公开(公告)号：US20210069112A1

公开(公告)日：2021-03-11

申请号：US16772273

申请日：2018-12-07

Applicant: BASF SE

Inventor： Ferdinand Paul Brandl ,  Theo Smit ,  Felicitas Guth ,  Karl Kolter ,  Maximilian Angel ,  Frank Schmidt

IPC: A61K9/16 ,  C08F220/18 ,  A61K47/32 ,  A61K31/635 ,  A61K31/58 ,  A61K31/216 ,  A61K31/5377

Abstract: Terpolymer, wherein 20 to 35% by weight of the structural units are derived from acrylic acid, 45 to 60% by weight of the structural units from a hydrophobic methacrylate selected from a group consisting of isopropyl methacrylate, tert-butyl methacrylate and cyclohexyl methacrylate and 15 to 40% by weight of the structural units from a third olefinic monomer selected from the group consisting of N-vinyl lactam, hydroxy ethyl methacrylate and phenoxyethyl acrylate with the proviso that the total amount of structural units derived from the three monomer groups adds up to 100% by weight, and the use of the terpolymers as crystallization inhibitors in pharmaceutical dosage forms for inhibiting the recrystallization in an aqueous environment of a human or animal body of an active ingredient.

公开(公告)号：US10912835B2

公开(公告)日：2021-02-09

申请号：US15848124

申请日：2017-12-20

Applicant: BASF SE

Inventor： Karl Kolter ,  Silke Gebert ,  Michael Klemens Müller ,  Maximilian Angel

IPC: A61K47/32 ,  A61K9/00 ,  A61K47/12 ,  A61K9/28 ,  A61K9/50

Abstract: Pharmaceutical coatings obtained from coating compositions based on film-forming copolymers of N,N-diethylaminoethyl methacrylate (DEAEMA) and methyl methacrylate (MMA) comprising a weight ratio of DEAEMA:MMA in the range of 35:65 to 55:45, where the copolymers are present partially neutralized with C3-C10-dicarboxylic acids.

公开(公告)号：US20180110858A1

公开(公告)日：2018-04-26

申请号：US15848124

申请日：2017-12-20

Applicant: BASF SE

Inventor： Karl Kolter ,  Silke Gebert ,  Michael Klemens Müller ,  Maximilian Angel

IPC: A61K47/32 ,  A61K9/50 ,  A61K9/28 ,  A61K47/12 ,  A61K9/00

CPC classification number: A61K47/32 ,  A61K9/0002 ,  A61K9/282 ,  A61K9/2846 ,  A61K9/5015 ,  A61K9/5026 ,  A61K47/12

Abstract: Pharmaceutical coatings obtained from coating compositions based on film-forming copolymers of N,N-diethylaminoethyl methacrylate (DEAEMA) and methyl methacrylate (MMA) comprising a weight ratio of DEAEMA:MMA in the range of 35:65 to 55:45, where the copolymers are present partially neutralized with C3-C10-dicarboxylic acids.

公开(公告)号：US09439971B2

公开(公告)日：2016-09-13

申请号：US13732833

申请日：2013-01-02

Applicant: BASF SE

Inventor： Kathrin Meyer-Böhm ,  Rainer Dobrawa ,  Angelika Maschke ,  Karl Kolter

IPC: A61K9/16 ,  A61K47/34 ,  A61K47/32 ,  A61K9/20

CPC classification number: A61K47/34 ,  A61K9/1641 ,  A61K9/2031 ,  A61K9/2095

Abstract: The use of water-soluble or water-dispersible copolymers which are obtained by free radical-initiated polymerization of a mixture of i) 30 to 80% by weight N-vinyllactam, ii) 10 to 50% by weight vinylacetate and iii) 10 to 50% by weight of a polyether, with the proviso that the total of i), ii) and iii) is equal to 100% by weight, as binders for producing solid active ingredient-containing dosage forms.

公开(公告)号：US12016926B2

公开(公告)日：2024-06-25

申请号：US16772273

申请日：2018-12-07

Applicant: BASF SE

Inventor： Ferdinand Paul Brandl ,  Theo Smit ,  Felicitas Guth ,  Karl Kolter ,  Maximilian Angel ,  Frank Schmidt

IPC: A61K9/16 ,  A61K31/216 ,  A61K31/5377 ,  A61K31/58 ,  A61K31/635 ,  A61K47/32 ,  C08F220/06 ,  C08F220/18 ,  C08F226/10

CPC classification number: A61K47/32 ,  A61K9/1635 ,  A61K31/216 ,  A61K31/5377 ,  A61K31/58 ,  A61K31/635 ,  C08F220/06 ,  C08F220/1803 ,  C08F220/1804 ,  C08F220/1806 ,  C08F226/10 ,  C08F220/1803 ,  C08F220/06 ,  C08F226/10 ,  C08F220/1806 ,  C08F220/06 ,  C08F226/10 ,  C08F220/1804 ,  C08F220/06 ,  C08F220/301

Abstract: Terpolymer, wherein 20 to 35% by weight of the structural units are derived from acrylic acid, 45 to 60% by weight of the structural units from a hydrophobic methacrylate selected from a group consisting of isopropyl methacrylate, tert-butyl methacrylate and cyclohexyl methacrylate and 15 to 40% by weight of the structural units from a third olefinic monomer selected from the group consisting of N-vinyl lactam, hydroxy ethyl methacrylate and phenoxyethyl acrylate with the proviso that the total amount of structural units derived from the three monomer groups adds up to 100% by weight, and the use of the terpolymers as crystallization inhibitors in pharmaceutical dosage forms for inhibiting the recrystallization in an aqueous environment of a human or animal body of an active ingredient.

公开(公告)号：US11980218B2

公开(公告)日：2024-05-14

申请号：US17256385

申请日：2019-05-29

Applicant: BASF SE

Inventor： Kathrin Meyer-Boehm ,  Andreas Habich ,  Daniel Wagner ,  Wolf Pelletier ,  Walter Dobler ,  Peter Schording ,  Karl Kolter

IPC: A23P10/47 ,  A23L33/10 ,  A61K8/02 ,  A61K8/25 ,  A61K9/16

CPC classification number: A23P10/47 ,  A23L33/10 ,  A61K8/022 ,  A61K8/25 ,  A61K9/1611 ,  A61K9/1682 ,  A61K2800/10 ,  A61K2800/412 ,  A61K2800/612 ,  A61K2800/621 ,  A61K2800/63

Abstract: The present invention relates to dust-free preparations dispersible in cold water. These preparations consist of particles comprising water-insoluble or only sparingly water-soluble active substance(s), said particles being coated with one or more layers, the outermost layer comprising as principal component one or more hydrophobic powdering agents on which at least one dispersant is absorbed. The invention also relates to a process for producing these particles and to the use thereof in food supplements, foodstuffs, animal feeds, personal-care products, and medicaments.

公开(公告)号：US20230272152A1

公开(公告)日：2023-08-31

申请号：US18029972

申请日：2021-10-05

Applicant: BASF SE

Inventor： Ferdinand Paul Brandl ,  Theo Smit ,  Karl Kolter ,  Felicitas Guth ,  Karl Haeberle ,  Frederic Lucas

IPC: C08G18/34 ,  C08G18/12 ,  A61K9/16 ,  C08G18/32

CPC classification number: C08G18/348 ,  A61K9/1641 ,  C08G18/12 ,  C08G18/3206 ,  C08G18/3212 ,  C08G18/3218

Abstract: The present invention relates to novel polyurethanes based on a diisocyanate, a carboxylic acid functionalized diol and an acid-free diol, their use as pharmaceutical excipients for improving gastrointestinal absorption, the respective pharmaceutical dosage forms and methods for making the polyurethanes.

公开(公告)号：US11723871B2

公开(公告)日：2023-08-15

申请号：US17052934

申请日：2019-05-15

Applicant: BASF SE

Inventor： Theo Smit ,  Matthias Karl ,  Felicitas Guth ,  Maximilian Angel ,  Karl Kolter ,  Frank Schmidt ,  Maximilian Blochberger-Claus

IPC: A61K9/20

CPC classification number: A61K9/2027 ,  A61K9/2031

Abstract: The use of powder-form, crosslinked, water-insoluble, low-swelling polyacrylates as disintegrants for solid pharmaceutical dosage forms.

公开(公告)号：US20180235885A1

公开(公告)日：2018-08-23

申请号：US15753186

申请日：2016-08-17

Applicant: BASF SE

Inventor： Heiko Alexander Schiffter ,  Maximilian Angel ,  Karl Kolter ,  Felicitas Guth

IPC: A61K9/16 ,  A61K47/69 ,  A61K9/20 ,  C08L39/06 ,  C08L33/08

CPC classification number: A61K9/1635 ,  A61K9/2027 ,  A61K31/00 ,  A61K31/426 ,  A61K31/451 ,  A61K31/4515 ,  A61K31/495 ,  A61K47/6933 ,  C08F220/06 ,  C08F220/18 ,  C08F226/10 ,  C08L33/08 ,  C08L39/06 ,  C08L2203/02

Abstract: Water-soluble polymeric salts of medicaments sparingly soluble in water consisting of a cationogenic medicament which, in uncharged form or as hydrochloride, has a solubility of less than 0.1% (m/m) in water, artificial intestinal juice or gastric juice, and an anionogenic water-soluble polymer having a solubility in water of at least 5% (m/m) in the pH range of 1 to 13 and which is obtained by free-radically initiated polymerization of a monomer mixture of i) 70 to 90% by weight N-vinylpyrrolidone and ii) 10 to 30% by weight acrylic acid, wherein the sum total of i) and ii) corresponds to 100% by weight.

公开(公告)号：US20180228730A1

公开(公告)日：2018-08-16

申请号：US15751889

申请日：2016-08-17

Applicant: BASF SE

Inventor： Heiko Alexander Schiffter ,  Maximilian Angel ,  Karl Kolter ,  Felicitas Guth

IPC: A61K9/16 ,  A61K9/14 ,  A61K9/48 ,  A61K31/4515

Abstract: Use of a water-soluble polymer having a solubility in water of greater than 5% (m/m) in the pH range of 1 to 13 and which is obtained by free-radically initiated polymerization of a monomer mixture of i) 70 to 90% by weight N-vinylpyrrolidone and ii) 10 to 30% by weight acrylic acid, wherein the sum total of i) and ii) corresponds to 100% by weight, for the formulation of basic active ingredients sparingly soluble in water, wherein the active ingredients in uncharged form or as hydrochloride have a solubility of less than 0.1% (m/m) in water, artificial intestinal juice or gastric juice.