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公开(公告)号：US20160264621A1
公开(公告)日：2016-09-15
申请号：US15064874
申请日：2016-03-09
发明人： Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy M. Travins , Shunqi Yan
IPC分类号： C07K5/065 , C07D409/12 , C07C237/22 , C07D471/04 , C07D319/20 , C07C311/13 , C07D317/68 , C07D237/14 , C07D241/12 , C07D213/30 , C07C271/58 , C07D333/24 , C07D209/26
CPC分类号： C07K5/06078 , A61K38/00 , C07C237/22 , C07C271/22 , C07C271/44 , C07C271/58 , C07C311/06 , C07C311/13 , C07C311/19 , C07C317/36 , C07C335/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/10 , C07D207/16 , C07D209/08 , C07D209/14 , C07D209/26 , C07D209/42 , C07D209/44 , C07D211/14 , C07D211/38 , C07D211/54 , C07D211/60 , C07D213/30 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/74 , C07D217/04 , C07D221/18 , C07D231/12 , C07D231/42 , C07D231/56 , C07D233/61 , C07D233/64 , C07D233/70 , C07D233/88 , C07D235/04 , C07D237/14 , C07D239/26 , C07D241/12 , C07D249/04 , C07D249/18 , C07D253/06 , C07D257/04 , C07D261/18 , C07D265/36 , C07D271/06 , C07D271/10 , C07D277/28 , C07D277/30 , C07D277/56 , C07D295/04 , C07D295/205 , C07D305/08 , C07D307/20 , C07D307/22 , C07D309/12 , C07D309/14 , C07D317/68 , C07D319/20 , C07D333/24 , C07D333/38 , C07D409/12 , C07D471/04
摘要： Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.
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公开(公告)号：US20150299152A1
公开(公告)日：2015-10-22
申请号：US14646239
申请日：2013-11-21
发明人： Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
IPC分类号： C07D285/135 , C07D471/04 , C07D417/12
CPC分类号： C07D285/135 , C07D285/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
摘要翻译： 本文描述了包含抑制谷氨酰胺酶的化合物的化合物和组合物。 本文还描述了使用抑制谷氨酰胺酶治疗癌症的化合物的方法。
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公开(公告)号：US20240360083A1
公开(公告)日：2024-10-31
申请号：US18507013
申请日：2023-11-10
IPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14
CPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , Y02P20/582
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：US11866411B2
公开(公告)日：2024-01-09
申请号：US17195243
申请日：2021-03-08
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , A61K31/497 , A61K31/5513 , A61K31/4164 , A61P9/00 , A61P9/10 , A61P35/00 , C07D215/36 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D319/18 , C07D295/192
CPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , Y02P20/582
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：USRE49582E1
公开(公告)日：2023-07-18
申请号：US17131562
申请日：2020-12-22
IPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14
CPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , Y02P20/582
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：US20210198206A1
公开(公告)日：2021-07-01
申请号：US17195243
申请日：2021-03-08
IPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , C07D295/192
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：US20170210749A1
公开(公告)日：2017-07-27
申请号：US15481908
申请日：2017-04-07
发明人： Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy M. Travins , Shunqi Yan , Zhixiong Ye
IPC分类号： C07D491/052 , C07D217/26 , C07D401/04 , A61K31/551 , A61K31/519 , A61K31/496 , C07D471/04 , C07D405/12 , C07D519/00
CPC分类号： C07D491/052 , A61K31/496 , A61K31/519 , A61K31/551 , C07D217/22 , C07D217/26 , C07D401/04 , C07D405/12 , C07D413/04 , C07D471/04 , C07D519/00
摘要： Provided are compounds of formula (I), wherein X, Y, Z, W, V, R2, R3 and m are defined as in the description. Their pharmaceutical compositions and their uses for treating cancers are also provided.
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公开(公告)号：US20160318903A1
公开(公告)日：2016-11-03
申请号：US15173519
申请日：2016-06-03
发明人： Giovanni Cianchetta , Byron DeLaBarre , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan , Tao Guo , Li Zhang
IPC分类号： C07D401/14 , A61K45/06 , A61K31/53
CPC分类号： C07D401/14 , A61K31/53 , A61K31/5377 , C07D251/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D493/08
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
摘要翻译： 提供的是用于治疗癌症的化合物和治疗癌症的方法，包括向有需要的受试者施用本文所述的化合物。
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公开(公告)号：US20130190287A1
公开(公告)日：2013-07-25
申请号：US13735467
申请日：2013-01-07
发明人： Giovanni Cianchetta , Byron DeLaBarre , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan , Tao Guo , Li Zhang
IPC分类号： A61K31/5377 , C07D413/14 , C07D401/12 , C07D251/18 , A61K31/53
CPC分类号： C07D401/14 , A61K31/53 , A61K31/5377 , C07D251/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D493/08
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
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公开(公告)号：US20220348554A1
公开(公告)日：2022-11-03
申请号：US16905736
申请日：2020-06-18
发明人： Giovanni Cianchetta , Byron DeLaBarre , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan , Tao Guo , Li Zhang
IPC分类号： C07D401/14 , A61K31/5377 , C07D251/18 , A61K31/53 , C07D401/12 , C07D413/14 , C07D405/14 , C07D403/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D493/08
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
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