公开(公告)号：US20140346344A1

公开(公告)日：2014-11-27

申请号：US14274707

申请日：2014-05-10

Applicant: Academia Sinica

Inventor： Chung-Hsuan Chen ,  Jung-Lee Lin ,  Huan Chang Lin

IPC: G01N27/66 ,  H01J49/42 ,  G01N33/483 ,  H01J49/36

CPC classification number: H01J49/36 ,  G01N33/4833 ,  H01J49/164 ,  H01J49/4225 ,  H01J49/424

Abstract: Apparatus and methods for performing mass spectrometry of a nanoparticle or virus analyte. Apparatus may include a laser desorption plate, a mass analyzer configured to measure mass over the range of m/z from 105 to 1010, an electrical shield surrounding the mass analyzer, and a charge sensitive detector, wherein the laser firing is phase lock synchronized with the applied radiofrequency voltages.

Abstract translation: 用于进行纳米颗粒或病毒分析物的质谱分析的装置和方法。 设备可以包括激光解吸板，质量分析器，被配置为测量从105到1010的m / z范围内的质量，围绕质量分析器的电屏蔽，以及电荷敏感检测器，其中激光点火与 应用的射频电压。

公开(公告)号：US11119078B2

公开(公告)日：2021-09-14

申请号：US16412704

申请日：2019-05-15

Applicant: ACADEMIA SINICA

Inventor： Chung-Hsuan Chen ,  Chen-Yu Hsieh ,  Jung-Lee Lin

IPC: G01N30/74 ,  G01N30/02 ,  G01N21/33

Abstract: Apparatus and methods for high performance liquid chromatography. The apparatus includes a preparation loop comprising two linear stepping pumps, a sample loop comprising a sample injector, a chromatography column, and a detector device. The detector device can include a flash lamp, a flow cell, and a light sensor comprising an entrance slit, a grating; and a charge-coupled device array.

公开(公告)号：US10317379B2

公开(公告)日：2019-06-11

申请号：US14551050

申请日：2014-11-23

Applicant: Academia Sinica

Inventor： Chung-Hsuan Chen ,  Chen-Yu Hsieh ,  Jung-Lee Lin

IPC: G01N21/33 ,  G01N30/02 ,  G01N30/74

Abstract: Apparatus and methods for high performance liquid chromatography. The apparatus includes a preparation loop comprising two linear stepping pumps, a sample loop comprising a sample injector, a chromatography column, and a detector device. The detector device can include a flash lamp, a flow cell, and a light sensor comprising an entrance slit, a grating; and a charge-coupled device array.

公开(公告)号：US09976146B2

公开(公告)日：2018-05-22

申请号：US15312667

申请日：2015-05-29

Applicant: Academia Sinica

Inventor： Chung-Hsuan Chen ,  Bai-Ling Lin ,  Chin-Yu Wang

IPC: C12N15/115 ,  A61K47/48

CPC classification number: C12N15/115 ,  A61K47/55 ,  C12N2310/16 ,  C12N2310/315 ,  C12N2310/3517 ,  C12N2320/13 ,  C12N2320/31 ,  C12N2320/32

Abstract: Disclosed herein is an aptamer targeting a MHC-presented peptide and its uses thereof. The MHC-presented peptide is expressed in various cancer cells; therefor, the aptamer of the disclosure is useful as a bio-tool to label and/or treat peptide-presenting cancer cells. Also disclosed herein is a pharmaceutical composition containing the aptamer.

公开(公告)号：US08637814B2

公开(公告)日：2014-01-28

申请号：US13691785

申请日：2012-12-01

Applicant: Academia Sinica

Inventor： Chung-Hsuan Chen ,  Jung-Lee Lin ,  Nien-Yeen Hsu ,  Yi-Sheng Wang

IPC: H01J49/26 ,  H01J49/40

CPC classification number: H05H5/047 ,  H01J49/06 ,  H01J49/40 ,  H01J49/403

Abstract: A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte.

Abstract translation: 提供了一种用于加速分析物的新系统和方法，包括但不限于分子离子，生物分子，聚合物，纳米和微粒。 本发明可用于在诸如质谱法，进行碰撞诱导的解离分子结构分析和使用加速分析物的探测表面和样品等应用中提高检测灵敏度。

公开(公告)号：US20130187042A1

公开(公告)日：2013-07-25

申请号：US13713792

申请日：2012-12-13

Applicant: Academia Sinica

Inventor： Kent J. Gillig ,  Chung-Hsuan Chen

IPC: H01J49/26 ,  H01J49/00

CPC classification number: H01J49/26 ,  G01N27/624 ,  H01J49/0031 ,  H01J49/22

Abstract: A periodic field differential mobility analyzer apparatus for separating and identifying ionic analytes employs a series of elongated parallel channels, a pump, a first voltage providing an electric field Ex in a direction opposing the gas flow, a second voltage providing an electric field Ey in a direction perpendicular to the gas flow, an ion source, and a detector. The periodic field differential mobility analyzer provides high resolution and sensitivity.

Abstract translation: 用于分离和鉴定离子分析物的周期性场差分迁移率分析仪装置采用一系列细长的平行通道，泵，在与气流相反的方向上提供电场Ex的第一电压，在第一电压中提供电场Ey 垂直于气流的方向，离子源和检测器。 周期场差分迁移率分析仪提供高分辨率和灵敏度。

公开(公告)号：US09324552B2

公开(公告)日：2016-04-26

申请号：US13713792

申请日：2012-12-13

Applicant: Academia Sinica

Inventor： Kent J. Gillig ,  Chung-Hsuan Chen

IPC: H01J49/28 ,  G01N27/62 ,  H01J49/26 ,  H01J49/22 ,  H01J49/00

CPC classification number: H01J49/26 ,  G01N27/624 ,  H01J49/0031 ,  H01J49/22

Abstract: A periodic field differential mobility analyzer apparatus for separating and identifying ionic analytes employs a series of elongated parallel channels, a pump, a first voltage providing an electric field Ex in a direction opposing the gas flow, a second voltage providing an electric field Ey in a direction perpendicular to the gas flow, an ion source, and a detector. The periodic field differential mobility analyzer provides high resolution and sensitivity.

Abstract translation: 用于分离和鉴定离子分析物的周期性场差分迁移率分析仪装置采用一系列细长的平行通道，泵，在与气流相反的方向上提供电场Ex的第一电压，在第一电压中提供电场Ey 垂直于气流的方向，离子源和检测器。 周期场差分迁移率分析仪提供高分辨率和灵敏度。