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11.发明授权公开(公告)号：US11680889B2
公开(公告)日：2023-06-20
申请号：US17226420
申请日：2021-04-09
Applicant: Becton, Dickinson and Company
Inventor： Jizuo Zou , Jorge Manzarraga , Eric D. Diebold
CPC classification number: G01N15/1436 , G01N15/1459 , G01N2015/1006 , G01N2015/1438
Abstract: Aspects of the disclosure include methods for generating angularly deflected laser beams for irradiating a sample in a flow stream. Methods according to certain embodiments include generating a first set of angularly deflected laser beams and a second set of angularly deflected laser beams, propagating the first set of angularly deflected laser beams along a different optical path from the second set of angularly deflected laser beams, combining the first set of angularly deflected laser beams with the second set of angularly deflected laser beams and directing the combined sets of laser beams onto a sample in a flow stream and detecting light from the sample. Systems having a laser, an acousto-optic device and an optical adjustment component configured to generate a first set of angularly deflected laser beams and a second set of angularly deflected laser beams are also described.
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公开(公告)号：US20210293690A1
公开(公告)日：2021-09-23
申请号：US17201853
申请日：2021-03-15
Applicant: Becton, Dickinson and Company
Inventor： Timothy W. Petersen , Pierce O. Norton , Henry Lankila , Eric D. Diebold
Abstract: Aspects of the present disclosure include methods for adjusting sensitivity of a photodiode in a light detection system. Methods according to certain embodiments include detecting light with a light detection system having a photodiode and an amplifier, determining responsivity of the photodiode over a plurality of wavelengths of light and adjusting one or more parameters of the amplifier in response to the responsivity of the photodiode over the plurality of wavelengths of light. Systems (e.g., particle analyzers) having a light source and a light detection system that includes a photodiode and an amplifier for practicing the subject methods are also described. Non-transitory computer readable storage medium are also provided.
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公开(公告)号：US20200309664A1
公开(公告)日：2020-10-01
申请号：US16817331
申请日：2020-03-12
Applicant: Becton, Dickinson and Company
Inventor： Matthew Bahr , Eric D. Diebold , Jonathan Lin , Keegan Owsley
Abstract: Aspects of the present disclosure include methods for characterizing particles of a sample in a flow stream. Methods according to certain embodiments include detecting light from a sample having cells in a flow stream, generating an image of an object in the flow stream in an interrogation region and determining whether the object in the flow stream is an aggregate based on the generated image. Systems having a processor with memory operably coupled to the processor having instructions stored thereon, which when executed by the processor, cause the processor to generate an image of an object in a flow stream and to determine whether the object is an aggregate are also described. Integrated circuit devices (e.g., field programmable gate arrays) having programming for practicing the subject methods are also provided.
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公开(公告)号：US20190324281A1
公开(公告)日：2019-10-24
申请号：US16381891
申请日：2019-04-11
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Eric D. Diebold , Jizuo Zou , Jorge Manzarraga
Abstract: Aspects of the present disclosure include systems with multiple lasers having modified beam profiles. Systems according to certain embodiments include a first laser that produces a first beam of light, a second laser that produces a second beam of light and a beam shaping component that receives the first beam of light and the second beam of light at substantially the same position from different angles of incidence and is configured to generate from the first beam of light and the second beam of light an output beam of light having a predetermined intensity profile along a horizontal axis. Methods for irradiating a sample in a flow stream with the output beam of light are also described. Kits having one or more lasers and a beam shaping component configured to generate from a first beam of light and a second beam of light an output beam of light having a predetermined intensity profile along a horizontal axis are also provided.
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公开(公告)号：US20180073974A1
公开(公告)日：2018-03-15
申请号：US15698506
申请日：2017-09-07
Applicant: Becton, Dickinson and Company
Inventor： Eric D. Diebold , Keegan Owsley , Matthew Bahr
CPC classification number: G01N15/1434 , G01N15/1459 , G01N2015/1006 , G01N2015/145 , G02F1/33 , G02F2203/18 , G02F2203/24 , H01S3/0071
Abstract: Aspects of the present disclosure include methods for producing an output laser beam having two or more angularly deflected laser beams (e.g., for irradiating a sample in a flow stream) with a predetermined intensity profile. Systems for practicing the subject methods having a laser, an acousto-optic device, a radiofrequency generator and a controller for adjusting the amplitude of the radiofrequency drive signals to produce an output laser beam of angularly deflected laser beams with a predetermined intensity profile are also described.
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Patent Agency Ranking
公开(公告)号：US12222518B2
公开(公告)日：2025-02-11
申请号：US16381891
申请日：2019-04-11
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Eric D. Diebold , Jizuo Zou , Jorge Manzarraga
IPC: G02B27/10 , G01N15/1434 , G02B3/00 , G02B19/00 , G02B27/09
Abstract: Aspects of the present disclosure include systems with multiple lasers having modified beam profiles. Systems according to certain embodiments include a first laser that produces a first beam of light, a second laser that produces a second beam of light and a beam shaping component that receives the first beam of light and the second beam of light at substantially the same position from different angles of incidence and is configured to generate from the first beam of light and the second beam of light an output beam of light having a predetermined intensity profile along a horizontal axis. Methods for irradiating a sample in a flow stream with the output beam of light are also described. Kits having one or more lasers and a beam shaping component configured to generate from a first beam of light and a second beam of light an output beam of light having a predetermined intensity profile along a horizontal axis are also provided.
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公开(公告)号：US20240353309A1
公开(公告)日：2024-10-24
申请号：US18734985
申请日：2024-06-05
Applicant: BECTON, DICKINSON AND COMPANY
Inventor： Eric D. Diebold , Keegan Owsley , Jonathan Lin
IPC: G01N15/1434 , G01N15/10 , G01N15/14 , G01N15/1429 , G01N15/1433 , G01N21/64 , G02B21/06
CPC classification number: G01N15/1434 , G01N15/14 , G01N15/1425 , G01N15/1429 , G01N15/1433 , G01N15/147 , G01N21/645 , G02B21/06 , G01N2015/1006 , G01N2015/1447 , G01N2015/1454 , G01N2021/6482
Abstract: In one aspect, the present teachings provide a system for performing cytometry that can be operated in three operational modes. In one operational mode, a fluorescence image of a sample is obtained by exciting one or more fluorophore(s) present in the sample by an excitation beam formed as a superposition of a top-hat-shaped beam with a plurality of beams that are radiofrequency shifted relative to one another. In another operational mode, a sample can be illuminated successively over a time interval by a laser beam at a plurality of excitation frequencies in a scanning fashion. The fluorescence emission from the sample can be detected and analyzed, e.g., to generate a fluorescence image of the sample. In yet another operational mode, the system can be operated to illuminate a plurality of locations of a sample concurrently by a single excitation frequency, which can be generated, e.g., by shifting the central frequency of a laser beam by a radiofrequency. For example, a horizontal extent of the sample can be illuminated by a laser beam at a single excitation frequency. The detected fluorescence radiation can be used to analyze the fluorescence content of the sample, e.g., a cell/particle.
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公开(公告)号：US11953420B2
公开(公告)日：2024-04-09
申请号：US17201738
申请日：2021-03-15
Applicant: Becton, Dickinson and Company
Inventor： Jizuo Zou , Matthew Bahr , Eric D. Diebold
IPC: G01N15/1434 , G01J1/04 , G01J1/42 , G01N21/47 , G01N21/53
CPC classification number: G01N15/1436 , G01J1/0477 , G01J1/4228 , G01N15/1434 , G01N21/532 , G01N2021/4707
Abstract: Light detection systems for measuring light (e.g., in a flow stream) are described. Light detection systems according to embodiments include a light scatter detector, a brightfield photodetector and an optical adjustment component configured to convey light to the light scatter detector and to the brightfield photodetector. Systems and methods for measuring light emitted by a sample (e.g., in a flow stream) and kits having a light scatter detector, a brightfield photodetector and a beam splitter component are also provided.
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公开(公告)号：US11874213B2
公开(公告)日：2024-01-16
申请号：US17201853
申请日：2021-03-15
Applicant: Becton, Dickinson and Company
Inventor： Timothy W. Petersen , Pierce O. Norton , Henry Lankila , Eric D. Diebold
CPC classification number: G01N15/1434 , G01R27/02 , H03F3/08 , G01N2015/149
Abstract: Aspects of the present disclosure include methods for adjusting sensitivity of a photodiode in a light detection system. Methods according to certain embodiments include detecting light with a light detection system having a photodiode and an amplifier, determining responsivity of the photodiode over a plurality of wavelengths of light and adjusting one or more parameters of the amplifier in response to the responsivity of the photodiode over the plurality of wavelengths of light. Systems (e.g., particle analyzers) having a light source and a light detection system that includes a photodiode and an amplifier for practicing the subject methods are also described. Non-transitory computer readable storage medium are also provided.
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公开(公告)号：US11698334B2
公开(公告)日：2023-07-11
申请号：US17003605
申请日：2020-08-26
Applicant: Becton, Dickinson and Company
Inventor： Eric D. Diebold , Keegan Owsley , Matthew Bahr
CPC classification number: G01N15/1434 , G01N15/1459 , G02F1/33 , H01S3/0071 , G01N2015/1006 , G01N2015/145 , G02F2203/18 , G02F2203/24
Abstract: Aspects of the present disclosure include methods for producing an output laser beam having two or more angularly deflected laser beams (e.g., for irradiating a sample in a flow stream) with a predetermined intensity profile. Systems for practicing the subject methods having a laser, an acousto-optic device, a radiofrequency generator and a controller for adjusting the amplitude of the radiofrequency drive signals to produce an output laser beam of angularly deflected laser beams with a predetermined intensity profile are also described.
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