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公开(公告)号：US11287379B2
公开(公告)日：2022-03-29
申请号：US16833235
申请日：2020-03-27
Applicant: Agilent Technologies, Inc.
Inventor： Nan Li , Jian Wu , Ye Chen , Tianxing Wang , Xiaobo Wang
Abstract: A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.
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公开(公告)号：US20210301245A1
公开(公告)日：2021-09-30
申请号：US16833651
申请日：2020-03-29
Applicant: Agilent Technologies, Inc.
Inventor： Nan Li , Xin Yao , Longbin Fang , Lingbo Kong , Qiting Ye , Caixia Yang , Brandon Lamarche , Xiaobo Wang
Abstract: A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.
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公开(公告)号：US20240076619A1
公开(公告)日：2024-03-07
申请号：US18361584
申请日：2023-07-28
Applicant: Agilent Technologies, Inc.
Inventor： Xiaoyu Zhang , Yama A. Abassi , Nan Li , Xiaobo Wang
CPC classification number: C12N5/0657 , C12N5/0018 , C12N5/0696 , C12N13/00 , G01N27/028 , C12N2506/45 , C12N2529/00
Abstract: A method of characterizing an effect of a compound on cardiomyocyte beating, including providing a system configured to culture, electrically pace, and monitor heating of beating cells: culturing two populations of immature cardiomyocytes in the system; adding a compound suspected of having an effect on cardiomyocyte maturation to one of the populations of immature cardiomyocytes; electrically pacing the two populations of immature cardiomyocytes according to a pulse profile that functionally matures immature cardiomyocytes until at least one of the two populations of cardiomyocytes is functionally mature; and Characterizing the compound as further driving maturation if the population with compound addition functionally matures before the other cardiomyocyte population.
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公开(公告)号：US20220291191A1
公开(公告)日：2022-09-15
申请号：US17824782
申请日：2022-05-25
Applicant: Agilent Technologies, Inc.
Inventor： Xiaobo Wang , Yama A. Abassi , Biao Xi , Wen Fu Zhang , Xiao Xu
IPC: G01N33/483 , G01N33/487 , G01N33/543 , G01N27/02
Abstract: A method for monitoring a cell beating parameter, which includes adding excitable cells capable of beating to a system for monitoring cell-substrate impedance, the system having an electrode array electrically coupled to an impedance analyzer that measures cell-substrate impedance at millisecond time resolution, and a software program that determines a cell beating parameter from measured cell-substrate impedance; monitoring cell-substrate impedance of the excitable cells; and determining the cell beating parameter from the monitored cell-substrate impedance.
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公开(公告)号：USD941488S1
公开(公告)日：2022-01-18
申请号：US29723537
申请日：2020-02-07
Applicant: Agilent Technologies, Inc.
Designer： Longbin Fang , Qiting Ye , Xin Yao , Zhi Tao , Jian Wu , Nan Li , Xiaobo Wang
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Patent Agency Ranking
公开(公告)号：US12049615B2
公开(公告)日：2024-07-30
申请号：US18194277
申请日：2023-03-31
Applicant: Agilent Technologies, Inc.
Inventor： Nan Li , Xin Yao , Longbin Fang , Lingbo Kong , Qiting Ye , Caixia Yang , Brandon Lamarche , Xiaobo Wang
CPC classification number: C12M41/06 , C12M23/12 , C12M31/02 , C12M41/36 , C12M41/48 , G01N21/6428 , G01N33/5005 , G01N2021/6439
Abstract: A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.
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公开(公告)号：US11906508B2
公开(公告)日：2024-02-20
申请号：US17993716
申请日：2022-11-23
Applicant: Agilent Technologies, Inc.
Inventor： Xiaobo Wang , Yama A. Abassi , Biao Xi , Wen Fu Zhang , Xiao Xu
IPC: G01N33/483 , G01N33/487 , G01N33/543 , G01N27/02
CPC classification number: G01N33/4836 , G01N27/02 , G01N33/4833 , G01N33/48728 , G01N33/5438
Abstract: A system for monitoring cells, which includes a device for monitoring cell-substrate impedance, the device having a plurality of wells on a nonconductive substrate, where each of the plurality of wells has an electrode array fabricated on the substrate for measurement of cell-substrate impedance; an impedance analyzer that measures cell-substrate impedance from the plurality of wells; electronic circuitry with multiple analogue-to-digital conversion channels, where the electronic circuitry electrically connects the electrode arrays to the impedance analyzer such that the electrode arrays are electrically monitored at millisecond time resolution; and a software program that analyzes the measured cell-substrate impedance.
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公开(公告)号：US11746328B2
公开(公告)日：2023-09-05
申请号：US16490302
申请日：2018-03-03
Applicant: Agilent Technologies, Inc.
Inventor： Xiaoyu Zhang , Yama A. Abassi , Nan Li , Xiaobo Wang
CPC classification number: C12N5/0657 , C12N5/0018 , C12N5/0696 , C12N13/00 , G01N27/028 , C12N2506/45 , C12N2529/00
Abstract: Methods of inducing functional maturation of immature cardiomyocytes derived from induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) by electrically pacing the immature cardiomyocytes according to a pulse profile that induces maturation until the immature cardiomyocytes mature into functionally adult cardiomyocytes.
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公开(公告)号：US20230235266A1
公开(公告)日：2023-07-27
申请号：US18194277
申请日：2023-03-31
Applicant: Agilent Technologies, Inc.
Inventor： Nan Li , Xin Yao , Longbin Fang , Lingbo Kong , Qiting Ye , Caixia Yang , Brandon Lamarche , Xiaobo Wang
CPC classification number: C12M41/06 , G01N21/6428 , G01N33/5005 , C12M31/02 , C12M41/48 , C12M41/36 , C12M23/12 , G01N2021/6439
Abstract: A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.
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公开(公告)号：US20230130050A1
公开(公告)日：2023-04-27
申请号：US17993716
申请日：2022-11-23
Applicant: Agilent Technologies, Inc.
Inventor： Xiaobo Wang , Yama A. Abassi , Biao Xi , Wen Fu Zhang , Xiao Xu
IPC: G01N33/483 , G01N33/487 , G01N33/543 , G01N27/02
Abstract: A system for monitoring cells, which includes a device for monitoring cell-substrate impedance, the device having a plurality of wells on a nonconductive substrate, where each of the plurality of wells has an electrode array fabricated on the substrate for measurement of cell-substrate impedance; an impedance analyzer that measures cell-substrate impedance from the plurality of wells; electronic circuitry with multiple analogue-to-digital conversion channels, where the electronic circuitry electrically connects the electrode arrays to the impedance analyzer such that the electrode arrays are electrically monitored at millisecond time resolution; and a software program that analyzes the measured cell-substrate impedance.
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