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公开(公告)号：US11021735B2
公开(公告)日：2021-06-01
申请号：US16009894
申请日：2018-06-15
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Man Cheng , Xiao-Song Gong , Yan Wang , Adam M. McCoy
IPC: C12Q1/6806 , C12Q1/686 , C12P19/34 , C12Q1/6853 , C12N15/10
Abstract: Methods of detecting and amplifying short RNAs are provided.
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12.发明申请公开(公告)号：US20140377767A1
公开(公告)日：2014-12-25
申请号：US14482756
申请日：2014-09-10
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Xiao-Song Gong , John Sullivan , Rongdian Fu , Yan Wang , Evan H. Bursey , Man Cheng
CPC classification number: C12P19/34 , C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2319/80 , C12N9/1252 , C12Q1/6804 , C12Q1/686 , C12Q2531/113 , C12Q2527/125 , C12Q2521/101
Abstract: The present invention provides methods and compositions for improving the efficiency of nucleic acid amplification reactions. The invention encompasses hybrid polymerases that show increased processivity over wild type polymerases as well as decreased exonucleases activity. The invention also encompasses methods, compositions and kits for conducting nucleic acid synthesis and amplification reactions in which non-specific amplification of primers is reduced.
Abstract translation: 本发明提供了提高核酸扩增反应效率的方法和组合物。 本发明包括与野生型聚合酶相比显示增加的活性以及降低的核酸外切酶活性的杂合聚合酶。 本发明还包括用于进行核酸合成和扩增反应的方法，组合物和试剂盒，其中引物的非特异性扩增减少。
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公开(公告)号：US20140170729A1
公开(公告)日：2014-06-19
申请号：US14186030
申请日：2014-02-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Man Cheng
IPC: C12N9/12
CPC classification number: C12N9/1241 , C07K2319/80 , C12N9/1252 , C12N9/96 , C12Q1/686
Abstract: Improved Sso7-polymerase conjugate proteins are provided.
Abstract translation: 提供了改进的Sso7聚合酶缀合蛋白。
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14.发明公开公开(公告)号：US20230182127A1
公开(公告)日：2023-06-15
申请号：US18076667
申请日：2022-12-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Vishal Sharma , Ronald Lebofsky , Man Cheng , Adam McCoy , Kalyan Handique , Eric Pomaranski
CPC classification number: B01L3/502 , C12N13/00 , B01L2200/026 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/047 , B01L2300/0893
Abstract: Inventions covered include methods, systems, and compositions for sample processing, involving morphology-adjustable (e.g., tunable on-demand) functionalized particles. In some embodiments, a method can include distributing a set of functionalized particles, in a first morphological state, across a set of partitions; transitioning the set of functionalized particles, at the set of partitions, from the first morphological state to a second morphological state; transitioning the set of functionalized particles, at the set of partitions, from the second morphological state to a third morphological state, and inducing interactions between the set of functionalized particles and a set of targets, within the set of partitions and according to a set of operations with a set of process fluids.
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Patent Agency Ranking
公开(公告)号：US10351831B2
公开(公告)日：2019-07-16
申请号：US15801114
申请日：2017-11-01
Applicant: Bio-Rad Laboratories, Inc.
Abstract: Fusion polypeptides having a heterologous 5′-3′ exonuclease domain linked to a polymerase that does not naturally have 5′-3′ exonuclease activity, as well as methods of their use are provided. Other aspects are also disclosed.
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公开(公告)号：US10072285B2
公开(公告)日：2018-09-11
申请号：US14828242
申请日：2015-08-17
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Man Cheng , Xiao-Song Gong , Yan Wang , Adam M. McCoy
IPC: C12Q1/68 , C12Q1/6806 , C12P19/34 , C12Q1/686
CPC classification number: C12Q1/6806 , C07K2319/80 , C12N15/1096 , C12P19/34 , C12Q1/6853 , C12Q1/686 , C12Q2521/107 , C12Q2521/131 , C12Q2521/327 , C12Q2525/207 , C12Q2521/101 , C12Q2522/101
Abstract: Methods of detecting and amplifying short RNAs are provided.
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公开(公告)号：US09840697B2
公开(公告)日：2017-12-12
申请号：US14562396
申请日：2014-12-05
Applicant: Bio-Rad Laboratories, Inc.
CPC classification number: C12N9/1252 , C07K2319/80 , C12N9/22 , C12Q1/686
Abstract: Fusion polypeptides having a heterologous 5′-3′ exonuclease domain linked to a polymerase that does not naturally have 5′-3′ exonuclease activity, as well as methods of their use are provided. Other aspects are also disclosed.
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公开(公告)号：US09322002B2
公开(公告)日：2016-04-26
申请号：US14186030
申请日：2014-02-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Man Cheng
CPC classification number: C12N9/1241 , C07K2319/80 , C12N9/1252 , C12N9/96 , C12Q1/686
Abstract: Improved Sso7-polymerase conjugate proteins are provided.
Abstract translation: 提供了改进的Sso7聚合酶缀合蛋白。
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公开(公告)号：US20160053305A1
公开(公告)日：2016-02-25
申请号：US14828242
申请日：2015-08-17
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Man Cheng , Xiao-Song Gong , Yan Wang , Adam M. McCoy
CPC classification number: C12Q1/6806 , C12P19/34 , C12Q1/6853 , C12Q1/686 , C12Q2521/107 , C12Q2521/131 , C12Q2521/327 , C12Q2525/207 , C12Q2525/121
Abstract: Methods of detecting and amplifying short RNAs are provided.
Abstract translation: 提供了检测和扩增短RNA的方法。
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