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公开(公告)号：US20170322402A1
公开(公告)日：2017-11-09
申请号：US15642434
申请日：2017-07-06
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Peter Hodges Gregson
IPC: G02B21/00
CPC classification number: G02B21/0008
Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
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公开(公告)号：US20170075099A1
公开(公告)日：2017-03-16
申请号：US15360724
申请日：2016-11-23
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Hershel Macaulay , Noah Hymes-Vandermeulen
CPC classification number: G02B21/34 , G01N1/28 , G01N1/4077 , G01N15/0606 , G01N15/0612 , G01N15/1468 , G01N21/59 , G01N33/49 , G01N35/00029 , G01N2015/008 , G01N2015/1087 , G01N2015/1486
Abstract: Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.
Abstract translation: 除其他之外，第一表面被配置为接收样品并且用于显微镜装置。 存在相对于第一表面移动到预定位置的第二表面以形成位于第一表面和第二表面之间并且包含至少部分样品的样品空间。 存在被配置为将第二表面从初始位置移动到预定位置以形成样本空间的机构。 当样品在第一表面上就位时，第二表面的运动包括不仅仅是第二表面朝向第一表面的线性运动的轨迹。
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公开(公告)号：US11733239B2
公开(公告)日：2023-08-22
申请号：US17674967
申请日：2022-02-18
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G01N21/41 , G01N21/55 , G01N21/59 , G01N33/543 , G01N33/569 , G01N21/17
CPC classification number: G01N33/54313 , G01N21/41 , G01N21/55 , G01N21/59 , G01N33/56983 , G01N2021/1772
Abstract: A method includes attaching two or more beads to each unit of one or more units of a chemical component in a sample, to form, for each unit of the chemical component, a multi-bead complex including two or more beads and the unit of the chemical component; placing the sample on a surface of an image sensor; at the image sensor, receiving light originating at a light source, the received light including light reflected by, refracted by, or transmitted through the beads of the multi-bead complexes; at the image sensor, capturing one or more images of the sample from the received light; and identifying, in at least one of the images of the sample, separate multi-bead complexes, the identifying of the separate multi-bead complexes including associating the two or more beads of each of the multi-bead complexes based on proximity to one another.
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公开(公告)号：US11598699B2
公开(公告)日：2023-03-07
申请号：US16994124
申请日：2020-08-14
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Hershel Macaulay
Abstract: Among other things, a diluted sample is generated based on mixing a small sample of blood with a one or more diluents. A thin film of the diluted sample is formed on the surface of a contact optical microscopy sensor. Red blood cells within a portion of the thin film of the diluted sample are illuminated using light of a predetermined wavelength. One or more images of the diluted sample are acquired based on illuminating the red blood cells within the portion of the thin film of the diluted sample. The acquired one or more images of the diluted sample are then processed. The mean corpuscular hemoglobin in the red blood cells within the portion of the thin film of the diluted sample is determined based on processing the acquired images of the diluted sample.
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公开(公告)号：US11255850B2
公开(公告)日：2022-02-22
申请号：US16845458
申请日：2020-04-10
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G01N21/59 , G01N33/543 , G01N33/569 , G01N21/41 , G01N21/55 , G01N21/17
Abstract: A method includes attaching two or more beads to each unit of one or more units of a chemical component in a sample, to form, for each unit of the chemical component, a multi-bead complex including two or more beads and the unit of the chemical component; placing the sample on a surface of an image sensor; at the image sensor, receiving light originating at a light source, the received light including light reflected by, refracted by, or transmitted through the beads of the multi-bead complexes; at the image sensor, capturing one or more images of the sample from the received light; and identifying, in at least one of the images of the sample, separate multi-bead complexes, the identifying of the separate multi-bead complexes including associating the two or more beads of each of the multi-bead complexes based on proximity to one another.
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Patent Agency Ranking
公开(公告)号：US11112347B2
公开(公告)日：2021-09-07
申请号：US16889430
申请日：2020-06-01
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
Abstract: Among other things, an imaging sensor includes a two-dimensional array of photosensitive elements and a surface to receive a sample within a near-field distance of the photosensitive elements. Electronics classify microbeads in the sample as belonging to different classes based on the effects of different absorption spectra of the different classes of microbeads on light received at the surface. In some examples, the number of different distinguishable classes of microbeads can be very large based on combinations of the effects on light received at the surface of the different absorption spectra together, spatial arrangements of colorants in the microbeads that impart the different absorption spectra, different sizes of microbeads, and different shapes of microbeads, among other things.
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公开(公告)号：US10900999B2
公开(公告)日：2021-01-26
申请号：US16820904
申请日：2020-03-17
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G01Q60/20 , G01N21/64 , G02B21/00 , G02B21/36 , H01L27/146
Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
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公开(公告)号：US20200309777A1
公开(公告)日：2020-10-01
申请号：US16845458
申请日：2020-04-10
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G01N33/569 , G01N21/41 , G01N21/59 , G01N21/55
Abstract: A method includes attaching two or more beads to each unit of one or more units of a chemical component in a sample, to form, for each unit of the chemical component, a multi-bead complex including two or more beads and the unit of the chemical component; placing the sample on a surface of an image sensor; at the image sensor, receiving light originating at a light source, the received light including light reflected by, refracted by, or transmitted through the beads of the multi-bead complexes; at the image sensor, capturing one or more images of the sample from the received light; and identifying, in at least one of the images of the sample, separate multi-bead complexes, the identifying of the separate multi-bead complexes including associating the two or more beads of each of the multi-bead complexes based on proximity to one another.
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公开(公告)号：US20200273900A1
公开(公告)日：2020-08-27
申请号：US16837640
申请日：2020-04-01
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Madhuranga Srinath Rankaduwa
IPC: H01L27/146 , G01N21/27 , G01N33/49 , G02B21/00
Abstract: Among other things, an integral image sensor includes a sensor surface having a surface area at which light-sensitive pixels are arranged in rows and columns. The surface area includes two or more light-sensitive subareas each of the subareas having been configured to have been diced from a wafer along two orthogonal dimensions to form a discrete image sensor. The two or more light-sensitive subareas are arranged along one of the two orthogonal dimensions. The sensor surface of the integral image sensor is flat and continuous across the two or more subareas.
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公开(公告)号：US20190341414A1
公开(公告)日：2019-11-07
申请号：US16514346
申请日：2019-07-17
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Madhuranga Srinath Rankaduwa
IPC: H01L27/146 , G01N33/49 , G01N21/27
Abstract: Among other things, an integral image sensor includes a sensor surface having a surface area at which light-sensitive pixels are arranged in rows and columns. The surface area includes two or more light-sensitive subareas each of the subareas having been configured to have been diced from a wafer along two orthogonal dimensions to form a discrete image sensor. The two or more light-sensitive subareas are arranged along one of the two orthogonal dimensions. The sensor surface of the integral image sensor is flat and continuous across the two or more subareas.
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