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1.发明授权Mass spectrometer and mass spectrometry method for analyzing compounds contained in a solution 有权用于分析溶液中所含化合物的质谱仪和质谱法
公开(公告)号：US6114693A
公开(公告)日：2000-09-05
申请号：US299638
申请日：1999-04-27
申请人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： G01N27/62 , G01N27/447 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： G01N30/7266 , H01J49/0468 , H01J49/167
摘要： A mass spectrometer comprising a passage through which a sample solution flows, the passage including a capillary having an open tip, the sample solution flowing through the capillary out of the open tip of the capillary, a gas passage which forms a gas flow around the open tip of the capillary, the gas flow spraying the sample solution flowing out of the open tip of the capillary, a first electrode which contacts the sample solution flowing in the passage and applies an electric potential to the sample solution flowing in the passage, a second electrode disposed around the capillary near the open tip of the capillary, the second electrode being downstream from the first electrode with respect to a direction in which the sample solution flows in the passage, there being no gap extending downstream from the open tip of the capillary to the second electrode in a direction in which the sample solution flows out of the open tip of the capillary, the second electrode being electrically isolated from the sample solution flowing in the capillary and applying an electric field to the sample solution flowing in the capillary, and an analyzer which analyzes a mass of gaseous ions formed from the sample solution sprayed by the gas flow.
摘要翻译： 一种质谱仪，包括样品溶液流过的通道，所述通道包括具有开口尖端的毛细管，所述样品溶液从毛细管的开口尖端流过毛细管，气体通道围绕开口形成气流 毛细管的尖端，气流喷射从毛细管的开口尖端流出的样品溶液，第一电极，其接触在通道中流动的样品溶液，并向在通道中流动的样品溶液施加电位，第二电极 设置在毛细管附近的毛细管周围的电极，第二电极相对于样品溶液在通道中流动的方向从第一电极下游，在毛细管的开口尖端的下游没有间隙 在样品溶液从毛细管的开口尖端流出的方向到第二电极，第二电极是电隔离的 从在毛细管中流动的样品溶液流出并向在毛细管中流动的样品溶液施加电场，以及分析器，其分析由气流喷射的样品溶液形成的气态离子的质量。
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公开(公告)号：US6075243A
公开(公告)日：2000-06-13
申请号：US827184
申请日：1997-03-27
CPC分类号： H01J49/424 , H01J49/044 , H01J49/4255
摘要： A mass spectrometer in which, in order to reduce noise due to other particles (large charge droplets, neutral particles, photons, or the like), the orbit of ions and the orbit of other particles are separated from each other in the inside of a mass analysis region so as to make it possible to prevent the other particles from reaching an ion detection region without using any deflector.
摘要翻译： 一种质谱仪，其中为了减少由于其它颗粒（大电荷液滴，中性粒子，光子等）引起的噪声，离子的轨道和其它颗粒的轨道在一个 质量分析区域，使得可以防止其他颗粒在不使用任何偏转器的情况下到达离子检测区域。
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公开(公告)号：US5825027A
公开(公告)日：1998-10-20
申请号：US831486
申请日：1997-03-31
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region and a ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
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公开(公告)号：US06465779B2
公开(公告)日：2002-10-15
申请号：US09968928
申请日：2001-10-03
IPC分类号： H01J4942
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectroscopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and an ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
摘要翻译： 一种质谱仪，其特征在于，包括：离子化装置，用于在大气压下对质谱进行质谱分析的样品化合物进行离子化;将含有所述样品化合物的溶液供给到所述电离装置的样品溶液供给装置，将由所述电离装置形成的离子供给 将设置在电极中的孔设置在真空区域中，以及离子阱型质谱分析装置，用于对通过孔进入真空区域的离子进行质谱分析，其中离子减速电场形成装置设置在 孔和设置有离子入口的电极，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，并且注入离子阱质谱分析装置的离子降低。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。
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公开(公告)号：US06316769B2
公开(公告)日：2001-11-13
申请号：US09739217
申请日：2000-12-19
IPC分类号： H01J4942
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region and a ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
摘要翻译： 一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分散分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置， 意味着通过设置在电极中的孔进入真空区域和离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置有 所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，以及注入离子阱质谱分析装置的离子。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。
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公开(公告)号：US6011260A
公开(公告)日：2000-01-04
申请号：US114945
申请日：1998-07-14
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and anion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
摘要翻译： 一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分散分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置， 意味着通过设置在电极中的孔进入真空区域，以及阴离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置有 所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，以及注入离子阱质谱分析装置的离子。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。
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公开(公告)号：US06180941B2
公开(公告)日：2001-01-30
申请号：US09447578
申请日：1999-11-23
IPC分类号： H01J4942
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and an ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
摘要翻译： 一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分析分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置， 意味着通过设置在电极中的孔进入真空区域，以及离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置的电极之间 其中所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，并且注入离子阱质谱分析装置的离子降低。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。
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公开(公告)号：US5969351A
公开(公告)日：1999-10-19
申请号：US796548
申请日：1997-02-06
CPC分类号： H01J49/168 , H01J49/0404 , H01J49/049 , G01N30/726
摘要： A semi-micro liquid chromatograph/mass spectrometer apparatus has an ion source. The space from the end portion of a flow passage of a liquid chromatograph shell to a vaporization portion is closed so as to prevent the inflow of a gas from outside the ion source into the space. Further, the nebulization and vaporization portions are joined together and heated by a common heater. Dilution of a sample to be analyzed is prevented, and high sensitivity detection becomes possible in a low velocity liquid chromatograph/mass spectrometer.
摘要翻译： 半微量液相色谱仪/质谱仪装置具有离子源。 从液相色谱仪壳体的流路端部到气化部分的空间被封闭，以防止从离子源外部的气体流入空间。 此外，将雾化和蒸发部分接合在一起并通过公共加热器加热。 防止要分析的样品的稀释，并且可以在低速液相色谱仪/质谱仪中进行高灵敏度检测。
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9.发明授权Mass spectrometer and mass spectrometry method for analyzing compounds contained in a solution 失效用于分析溶液中所含化合物的质谱仪和质谱法
公开(公告)号：US5898175A
公开(公告)日：1999-04-27
申请号：US708415
申请日：1996-09-05
申请人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： G01N27/62 , G01N27/447 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： G01N30/7266 , H01J49/0468 , H01J49/167
摘要： A mass spectrometer employing an ion source includes a capillary for spraying therethrough liquid into the atmospheres and an orifice through which a portion in the vicinity of a tip of the capillary is inserted, the orifice being designed in such a way that gases are caused to flow up to the tip of the capillary along a peripheral wall face of the capillary. The flow rate of gas in the vicinity of the tip of the capillary is about the sonic velocity, and a voltage is applied across the liquid flowing through the capillary and the orifice or an electrode arranged in the vicinity of the tip of the capillary.
摘要翻译： 使用离子源的质谱仪包括用于将液体喷射到气氛中的毛细管和插入毛细管的尖端附近的部分的孔，孔被设计成使气体流动 直到毛细管的尖端沿着毛细管的周壁面。 毛细管尖端附近的气体的流速大约是声速，并且在流过毛细管的液体和布置在毛细管尖端附近的孔或电极之间施加电压。
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公开(公告)号：US5986259A
公开(公告)日：1999-11-16
申请号：US837216
申请日：1997-04-22
CPC分类号： H01J49/067 , H01J49/044 , H01J49/045
摘要： In a mass spectrometer using a sonic spray ion source, a technique of controlling the density of droplets in a nebulized sample solution which is passed into a mass spectrometer at high vacuum to an appropriate value to thereby reduce analysis noises is disclosed. A sample solution in a sample solution injection unit 1 is introduced into a capillary 2 disposed in an ion source 6. A gas is introduced from a gas supply unit 4 by way of a gas pipe 5 into the ion source 6 and is caused to flow along the outer circumferential surface at the top end of the capillary 2 and is jetted out from the orifice 3 as a gas flow into atmospheric air. The sample solution jetted from the top end of the capillary 2 is ionized by the gas flow in the atmospheric air. Fine droplets or ions formed by the sonic spray method are collide against a diffuser 7, droplets and ions reduced for the density by the diffusion pass through the holes 8 disposed in the diffuser 7, and pass from the sample orifice 10 into a mass spectrometer 11 and mass analyzed. Provision of the diffuser 7 can suppress generation of analysis noises caused by the clustering phenomenon resulting from introduction of droplets or ions at high density into the mass spectrometer 11, thereby enabling to conduct analysis at high S/N ratio.
摘要翻译： 在使用声波喷射离子源的质谱仪中，公开了一种在雾化样品溶液中控制液滴的密度的技术，其以高真空度进入质谱仪至适当的值，从而降低分析噪声。 将样品溶液注入单元1中的样品溶液引入设置在离子源6中的毛细管2.将气体从气体供给单元4通过气体管道5引入离子源6中并使其流动 沿着毛细管2的顶端的外周面，并且作为气流从孔3喷出到大气中。 从毛细管2的顶端喷出的样品溶液通过大气中的气流被离子化。 通过声波喷射法形成的细小液滴或离子与扩散器7碰撞，通过扩散通过设置在扩散器7中的孔8而使密度减小的液滴和离子，并从样品孔10通过到质谱仪11 并进行质量分析。 扩散器7的设置可以抑制由高密度地将液滴或离子引入质谱仪11而产生的聚集现象引起的分析噪声的产生，从而能够以高S / N比进行分析。
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