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11.发明授权Mass spectrometer and mass spectrometry method for analyzing compounds contained in a solution 有权用于分析溶液中所含化合物的质谱仪和质谱法
公开(公告)号：US6114693A
公开(公告)日：2000-09-05
申请号：US299638
申请日：1999-04-27
申请人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： G01N27/62 , G01N27/447 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： G01N30/7266 , H01J49/0468 , H01J49/167
摘要： A mass spectrometer comprising a passage through which a sample solution flows, the passage including a capillary having an open tip, the sample solution flowing through the capillary out of the open tip of the capillary, a gas passage which forms a gas flow around the open tip of the capillary, the gas flow spraying the sample solution flowing out of the open tip of the capillary, a first electrode which contacts the sample solution flowing in the passage and applies an electric potential to the sample solution flowing in the passage, a second electrode disposed around the capillary near the open tip of the capillary, the second electrode being downstream from the first electrode with respect to a direction in which the sample solution flows in the passage, there being no gap extending downstream from the open tip of the capillary to the second electrode in a direction in which the sample solution flows out of the open tip of the capillary, the second electrode being electrically isolated from the sample solution flowing in the capillary and applying an electric field to the sample solution flowing in the capillary, and an analyzer which analyzes a mass of gaseous ions formed from the sample solution sprayed by the gas flow.
摘要翻译： 一种质谱仪，包括样品溶液流过的通道，所述通道包括具有开口尖端的毛细管，所述样品溶液从毛细管的开口尖端流过毛细管，气体通道围绕开口形成气流 毛细管的尖端，气流喷射从毛细管的开口尖端流出的样品溶液，第一电极，其接触在通道中流动的样品溶液，并向在通道中流动的样品溶液施加电位，第二电极 设置在毛细管附近的毛细管周围的电极，第二电极相对于样品溶液在通道中流动的方向从第一电极下游，在毛细管的开口尖端的下游没有间隙 在样品溶液从毛细管的开口尖端流出的方向到第二电极，第二电极是电隔离的 从在毛细管中流动的样品溶液流出并向在毛细管中流动的样品溶液施加电场，以及分析器，其分析由气流喷射的样品溶液形成的气态离子的质量。
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公开(公告)号：US6075243A
公开(公告)日：2000-06-13
申请号：US827184
申请日：1997-03-27
CPC分类号： H01J49/424 , H01J49/044 , H01J49/4255
摘要： A mass spectrometer in which, in order to reduce noise due to other particles (large charge droplets, neutral particles, photons, or the like), the orbit of ions and the orbit of other particles are separated from each other in the inside of a mass analysis region so as to make it possible to prevent the other particles from reaching an ion detection region without using any deflector.
摘要翻译： 一种质谱仪，其中为了减少由于其它颗粒（大电荷液滴，中性粒子，光子等）引起的噪声，离子的轨道和其它颗粒的轨道在一个 质量分析区域，使得可以防止其他颗粒在不使用任何偏转器的情况下到达离子检测区域。
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公开(公告)号：US6060706A
公开(公告)日：2000-05-09
申请号：US23461
申请日：1998-02-13
CPC分类号： H01J49/424 , H01J49/061
摘要： In an analytical apparatus, an ion trap mass spectrometer and a detector for detecting ions separated in the mass spectrometer are installed in different chambers. Ions generated from an ion source and passing through two differential pumping chambers into a third chamber containing the detector are deflected from their initial trajectory into the mass spectrometer in a fourth chamber for separation. In a first embodiment, the separated ions are returned along the same path into the detector in the third chamber. According to a second embodiment, the detector is located along the path of ion travel beyond the mass spectrometer, and the separated ions pass through a second orifice in the mass spectrometer and into the detector in the third chamber.
摘要翻译： 在分析装置中，离子阱质谱仪和用于检测在质谱仪中分离的离子的检测器安装在不同的室中。 从离子源产生并且通过两个差分泵送室的包含检测器的第三室中的离子从第一个进入第四室的初始轨迹偏转到质谱仪中进行分离。 在第一实施例中，分离的离子沿相同的路径返回到第三室中的检测器中。 根据第二实施例，检测器沿着离子行进的路径位于质谱仪之外，并且分离的离子通过质谱仪中的第二孔并进入第三室中的检测器。
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公开(公告)号：US06723286B2
公开(公告)日：2004-04-20
申请号：US09987094
申请日：2001-11-13
申请人： Minoru Sakairi , Yoshiaki Kato , Mamoru Mizumoto , Yuichiro Hashimoto , Jiro Tokita , Masao Suga
发明人： Minoru Sakairi , Yoshiaki Kato , Mamoru Mizumoto , Yuichiro Hashimoto , Jiro Tokita , Masao Suga
IPC分类号： G01N3000
CPC分类号： G01N1/2258 , G01N33/0014 , G01N33/0047 , G01N33/0049 , H01J49/00 , Y10T436/19 , Y10T436/196666 , Y10T436/24
摘要： There was previously no monitoring method and monitoring apparatus which could measure dioxins at ppt levels and dioxin precursors at ppb levels with high sensitivity. According to this invention, organic and inorganic compounds containing highly electronegative elements are selectively ionized by atmospheric pressure chemical ionization, the ions produced are detected by a mass spectrometer, and their amount is measured. As a result, interfering substances such as nitrogen, air, hydrocarbons and carbon dioxide which are the main components of flue gas are eliminated, and dioxins or organochlorine compounds such as dioxin precursors can be selectively monitored.
摘要翻译： 以前没有监测方法和监测装置可以以高灵敏度测量ppp水平的二恶英和ppb水平的二恶英前体。根据本发明，含有高电荷性元素的有机和无机化合物通过大气压化学电离选择性离子化，离子 通过质谱仪检测产生的量，测量其量。结果，消除了作为烟道气主要成分的氮，空气，烃和二氧化碳等干扰物质，二恶英或有机氯化合物如二恶英前体 可以选择性地监测。
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公开(公告)号：US06596991B1
公开(公告)日：2003-07-22
申请号：US09890063
申请日：2001-07-26
IPC分类号： H01J4932
CPC分类号： H01J49/0031 , H01J49/32
摘要： The analysis of isotopomers is conveniently performed using a double focusing high mass resolution magnetic mass spectrometer comprising an electric field and a magnetic field by a constant accelerating voltage slightly less than the accelerating voltage corresponding to the masses of the ions comprising the majority of a sample to be analyzed, and scanning part of an ion accelerating voltage so that it varies within a range effectively corresponding to the masses of the ions of isotopomers of the ions comprising the majority of the sample to be analyzed.
摘要翻译： 使用双重聚焦高质量分辨率的磁质量分析仪方便地进行同位素体的分析，所述双重聚焦高质量分辨率磁性质谱仪通过稍微小于对应于包含大部分样品的离子质量的加速电压的恒定加速电压而包括电场和磁场， 分析和扫描部分离子加速电压，使其在与包括待分析的大部分样品的离子的同位素的离子质量有效的范围内变化。
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公开(公告)号：US06586730B1
公开(公告)日：2003-07-01
申请号：US09505428
申请日：2000-02-16
申请人： Seiji Kamimura , Isamu Takekoshi , Yasushi Terui , Yasuaki Takada , Takayuki Nabeshima , Minoru Sakairi
发明人： Seiji Kamimura , Isamu Takekoshi , Yasushi Terui , Yasuaki Takada , Takayuki Nabeshima , Minoru Sakairi
IPC分类号： H01J4900
CPC分类号： H01J49/282 , H01J49/04 , H01J49/42
摘要： A compact, easy-to-use device is provided which takes in a sample over a shorter distance, the sample introducing time is shortened, and contamination is prevented when the sample is introduced. A burner for generating a plasma, a deflecting portion provided with parallel electrodes for deflecting ions, and an analyzer room for performing mass separation of the deflected ions, these being disposed in a plane in the horizontal direction, and a sample setting portion for setting a sample, a peristaltic pump for aspirating the sample and the burner for introducing and burning the aspirated sample are disposed in a plane in the vertical direction relative to the aforesaid plane. The sample is supplied to the burner from below, and the ions generated by the plasma are made to flow on a horizontal plane.
摘要翻译： 提供了一种紧凑，易于使用的装置，其在较短距离内吸收样品，缩短了样品引入时间，并且在引入样品时防止污染。 用于产生等离子体的燃烧器，设置有用于偏转离子的平行电极的偏转部分和用于进行偏转离子的质量分离的分析器室，这些离子被设置在水平方向的平面中;以及样品设定部， 样品，抽吸样品的蠕动泵和用于引入和燃烧吸气样品的燃烧器相对于上述平面设置在垂直方向上的平面中。 将样品从下方供应到燃烧器，并且使由等离子体产生的离子在水平面上流动。
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公开(公告)号：US06541769B1
公开(公告)日：2003-04-01
申请号：US09660359
申请日：2000-09-12
IPC分类号： B01D5944
CPC分类号： H01J49/424 , H01J49/061
摘要： An ion-deflecting device is located between a mass spectrometer and a detector, and undesired signal sources are prevented from reaching the detector during the ion-trapping period by switching the voltage applied to the detector between the ion-trapping period and the mass-analyzing period. A first voltage is applied to the detector during an ion-trapping period while a second voltage is applied to the detector during a mass-analyzing period. An ion-deflecting device deflects ions such that they do not reach the detector during an ion-trapping period while they do reach the detector during a mass-analyzing period. This way, the life of the detector is increased.
摘要翻译： 离子偏转装置位于质谱仪和检测器之间，并且在离子捕获期间通过切换在离子捕获期和质量分析之间施加到检测器的电压来防止不期望的信号源到达检测器 期。 在离子捕获期间将第一电压施加到检测器，同时在质量分析期间将第二电压施加到检测器。 离子偏转装置使离子偏转，使得它们在离子捕获期间不会在质量分析期间到达检测器时到达检测器。 这样，检测器的寿命就会增加。
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公开(公告)号：US06423965B1
公开(公告)日：2002-07-23
申请号：US09378767
申请日：1999-08-23
IPC分类号： H01J4900
CPC分类号： H01J49/04
摘要： Plasma ion source mass spectrometers or liquid chromatograph/mass spectrometers are provided: wherein photon noises and matrix molecule ions produced by the ion source are decreased, the decrease of the quantity of signal is suppressed, and the apparatus maintenance is improved. The photon noises are decreased with a shielding plate and a 90 degrees deflector. The maintainability in cleaning is improved by a combination of a leading electrode, the shielding plate having a small hole, and a gate valve. The decrease in the quantity of signal is suppressed with the leading electrode, and a double cylindrical type static lens. Position adjustment of the leading electrode is performed with a flat plate having plural holes. Using an ion trap mass analyzer, matrix molecule ions are eliminated by applying a resonance voltage between its end cap electrodes. Decrease in the quantity of signals, which has been a problem, can be prevented, and a high transmission can be realized with a preferable reproducibility against disturbance of an electric field caused by ion lens and the like. A detectable limit of atomic ions of the sample can be improved by eliminating the matrix molecule ions.
摘要翻译： 提供了等离子体离子源质谱仪或液相色谱仪/质谱仪：其中由离子源产生的光子噪声和基质分子离子减少，抑制了信号量的减少，从而改善了设备的维护。 光子噪声随屏蔽板和90度偏转器而减小。 通过前导电极，具有小孔的屏蔽板和闸阀的组合来提高清洁的可维护性。 用前导电极和双圆柱形静电透镜抑制信号量的减少。 引导电极的位置调整用具有多个孔的平板进行。 使用离子阱质量分析仪，通过在其端盖电极之间施加谐振电压来消除基质分子离子。 可以防止已经存在问题的信号量的减少，并且以离子透镜等引起的电场干扰的优选再现性可以实现高透射率。 可以通过消除基质分子离子来改善样品的原子离子的可检测极限。
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公开(公告)号：US06295860B1
公开(公告)日：2001-10-02
申请号：US09348565
申请日：1999-07-07
IPC分类号： G01N100
CPC分类号： H01J49/0422 , G01N1/22 , G01N2001/024
摘要： An explosive detection system in which vapor leaking from luggage is sampled by a sampling probe, negative corona discharge is used to ionize the vapor, and a mass spectrometer is used to detect the ionized vapor, thereby judging whether an explosive is present or not.
摘要翻译： 一种爆炸检测系统，其中通过采样探针对从行李箱泄漏的蒸气进行采样，使用负电晕放电来电离蒸气，并使用质谱仪检测电离蒸汽，从而判断是否存在爆炸物。
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公开(公告)号：US5825027A
公开(公告)日：1998-10-20
申请号：US831486
申请日：1997-03-31
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region and a ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
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