公开(公告)号：US10456361B2

公开(公告)日：2019-10-29

申请号：US14614928

申请日：2015-02-05

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven L. Kangas

IPC: A61K9/14 ,  A61K31/337 ,  A61K47/34 ,  A61K47/36 ,  A61K47/44

Abstract: In accordance with one aspect, embolic particles are provided which comprise sub-particles that comprise a therapeutic agent of low solubility dispersed in a matrix that comprises a biodegradable polymer. Other aspects pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions. Still other aspects pertain to methods of making such particles.

公开(公告)号：US10098650B2

公开(公告)日：2018-10-16

申请号：US14734446

申请日：2015-06-09

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven L. Kangas ,  Yen-Lane Chen

IPC: A61B17/22 ,  A61B17/3207

Abstract: A system and method for treating atherosclerotic plaque. The system includes a first catheter including an expandable balloon and a second catheter including a lumen in fluid communication with a distal hole. The method includes inserting the first catheter into a body lumen adjacent to a plaque formation, and deploying a balloon from the first catheter adjacent to the plaque formation. In addition, the method includes inserting the second catheter adjacent to the first catheter, and routing the distal end portion of second catheter along at least a portion of the deployed balloon of the first catheter. Further, the method includes routing at least a portion of the second catheter into a subintimal space adjacent to the atherosclerotic plaque. Furthermore, the method includes injecting a therapeutic agent into the subintimal space adjacent to the atherosclerotic plaque.

公开(公告)号：US20150182732A1

公开(公告)日：2015-07-02

申请号：US14583941

申请日：2014-12-29

Applicant: Boston Scientific Scimed, Inc.

Inventor： Hongxia Zeng ,  Yen-Lane Chen ,  Steven L. Kangas

IPC: A61M25/10

CPC classification number: A61M25/1029 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/63 ,  A61M2025/1031

Abstract: A catheter comprises a medical balloon having a drug coating. The drug coating comprises drug crystals on a surface of the balloon. The majority of the drug crystals on the surface of the balloon are oriented drug crystals which extend within 5° of a predetermined, non-zero common angle relative to the surface of the balloon from which the crystals extend.

Abstract translation: 导管包括具有药物包衣的医用气囊。 药物涂层包括在气球表面上的药物晶体。 球囊表面上的大部分药物晶体是定向药物晶体，其相对于晶体延伸的球囊表面在预定的非零公共角度的5°内延伸。

公开(公告)号：US20240115270A1

公开(公告)日：2024-04-11

申请号：US18490400

申请日：2023-10-19

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Steven L. Kangas ,  Edward Kopesky ,  Yen-Lane Chen

IPC: A61B17/12 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377

CPC classification number: A61B17/12177 ,  A61B17/12122 ,  A61B17/12172 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61B2017/00526

Abstract: A device for permanent placement across an atrial appendage ostium in a patient includes a support structure having a contracted delivery configuration and an expanded deployed configuration defining a radially enlarged portion to permanently engage an interior wall of the atrial appendage, a membrane attached to the support structure and configured to extend across the ostium of the atrial appendage when the support structure is in the expanded deployed configuration, and a polymer coating disposed on at least one of the support structure and the membrane, the polymer coating including a direct oral anticoagulant (DOAC) dispersed in a polymer.

公开(公告)号：US11090267B2

公开(公告)日：2021-08-17

申请号：US16587244

申请日：2019-09-30

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Steven L. Kangas

IPC: A61K9/14 ,  A61L24/00 ,  A61K31/337 ,  A61K47/34 ,  A61K47/36 ,  A61K47/44

Abstract: In accordance with one aspect, embolic particles are provided which comprise sub-particles that comprise a therapeutic agent of low solubility dispersed in a matrix that comprises a biodegradable polymer. Other aspects pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions. Still other aspects pertain to methods of making such particles.

公开(公告)号：US10575855B2

公开(公告)日：2020-03-03

申请号：US15085999

申请日：2016-03-30

Applicant: Boston Scientific Scimed, Inc.

Inventor： Cass A. Hanson ,  Joseph M. Connolly ,  Katherine Routh ,  Jaydeep Y. Kokate ,  Gary J. Pederson ,  Derek C. Sutermeister ,  Michele C. Tessmer ,  Jeffrey S. Lindquist ,  Robert N. Squire ,  Steven L. Kangas ,  David Raab ,  Joel Munsinger ,  Derek K. Larson ,  Martin R. Willard

IPC: A61B17/12 ,  A61M25/10 ,  A61B17/00

Abstract: Medical devices and methods for forming the medical devices are disclosed in the present application. In one illustrative example an occlusion balloon comprises an outer balloon member, and an inner balloon member having an inner wall and an outer wall and extending through at least a portion of the outer balloon member. In at least some examples, when forces acting on the inner wall of the inner balloon member equal forces acting on the outer wall of the inner balloon member, the inner balloon member defines a lumen.

公开(公告)号：US10471012B2

公开(公告)日：2019-11-12

申请号：US14986774

申请日：2016-01-04

Applicant: Boston Scientific Scimed, Inc.

Inventor： Hongxia Zeng ,  Steven L. Kangas ,  Yen-Lane Chen

IPC: A61K9/16 ,  A61K31/337 ,  A61K49/00

Abstract: Polymer microspheres for embolizing blood vessels and optionally delivering therapeutic agents are provided. The microspheres include PLGA 50:50 and/or Ptx, and are generally formed by emulsion means.

公开(公告)号：US20240342348A1

公开(公告)日：2024-10-17

申请号：US18632758

申请日：2024-04-11

Applicant: Boston Scientific Scimed, Inc.

Inventor： Thomas John Herbst ,  Edward Kopesky ,  Steven L. Kangas ,  Hongxia Zeng ,  Aaron Cooper Foss

IPC: A61L33/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61L33/0041 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/204 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/61 ,  A61L2300/622 ,  A61L2300/802 ,  A61L2420/02 ,  A61L2420/08

Abstract: A medical device may be coated with a therapeutic composition that includes a direct oral anticoagulant. An illustrative drug coating composition may comprise an excipient including polylactic acid (PLA), poly(lactic-co-glycolic acid) (PLGA), or poly(vinylidene fluoride)-co-hexafluoropropylene (PVDF-HFP) and a direct oral anticoagulant (DOAC). The illustrative drug coating may be applied to an outer surface of a medical device.

公开(公告)号：US20240325594A1

公开(公告)日：2024-10-03

申请号：US18618262

申请日：2024-03-27

Applicant: Boston Scientific Scimed, Inc.

Inventor： Nicolas Ball-Jones ,  Victoria Szlag ,  Paul Vincent Grosso ,  Samuel Michael Hanson ,  Sasha Viola Rios ,  Steven L. Kangas ,  Boxin Tang

IPC: A61L24/06 ,  A61L24/00

CPC classification number: A61L24/06 ,  A61L24/0015 ,  A61L2400/04 ,  A61L2400/06

Abstract: Aqueous liquid embolic compositions as well as method for making and using aqueous liquid embolic compositions are disclosed. An example aqueous liquid embolic composition may include a di-block or tri-block copolymer including a hydrophobic monomer block and a charged (polycationic or polyanionic) block. The charged (polycationic or polyanionic) block may include one or more anions. The aqueous liquid embolic composition may also include templating agent.

公开(公告)号：US20240325592A1

公开(公告)日：2024-10-03

申请号：US18618015

申请日：2024-03-27

Applicant: Boston Scientific Scimed, Inc.

Inventor： Nicolas Ball-Jones ,  Steven L. Kangas ,  Samuel Michael Hanson

IPC: A61L24/04

CPC classification number: A61L24/046 ,  A61L2400/04 ,  A61L2400/06

Abstract: Aqueous liquid embolic compositions, for example formed from amino acids, as well as method for making and using aqueous liquid embolic compositions are disclosed. An example aqueous liquid embolic composition may include a di-block or tri-block copolymer including a charged block and a hydrophobic block. The aqueous liquid embolic composition may also include templating agent.