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    Non-leaching adhesive system and its use in a liquid immersion objective
    11.
    发明授权
    Non-leaching adhesive system and its use in a liquid immersion objective 有权
    非浸出粘合剂系统及其在液体浸入物中的应用

    公开(公告)号：US07642297B2

    公开(公告)日：2010-01-05

    申请号：US10568837

    申请日：2004-08-05

    申请人： Emile Johannes Karel Verstegen ,  Johan George Kloosterboer ,  Hendrik Roelof Stapert ,  Jacobus Hermanus Maria Neijzen ,  Helmar Van Santen

    发明人： Emile Johannes Karel Verstegen ,  Johan George Kloosterboer ,  Hendrik Roelof Stapert ,  Jacobus Hermanus Maria Neijzen ,  Helmar Van Santen

    IPC分类号： C08F2/46 ,  C09J4/02

    CPC分类号： C09J135/02

    摘要： A non-leaching adhesive system and its use in a liquid immersion objective for immersion-writing of masters for optical discs are disclosed. The adhesive system comprises at least one monomer, selected from among the group of acrylate and methacrylate monomers, allylic monomers, norbornene monomers, hybrid monomers thereof, containing chemically different polymeriazble groups, and multifunctional thiol monomers, provided that said thiol is used in combination with at least one of said non-thiol monomers; and a polymerization initiator. At least one of said monomers, not being a thiol, is provided with at least two functional polymerizable groups to obtain a crosslinked polymer network. The polymerization initiator is preferably an initiator that can be activated both thermally and with UV radiation. The adhesive system may further contain a reactive diluent. Further the use of the present adhesive system in mounting a liquid immersion objective is disclosed.

    摘要翻译： 公开了一种非浸出粘合剂系统及其在用于浸入式写入光盘的液浸物镜中的用途。 粘合剂体系包含至少一种选自丙烯酸酯和甲基丙烯酸酯单体的单体，烯丙基单体，降冰片烯单体，含有化学上不同的聚合物基团的杂化单体和多官能硫醇单体，条件是所述硫醇与 所述非硫醇单体中的至少一种; 和聚合引发剂。 至少一种所述单体（不是硫醇）具有至少两个官能的可聚合基团以获得交联的聚合物网络。 聚合引发剂优选是能够以热辐射和UV辐射活化的引发剂。 粘合剂体系还可以含有反应性稀释剂。 此外，公开了本发明的粘合剂系统在安装液浸物镜中的用途。

    LENS SYSTEM
    12.
    发明申请
    LENS SYSTEM 审中-公开
    镜头系统

    公开(公告)号：US20090116125A1

    公开(公告)日：2009-05-07

    申请号：US12302049

    申请日：2007-05-25

    申请人： Aleksey Kolesnychenko ,  Sjoerd Stallinga ,  Hendrik Roelof Stapert

    发明人： Aleksey Kolesnychenko ,  Sjoerd Stallinga ,  Hendrik Roelof Stapert

    IPC分类号： G02B9/00 ,  G02B17/00 ,  G01J5/08

    CPC分类号： G01J5/08 ,  G01J5/0037 ,  G01J5/0806 ,  G01J5/0809 ,  G01J5/0846 ,  G01J5/0862 ,  G01J5/089 ,  G01J5/602 ,  G01J2005/0077 ,  G01N2021/6478 ,  G02B27/42 ,  G02B27/4233

    摘要： The present invention concerns a lens system. More specifically, it concerns a lens system comprising a first lens (3), a deflection element (5) and a second lens (6), wherein the deflection element (5) is arranged between the first lens (3) and the second lens (6). The deflection element comprises at least a first annular zone and a second annular zone, the annular zones being arranged in a concentric fashion and wherein the deflection angle of each annular zone is different from the deflection angle of every other annular zone. Furthermore, the present invention concerns a temperature analysis system comprising a lens system and the use of a temperature analysis system.

    摘要翻译： 本发明涉及一种透镜系统。 更具体地，涉及一种包括第一透镜（3），偏转元件（5）和第二透镜（6）的透镜系统，其中偏转元件（5）布置在第一透镜（3）和第二透镜 （6）。 偏转元件至少包括第一环形区域和第二环形区域，环形区域以同心方式布置，并且其中每个环形区域的偏转角度与每隔一个环形区域的偏转角度不同。 此外，本发明涉及包括透镜系统和使用温度分析系统的温度分析系统。

    INTEGRATED DEVICE HAVING AN ARRAY OF PHOTODETECTORS AND AN ARRAY OF SAMPLE SITES
    13.
    发明申请
    INTEGRATED DEVICE HAVING AN ARRAY OF PHOTODETECTORS AND AN ARRAY OF SAMPLE SITES 审中-公开
    具有照相机阵列和样品库阵列的集成设备

    公开(公告)号：US20100230610A1

    公开(公告)日：2010-09-16

    申请号：US12294469

    申请日：2007-03-20

    申请人： Pieter Jan Van Der Zaag ,  Nigel David Young ,  Hendrik Roelof Stapert

    发明人： Pieter Jan Van Der Zaag ,  Nigel David Young ,  Hendrik Roelof Stapert

    IPC分类号： G01J1/58 ,  B23P17/04

    CPC分类号： G01N21/6454 ,  G01N21/6428 ,  G01N21/76 ,  Y10T29/49826

    摘要： An integrated device for detecting emissions from a sample (70) involves forming an array of photo detectors (20) for detecting the emissions and forming an array of sites for receiving the sample such that edges of the sites are defined by edges of the photo detectors. A side wall of a site using a diode can provide a side wall suitable for ink-jet printing samples such as biomolecules with no extra mask steps. This helps enable the sample and the photo detector to be mutually aligned more easily or more cost effectively than conventional devices where the site for receiving the sample is formed separately from the photo detector. The detection can be in any direction, such as lateral or vertical detection. Lateral optical detection with a shielded photodiode means only light emanating from one pixel/spot is detected. A light source (200) to stimulate emissions can be integrated.

    摘要翻译： 用于检测来自样品（70）的发射的集成装置涉及形成用于检测发射的光电检测器（20）的阵列，并形成用于接收样品的位置阵列，使得位置的边缘由光电检测器的边缘限定 。 使用二极管的位点的侧壁可以提供适合于喷墨打印样品的侧壁，例如没有额外掩模步骤的生物分子。 这有助于样品和光电检测器与传统的接收样品的部位与光电检测器分开形成的装置更容易或更经济地相互对准。 检测可以在任何方向，例如横向或垂直检测。 使用屏蔽光电二极管的横向光学检测意味着仅检测到从一个像素/点发出的光。 可以集成用于刺激排放物的光源（200）。

    MICROELECTRONIC SENSOR DEVICE FOR DNA DETECTION
    14.
    发明申请
    MICROELECTRONIC SENSOR DEVICE FOR DNA DETECTION 有权
    用于DNA检测的微电子传感器装置

    公开(公告)号：US20090325164A1

    公开(公告)日：2009-12-31

    申请号：US12303448

    申请日：2007-05-24

    申请人： Erik Robert Vossenaar ,  Marc Wilhelmus Gisbert Ponjee ,  Hendrik Roelof Stapert ,  Mark Thomas Johnson

    发明人： Erik Robert Vossenaar ,  Marc Wilhelmus Gisbert Ponjee ,  Hendrik Roelof Stapert ,  Mark Thomas Johnson

    IPC分类号： C12Q1/68 ,  C12M1/00

    CPC分类号： G01N21/6454 ,  B01L3/5027 ,  B01L3/50851 ,  B01L7/525 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12Q1/6825 ,  G01N21/0332 ,  G01N21/6428 ,  G01N2021/6439 ,  C12Q2565/1015 ,  C12Q2527/101 ,  C12Q2527/107

    摘要： The invention relates to a microelectronic sensor device and a method for the investigation of biological target substances (20), for example oligonucleotides like DNA fragments. In one embodiment, the device comprises a reaction surface (RS) to which target specific reactants (10) are attached and which lies between a sample chamber (SC) and an array of selectively controllable heating elements (HE). The temperature profile in the sample chamber (SC) can be controlled as desired to provide for example conditions for a PCR and/or for a controlled melting of hybridizations. The reactant (10) and/or the target substance (20) comprises a label (12) with an observable property, like fluorescence, that changes if the target substance (20) is bound to the reactant (10), said property being detected by an array of sensor elements, for example photosensors (SE). The fluorescence of the label (12) may preferably be transferred by FRET to a different fluorescent label (22) or quenched if the target substance (20) is bound.

    摘要翻译： 本发明涉及一种微电子传感器装置和一种用于研究生物靶物质（20）的方法，例如DNA片段等寡核苷酸。 在一个实施方案中，所述装置包括反应表面（RS），目标特异性反应物（10）附着到所述反应表面（RS），并且位于样品室（SC）和选择性可控制的加热元件（HE）阵列之间。 样品室（SC）中的温度曲线可以根据需要进行控制，以提供例如PCR和/或受控熔化杂交的条件。 反应物（10）和/或目标物质（20）包含具有可观察性质（如荧光）的标记物（12），如果目标物质（20）与反应物（10）结合，则其变化，所述性质被检测 通过传感器元件阵列，例如光电传感器（SE）。 标记物（12）的荧光优选通过FRET转移到不同的荧光标记物（22），或者如果靶物质（20）被结合则被淬灭。

    Luminescence sensor operating in reflection mode
    17.
    发明授权
    Luminescence sensor operating in reflection mode 有权
    发光传感器以反射模式工作

    公开(公告)号：US08039814B2

    公开(公告)日：2011-10-18

    申请号：US12158451

    申请日：2006-12-19

    申请人： Maarten Marinus Johannes Wilhelm Van Herpen ,  Derk Jan Wilfred Klunder ,  Hendrik Roelof Stapert

    发明人： Maarten Marinus Johannes Wilhelm Van Herpen ,  Derk Jan Wilfred Klunder ,  Hendrik Roelof Stapert

    IPC分类号： G01N21/64

    CPC分类号： G01N21/648 ,  G01N21/6428

    摘要： A luminescence sensor, such as a luminescence biosensor or a luminescence chemical sensor, includes a substrate having at least one aperture filled with a medium. The aperture has a first lateral dimension larger than the diffraction limit of excitation radiation in the medium, and a second lateral dimension smaller than the diffraction limit of the excitation radiation in the medium. A method is also provided for the detection of luminescence radiation, e.g. fluorescence radiation, generated by at least one optically variable molecule, e.g. fluorophore, in the at least one aperture. Beneficially, the excitation radiation is polarized to suppress the excitation radiation in the apertures. The luminescence sensor and the method are able to detect relatively low concentrations of optically variable molecules, e.g. fluorophores.

    摘要翻译： 诸如发光生物传感器或发光化学传感器的发光传感器包括具有填充有介质的至少一个孔的基板。 该孔具有比介质中的激发辐射的衍射极限大的第一横向尺寸，以及小于介质中的激发辐射的衍射极限的第二横向尺寸。 还提供了一种用于检测发光辐射的方法，例如， 由至少一个光学可变分子产生的荧光辐射，例如。 荧光团，在至少一个孔中。 有利地，激发辐射被极化以抑制孔中的激发辐射。 发光传感器和方法能够检测相对低浓度的光学可变分子，例如， 荧光团

    Luminescence Sensor Operating in Reflection Mode
    19.
    发明申请
    Luminescence Sensor Operating in Reflection Mode 有权
    发光传感器在反射模式下工作

    公开(公告)号：US20080272313A1

    公开(公告)日：2008-11-06

    申请号：US12158451

    申请日：2006-12-19

    申请人： Maarten Marinus Johannes Wilhemus Van Herpen ,  Derk Jan Wilfred Klunder ,  Hendrik Roelof Stapert

    发明人： Maarten Marinus Johannes Wilhemus Van Herpen ,  Derk Jan Wilfred Klunder ,  Hendrik Roelof Stapert

    IPC分类号： G01N21/64

    CPC分类号： G01N21/648 ,  G01N21/6428

    摘要： The present invention relates to a luminescence sensor (10), such as a luminescence biosensor or a luminescence chemical sensor, comprising at least one aperture (1) having a first lateral dimension larger than the diffraction limit of excitation radiation (3) in a medium the at least one aperture (1) is filled with and a second lateral dimension below the diffraction limit of excitation radiation (3) in a medium the at least one aperture (1) is filled with. The invention furthermore relates to a method for the detection of luminescence radiation (5), e.g. fluorescence radiation, generated by at least one optically variable molecule (2), e.g. fluorophore, in the at least one aperture (1). The excitation radiation (3) is preferably polarised to suppress the excitation radiation (3) in the apertures (1). The luminescence sensor (10) according to the present invention is able to detect relatively low concentrations of optically variable molecules (2), e.g. fluorophores.

    摘要翻译： 本发明涉及一种发光传感器（10），例如发光生物传感器或发光化学传感器，其包括至少一个孔（1），其具有比介质中的激发辐射（3）的衍射极限大的第一横向尺寸 所述至少一个孔（1）在所述至少一个孔（1）填充的介质中填充有低于激发辐射（3）的衍射极限的第二横向尺寸。 本发明还涉及用于检测发光辐射（5）的方法，例如， 由至少一个光学可变分子（2）产生的荧光辐射，例如。 在所述至少一个孔（1）中的荧光团。 激发辐射（3）优选地被极化以抑制孔（1）中的激发辐射（3）。 根据本发明的发光传感器（10）能够检测相对低浓度的光学可变分子（2），例如， 荧光团