摘要:
Aromatic bromomethyl compounds play a major role in the synthesis of active substances. They can be obtained in particularly pure form by the free-radical bromination of aromatic methyl compounds in the solvent chlorobenzene.
摘要:
Angiotensin II receptor antagonists for the treatment of disturbances in cardiac rhythm.Antagonists for angiotensin II receptors of the AT, subtype can be employed for combating cardiac arrhythmias, using azole derivatives.
摘要:
A mechanical rotational drive has a bar-like torsion element, whereby the torsion element is firmly clamped with a first end in a bearing device. The torsion element can be pivoted with a second free end with respect to the clamped end about the longitudinal axis, forming a rotation axis, of the torsion element between a relaxed position and a tensioned position, whereby the length of the torsion element is reduced with respect to the relaxed position when the torsion element is brought into its tensioned position. A device for transmitting a torque into the torsion element or out of the torsion element is provided in the area of the free end, and a damping device is arranged in the axial direction of the torsion element at a fixed distance from the bearing device and adjacent to the free end of the torsion element, and a damping part is provided on the torsion element in the area of the free end of the torsion element, which damping part in the relaxed position is in friction engagement with the damping device and which in the tensioned position is not engaged with the damping device.
摘要:
A process for preventing overturning during the landing of an aircraft or spacecraft using an air bag type landing impact-damping system, which is inflated with gas before the landing and from which gas is discharged via discharge valves during the landing. The process includes using as the air bag type landing impact-damping system a system that is divided into a plurality of chambers that can be inflated with gas and from which gas is released independently from one another, and that a pressure difference is generated during landing in the individual chambers of the air bag type landing impact-damping system.
摘要:
Biphenyl derivatives and processes for the preparation of biphenyl derivatives are described. A compound of formula (I) is disclosed ##STR1## in which the substituent X is --CHO or --CH(OR.sup.1)OR.sup.2, where R.sup.1 and R.sup.2 independently of one another are (C.sub.1 -C.sub.6)-alkyl or R.sup.1 and R.sup.2 together are an alkylene group (--CH.sub.2).sub.n --, where n is 2, 3 4 or 5 and R is --F, --Cl, --NO.sub.2, --(CH.sub.2).sub.m --COOR.sup.3, --(CH.sub.2).sub.m --CONHR.sup.3, --(CH.sub.2).sub.m --CN, --SO.sub.2 NH--COOR.sup.3, --SO.sub.2 NH--CO--NHR.sup.3, --SO.sub.2 NH--SO.sub.2 --R.sup.3, --NHSO.sub.2 R.sup.3, ##STR2## --PO.sub.3 R.sup.3, --NH--SO.sub.2 --CF.sub.3, --SO.sub.2 NR.sup.4 where R.sup.3 is hydrogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.3 -C.sub.6)cycloalkyl, or (C.sub.1 -C.sub.6)-alkyl-(C.sub.3 -C.sub.6)cycloalkyl and R.sup.4 is a group .dbd.C--N(CH.sub.3).sub.2, and m is 0, 1, 2, 3, or 4. The invention also relates to a process for the preparation of a compound of the formula (I) in which X is an optionally protected formyl group and R is a group which is itself inert to the reaction conditions of the synthesis, which comprises reacting a compound of the formula (II) ##STR3## with a substituted phenyl-halogen compound of the formula (III) ##STR4## wherein the substituent Hal is a halogen group.
摘要:
Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain, process for their preparation and their useCompounds of the formula (I) ##STR1## in which R.sup.1 is, for example, ethyl,R.sup.2 is, for example, methyl,n is, for example, zero,R.sup.3 is, for example, COOH, andR.sup.4 is, for example, SO.sub.2 NHCONHCH.sub.3are highly active antagonists of angiotensin II receptors.
摘要:
A mechanical rotational drive has a bar-like torsion element, whereby the torsion element is firmly clamped with a first end in a bearing device. The torsion element can be pivoted with a second free end with respect to the clamped end about the longitudinal axis, forming a rotation axis, of the torsion element between a relaxed position and a tensioned position, whereby the length of the torsion element is reduced with respect to the relaxed position when the torsion element is brought into its tensioned position. A device for transmitting a torque into the torsion element or out of the torsion element is provided in the area of the free end, and a damping device is arranged in the axial direction of the torsion element at a fixed distance from the bearing device and adjacent to the free end of the torsion element, and a damping part is provided on the torsion element in the area of the free end of the torsion element, which damping part in the relaxed position is in friction engagement with the damping device and which in the tensioned position is not engaged with the damping device.
摘要:
Benzyloxy-substituted, fused N-heterocycles, because of their ability to act as bradykinin receptor antagonists, have been found to be useful as therapeutics for the treatment and prevention of liver cirrhosis or Alzheimer's disease. This application describes such compounds, as well as processes for their preparation and use. The compounds according to this invention include compounds of formula (I) in which B, D, R1, and R2 have the meanings indicated herein.
摘要:
The detonating valve for releasing openings of air bag landing systems for aircraft and spacecraft has a wedge type charge and a cover closing the opening, which cover is shorn off during the ignition of the wedge type charge. The cover is a thin-walled disk or a membrane, which is integrated either within the aircraft and spacecraft or within the air bag landing system.
摘要:
The invention relates to the use of nonpeptide bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders (hepatic cirrhosis and hepatic fibrosis), acute liver disorders and for the prevention of complications, in particular for the prophylaxis or treatment of portal hypertension, decompensation symptoms such as ascites, edema formation, hepatorenal syndrome, hypertensive gastropathy and colopathy, splenomegaly and hemorrhagic complications in the gastrointestinal tract due to portal hypertension, collateral circulation and hyperemia and a cardiopathy as a result of a chronically hyperdynamic circulatory situation and its consequences.