中。 本发明还提供了一种治疗涉及肿瘤细胞衰老程序与先天免疫系统之间协同作用的癌症的方法。

    Regulating internet traffic that is communicated through anonymizing gateways
    4.
    发明授权
    Regulating internet traffic that is communicated through anonymizing gateways 有权
    调节通过匿名网关传送的互联网流量

    公开(公告)号：US08683063B1

    公开(公告)日：2014-03-25

    申请号：US12691499

    申请日：2010-01-21

    申请人： Raymond Emilio Reeves ,  Prabhat Karki ,  Wen Xue ,  Ryan Alan Wick

    发明人： Raymond Emilio Reeves ,  Prabhat Karki ,  Wen Xue ,  Ryan Alan Wick

    IPC分类号： G06F15/16

    CPC分类号： H04L63/1441 ,  H04L61/103 ,  H04L61/2539 ,  H04L63/0227 ,  H04L2463/146

    摘要： A medium and method are provided for preventing undesired data from being communicated through a network. In one aspect, the method comprises the method comprises receiving from an anonymizing device an indication of an undesired data communication and an identification of one or more of a computing device responsible for said communication and a user responsible for said communication; on the basis of specified criteria, determining whether said indication is valid; when said indication is valid, incrementing a cumulative instance count that sums a number of instances associated with one or more of the computing device and the user; and, when said cumulative count exceeds a predetermined threshold number of instances, implementing a measure to prevent a further undesired data communication from said computing device.

    摘要翻译： 提供了一种介质和方法，用于防止通过网络传送不期望的数据。 一方面，该方法包括该方法包括从匿名设备接收不期望的数据通信的指示和负责所述通信的计算设备中的一个或多个的标识以及负责所述通信的用户; 根据指定的标准确定所述指示是否有效; 当所述指示有效时，递增累积实例计数，其累加与所述计算设备中的一个或多个与所述用户相关联的实例的数量; 并且当所述累积计数超过预定阈值数量的实例时，实施用于防止来自所述计算设备的进一步不期望的数据通信的措施。

    Wireless device content searching
    6.
    发明授权
    Wireless device content searching 有权
    无线设备内容搜索

    公开(公告)号：US08484182B1

    公开(公告)日：2013-07-09

    申请号：US13014133

    申请日：2011-01-26

    申请人： Ryan Wick ,  Raymond Emilio Reeves ,  Wen Xue

    发明人： Ryan Wick ,  Raymond Emilio Reeves ,  Wen Xue

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30943

    摘要： A system and method of searching data stored on a wireless device is provided. Using a search request to search data stored on a wireless device which is received at a first processing node from a second processing node, the first processing node performs a search of the data stored on the wireless device. Search results are generated at the first processing node based on the search, and the search results are provided from the first processing node to the second processing node.

    摘要翻译： 提供了一种搜索存储在无线设备上的数据的系统和方法。 使用搜索请求从第二处理节点搜索存储在第一处理节点处接收的无线设备上的数据，第一处理节点执行对存储在无线设备上的数据的搜索。 基于搜索在第一处理节点生成搜索结果，并且从第一处理节点向第二处理节点提供搜索结果。

    Method and system for facilitating determination of call-drop locations in a wireless network
    7.
    发明授权
    Method and system for facilitating determination of call-drop locations in a wireless network 有权
    用于有助于确定无线网络中的呼叫丢弃位置的方法和系统

    公开(公告)号：US07206573B1

    公开(公告)日：2007-04-17

    申请号：US10658353

    申请日：2003-09-09

    申请人： Farni Weaver ,  Shiva Narayanabhatla ,  Piyush Jethwa ,  Jesse Grindeland ,  Wen Xue

    发明人： Farni Weaver ,  Shiva Narayanabhatla ,  Piyush Jethwa ,  Jesse Grindeland ,  Wen Xue

    IPC分类号： H04Q7/20

    CPC分类号： H04W16/18 ,  H04W4/02 ,  H04W24/08

    摘要： A method and system for automatically providing to a network entity in a wireless network, a location of a mobile station where a call is dropped (i.e., a call-drop location). The mobile station or base station may determine that a call in which the mobile station was engaged has been dropped. In response to determining that a call has been dropped, the mobile station or base station may obtain the location of the mobile station. The call-drop location can be used to identify those areas of the wireless network needing improved radio coverage.

    摘要翻译： 一种用于向无线网络中的网络实体自动提供呼叫被丢弃的移动站的位置（即，呼叫丢弃位置）的方法和系统。 移动站或基站可以确定移动站所在的呼叫已经被丢弃。 响应于确定呼叫已经被丢弃，移动台或基站可以获得移动台的位置。 呼叫丢弃位置可用于识别需要改进的无线覆盖的无线网络的那些区域。

    Methods and systems for selective scanning and connecting to a wireless network
    8.
    发明授权
    Methods and systems for selective scanning and connecting to a wireless network 有权

    公开(公告)号：US09907007B1

    公开(公告)日：2018-02-27

    申请号：US13558419

    申请日：2012-07-26

    申请人： Wen Xue ,  Jay Cole

    发明人： Wen Xue ,  Jay Cole

    IPC分类号： H04W24/00 ,  H04W36/30 ,  H04W88/06

    CPC分类号： H04W36/30 ,  H04W88/06 ,  Y02D70/00

    摘要： Methods and systems for selective scanning and connecting to a wireless network are described. In an example, a mobile device may be configured to scan for availability of a wireless network and measure, at the mobile device, signal strengths of a wireless signal from the wireless network. Also, the mobile device may be configured to determine a rate of signal strength change for the wireless signal from the wireless network based on the measured signal strengths; and compare the rate of signal strength change to a threshold value. If the rate of signal strength change is less than the threshold value, the mobile device may be configured to establish a connection with the wireless network; if not, the mobile device may be configured to stop scanning for the wireless network.

    Intelligent routing of voice-over-packet calls
    10.
    发明授权
    Intelligent routing of voice-over-packet calls 有权
    语音数据包呼叫的智能路由

    公开(公告)号：US08767555B1

    公开(公告)日：2014-07-01

    申请号：US12464242

    申请日：2009-05-12

    申请人： Wen Xue ,  Stevan A. Klesper ,  Arun Manroa

    发明人： Wen Xue ,  Stevan A. Klesper ,  Arun Manroa

    IPC分类号： H04M7/12 ,  H04W40/00

    CPC分类号： H04M7/1205 ,  H04L45/00 ,  H04L65/1069 ,  H04W40/00 ,  H04W40/02

    摘要： What is disclosed is a method of operating a call processing system to route a voice-over-packet call between a wireless communication device and a destination device, where the destination device is located in a geographic area served by a communication network. The method includes receiving a request for the call originating from the wireless communication device, where the request comprises a destination identifier of the destination device and a location identifier of the wireless communication device. The method also includes processing the destination identifier and the location identifier to determine if the wireless communication device is located in the geographic area served by the communication network. The method also includes selecting a first route for the call from a packet network serving the wireless communication device to the communication network serving the destination device if the wireless communication device is located in the geographic area served by the communication network, and selecting a second route for the call from the packet network serving the wireless communication device to the communication network serving the destination device if the wireless communication device is not located in the geographic area served by the communication network. The method also includes transferring routing instructions for the call.

    摘要翻译： 公开的是一种操作呼叫处理系统以在无线通信设备和目的地设备之间路由分组呼叫的方法，其中目的地设备位于由通信网络服务的地理区域中。 该方法包括接收对于从无线通信设备发起的呼叫的请求，其中请求包括目的地设备的目的地标识符和无线通信设备的位置标识符。 该方法还包括处理目的地标识符和位置标识符，以确定无线通信设备是否位于由通信网络服务的地理区域中。 该方法还包括：如果无线通信设备位于由通信网络服务的地理区域中，则从服务于无线通信设备的分组网络到服务目的地设备的通信网络，选择用于呼叫的第一路由，并且选择第二路由 用于如果无线通信设备不在通信网络所服务的地理区域中，则从服务于无线通信设备的分组网络到服务目的设备的通信网络的呼叫。 该方法还包括传送呼叫的路由指令。