公开(公告)号：US20150060363A1

公开(公告)日：2015-03-05

申请号：US14014542

申请日：2013-08-30

申请人： Benjamin E. Kusters ,  Christopher J. Wegener ,  Kyungyoon Min

发明人： Benjamin E. Kusters ,  Christopher J. Wegener ,  Kyungyoon Min

IPC分类号： A61M1/34

CPC分类号： A61M1/3496 ,  A61M1/0218 ,  A61M1/265 ,  A61M2205/103 ,  A61M2205/75 ,  B01D63/16 ,  B01D2317/02 ,  B01D2319/02 ,  B01D2319/06

摘要： A system and method are provided, including an integrated single-use kit, for processing whole blood to produce platelet rich plasma. A two stage spinning membrane separator, has a first stage for receiving whole blood and separating substantially all red blood cells from plasma and platelets, and a second stage for further separating platelet rich plasma from plasma. A first waste container is in fluid communication with the first stage of the separator for receiving separated red blood cells, while a second waste container is in fluid communication with the second stage of the separator for receiving separated plasma. An outlet line is in fluid communication with the second stage of the separator for receiving platelet rich plasma, and a reinfusion container is removably connected to the outlet line for receiving platelet rich plasma from the second stage of the separator.

摘要翻译： 提供了一种系统和方法，包括一体化的一次性使用试剂盒，用于处理全血以产生富血小板血浆。 两级纺丝膜分离器具有第一阶段，用于接收全血并将血浆和血小板基本上全部红细胞分离，以及用于从血浆中进一步分离富血小板血浆的第二阶段。 第一废物容器与分离器的第一级流体连通，用于接收分离的红细胞，而第二废物容器与分离器的第二级流体连通以接收分离的等离子体。 出口管线与分离器的第二级流体连通，用于接收富血小板血浆，并且再输注容器可移除地连接到出口管线，用于从分离器的第二级接收富血小板血浆。

公开(公告)号：US09895482B2

公开(公告)日：2018-02-20

申请号：US14003298

申请日：2012-03-09

申请人： Benjamin E. Kusters ,  Christopher J. Wegener ,  Kyungyoon Min

发明人： Benjamin E. Kusters ,  Christopher J. Wegener ,  Kyungyoon Min

IPC分类号： A61M1/34 ,  A61M1/36 ,  A61M1/02 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  A61M1/38 ,  A61M1/26 ,  B01D33/06 ,  G06F19/00

CPC分类号： A61M1/34 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/265 ,  A61M1/3403 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/38 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/60 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2315/02 ,  G16H10/40

摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

公开(公告)号：US09408961B2

公开(公告)日：2016-08-09

申请号：US14003281

申请日：2012-03-09

申请人： Christopher J. Wegener ,  Kyungyoon Min ,  Laurent Forcioli ,  Mark J. Brierton ,  Daniel R. Boggs

发明人： Christopher J. Wegener ,  Kyungyoon Min ,  Laurent Forcioli ,  Mark J. Brierton ,  Daniel R. Boggs

IPC分类号： A61M1/34 ,  A61M1/02 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  A61M1/38 ,  A61M1/26 ,  A61M1/36

CPC分类号： A61M1/34 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/265 ,  A61M1/3403 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/38 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/60 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2315/02 ,  G16H10/40

摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

摘要翻译： 公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。 在一个实施例中，提供了一种纺丝膜分离器，其中在膜和壳体之间的间隙中产生至少两个区域或区域，使得两个区域之间的流体的混合被与膜相关联的径向肋 这减小了膜和壳体之间的间隙以限定两个流体区域，脊部分离两个区域中的流体以最小化两者之间的混合。 公开了自动化系统和方法，用于将先前收集的全血的单元分离成诸如浓红细胞和血浆的组分，用于在单次通过中从供体直接收集红细胞和血浆，以及用于细胞洗涤。 还公开了数据管理系统和方法以及启动方法。

公开(公告)号：US08469916B2

公开(公告)日：2013-06-25

申请号：US13036814

申请日：2011-02-28

申请人： Christopher J. Wegener ,  Daniel R. Boggs ,  Kyungyoon Min ,  Prakash Mathew ,  Marc N. Weasler ,  Benjamin E. E. Kusters

发明人： Christopher J. Wegener ,  Daniel R. Boggs ,  Kyungyoon Min ,  Prakash Mathew ,  Marc N. Weasler ,  Benjamin E. E. Kusters

IPC分类号： A61M37/00

CPC分类号： A61M1/3496 ,  A61M1/262 ,  A61M1/3603 ,  A61M1/38 ,  A61M2202/0415

摘要： Certain examples describe systems and methods for increasing plasma extracted from donor blood. An example method includes receiving blood extracted from a donor connected to a blood collection machine. The example method includes filtering the blood using a filtration device to remove at least a portion of plasma included in the blood to separate the plasma removed from remaining blood. The example method includes routing the plasma removed for collection. The example method includes re-filtering the remaining blood using a or the filtration device to remove additional plasma from the remaining blood. The example method includes routing the additional plasma removed for collection.

公开(公告)号：US20130341291A1

公开(公告)日：2013-12-26

申请号：US14003281

申请日：2012-03-09

申请人： Christopher J. Wegener ,  Kyungyoon Min ,  Laurent Forcioli ,  Mark J. Brierton ,  Daniel R. Boggs

发明人： Christopher J. Wegener ,  Kyungyoon Min ,  Laurent Forcioli ,  Mark J. Brierton ,  Daniel R. Boggs

IPC分类号： A61M1/34

CPC分类号： A61M1/34 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/265 ,  A61M1/3403 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/38 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/60 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2315/02 ,  G16H10/40

摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

摘要翻译： 公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。 在一个实施例中，提供了一种纺丝膜分离器，其中在膜和壳体之间的间隙中产生至少两个区域或区域，使得两个区域之间的流体的混合被与膜相关联的径向肋 这减小了膜和壳体之间的间隙以限定两个流体区域，脊部分离两个区域中的流体以最小化两者之间的混合。 公开了自动化系统和方法，用于将先前收集的全血的单元分离成诸如浓红细胞和血浆的组分，用于在单次通过中从供体直接收集红细胞和血浆，以及用于细胞洗涤。 还公开了数据管理系统和方法以及启动方法。

公开(公告)号：US09764075B2

公开(公告)日：2017-09-19

申请号：US14003294

申请日：2012-03-09

申请人： Bryan Blickhan ,  Kyungyoon Min ,  William H. Cork

发明人： Bryan Blickhan ,  Kyungyoon Min ,  William H. Cork

IPC分类号： C02F1/44 ,  B01D11/00 ,  B01D61/00 ,  A61M1/34 ,  A61M1/36 ,  A61M1/02 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  A61M1/38 ,  A61M1/26 ,  B01D35/00 ,  G06F19/00 ,  G09G5/00

CPC分类号： A61M1/34 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/265 ,  A61M1/3403 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/38 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/60 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2315/02 ,  G16H10/40

摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

公开(公告)号：US20130334139A1

公开(公告)日：2013-12-19

申请号：US14003294

申请日：2012-03-09

申请人： Bryan Blickhan ,  Kyungyoon Min ,  William H. Cork

发明人： Bryan Blickhan ,  Kyungyoon Min ,  William H. Cork

IPC分类号： A61M1/38

CPC分类号： A61M1/34 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/265 ,  A61M1/3403 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/38 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/60 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2315/02 ,  G16H10/40

摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

公开(公告)号：US20140043930A1

公开(公告)日：2014-02-13

申请号：US14113077

申请日：2012-05-02

申请人： Fletcher C. Belt ,  Michael J. Kast ,  Kyungyoon Min ,  Katherine Radwanski ,  William H. Cork

发明人： Fletcher C. Belt ,  Michael J. Kast ,  Kyungyoon Min ,  Katherine Radwanski ,  William H. Cork

IPC分类号： A61M1/02

CPC分类号： A61M1/025 ,  A61M1/0281 ,  A61M1/3693 ,  A61M1/3696

摘要： A method is disclosed for resuspending a concentrated blood component collected in a single-use processing chamber that is mounted to a rotatable support of a centrifugal collection system. A resuspension solution is introduced to the single-use processing chamber constraining the concentrated blood component. The rotatable support with the single-use processing chamber mounted thereto is removed from the centrifugal collection system and mounted to a resuspension device. The device is then activated for a period of time sufficient to resuspend the concentrated blood component in the resuspension solution. In another aspect, the resuspension device is configured to impart a reciprocating arcuate motion to the support and its associated single-use processing chamber. A frequency of approximately 300 to 325 rpm over a period of time of approximately 1.5 to 2.5 minutes has been found effective for resuspending platelets. Reciprocation through an arc of less than 200° is provided.

摘要翻译： 公开了一种用于将收集在一次性处理室中的浓缩血液成分重新悬浮的方法，所述一次性处理室安装在离心收集系统的可旋转支撑件上。 将再悬浮溶液引入约束浓缩血液成分的一次性加工室中。 安装在其上的一次性处理室的可旋转支撑件从离心收集系统中移除并安装到再悬挂装置。 然后将该装置激活足以将浓缩血液成分重悬于再悬浮液中的一段时间。 在另一方面，再悬浮装置被配置为向支撑件及其相关联的一次性使用处理室施加往复的弓形运动。 发现在约1.5至2.5分钟的时间段内约300至325rpm的频率已经被有效用于重悬血小板。 提供通过小于200°的弧的往复运动。

公开(公告)号：US5980760A

公开(公告)日：1999-11-09

申请号：US886780

申请日：1997-07-01

申请人： Kyungyoon Min ,  Richard I Brown ,  Daniel F Bischof ,  William H Cork ,  Robert J Cantu

发明人： Kyungyoon Min ,  Richard I Brown ,  Daniel F Bischof ,  William H Cork ,  Robert J Cantu

IPC分类号： A61M1/02 ,  A61M1/36 ,  B01D21/26 ,  B04B5/04 ,  B04B11/02 ,  B04B13/00

CPC分类号： B01D21/302 ,  A61M1/3696 ,  B01D21/262 ,  B04B13/00 ,  B04B5/0442 ,  B01D2221/10 ,  B04B2005/045

摘要： A blood separation system operates in a first mode to convey whole blood into the inlet region of a blood processing chamber for centrifugal separation into packed red blood cells, a plasma constituent, and an interface, which carries mononuclear cells, between the packed red blood cells and the plasma constituent. The system removes packed red blood cells and the plasma constituent from the chamber, while maintaining the interface within the chamber. The system operates in a second mode to remove the interface from the chamber by conveying packed red blood cells into the inlet region. An outlet path conveys the removed interface from the chamber. The outlet path includes a first sensing element to locate mononuclear cells in the removed interface and provide a sensed output upon locating mononuclear cells.

摘要翻译： 血液分离系统以第一模式操作，以将全血输送到血液处理室的入口区域，用于离心分离成装填的红血细胞，血浆成分和携带单核细胞的界面， 和等离子体成分。 该系统在保持室内的界面的同时从腔室中去除填充的红细胞和等离子体成分。 该系统以第二模式操作，以通过将填充的红血细胞输送到入口区域来从腔室去除界面。 出口路径从腔室传送去除的界面。 出口路径包括第一感测元件，以将去除界面中的单核细胞定位，并在定位单核细胞时提供感测输出。

公开(公告)号：US20120041777A1

公开(公告)日：2012-02-16

申请号：US13209161

申请日：2011-08-12

申请人： Brian C. Case ,  Jonathan Prendergast ,  John W. Barry, JR. ,  Kyungyoon Min ,  William H. Cork ,  Daryl Richard Calhoun ,  Christine M. Larson

发明人： Brian C. Case ,  Jonathan Prendergast ,  John W. Barry, JR. ,  Kyungyoon Min ,  William H. Cork ,  Daryl Richard Calhoun ,  Christine M. Larson

IPC分类号： G06Q10/08 ,  G06Q50/22

CPC分类号： G16H40/63 ,  G06F19/3418 ,  G06Q10/087 ,  G06Q10/1093 ,  G06Q50/22 ,  G06T11/206 ,  G16H10/60

摘要： Certain examples provide systems, methods, and apparatus to provide information regarding blood collection instruments via a mobile device. An example method for blood collection instrument management includes providing a graphical representation of one or more blood collection instruments with a visual indication of a status for each instrument. The graphical representation is to visually convey information regarding each of the one or more blood collection instruments and is selectable by a user to provide additional information regarding each of the one or more blood collection instruments. The method includes facilitating access to troubleshoot and interact with the one or more blood collection instruments via the mobile device. The method includes dynamically updating the status for each instrument via communication between the mobile device and one or more blood collection facilities at which the one or more blood collection instruments are located.

摘要翻译： 某些实例提供了通过移动设备提供关于采血仪器的信息的系统，方法和装置。 用于采血仪器管理的示例性方法包括提供一个或多个采血器具的图形表示，其具有每个器械的状态的视觉指示。 图形表示是视觉地传达关于一个或多个采血器具中的每一个的信息，并且可由用户选择以提供关于一个或多个采血器械中的每一个的附加信息。 该方法包括便利访问以经由移动设备对一个或多个采血器具进行故障排除和交互。 该方法包括通过移动设备与一个或多个采血设备所在的一个或多个血液采集设备之间的通信动态地更新每个仪器的状态。