公开(公告)号：US09403029B2

公开(公告)日：2016-08-02

申请号：US12418562

申请日：2009-04-03

申请人： Ashok Gowda ,  Roger McNichols

发明人： Ashok Gowda ,  Roger McNichols

IPC分类号： A61B18/18 ,  A61N5/06 ,  A61N5/067

CPC分类号： A61B18/20 ,  A61B18/1815 ,  A61B18/22 ,  A61B2018/00023 ,  A61N5/0601 ,  A61N7/00 ,  A61N2005/0643 ,  A61N2005/067

摘要： The present invention is directed to systems and methods for thermal therapy, especially to detection-guided, -controlled, and temperature-modulated interstitial thermal therapy. Thermal therapy may be used to treat the tissues of a patient. In the case of interstitial thermal therapy, energy is applied to generate heating of the tissue to affect treatment, such as, for example, thermally inducing tissue damage (e.g. thermally-induced tissue necrosis), which may be useful in treating tumors and/or other diseased tissues. Since targets for thermal therapy are internal to the patient, the use of detection guidance may be useful in locating and monitoring treatment of a target tissue.

摘要翻译： 本发明涉及用于热疗法的系统和方法，特别是用于检测引导的，受控制的和温度调制的间质热疗法。 热疗可用于治疗患者的组织。 在间质热治疗的情况下，施加能量以产生组织的加热以影响治疗，例如热诱导组织损伤（例如热诱导的组织坏死），其可用于治疗肿瘤和/或 其他病变组织。 由于热疗的目标是患者内部，所以使用检测指导可能有助于定位和监测对象组织的治疗。

公开(公告)号：US08404495B2

公开(公告)日：2013-03-26

申请号：US11656073

申请日：2007-01-22

申请人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

发明人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

IPC分类号： G01N33/544

CPC分类号： G01N21/78 ,  G01N33/542 ,  G01N33/54366

摘要： In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid or matrix. The analyte may be glucose or any other chemical of interest. The fluid or matrix may be, for example, the fluid in a bioreactor, a food or agricultural product, any fluid or matrix in the body of an animal, or any other fluid or matrix whose concentration of an analyte is under investigation. In one embodiment, the analyte sensing device includes a housing having an interior space. Contained within the housing and in the interior space is one or more analyte sensing component(s). The analyte sensing component, in one embodiment, includes one or more radiation converting element(s), for example, converting chromophores. The radiation converting element(s) are capable of converting or modifying radiation of one or more wavelengths into radiation of one or more different wavelengths. The conversion efficiency of the radiation converting element(s) is at least partially dependent on the local concentration of an analyte within the analyte sensing component.

摘要翻译： 在一个方面，本发明是用于感测流体或基质中分析物的浓度的系统，装置和方法。 分析物可以是葡萄糖或任何其它感兴趣的化学物质。 流体或基质可以是例如生物反应器中的流体，食物或农产品，动物体内的任何流体或基质，或其分析物浓度正在研究的任何其它流体或基质。 在一个实施例中，分析物感测装置包括具有内部空间的壳体。 包含在壳体内部和内部空间中的是一种或多种分析物感测组件。 在一个实施例中，分析物感测部件包括一个或多个辐射转换元件，例如转换发色团。 辐射转换元件能够将一个或多个波长的辐射转换或修改为一个或多个不同波长的辐射。 辐射转换元件的转换效率至少部分地取决于分析物感测组件内的分析物的局部浓度。

公开(公告)号：US20130053867A1

公开(公告)日：2013-02-28

申请号：US13592280

申请日：2012-08-22

申请人： Ashok Gowda ,  Roger McNichols ,  Charles Houssiere

发明人： Ashok Gowda ,  Roger McNichols ,  Charles Houssiere

IPC分类号： A61B19/00

CPC分类号： A61B90/11 ,  A61B17/00234 ,  A61B90/14 ,  A61B2090/103 ,  A61B2090/3983

摘要： This invention is directed to devices and methods for stereotactic access, and particularly to a frameless stereotactic access device for accessing a body cavity and methods therefor. In general, a stereotactic device may include portions or features for fixing the device to a portion of a patient's body, such as, for example, a skull, such that the device may be generally spatially fixed in relation to the patient's body or part thereof. The stereotactic device may also generally include portions or features for guiding a medical device or other device at a particular trajectory in relation to the patient's body or part thereof.

摘要翻译： 本发明涉及用于立体定向存取的装置和方法，特别涉及用于进入体腔的无框立体定向存取装置及其方法。 通常，立体定向装置可以包括用于将装置固定到患者身体的一部分（例如颅骨）的部分或特征，使得该装置可以相对于患者的身体或其一部分通常在空间上固定 。 立体定向装置还可以通常包括用于在相对于患者身体或其一部分的特定轨迹处引导医疗装置或其它装置的部分或特征。

公开(公告)号：US20130034915A1

公开(公告)日：2013-02-07

申请号：US13490392

申请日：2012-06-06

申请人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

发明人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

IPC分类号： G01N21/64 ,  G01N21/63

CPC分类号： G01N21/78 ,  G01N33/543 ,  G01N33/66

摘要： The present invention is directed to a system, device and method for measuring the concentration of an analyte in a fluid or matrix. A thermodynamically stabilized analyte binding ligand for use in the system, device and method is disclosed. The thermodynamically stabilized analyte binding ligand is resistant to degradation at physiological temperatures and its use within the device provides a minimally invasive sensor for monitoring the concentration of an analyte in a fluid or matrix as are present in the body of an animal.

摘要翻译： 本发明涉及用于测量流体或基质中分析物浓度的系统，装置和方法。 公开了一种用于该系统，装置和方法的热力学稳定的分析物结合配体。 热力学稳定的分析物结合配体对生理温度下的降解具有抗性，并且其在该装置内的使用提供了用于监测存在于动物体内的流体或基质中分析物的浓度的微创传感器。

公开(公告)号：US08364217B2

公开(公告)日：2013-01-29

申请号：US11811083

申请日：2007-06-08

申请人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

发明人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

IPC分类号： A61B5/1455

CPC分类号： A61B5/0066 ,  A61B5/14532 ,  A61B5/1459 ,  G01N21/4795 ,  G01N21/6428 ,  G01N2021/1787 ,  G01N2201/06193 ,  Y10S436/805 ,  Y10T436/144444

摘要： There are many inventions described and illustrated herein. In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid (for example, a fluid sample) or matrix. The analyte may be glucose or other chemical of interest. The fluid or matrix may be, for example, the fluid or matrix in the body of an animal (for example, human), or any other suitable fluid or matrix in which it is desired to know the concentration of an analyte. In one embodiment, the invention is a system and/or device that includes one or more layers having a plurality of analyte-equivalents and mobile or fixed receptor molecules with specific binding sites for the analyte-equivalents and analytes under analysis (for example, glucose). The receptor molecules, when exposed to or in the presence of analyte (that resides, for example, in a fluid in an animal), bind with the analyte (or vice versa). As such, some or all (or substantially all) of the receptor molecules within a given layer may bind with the analyte, which results in a change in the optical properties of one or more of the layers. These layer(s) may be examined or interrogated, via optical techniques, whereby the optical response of the layers and/or, in particular, the substance within the layer(s), may be measured, evaluated and/or analyzed.

摘要翻译： 这里描述和说明了许多发明。 一方面，本发明是用于感测流体（例如，流体样品）或基质中的分析物的浓度的系统，装置和方法。 分析物可以是葡萄糖或其他感兴趣的化学品。 流体或基质可以是例如动物（例如人）体内的流体或基质，或其中希望了解分析物浓度的任何其它合适的流体或基质。 在一个实施方案中，本发明是一种系统和/或装置，其包括具有多个分析物等价物和具有分析物等同物和分析物分析物的特异性结合位点的可移动或固定受体分子的一个或多个层（例如葡萄糖 ）。 受体分子当被分析物（例如在动物中存在的流体中）暴露或存在时，与分析物结合（反之亦然）。 因此，给定层内的受体分子中的一些或全部（或基本上全部）受体分子可与分析物结合，这导致一个或多个层的光学性质的变化。 可以通过光学技术检查或询问这些层，由此可以测量，评估和/或分析层和/或特别是层内的物质的光学响应。

公开(公告)号：US08216854B2

公开(公告)日：2012-07-10

申请号：US11591065

申请日：2006-11-01

申请人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

发明人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

IPC分类号： G01N33/543

CPC分类号： G01N21/78 ,  G01N33/543 ,  G01N33/66

摘要： The present invention is directed to a system, device and method for measuring the concentration of an analyte in a fluid or matrix. A thermodynamically stabilized analyte binding ligand for use in the system, device and method is disclosed. The thermodynamically stabilized analyte binding ligand is resistant to degradation at physiological temperatures and its use within the device provides a minimally invasive sensor for monitoring the concentration of an analyte in a fluid or matrix as are present in the body of an animal.

摘要翻译： 本发明涉及用于测量流体或基质中分析物浓度的系统，装置和方法。 公开了一种用于该系统，装置和方法的热力学稳定的分析物结合配体。 热力学稳定的分析物结合配体对生理温度下的降解具有抗性，并且其在该装置内的使用提供了用于监测存在于动物体内的流体或基质中分析物的浓度的微创传感器。

公开(公告)号：US20100016930A1

公开(公告)日：2010-01-21

申请号：US12559267

申请日：2009-09-14

申请人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

发明人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

IPC分类号： A61N5/06 ,  B29D11/00

CPC分类号： G02B6/241 ,  A61N5/0603 ,  A61N5/062 ,  G02B6/262

摘要： A light diffusing tip is provided. The light diffusing tip comprises a housing and a monolithic light scattering medium disposed within the housing. The monolithic light scattering medium comprises a first scattering region at a first position, the scattering region having a first scattering property and a second scattering region at a second position, the second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing. A light diffusing applicator also is provided. The light diffusing applicator comprises at least one optical waveguide, a first termination coupled to a first end of the at least one optical waveguide, the first termination to couple to a light source and a light diffusing tip coupled to a second end of the at least one optical waveguide.

摘要翻译： 提供光扩散尖端。 光扩散尖端包括壳体和布置在壳体内的单片光散射介质。 单片光散射介质包括在第一位置处的第一散射区域，具有第一散射特性的散射区域和第二位置处的第二散射区域，第二散射区域具有不同于第一散射特性的第二散射特性，其中 第一散射区域和第二散射区域沿着壳体的长度的大部分共同延伸。 还提供了光漫射施加器。 所述光漫射施加器包括至少一个光波导，耦合到所述至少一个光波导的第一端的第一终端，耦合到光源的第一终端和耦合到所述至少一个光波导的第二端的光漫射末端 一个光波导。

公开(公告)号：US20070219544A1

公开(公告)日：2007-09-20

申请号：US11749854

申请日：2007-05-17

申请人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

发明人： Ashok Gowda ,  Roger McNichols ,  Marc Gelnett ,  Matthew Fox

IPC分类号： A61B18/18

CPC分类号： A61B18/22 ,  A61B18/20 ,  A61B90/39 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00035 ,  A61B2018/00065 ,  A61B2018/0013 ,  A61B2018/00577 ,  A61B2018/2261 ,  A61B2018/2272 ,  A61N5/0601

摘要： In one embodiment, the disclosure is directed to an integrated apparatus for delivering energy to a tissue. The integrated apparatus included a housing having a distal end and a tubular structure located within the housing forming a first annulus between the tubular structure and the housing. The tubular structure is configured to accept an energy delivery component and is configured to form a second annulus between the tubular structure and the energy delivery component. The first annulus and the second annulus are configured to communicate with each other proximate to the distal end of the housing.

摘要翻译： 在一个实施例中，本发明涉及用于将能量传递给组织的集成装置。 集成设备包括具有远端的壳体和位于壳体内的管状结构，形成管状结构和壳体之间的第一环形空间。 管状结构被配置为接受能量输送部件并被构造成在管状结构和能量输送部件之间形成第二环形部分。 第一环和第二环被配置为相对于壳体的远端彼此连通。

公开(公告)号：US20070117223A1

公开(公告)日：2007-05-24

申请号：US11656073

申请日：2007-01-22

申请人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

发明人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

IPC分类号： G01N33/543

CPC分类号： G01N21/78 ,  G01N33/542 ,  G01N33/54366

摘要： In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid or matrix. The analyte may be glucose or any other chemical of interest. The fluid or matrix may be, for example, the fluid in a bioreactor, a food or agricultural product, any fluid or matrix in the body of an animal, or any other fluid or matrix whose concentration of an analyte is under investigation. In one embodiment, the analyte sensing device includes a housing having an interior space. Contained within the housing and in the interior space is one or more analyte sensing component(s). The analyte sensing component, in one embodiment, includes one or more radiation converting element(s), for example, converting chromophores. The radiation converting element(s) are capable of converting or modifying radiation of one or more wavelengths into radiation of one or more different wavelengths. The conversion efficiency of the radiation converting element(s) is at least partially dependent on the local concentration of an analyte within the analyte sensing component.

摘要翻译： 在一个方面，本发明是用于感测流体或基质中分析物的浓度的系统，装置和方法。 分析物可以是葡萄糖或任何其它感兴趣的化学物质。 流体或基质可以是例如生物反应器中的流体，食物或农产品，动物体内的任何流体或基质，或其分析物浓度正在研究的任何其它流体或基质。 在一个实施例中，分析物感测装置包括具有内部空间的壳体。 包含在壳体内部和内部空间中的是一种或多种分析物感测组件。 在一个实施例中，分析物感测部件包括一个或多个辐射转换元件，例如转换发色团。 辐射转换元件能够将一个或多个波长的辐射转换或修改为一个或多个不同波长的辐射。 辐射转换元件的转换效率至少部分地取决于分析物感测组件内的分析物的局部浓度。

公开(公告)号：US07166458B2

公开(公告)日：2007-01-23

申请号：US10735153

申请日：2003-12-12

申请人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

发明人： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

IPC分类号： C12M1/34 ,  C12M3/00

CPC分类号： G01N21/78 ,  G01N33/542 ,  G01N33/54366

摘要： In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid or matrix. The analyte may be glucose or any other chemical of interest. The fluid or matrix may be, for example, the fluid in a bioreactor, a food or agricultural product, any fluid or matrix in the body of an animal, or any other fluid or matrix whose concentration of an analyte is under investigation. In one embodiment, the analyte sensing device includes a housing having an interior space. Contained within the housing and in the interior space is one or more analyte sensing component(s). The analyte sensing component, in one embodiment, includes one or more radiation converting element(s), for example, converting chromophores. The radiation converting element(s) are capable of converting or modifying radiation of one or more wavelengths into radiation of one or more different wavelengths. The conversion efficiency of the radiation converting element(s) is at least partially dependent on the local concentration of an analyte within the analyte sensing component.

摘要翻译： 在一个方面，本发明是用于感测流体或基质中分析物的浓度的系统，装置和方法。 分析物可以是葡萄糖或任何其它感兴趣的化学物质。 流体或基质可以是例如生物反应器中的流体，食物或农产品，动物体内的任何流体或基质，或其分析物浓度正在研究的任何其它流体或基质。 在一个实施例中，分析物感测装置包括具有内部空间的壳体。 包含在壳体内部和内部空间中的是一种或多种分析物感测组件。 在一个实施例中，分析物感测部件包括一个或多个辐射转换元件，例如转换发色团。 辐射转换元件能够将一个或多个波长的辐射转换或修改为一个或多个不同波长的辐射。 辐射转换元件的转换效率至少部分地取决于分析物感测组件内的分析物的局部浓度。