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    PROCESS FOR PRODUCING AN ORGANIC COMPOUND
    11.
    发明申请
    PROCESS FOR PRODUCING AN ORGANIC COMPOUND 审中-公开

    公开(公告)号：US20200181653A1

    公开(公告)日：2020-06-11

    申请号：US16614772

    申请日：2018-05-18

    Applicant: BASF SE

    Inventor： Hartwig Schroeder ,  Stefan Haefner ,  Oskar Zelder ,  Christoph Wittmann ,  Anna Christine Schroer ,  Birgit Hoff ,  Nico Boehmer

    IPC: C12P7/18 ,  C12N1/20

    Abstract: Described herein is a process of producing an organic compound, the process including: I) cultivating a genetically modified microorganism in a culture medium including sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, and II) recovering the organic compound from the fermentation broth obtained in process step I) The genetically modified microorganism includes A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK-gene, compared to the original microorganism that has not been genetically modified, and the original microorganism belongs to the family Pasteurellaceae. Also described herein are a genetically modified microorganism and the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.

    Genetically Modified Microorganism for Improved Production of Fine Chemicals on Sucrose
    15.
    发明申请
    Genetically Modified Microorganism for Improved Production of Fine Chemicals on Sucrose 审中-公开
    用于改善蔗糖精细化学品生产的转基因微生物

    公开(公告)号：US20170073665A1

    公开(公告)日：2017-03-16

    申请号：US15308874

    申请日：2015-05-07

    Applicant: BASF SE

    Inventor： Joanna Martyna Krawczyk ,  Stefan Haefner ,  Hartwig Schroeder ,  Oskar Zelder

    IPC: C12N15/10 ,  C12N15/74 ,  C12P7/46

    CPC classification number: C12N15/102 ,  C07K14/195 ,  C12N15/74 ,  C12N2510/02 ,  C12P7/46 ,  C12Y207/11

    Abstract: The present invention relates to a modified microorganism having, compared to its wildtype,—a reduced activity of an enzyme encoded by the ptsA-gene,—a reduced activity of an enzyme encoded by the ptsH-gene or—a reduced activity of an enzyme encoded by the ptsA-gene and a reduced activity of an enzyme encoded by the ptsH-gene, wherein the wildtype from which the modified microorganism has been derived belongs to the family of Pasteurellaceae. The present invention also relates to a method for producing succinic acid and to the use of modified microorganisms.

    Abstract translation: 本发明涉及一种经修饰的微生物，其与野生型相比具有降低的由ptsA基因编码的酶的活性， - 由ptsH基因编码的酶的活性降低或酶活性降低 由ptsA基因编码并且由ptsH基因编码的酶的活性降低，其中来源于修饰微生物的野生型属于巴氏杆菌科。 本发明还涉及生产琥珀酸的方法和使用改性微生物。

    Genetically Modified Microorganisms Capable of Producing Beta-Glucans and Methods for Producing Beta-Glucans
    17.
    发明申请
    Genetically Modified Microorganisms Capable of Producing Beta-Glucans and Methods for Producing Beta-Glucans 有权
    能够生产β-葡聚糖的转基因微生物和生产β-葡聚糖的方法

    公开(公告)号：US20140011243A1

    公开(公告)日：2014-01-09

    申请号：US13935043

    申请日：2013-07-03

    Applicant: Wintershall Holding GmbH ,  BASF SE

    Inventor： Beata Brockmann ,  Andrea Herold ,  Oskar Zelder ,  Stefan Haefner ,  Christian Fleck ,  Hartwig Schröder ,  Mari Granström ,  Julia Kristiane Schmidt

    IPC: C12P19/04 ,  C12N15/80

    CPC classification number: C12P19/04 ,  C08B37/0024 ,  C08L5/00 ,  C12N9/1051 ,  C12N15/80 ,  C12P19/18 ,  C12Y204/01034 ,  Y02P20/52

    Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-β-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity or the use of such a polypeptide for producing β-glucans. Furthermore, the present invention relates to methods for producing β-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity into a microorganism being able to synthesize β-glucans.

    Abstract translation: 本发明涉及能够产生β-葡聚糖的转基因微生物，其特征在于所述遗传修饰的微生物过表达（i）编码具有1,3-β-D-葡聚糖合酶活性的多肽的多核苷酸和/或（ii ）具有1,3-β-D-葡聚糖合酶活性的多肽，与相同菌株的相应未修饰的对照微生物相比较。 本发明还涉及编码具有1,3-β-D-葡聚糖合酶活性的多肽的多核苷酸的用途或这种多肽用于产生β-葡聚糖的用途。 此外，本发明涉及生产β-葡聚糖的方法，包括在编码具有1,3-β-D-葡聚糖合酶活性的多肽的多核苷酸上游引入启动子，从而增加所述多核苷酸的表达，或多核苷酸 将具有1,3-β-D-葡聚糖合酶活性的多肽编码成能够合成β-葡聚糖的微生物。

    Genetically modified microorganisms capable of producing β-glucans and methods for producing β-glucans
    19.
    发明授权
    Genetically modified microorganisms capable of producing β-glucans and methods for producing β-glucans 有权
    能够生产葡聚糖的转基因微生物和生产葡聚糖的方法

    公开(公告)号：US09388441B1

    公开(公告)日：2016-07-12

    申请号：US15074330

    申请日：2016-03-18

    Applicant: BASF SE ,  Wintershall Holding GmbH

    Inventor： Beata Brockmann ,  Andrea Herold ,  Oskar Zelder ,  Stefan Haefner ,  Christian Fleck ,  Hartwig Schröder ,  Mari Granström ,  Julia Kristiane Schmidt

    IPC: C12P19/04 ,  C12P19/18 ,  C12N9/10

    CPC classification number: C12P19/04 ,  C08B37/0024 ,  C08L5/00 ,  C12N9/1051 ,  C12N15/80 ,  C12P19/18 ,  C12Y204/01034 ,  Y02P20/52

    Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-β-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity or the use of such a polypeptide for producing β-glucans. Furthermore, the present invention relates to methods for producing β-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity thereby increasing the expression of the polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity into a microorganism being able to synthesize β-glucans.

    Abstract translation: 本发明涉及能够产生β-葡聚糖的转基因微生物，其特征在于，遗传修饰的微生物过表达（i）编码具有1,3-葡聚糖合酶活性的多肽的多核苷酸和/或（ ii）与相同菌株的相应未修饰的对照微生物相比，具有1,3-葡聚糖 - D-葡聚糖合酶活性的多肽。 本发明还涉及编码具有1,3-葡萄糖 - D-葡聚糖合酶活性的多肽的多核苷酸的用途或这种多肽用于生产葡聚糖的用途。 此外，本发明涉及生产葡聚糖的方法，包括在编码具有1,3-葡萄糖-D-葡聚糖合酶活性的多肽的多核苷酸上游引入启动子，从而增加多核苷酸的表达，或 编码具有1,3-葡聚糖合酶活性的多肽的多核苷酸能够合成葡聚糖。

    Gene Cluster for Biosynthesis of Cornexistin and Hydroxycornexistin
    20.
    发明申请
    Gene Cluster for Biosynthesis of Cornexistin and Hydroxycornexistin 有权
    用于生物合成Cornexistin和羟基角质素的基因簇

    公开(公告)号：US20140141440A1

    公开(公告)日：2014-05-22

    申请号：US14084030

    申请日：2013-11-19

    Applicant: BASF SE

    Inventor： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schröder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingruber ,  Jakob Weber

    IPC: C12P17/04

    CPC classification number: C12P17/04 ,  C12N15/52 ,  C12P7/50

    Abstract: The invention pertains to/the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

    Abstract translation: 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。

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