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公开(公告)号：US20190203205A1
公开(公告)日：2019-07-04
申请号：US16236259
申请日：2018-12-28
申请人： Adimab, LLC
CPC分类号： C12N15/1093 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
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公开(公告)号：US10189894B2
公开(公告)日：2019-01-29
申请号：US14150129
申请日：2014-01-08
申请人： ADIMAB, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
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公开(公告)号：US10138478B2
公开(公告)日：2018-11-27
申请号：US15151626
申请日：2016-05-11
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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公开(公告)号：US20180057604A1
公开(公告)日：2018-03-01
申请号：US15525821
申请日：2015-11-18
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan WU , Eric Krauland , Michael Feldhaus , Yin Zhang , Joy Yu Zuchero , Jessica Couch , Mark S Dennis , James A Ernst , Gregory A Lazar
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/22 , C07K16/2881 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C12Y304/23046 , G01N33/6896 , G01N2333/70582 , G01N2333/96472 , G01N2800/28 , G01N2800/52
摘要： The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.
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公开(公告)号：US20210206877A1
公开(公告)日：2021-07-08
申请号：US17113711
申请日：2020-12-07
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan Wu , Eric Krauland , Michael Feldhaus
IPC分类号： C07K16/40 , A61K47/68 , G01N33/573
摘要： The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders
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公开(公告)号：US20190225677A1
公开(公告)日：2019-07-25
申请号：US16215523
申请日：2018-12-10
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
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公开(公告)号：US20180371454A1
公开(公告)日：2018-12-27
申请号：US16126987
申请日：2018-09-10
申请人： Adimab, LLC
IPC分类号： C12N15/10 , G01N33/543
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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公开(公告)号：US20140221250A1
公开(公告)日：2014-08-07
申请号：US14256126
申请日：2014-04-18
申请人： Adimab, LLC
CPC分类号： C12N15/1093 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
摘要翻译： 本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。 图书馆旨在反映人类免疫系统自然产生的免疫缺陷病毒库，具有或不具有衍生自其他物种的DH区段，并且基于通过检查可公开获得的抗体序列数据库而得出的合理设计。
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