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公开(公告)号：US20250035846A1
公开(公告)日：2025-01-30
申请号：US18917989
申请日：2024-10-16
Applicant: Access Medical Systems, Ltd.
Inventor： Hong Tan , Jianbo Yao , Genqian Li , Erhua Cao
Abstract: Introduced here is an approach to mitigating (e.g., lessening or eliminating) the high-frequency interference pattern that is caused by uneven surfaces along the coupling interface formed between the waveguide and probe of an interferometric sensing system. The approach is to reduce the high-frequency interference pattern caused by the interference when a waveguide−for example, in the form of an optical fiber−and a probe are directly coupled to one another. Specifically, the coupling surface of the waveguide can be treated, for example, with sandpaper, sandblasting, or acid etching, to create a frosted surface texture. In operation, the frosted surface scatters the light transmitted through the waveguide, preventing the high-frequency interference pattern from occurring.
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公开(公告)号：US20230194425A1
公开(公告)日：2023-06-22
申请号：US18173056
申请日：2023-02-22
Applicant: ACCESS MEDICAL SYSTEMS, LTD.
Inventor： Hong Tan
CPC classification number: G01N21/45 , G01J3/0208 , G01J3/0218 , G01J3/0224 , G01J3/024 , G01J3/45 , G01N21/7703 , G01N21/8507 , G01N2021/458 , G01N2201/0826 , G01N2201/0833 , G01N2021/772 , G01N21/55
Abstract: The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly includes a light source to emit light signals; a light detector to detect light signals; a coupler to optically couple the light source and the light detector to a waveguide tip; a monolithic substrate having a coupling side and a sensing side; and a lens between the waveguide tip and the monolithic substrate. The lens relays optical signals between the waveguide tip and the monolithic substrate.
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公开(公告)号：US11598784B2
公开(公告)日：2023-03-07
申请号：US17644064
申请日：2021-12-13
Applicant: Access Medical Systems, LTD.
Inventor： Hong Tan , Ming Xia , Yushan Tan , Jun Chen , Erhua Cao , Genqian Li , Robert F. Zuk
Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.
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公开(公告)号：US10928406B2
公开(公告)日：2021-02-23
申请号：US16217730
申请日：2018-12-12
Applicant: Access Medical Systems, LTD.
Inventor： Hong Tan , Yongli Ren , Ming Xia , Genqian Li
Abstract: This invention relates to a cartridge assembly tray for conducting automated biochemical tests, such as immunoassay tests. The tray comprises a base member, a hinged frame and a locking mechanism. The base member includes a plurality of slots within the base member. Each of the plurality of slots is to receive a test cartridge. The hinged frame is coupled to the base member. The hinged frame is capable to rotate to an opened position or a closed position. The hinged frame includes a horizontal push bar configured to apply a downward force to test cartridges received in the plurality of slots when the hinged frame is in the closed position. The locking mechanism is to lock the hinged frame in the closed position when the hinged frame rotates to the closed position.
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公开(公告)号：US09616427B2
公开(公告)日：2017-04-11
申请号：US15089812
申请日：2016-04-04
Applicant: Access Medical Systems, LTD.
Inventor： Hong Tan , Yongli Ren , Ming Xia , Genqian Li
CPC classification number: G01N35/00029 , B01L3/50855 , B01L9/00 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/04 , B01L2300/043 , B01L2300/0609 , B01L2300/0809 , G01N33/5304 , G01N33/536 , G01N2035/00148 , G01N2035/0418 , G01N2035/0436
Abstract: This invention relates to a cartridge assembly tray for conducting automated biochemical tests, such as immunoassay tests. The tray comprises a base member, a hinged frame and a locking mechanism. The base member includes a plurality of slots within the base member. Each of the plurality of slots is to receive a test cartridge. The hinged frame is coupled to the base member. The hinged frame is capable to rotate to an opened position or a closed position. The hinged frame includes a horizontal push bar configured to apply a downward force to test cartridges received in the plurality of slots when the hinged frame is in the closed position. The locking mechanism is to lock the hinged frame in the closed position when the hinged frame rotates to the closed position.
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Patent Agency Ranking
公开(公告)号：US08753574B2
公开(公告)日：2014-06-17
申请号：US13936047
申请日：2013-07-05
Applicant: Access Medical Systems, Ltd.
Inventor： Hong Tan , Ming Xia , Yushan Tan , Jun Chen , Erhua Cao , Genqian Li , Robert F. Zuk
IPC: G01N33/53
CPC classification number: B01L3/52 , B01L3/502 , B01L3/527 , B01L2300/042 , B01L2300/045 , G01N33/54306 , G01N33/54353 , G01N33/54366 , G01N35/026 , G01N2035/0436
Abstract: This invention relates to a cartridge for an immunoassay test. The cartridge comprises (a) a probe well comprising a probe and a cap, the cap being in a closed position to enclose the probe in the probe well, wherein the probe has a bottom tip coated with analyte-binding molecules; (b) a sample well to receive a sample; (c) one or more reagent wells; (d) a plurality of wash wells each containing a first aqueous solution; and (e) a measurement well having a light transmissive bottom, the measurement well containing a second aqueous solution; wherein the openings of the sample well, reagent well, measurement well and wash wells are sealed. The present invention also relates to an apparatus for loading and releasing a probe. The apparatus comprises a push pin and a groove to load and transfer the probe to a plurality of locations, such as different wells in the above-mentioned cartridge, to conduct the immunoassay test.
Abstract translation: 本发明涉及用于免疫测定试验的药筒。 所述筒包括（a）包括探针和帽的探针孔，所述盖处于闭合位置以将所述探针包围在探针中，其中所述探针具有涂覆有分析物结合分子的底部尖端; （b）样品孔以接收样品; （c）一个或多个试剂孔; （d）多个洗涤孔，每个洗涤孔含有第一水溶液; 和（e）具有透光底部的测量井，所述测量井含有第二水溶液; 其中样品阱，试剂阱，测量井和洗涤井的开口被密封。 本发明还涉及一种用于装载和释放探针的装置。 该装置包括推针和凹槽，以将探针加载并转移到多个位置，例如上述药筒中的不同的孔，以进行免疫测定。
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公开(公告)号：US08501496B2
公开(公告)日：2013-08-06
申请号：US13654299
申请日：2012-10-17
Applicant: Access Medical Systems, Ltd.
Inventor： Robert F. Zuk , Hong Tan
IPC: G01N33/543
CPC classification number: G01N33/54386
Abstract: The present invention is directed immunoassay cuvettes that comprise diffusely bound and non-diffusely bound reagents for carrying out an immunoassay. The reaction and detection are carried out in the immunoassay cuvette. The immunoassay cuvette comprises a transparent front wall, a back wall, side walls, a bottom, and a top opening. The back wall of the cuvette has a substantially planar surface made of a non-porous material and comprises a capture zone having reagents non-diffusedly bound and a signal reagent zone having reagents diffusedly bound.
Abstract translation: 本发明涉及包含扩散结合和非扩散结合试剂进行免疫测定的免疫测定试管。 反应和检测在免疫测定试管中进行。 免疫测定试管包括透明的前壁，后壁，侧壁，底部和顶部开口。 试管的后壁具有由无孔材料制成的基本平坦的表面，并且包括具有非扩散结合的试剂的捕获区和具有扩散结合的试剂的信号试剂区。
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公开(公告)号：US12153061B2
公开(公告)日：2024-11-26
申请号：US17181868
申请日：2021-02-22
Applicant: Access Medical Systems, LTD.
Inventor： Hong Tan , Yongli Ren , Ming Xia , Genqian Li
Abstract: This invention relates to a cartridge assembly tray for conducting automated biochemical tests, such as immunoassay tests. The tray comprises a base member, a hinged frame and a locking mechanism. The base member includes a plurality of slots within the base member. Each of the plurality of slots is to receive a test cartridge. The hinged frame is coupled to the base member. The hinged frame is capable to rotate to an opened position or a closed position. The hinged frame includes a horizontal push bar configured to apply a downward force to test cartridges received in the plurality of slots when the hinged frame is in the closed position. The locking mechanism is to lock the hinged frame in the closed position when the hinged frame rotates to the closed position.
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公开(公告)号：US20240082836A1
公开(公告)日：2024-03-14
申请号：US18517999
申请日：2023-11-22
Applicant: Access Medical Systems, Ltd.
Inventor： Hong Tan , Haode Chen , Genqian Li
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L2200/04 , B01L2300/0663 , B01L2300/0861 , B01L2400/043
Abstract: Introduced here are rotors that can be placed inside of microplate wells that include liquid samples. Each rotor can be comprised of a ferromagnetic material. Accordingly, when a rotor is subjected to an external rotational magnetic field, the rotor spins and agitates the liquid sample inside the corresponding well. The spin speed may be adjusted by changing the rotation speed, direction, and/or orientation of the external rotational magnetic field. The rotor typically includes a central cavity within which a probe can be suspended during the biochemical test.
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公开(公告)号：US20220146422A1
公开(公告)日：2022-05-12
申请号：US17648871
申请日：2022-01-25
Applicant: Access Medical Systems, LTD.
Inventor： Jianbo Yao , Hong Tan
IPC: G01N21/45
Abstract: Introduced here are interferometric sensors that can be used to conduct biochemical tests. Each interferometric sensor includes an interference layer that is secured along the surface of a monolithic substrate. Analyte-binding molecules can be coated along the surface of the interference layer. Over the course of a biochemical test, a biolayer will form as analyte molecules in a sample bind to the analyte-binding molecules. The refractive index of the monolithic substrate is higher than the refractive index of the interference layer. Moreover, the interference layer may be designed such that its refractive index is substantially similar to the refractive index of the biolayer.
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