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11.发明授权Method to minimize chain scission and monomer generation in processing of poly(L-lactide) stent 有权在聚（L-丙交酯）支架加工过程中减少链断裂和单体产生的方法公开(公告)号：US08703038B2
公开(公告)日：2014-04-22
申请号：US13946964
申请日：2013-07-19
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , James Oberhauser
IPC: A61F2/82
CPC classification number: A61F2/82 , A61F2/958 , A61F2002/9583 , A61L31/06 , A61L31/148 , H01J2237/31 , C08L67/04
Abstract: Methods of fabricating an implantable medical devices such as stents made from biodegradable polymers are disclosed that reduce or minimize chain scission and monomer generation during processing steps. The method includes processing a poly(L-lactide) resin having an number average molecular weight between 150 to 200 kD in an extruder in a molten state. A poly(L-lactide) tube is formed from the processed resin and a stent is fabricated from the tube. The number average molecular weight of the poly(L-lactide) of the stent after sterilization is 70 to 100 kD.
Abstract translation: 公开了制造可植入医疗装置的方法，例如由可生物降解的聚合物制成的支架，其可减少或最小化加工步骤期间的链断裂和单体产生。 该方法包括在熔融状态的挤出机中加工数均分子量为150〜200kD的聚（L-丙交酯）树脂。 由处理后的树脂形成聚（L-丙交酯）管，并由管制造支架。 灭菌后支架的聚（L-丙交酯）数均分子量为70〜100kD。
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公开(公告)号：US20130187313A1
公开(公告)日：2013-07-25
申请号：US13734879
申请日：2013-01-04
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Thierry Glauser , Vincent Gueriguian , Bethany Steichen , James Oberhauser , Manish Gada , Lothar Kleiner , Mary Beth Kossuth
CPC classification number: B29D22/00 , A61F2/91 , B29C49/0005 , B29C49/02 , B29C49/04 , B29C49/08 , B29C49/78 , B29C55/26 , B29C2793/009 , B29K2995/004 , B29K2995/0041 , B29K2995/0046 , B29K2995/0056 , B29K2995/006 , B29K2995/0077 , B29K2995/0089 , B29L2031/7542
Abstract: Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stem manufacture and fabrication of a stent therefrom are disclosed.
Abstract translation: 公开了扩展聚合物管的方法，其具有用于茎的制造和制造支架的所需或最佳形态和机械性能。
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公开(公告)号：US10213949B2
公开(公告)日：2019-02-26
申请号：US14852135
申请日：2015-09-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bethany Steichen , Stephen Pacetti , Manish Gada , Thierry Glauser , Lothar Kleiner , Yunbing Wang , James Oberhauser , Ni Ding
Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
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公开(公告)号：US20170252493A1
公开(公告)日：2017-09-07
申请号：US15597962
申请日：2017-05-17
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , James Oberhauser
CPC classification number: A61L31/148 , A61F2/82 , A61F2/89 , A61F2/958 , A61F2002/30062 , A61F2210/0004 , A61K9/1647 , A61K9/204 , A61L31/06 , B29C47/0066 , B29K2067/046 , B29L2031/7534 , C08G63/08 , C08G63/90 , C08J2367/04 , C08L67/04 , C09D167/04 , C09J167/04
Abstract: Methods of treating with a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal.
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公开(公告)号：US20160157988A1
公开(公告)日：2016-06-09
申请号：US15042045
申请日：2016-02-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , James Oberhauser , Manish Gada
CPC classification number: A61F2/06 , A61L31/041 , A61L31/129 , A61L31/148 , A61L31/16 , A61L2300/422 , C08L67/04
Abstract: A medical device implantable within a peripheral vessel of the body composed of a bioresorbable polymer is disclosed. The device has a high resistance to fracture, is very flexible, and has a high crush recovery when subjected to crushing, axial, or torsional forces.
Abstract translation: 公开了一种可植入在由生物可再吸收的聚合物组成的身体的外周血管内的医疗装置。 该装置具有高抗断裂性，非常柔软，并且当受到破碎，轴向或扭转力时具有高的压碎恢复性。
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Patent Agency Ranking
公开(公告)号：US20160038320A1
公开(公告)日：2016-02-11
申请号：US14918318
申请日：2015-10-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Rommel Lumauig , James Oberhauser
CPC classification number: A61F2/958 , A61F2/915 , A61F2002/9522 , B23P11/005 , B23P11/025 , B29C53/02 , B29C2793/0009 , B29K2067/046 , B29K2995/006 , B29L2031/7534 , Y10T29/49865 , Y10T29/49913
Abstract: A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes one or more balloon pressurization steps. The balloon pressurization steps are selected to enhance scaffold retention to the balloon and maintain a relatively uniform arrangement of balloon folds about the inner surface of the crimped scaffold so that the scaffold expands in a uniform manner when the balloon is inflated.
Abstract translation: 一种医疗装置 - 包括卷曲到具有膨胀气囊的导管的支架。 支架通过包括一个或多个气囊加压步骤的过程卷曲到气囊。 选择球囊加压步骤以增强对球囊的支架保持性，并且保持围绕卷曲的支架的内表面的气球折叠的相对均匀的布置，使得当气囊膨胀时，支架以均匀的方式膨胀。
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17.发明申请CONTROLLING MOISTURE IN AND PLASTICIZATION OF BIORESORBABLE POLYMER FOR MELT PROCESSING 审中-公开控制用于熔融加工的可生物降解聚合物的水分和塑化公开(公告)号：US20150375437A1
公开(公告)日：2015-12-31
申请号：US14852135
申请日：2015-09-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bethany Steichen , Stephen Pacetti , Manish Gada , Thierry Glauser , Lothar Kleiner , Yunbing Wang , James Oberhauser , Ni Ding
IPC: B29C47/00
CPC classification number: B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/0066 , B29C47/0869 , B29C47/0893 , B29C47/0894 , B29C47/1018 , B29C47/1027 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92333 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006
Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。
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18.发明申请METHOD TO MINIMIZE MOLECULAR WEIGHT DROP OF POLY(L-LACTIDE) STENT DURING PROCESSING 审中-公开在加工过程中最小化聚（L-LACTIDE）STENT分子量降低的方法公开(公告)号：US20150054202A1
公开(公告)日：2015-02-26
申请号：US14530151
申请日：2014-10-31
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Byron Lambert , Yunbing Wang , James Oberhauser
CPC classification number: B29C47/0076 , A61F2/82 , A61L31/041 , A61L31/06 , A61L31/143 , A61L31/148 , B29D23/20 , B29K2005/00 , B29L2023/20 , B29L2031/753 , C08J3/28 , C08J2367/04 , C08L67/04
Abstract: A method to reduce or minimize the reduction in molecular weight of a stent during processing is disclosed. The stent has a scaffolding including a polymer formulation comprising PLLA and polymandelide. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.
Abstract translation: 公开了减少或最小化处理期间支架分子量降低的方法。 支架具有包括PLLA和聚扁桃酸酯的聚合物制剂的脚手架。 聚对苯二甲酸丁二醇酯降低加工过程中的分子量下降，特别是在灭菌过程中。 支架支架还可包括一种或多种附加的稳定剂，其另外降低加工过程中的分子量下降。
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19.发明申请METHOD OF IMPROVING FRACTURE TOUGHNESS OF IMPLANTABLE MEDICAL DEVICES THROUGH ANNEALING 有权通过退火改善可植入医疗器械的断裂韧性的方法公开(公告)号：US20130207314A1
公开(公告)日：2013-08-15
申请号：US13794537
申请日：2013-03-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , James Oberhauser
IPC: B29C51/00
CPC classification number: B29C51/002 , A61L31/06 , A61L31/14 , Y10T29/49 , C08L67/04
Abstract: Methods of fabricating a polymeric implantable device with improved fracture toughness through annealing are disclosed herein. A polymeric construct is annealed with no or substantially no crystal growth to increase nucleation density. After the annealing, crystallites are grown around the formed nuclei. An implantable medical device, such as a stent, can be fabricated from the polymer construct after the crystallite growth.
Abstract translation: 本文公开了通过退火制造具有改善的断裂韧性的聚合物可植入装置的方法。 将聚合物构件退火，没有或基本上没有晶体生长以增加成核密度。 退火后，在形成的核周围生长微晶。 在微晶生长之后，可由聚合物构造体制造诸如支架的可植入医疗装置。
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公开(公告)号：US10709589B2
公开(公告)日：2020-07-14
申请号：US15590817
申请日：2017-05-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Jana Buccola , Joel Harrington , Syed Hossainy , Mary Beth Kossuth , Annie Liu , James Oberhauser , Fuh-Wei Tang
Abstract: A method of accelerated aging of bioresorbable polymer scaffolds including exposing the scaffold to water is disclosed. The scaffold is exposed to water at a controlled temperature for a selected aging time. The functional outputs, such as radial strength, expandability, and % recoil obtained from aged scaffolds predict those of real-time aging of the scaffold. The accelerated aging factor, which is the required shelf life divided by the aging time, is significantly higher for poly(L-lactide) scaffolds tested than thermal aging.
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