公开(公告)号：US20050251030A1

公开(公告)日：2005-11-10

申请号：US11107640

申请日：2005-04-15

申请人： Fred Azar ,  Ali Khamene ,  Frank Sauer ,  Sebastian Vogt

发明人： Fred Azar ,  Ali Khamene ,  Frank Sauer ,  Sebastian Vogt

IPC分类号： A61B5/05 ,  A61B6/00 ,  A61B19/00

CPC分类号： A61B90/36 ,  A61B34/10 ,  A61B34/20 ,  A61B90/11 ,  A61B90/361 ,  A61B2034/107 ,  A61B2090/365

摘要： A system and method for instrument placement using an image based navigation system is disclosed. A target of interest is identified in a medical image of a patient. An image plane is displayed that goes through a center of the target. The image plane has a configurable orientation. The image plane is used to select a path for an instrument from a position on the patient's skin to the center of the target. A trajectory plane is viewed from a tip of the instrument to the center of the target. The trajectory plane reflects an orientation of the instrument. A particular trajectory plane is selected that is representative of a desired orientation of the instrument. An image of the particular trajectory plane is frozen. The instrument can then be inserted using a virtual guide and is navigated toward the target.

摘要翻译： 公开了一种使用基于图像的导航系统进行仪器放置的系统和方法。 在患者的医学图像中识别感兴趣的目标。 显示穿过目标中心的图像平面。 图像平面具有可配置的方向。 图像平面用于从患者皮肤上的位置到目标的中心选择仪器的路径。 从仪器的尖端到目标的中心观察轨迹平面。 轨迹平面反映了仪器的方向。 选择代表仪器的期望取向的特定轨迹平面。 特定轨迹平面的图像被冻结。 然后可以使用虚拟指南插入仪器并导航到目标。

公开(公告)号：US07949385B2

公开(公告)日：2011-05-24

申请号：US11405304

申请日：2006-04-17

申请人： Ali Khamene ,  Martin W. Masters ,  Frank Sauer ,  Therese Velde

发明人： Ali Khamene ,  Martin W. Masters ,  Frank Sauer ,  Therese Velde

IPC分类号： A61B5/05

CPC分类号： A61B5/1077 ,  A61B5/0066 ,  H04R25/652 ,  H04R25/658 ,  H04R2225/77

摘要： A method for reconstructing an ear canal from optical coherence tomography (OCT) scan data of an ear comprises extracting frame numbers and line numbers of interference intensities corresponding to one or more markers on an OCT scan guide, receiving reference frame numbers and lines numbers for one or more markers, determining a starting position and direction for the OCT ear scan from the ear scan marker frame and line numbers and the reference marker frame and line numbers, for each scan line, finding a pixel number of a maximum interference intensity value, and determining an offset distance of said pixel from said scan guide, and reconstructing a surface of the ear canal from the distance offset data.

摘要翻译： 用于从耳朵的光学相干断层扫描（OCT）扫描数据重建耳道的方法包括在OCT扫描引导件上提取对应于一个或多个标记的干扰强度的帧号和干扰强度的行号，接收参考帧编号和一个 或更多的标记，为每个扫描线确定来自耳朵扫描标记帧和线号以及参考标记帧和线号的OCT耳朵扫描的起始位置和方向，找到最大干扰强度值的像素数，以及 确定所述像素与所述扫描引导件的偏移距离，以及从所述距离偏移数据重建所述耳道的表面。

公开(公告)号：US07940999B2

公开(公告)日：2011-05-10

申请号：US11686533

申请日：2007-03-15

申请人： Rui Liao ,  Christoph Guetter ,  Chenyang Xu ,  Yiyong Sun ,  Ali Khamene ,  Frank Sauer

发明人： Rui Liao ,  Christoph Guetter ,  Chenyang Xu ,  Yiyong Sun ,  Ali Khamene ,  Frank Sauer

IPC分类号： G06K9/00 ,  G06K9/32 ,  G06K9/62

CPC分类号： G06K9/00208 ,  G06K9/6212 ,  G06T7/33 ,  G06T7/35 ,  G06T2207/30101

摘要： A method of registering 3-dimensional digitized images to 2-dimensional digitized images during a medical procedure includes providing a pair of correctly-registered training images L={lr, lf} and their joint intensity distribution pl(ir, if), wherein ir and if are reference and floating images, respectively, providing a pair of observed images O={or, of} and their joint intensity distribution po(ir, if), mapping a marginal intensity distribution of the observed pair O={or, of} to a marginal intensity distribution of the training pair L={lr, lf}, and estimating a set of parameters T that registers image of to image or by maximizing a weighted sum of a Jensen-Shannon divergence (JSD) of a joint intensity distribution of the observed pair and a joint intensity distribution of the training pair and a similarity measure between the observed images.

摘要翻译： 在医疗过程中将三维数字化图像注册到二维数字化图像的方法包括提供一对正确注册的训练图像L = {lr，lf}及其联合强度分布pl（ir，if），其中ir 并且如果分别是参考和浮动图像，则提供一对观察图像O = {或，}和它们的联合强度分布po（ir，if），映射观察到的对的边缘强度分布O = {或， }到训练对的边缘强度分布L = {lr，lf}，并且估计登记到图像的图像的一组参数T或者通过最大化联合强度的Jensen-Shannon散度（JSD）的加权和 观察对的分布和训练对的联合强度分布以及观察图像之间的相似性度量。

公开(公告)号：US07853308B2

公开(公告)日：2010-12-14

申请号：US11056318

申请日：2005-02-11

申请人： Frank Sauer ,  Ali Khamene

发明人： Frank Sauer ,  Ali Khamene

IPC分类号： A61B5/05

CPC分类号： A61N5/1049 ,  A61B5/1135 ,  A61B5/7289 ,  A61B6/12 ,  A61N5/1037 ,  A61N2005/1061 ,  A61N2005/1062

摘要： A system and method for positioning a patient for radiotherapy is provided. The method comprises: acquiring a first x-ray image sequence of a target inside the patient at a first angle; acquiring first respiratory signals of the patient while acquiring the first x-ray image sequence; acquiring a second x-ray image sequence of the target at a second angle; acquiring second respiratory signals of the patient while acquiring the second x-ray image sequence; synchronizing the first and second x-ray image sequences with the first and second respiratory signals to form synchronized first and second x-ray image sequences; identifying the target in the synchronized first and second x-ray image sequences; and determining three-dimensional (3D) positions of the target through time in the synchronized first and second x-ray image sequences.

摘要翻译： 提供了一种放射治疗患者定位系统和方法。 该方法包括：以第一角度获取患者内的目标的第一x射线图像序列; 在获取第一x射线图像序列的同时获取患者的第一呼吸信号; 以第二角度获取目标的第二x射线图像序列; 在获取第二X射线图像序列的同时获取患者的第二呼吸信号; 使第一和第二X射线图像序列与第一和第二呼吸信号同步以形成同步的第一和第二X射线图像序列; 识别同步的第一和第二X射线图像序列中的目标; 以及在所述同步的第一和第二X射线图像序列中确定所述目标通过时间的三维（3D）位置。

公开(公告)号：US20070219450A1

公开(公告)日：2007-09-20

申请号：US11292338

申请日：2005-12-01

申请人： Fred Azar ,  Ali Khamene ,  Frank Sauer ,  Bruce Tromberg ,  Albert Cerussi

发明人： Fred Azar ,  Ali Khamene ,  Frank Sauer ,  Bruce Tromberg ,  Albert Cerussi

IPC分类号： A61B6/00

CPC分类号： A61B5/4312 ,  A61B5/0091 ,  A61B34/20 ,  A61B2034/105 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/373 ,  G01N21/359 ,  G01N21/474 ,  G01N21/4795 ,  G01N2021/1787 ,  G01N2021/4745 ,  G01N2201/0221 ,  G01N2201/0612 ,  G01N2201/0691 ,  G01N2201/08

摘要： A diffuse optical spectroscopy system comprises a laser breast scanner, a handheld probe connected to the laser breast scanner for scanning a breast, and a tracking device coupled to the handheld probe, wherein the tracking device determines locations of the handheld probe relative to the breast. The tracking device comprises a magnetic tracking device, an optical tracking device or a laser tracking device.

摘要翻译： 扩散光谱系统包括激光乳房扫描器，连接到用于扫描乳房的激光乳房扫描器的手持式探头以及耦合到手持探针的跟踪装置，其中跟踪装置确定手持式探针相对于乳房的位置。 跟踪装置包括磁跟踪装置，光学跟踪装置或激光跟踪装置。

公开(公告)号：US06695779B2

公开(公告)日：2004-02-24

申请号：US10222333

申请日：2002-08-16

申请人： Frank Sauer ,  Ali Khamene ,  Benedicte Bascle

发明人： Frank Sauer ,  Ali Khamene ,  Benedicte Bascle

IPC分类号： A61B800

CPC分类号： A61B8/467 ,  A61B8/00 ,  A61B8/4245 ,  A61B8/462 ,  A61B8/466 ,  A61B8/483 ,  A61B8/5238 ,  A61B17/3403 ,  A61B90/37 ,  A61B2017/3413 ,  G01S7/52034 ,  G01S7/52036 ,  G01S7/52068 ,  G01S7/52084 ,  G01S15/8993

摘要： A method for visualization of ultrasound images comprises the steps of deriving ultrasound images of an object; freezing and storing in space and time selected ones of the images; displaying the selected ones of the images as a set; selectively freezing and adding to the set a further one of the images; and, optionally, selectively removing an image from the set.

摘要翻译： 一种用于超声图像可视化的方法包括：导出对象的超声图像的步骤; 冻结和存储空间和时间选择的图像; 将所选择的图像显示为一组; 选择性地冷冻并添加到另一个图像中; 并且可选地，选择性地从组中去除图像。

公开(公告)号：US06612991B2

公开(公告)日：2003-09-02

申请号：US10222170

申请日：2002-08-16

申请人： Frank Sauer ,  Ali Khamene

发明人： Frank Sauer ,  Ali Khamene

IPC分类号： A61B800

CPC分类号： G01S7/52068 ,  A61B8/00 ,  A61B8/461 ,  A61B8/469 ,  A61B8/483 ,  A61B8/5238 ,  A61B17/3403 ,  A61B90/37 ,  A61B2017/3413 ,  G01S7/52034 ,  G01S7/52036 ,  G01S7/52084 ,  G01S15/8993

摘要： A method for video assistance for ultrasound guided needle biopsy of a patient, includes the steps of obtaining an ultrasound image of said patient in an ultrasound imaging plane by way of a transducer head; obtaining a body surface video image of said patient including an area wherein said ultrasound imaging plane intersects said body surface, by way of a video camera mounted on said transducer head and having an optical axis lying in said ultrasound imaging plane such that said ultrasound imaging plane corresponds to a line in said video image; and overlaying graphic markers onto said video image for indicating said ultrasound imaging plane as a line of possible entry points for needle biopsy.

摘要翻译： 一种用于患者的超声引导针活检的视频辅助的方法，包括以下步骤：通过换能器头在超声成像平面中获得所述患者的超声图像; 获得所述患者的体表视频图像，其包括其中所述超声成像平面与所述体表相交的区域，通过安装在所述换能器头上的摄像机，并且具有位于所述超声成像平面中的光轴，使得所述超声成像平面 对应于所述视频图像中的行; 以及将图形标记叠加到所述视频图像上，用于将所述超声成像平面指示为用于针活检的可能入口点的一行。

公开(公告)号：US07787683B2

公开(公告)日：2010-08-31

申请号：US11303564

申请日：2005-12-16

申请人： Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James P. Williams

发明人： Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James P. Williams

IPC分类号： G06K9/00

CPC分类号： G06K9/00208 ,  G06K2009/00932 ,  G06K2209/05

摘要： A system and method for tree structure based two-dimensional to three-dimensional registration are provided for receiving three-dimensional (3D) data indicative of vessels, segmenting the 3D data with a vessel tree, simulating two-dimensional (2D) data responsive to the segmented 3D data to form a simulated 2D image, receiving 2D data indicative of vessels, segmenting the received 2D data with a vessel tree, finding a distance transform of the segmented 2D data to form a 2D distance map image, considering a set of poses as state vectors with the corresponding probability computed using the similarity measure computation, re-sampling the pose vector to find a set of most probable poses and considering them as hypothesized poses, recomputing the projection and re-evaluating the probability of the hypothesized poses and updating the state vector until the optimal pose is found.

摘要翻译： 提供了一种用于基于树结构的二维至三维配准的系统和方法，用于接收指示血管的三维（3D）数据，用血管树分割3D数据，模拟二维（2D）数据，响应于 分割的3D数据以形成模拟2D图像，接收指示血管的2D数据，用血管树分割接收的2D数据，找到分割的2D数据的距离变换以形成2D距离图图像，考虑一组姿势 作为具有使用相似度测量计算计算的相应概率的状态向量，重新采样姿态向量以找到一组最可能的姿势并将其视为假设姿势，重新计算投影并重新估计假设姿势的概率和更新 状态矢量，直到找到最佳姿势。

公开(公告)号：US07774044B2

公开(公告)日：2010-08-10

申请号：US11056317

申请日：2005-02-11

申请人： Frank Sauer ,  Ali Khamene ,  Sebastian Vogt

发明人： Frank Sauer ,  Ali Khamene ,  Sebastian Vogt

IPC分类号： A61B5/05 ,  G09G5/00

CPC分类号： G02B7/002 ,  A61B34/10 ,  A61B34/20 ,  A61B90/20 ,  A61B90/36 ,  A61B90/361 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/2072 ,  A61B2090/371 ,  G02B27/017 ,  G02B2027/0138 ,  G02B2027/0187 ,  G06F3/012

摘要： A method for augmented reality navigation of a medical intervention includes providing a stereoscopic head mounted display, the display including a pair of stereo viewing cameras, at least one tracking camera, and a stereoscopic guidance display. During a medical intervention on a patient, the patient's body pose is determined from a rigid body transformation between the tracking camera and frame markers on the scanning table, and the pose of an intervention instrument with respect to the table is determined. A visual representation of the patient overlaid with an image of the intervention target, the instrument, and a path for guiding the instrument to perform said medical intervention is displayed in the stereoscopic guidance display.

摘要翻译： 用于医疗干预的增强现实导航的方法包括提供立体头戴式显示器，所述显示器包括一对立体观看照相机，至少一个跟踪相机和立体指导显示器。 在患者的医疗干预中，患者的身体姿势由跟踪摄像机和扫描台上的帧标记之间的刚性身体变换确定，并且确定干预仪器相对于桌子的姿势。 在立体指导显示中显示覆盖有介入目标图像，仪器和用于引导仪器执行所述医疗干预的路径的患者的视觉表示。

公开(公告)号：US20080287787A1

公开(公告)日：2008-11-20

申请号：US11649391

申请日：2007-01-03

申请人： Frank Sauer ,  Ali Khamene ,  Oliver Kutter ,  Sebastian Kassner

发明人： Frank Sauer ,  Ali Khamene ,  Oliver Kutter ,  Sebastian Kassner

IPC分类号： A61B8/13

CPC分类号： A61B8/12 ,  A61B5/062 ,  A61B8/0833 ,  A61B8/4254 ,  A61B8/483 ,  A61B8/587 ,  B33Y80/00

摘要： Apparatus for calibrating an ultrasound transducer providing B-scans for two-dimensional (2D) images, includes: an ultrasound probe for providing B-scans; a position sensing device, the position sensing device being attached to the ultrasound probe and operating as part of a position sensing system in cooperation with a fixed sensing control unit, for labeling the B-scans with their respective relative positions and orientations (pose); a phantom marker for being imaged by the ultrasound probe for providing measurements which together with known physical properties of the phantom marker are used to derive calibration information for relating measurement data from the position sensing device to the poses of the B-scans to construct a 3D image; and the phantom marker comprising an encoded line object with distinctive calibration characteristics indicative of position along the line object, wherein the line object is disposed in a generally circumferential manner about a common axis with the probe.

摘要翻译： 用于校准提供二维（2D）图像的B扫描的超声换能器的装置包括：用于提供B扫描的超声探头; 位置感测装置，所述位置感测装置附接到所述超声波探头，并且作为与固定感测控制单元协作的位置感测系统的一部分进行操作，用于以它们各自的相对位置和取向（姿势）标记B扫描; 用于由超声波探头成像的用于提供测量的幻影标记，其与模拟标记的已知物理特性一起用于导出校准信息，用于将来自位置感测装置的测量数据与B扫描的姿态相关联以构建3D 图片; 并且所述假想标记包括具有指示沿着所述线对象的位置的独特校准特性的编码线对象，其中所述线对象以围绕所述探针的公共轴线大致圆周方式设置。