公开(公告)号：US09313831B2

公开(公告)日：2016-04-12

申请号：US14002229

申请日：2012-07-05

Applicant: Teruo Hayashinaka ,  Yoshihiro Yamashita ,  Yuji Fujii

Inventor： Teruo Hayashinaka ,  Yoshihiro Yamashita ,  Yuji Fujii

IPC: H05B6/08 ,  H05B6/12 ,  H05B6/06

CPC classification number: H05B6/08 ,  H05B6/065

Abstract: When the control unit makes both the first and second inverter circuits operational, the control unit controls the first and second inverter circuits by duty control such that an average heating output from the first inverter circuit reaches a predetermined first target heating output, and an average heating output from the second inverter circuit reaches a predetermined second target heating output. When the control unit makes one of the first and second inverter circuits operational in an automatic heating mode for automatic heating control according to a predetermined heating output sequence, the control unit inhibits the first and second inverter circuits from being controlled by the duty control.

Abstract translation: 当控制单元使第一和第二逆变器电路都工作时，控制单元通过占空比控制来控制第一和第二逆变器电路，使得来自第一逆变器电路的平均加热输出达到预定的第一目标加热输出，平均加热 来自第二逆变器电路的输出达到预定的第二目标加热输出。 当控制单元使第一和第二逆变器电路中的一个在根据预定加热输出顺序的自动加热控制的自动加热模式下运行时，控制单元禁止第一和第二逆变器电路由占空比控制。

公开(公告)号：US08916096B2

公开(公告)日：2014-12-23

申请号：US13618248

申请日：2012-09-14

Applicant: Yukinori Sakashita ,  Katsuaki Takahashi ,  Susumu Sakairi ,  Taku Sakazume ,  Yoshihiro Yamashita

Inventor： Yukinori Sakashita ,  Katsuaki Takahashi ,  Susumu Sakairi ,  Taku Sakazume ,  Yoshihiro Yamashita

IPC: G01N35/04 ,  G01N35/10 ,  G01N35/00

CPC classification number: G01N35/025 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1002 ,  G01N2035/00435 ,  G01N2035/00524 ,  G01N2035/00534 ,  G01N2035/0425 ,  G01N2035/0443 ,  G01N2035/0453 ,  G01N2035/0455 ,  G01N2035/0465 ,  Y10T436/11 ,  Y10T436/114165

Abstract: According to an embodiment of the disclosure, the analyzer includes a reagent driving disk that accommodates a reagent configured for analysis and that transports the reagent to a desired position, and a fixed disk that has a reagent stand-by position in which to make a reagent container containing the reagent, temporarily stand by, and a magnetic particles stirring position for stirring magnetic particles. A portion of the reagent stand-by position is constituted by a loading system. A reagent container moving unit moves reagent containers containing the reagent, between the reagent driving unit and the fixed disk, according to analytical request status. Providing in a part of the fixed disk the loading system constructed so that reagent containers containing the reagent can be mounted therein during operation enables changing of reagent containers, irrespective of an operational status of the reagent driving disk, and the system to having cold-storage functionality.

Abstract translation: 根据本公开的实施例，分析仪包括试剂驱动盘，其容纳配置用于分析的试剂并将试剂输送到期望的位置，以及固定盘，其具有试剂待机位置，以制备试剂 含有试剂的容器，临时待机，以及用于搅拌磁性颗粒的磁性颗粒搅拌位置。 试剂待机位置的一部分由加载系统构成。 试剂容器移动单元根据分析请求状态移动在试剂驱动单元和固定盘之间容纳试剂的试剂容器。 在固定盘的一部分中提供装载系统，其构造使得在操作期间可以将容纳有试剂的试剂容器安装在其中，从而能够改变试剂容器，而与试剂驱动盘的操作状态无关，并且具有冷藏 功能。

公开(公告)号：US08714332B2

公开(公告)日：2014-05-06

申请号：US13442136

申请日：2012-04-09

Applicant: Hitoshi Noguchi ,  Hiroshi Okada ,  Hiroyuki Usami ,  Yoshihiro Yamashita

Inventor： Hitoshi Noguchi ,  Hiroshi Okada ,  Hiroyuki Usami ,  Yoshihiro Yamashita

IPC: B60K6/387 ,  B60K6/48 ,  F16D25/0638 ,  F16D25/12

CPC classification number: B60K6/405 ,  B60K6/48 ,  F16H57/0412 ,  F16H57/0473 ,  F16H57/0476 ,  Y02T10/6221

Abstract: A main shaft has a shaft cylindrical portion extending from an outer periphery of a large-diameter portion. A drum has a drum cylindrical portion extending from an outer periphery of a drum plate portion. An axial forward end of the drum cylindrical portion is arranged in an inside of the shaft cylindrical portion. A frictional engagement unit of a clutch is provided in an inside of the shaft cylindrical portion. A motor generator has a rotor, which is firmly fitted to outer walls of the large-diameter portion and the shaft cylindrical portion and rotatable relative to a stator. A working-oil supply passage is formed in an inside of an input shaft.

Abstract translation: 主轴具有从大直径部的外周延伸的轴筒部。 滚筒具有从鼓板部分的外周延伸的滚筒圆柱形部分。 鼓圆筒部的轴向前端配置在轴圆筒部的内侧。 离合器的摩擦接合单元设置在轴圆筒部的内侧。 电动发电机具有转子，该转子牢固地配合到大直径部分的外壁和轴圆筒部分上并相对于定子可旋转。 工作油供给通道形成在输入轴的内侧。

公开(公告)号：US08132785B2

公开(公告)日：2012-03-13

申请号：US12309078

申请日：2007-07-11

Applicant: Yasunori Sugita ,  Yoshihiro Yamashita

Inventor： Yasunori Sugita ,  Yoshihiro Yamashita

IPC: F16J15/00

CPC classification number: F16K41/046 ,  F16J15/20 ,  F16K5/0694

Abstract: A shaft seal packing exhibits high sealability at the time of initial assembly and also exhibits, even after the packing is retightened, excellent sealability by an increased seal surface pressure obtained through an effect of pressing and by self-sealability obtained through an effect of fluid pressure. A shaft seal structure for a valve includes a body for a valve, a valve shaft, a valve disc disposed within the body so as to be rotatable or capable of ascending and descending, a valve shaft seal chamber having the valve shaft axially attached thereto, a shaft seal packing that is attached to the shaft seal chamber and comprises annular packing bodies stacked and substantially V-shaped in cross section, with stacked layer faces on the inner-diameter side of the packing bodies brought into tight contact with one another and stacked layer faces on the outer-diameter side of the packing bodies formed with prescribed gaps between the adjacent stacked layer faces. In the shaft seal structure for a valve, a tightening load on the packing bodies and fluid pressure are converted to a force in the diametrical direction owing to inclined angles of stacked layer faces on the inner-diameter side to attain a seal by a surface contact between the inner peripheral surface on the inner-diameter side and the outer peripheral surface of the valve shaft on a sliding side, and a lip part on the outer-diameter side is pushed and spread owing to the gaps to attain a seal by a line contact with the shaft seal chamber on a fixed side.

Abstract translation: 轴封衬垫在初始组装时表现出高的密封性，并且即使在包装被重新密封之后也显示出通过压制效果获得的增加的密封表面压力和通过流体压力的效果获得的自密封性而具有优异的密封性 。 一种用于阀的轴密封结构，包括一阀体，一阀体，一阀体，其设置在本体内以便可转动或能够上下升降;阀轴密封室，其阀轴轴向安装在其上， 轴封衬垫，其安装在所述轴密封室上，并且包括层叠并大致V形横截面的环状填料体，所述填料体的内径侧上的堆叠层面彼此紧密接触并堆叠 在相邻的堆叠层面之间形成有规定间隙的包装体的外径侧的层面。 在阀的轴封结构中，由于内径侧的层叠面的倾斜角度，由于表面接触而形成密封，因此将包装体上的紧固负荷和流体压力转换为直径方向的力 在内径侧的内周面和滑动侧的阀轴的外周面之间，由于间隙而在外径侧的唇部被推压扩张以通过线来进行密封 在固定侧与轴封室接触。

公开(公告)号：US08048681B2

公开(公告)日：2011-11-01

申请号：US11529418

申请日：2006-09-29

Applicant: Yoshihiro Yamashita ,  Toshinari Sakurai

Inventor： Yoshihiro Yamashita ,  Toshinari Sakurai

IPC: C07H21/00

CPC classification number: C07H21/00 ,  C12N15/1006 ,  Y10T436/107497 ,  Y10T436/173845

Abstract: The present invention relates to a technique for efficient isolation of long nucleic acids and short nucleic acids from a sample containing long nucleic acids and short nucleic acids via safe and convenient operations. Specifically, long nucleic acids and short nucleic acids are isolated from a sample containing nucleic acids by mixing a chaotropic agent with the sample containing nucleic acids, allowing the mixed solution to pass at least twice through a first solid phase containing silica that has passage pores having predetermined pore sizes, allowing the mixed solution to pass at least twice through a second solid phase containing silica that has passage pores having pore sizes smaller than those of the first solid phase containing silica, and separately recovering nucleic acids that have bound to the first solid phase containing silica and those that have bound to the second solid phases containing silica.

Abstract translation: 本发明涉及通过安全和方便的操作从含有长核酸和短核酸的样品有效分离长核酸和短核酸的技术。 具体地说，通过将离液剂与含有核酸的样品混合，从含有核酸的样品中分离长核酸和短核酸，使混合溶液至少通过含有二氧化硅的第二固体，所述第一固相具有通道孔， 允许混合溶液通过含有二氧化硅的第二固相至少两次，所述第二固相具有孔径小于含有二氧化硅的第一固相孔的通道孔，并分别回收与第一固体结合的核酸 相和含有二氧化硅的第二固相结合的二氧化硅。

公开(公告)号：US20090221060A1

公开(公告)日：2009-09-03

申请号：US12372343

申请日：2009-02-17

Applicant: Shuhei Yamamoto ,  Toshinari Sakurai ,  Yoshiyuki Shoji ,  Takehiko Hosoiri ,  Yoshihiro Yamashita ,  Tomoyuki Tobita

Inventor： Shuhei Yamamoto ,  Toshinari Sakurai ,  Yoshiyuki Shoji ,  Takehiko Hosoiri ,  Yoshihiro Yamashita ,  Tomoyuki Tobita

IPC: C12M1/00

CPC classification number: B01L7/52 ,  B01L3/50851 ,  B01L3/50853 ,  B01L2200/142 ,  B01L2300/1844 ,  B01L2300/1861 ,  G01N35/025

Abstract: It is an object of the present invention to prevent condensation occurring when reaction solutions in sealed vessels are heated in a nucleic acid analyzer for performing sequential processing in which individual reaction vessels are sequentially fed to a nucleic acid amplification unit in a given cycle. This invention relates to a nucleic acid analyzer including a vessel mounting rack capable of holding the plurality of reaction vessels, wherein the reaction vessel mounted on the vessel mounting rack is heated by an adjacent noncontact heat source and air circulation from the heat source to a reaction vessel upper portion, and a temperature of the reaction vessel upper portion is kept higher than a temperature of a reaction vessel lower portion. With this invention, condensation possibly occurring on the inner wall of the sealed vessel upper portion due to heating during nucleic acid amplification can be prevented, and more accurate nucleic acid analysis is enabled.

Abstract translation: 本发明的目的是防止在密封容器中的反应溶液在核酸分析仪中加热以进行顺序加工的冷凝，其中将各个反应容器依次加入到给定循环中的核酸扩增单元中。 本发明涉及一种核酸分析仪，其包括能够保持多个反应容器的容器安装架，其中安装在容器安装架上的反应容器被相邻的非接触式热源加热，并且从热源到反应的空气循环 容器上部，并且反应容器上部的温度保持高于反应容器下部的温度。 通过本发明，可以防止由于核酸扩增期间的加热而在密封容器上部的内壁上发生的冷凝，从而能够进行更准确的核酸分析。

公开(公告)号：US07535251B2

公开(公告)日：2009-05-19

申请号：US11852032

申请日：2007-09-07

Applicant: Chikayoshi Morishima ,  Tokuya Osawa ,  Masaru Haraguchi ,  Yoshihiro Yamashita

Inventor： Chikayoshi Morishima ,  Tokuya Osawa ,  Masaru Haraguchi ,  Yoshihiro Yamashita

IPC: H03K17/16 ,  H03K19/003 ,  H03K19/094 ,  H03K19/0175 ,  H03K19/084 ,  G11C8/00

CPC classification number: H03K19/0005 ,  H03K19/018578

Abstract: There is provided a semiconductor device including an output buffer circuit which reduces an area occupied by a circuit for impedance adjustment and allows high-speed impedance adjustment. In an impedance measuring circuit, the impedance values of reference transistors having the same sizes as those of a plurality of transistors composing the output buffer circuit which are equal in size are measured. An impedance code generating circuit outputs impedance codes corresponding to the impedance values of the reference transistors to an output buffer code generating circuit based on the result of the measurement from the impedance measuring circuit. The output buffer code generating circuit generates output buffer codes for adjusting the impedance of the output buffer circuit by performing an arithmetic operation process to provide an objective impedance based on the impedance codes.

Abstract translation: 提供了一种包括输出缓冲电路的半导体器件，其减少用于阻抗调整的电路占据的面积，并允许高速阻抗调节。 在阻抗测量电路中，测量与构成输出缓冲电路的多个晶体管尺寸相同尺寸的参考晶体管的尺寸相等的阻抗值。 基于来自阻抗测量电路的测量结果，阻抗代码产生电路将对应于参考晶体管的阻抗值的阻抗代码输出到输出缓冲器代码产生电路。 输出缓冲器代码产生电路通过执行算术运算处理产生用于调节输出缓冲器电路的阻抗的输出缓冲器代码，以提供基于阻抗代码的物镜阻抗。

公开(公告)号：US20070269829A1

公开(公告)日：2007-11-22

申请号：US11798806

申请日：2007-05-17

Applicant: Yoshihiro Yamashita ,  Toshinari Sakurai

Inventor： Yoshihiro Yamashita ,  Toshinari Sakurai

IPC: C12Q1/68 ,  B01D15/08 ,  C12M3/00

CPC classification number: B01L3/502 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/0854 ,  B01L2300/087 ,  B01L2300/14 ,  B01L2400/0478

Abstract: A nucleic acid isolation apparatus and method enables nucleic acid isolation from a nucleic-acid-containing sample quickly with high nucleic acid yield and purity. A nucleic acid isolation instrument 11 is supported by a stand 41 via a rib 19 (A). A solution is loaded into a first container 15 via a first opening portion 14 with a loading pipette tip 42. A pressurizing/depressurizing device 43 for controlling the pressure inside the first container 15 and the second container 13 individually is closely fitted in the first opening portion 14 and the second opening portion 12 via a connecting member 44 (B). The pressurizing/depressurizing device 43 pressurizes the inside of the first container 15 while it depressurizes the inside of the second container 13 so as to move the solution from the container 15 to the container 13 via a solid phase 16 (C). After the operation of moving the solution through the solid phase 16 is conducted an appropriate number of times, the pressurizing/depressurizing device 43 is detached from the first and second opening portions 14 and 12. The solution that has moved into the second container 13 is aspirated with an unloading pipette tip 45 via the second opening portion 12 and then unloaded out of the instrument 11 (D).

Abstract translation: 核酸分离装置和方法使得能够以高核酸产率和纯度快速地从含有核酸的样品中分离核酸。 核酸分离装置11经由肋19（A）由支架41支撑。 溶液通过具有加载移液管末端42的第一开口部分14装载到第一容器15中。用于分别控制第一容器15和第二容器13内的压力的加压/减压装置43紧密地配合在第一开口 部分14和第二开口部分12经由连接构件44（B）。 加压减压装置43对第一容器15的内部进行加压，同时使第二容器13的内部减压，从而将溶液从容器15经由固相16（C）移动到容器13。 在将溶液移动通过固相16的操作进行适当次数之后，加压/减压装置43从第一开口部14和第二开口部12分离。已经移入第二容器13的溶液为 通过第二开口部分12用卸载移液管尖端45抽吸，然后从仪器11（D）中卸载。

公开(公告)号：US20070106071A1

公开(公告)日：2007-05-10

申请号：US11529418

申请日：2006-09-29

Applicant: Yoshihiro Yamashita ,  Toshinari Sakurai

Inventor： Yoshihiro Yamashita ,  Toshinari Sakurai

IPC: C07H21/00

CPC classification number: C07H21/00 ,  C12N15/1006 ,  Y10T436/107497 ,  Y10T436/173845

Abstract: The present invention relates to a technique for efficient isolation of long nucleic acids and short nucleic acids from a sample containing long nucleic acids and short nucleic acids via safe and convenient operations. Specifically, long nucleic acids and short nucleic acids are isolated from a sample containing nucleic acids by mixing a chaotropic agent with the sample containing nucleic acids, allowing the mixed solution to pass at least twice through a first solid phase containing silica that has passage pores having predetermined pore sizes, allowing the mixed solution to pass at least twice through a second solid phase containing silica that has passage pores having pore sizes smaller than those of the first solid phase containing silica, and separately recovering nucleic acids that have bound to the first solid phase containing silica and those that have bound to the second solid phases containing silica.

Abstract translation: 本发明涉及通过安全和方便的操作从含有长核酸和短核酸的样品有效分离长核酸和短核酸的技术。 具体地说，通过将离液剂与含有核酸的样品混合，从含有核酸的样品中分离长核酸和短核酸，使混合溶液至少通过含有二氧化硅的第二固体，所述第一固相具有通道孔， 允许混合溶液通过含有二氧化硅的第二固相至少两次，所述第二固相具有孔径小于含有二氧化硅的第一固相孔的通道孔，并分别回收与第一固体结合的核酸 相和含有二氧化硅的第二固相结合的二氧化硅。

公开(公告)号：US20070103701A1

公开(公告)日：2007-05-10

申请号：US11586002

申请日：2006-10-25

Applicant: Yoshihiro Yamashita ,  Hirotaka Nakashima ,  Masahiro Kawachi

Inventor： Yoshihiro Yamashita ,  Hirotaka Nakashima ,  Masahiro Kawachi

IPC: G01B11/14

CPC classification number: G01B11/026

Abstract: In a sensor head, parallel rays or approximately parallel rays are generated by a pair of condenser lenses that reciprocate according to vibrations of a collimate lens and a tuning fork, and go out from a light port. To the light port, a lens holder in which an objective lens is supported is detachably attached. The light from the light port is processed to measurement beams that are condensed by the objective lens to a predetermined position.

Abstract translation: 在传感器头中，通过一对聚光透镜产生平行光线或大致平行光线，该聚光透镜根据准直透镜和音叉的振动而往复运动，并从光端口出射。 对于光端口，可拆卸地安装有支撑物镜的透镜架。 来自光端口的光被处理成由物镜会聚到预定位置的测量光束。