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    BORONATED HYDROGELS AND METHODS OF MAKING AND USING THE SAME
    11.
    发明申请
    BORONATED HYDROGELS AND METHODS OF MAKING AND USING THE SAME 有权

    公开(公告)号：US20250017955A1

    公开(公告)日：2025-01-16

    申请号：US18761777

    申请日：2024-07-02

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Yen-Hao Hsu ,  Joseph Thomas Delaney, JR. ,  Cristian Parisi

    IPC: A61K31/738 ,  C08K3/011

    Abstract: This disclosure pertains to boronated hydrogel compositions, which comprise a boronated polysaccharide compound that comprises a plurality of boronated moieties covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide. The disclosure also pertains to kits that comprise a reservoir, a boronated hydrogel composition comprising a boronated polysaccharide compound that comprises a plurality of boronated moieties covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide disposed in the reservoir, and a device for administering the boronated hydrogel composition to a subject. The disclosure further pertains to methods of treatment that comprise applying or injecting a boronated hydrogel composition comprising a boronated polysaccharide compound that comprises a plurality of boronated moieties covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide onto or into target cells of a subject and delivering neutron beam radiation to the target cells.

    MEDICAL DEVICES FORMED FROM HIGH PURITY POLYURETHANE
    12.
    发明公开
    MEDICAL DEVICES FORMED FROM HIGH PURITY POLYURETHANE 审中-公开

    公开(公告)号：US20240197967A1

    公开(公告)日：2024-06-20

    申请号：US18516494

    申请日：2023-11-21

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Yen-Hao Hsu ,  Joseph Thomas Delaney, JR.

    IPC: A61L29/06 ,  B33Y70/00 ,  C08G18/28 ,  C08L77/12

    CPC classification number: A61L29/06 ,  B33Y70/00 ,  C08G18/2895 ,  C08L77/12 ,  C08L2203/02

    Abstract: In some aspects, the present disclosure pertains to medical devices, at least a portion of which comprises a polymeric region comprising a poly(urethane amide) that comprises urethane (—O—CO—NH—) groups, and amide (—CO—NH—) groups. In other aspects, the present disclosure pertains to 3-D printing processes that comprise reacting (a) a urethane-based acrylamide reactant that comprises a residue of a C4-C10 hydroxyalkyl acrylamide and a diisocyanate residue selected from a C6-C20 aromatic diisocyanate residue, a C4-C20 aliphatic diisocyanate residue, and a C6-C20 cycloaliphatic diisocyanate residue and (b) a multi-arm polymer comprising 3 or more polymer arms and three or more terminal groups selected from thiol groups, amino groups and hydroxyl groups.

    BIOERODIBLE CROSSLINKING HYDROGEL BASED ON MULTI-ARM POLYOXAZOLINES WITH CAGE-LIKE SILICON-OXYGEN CORES
    13.
    发明公开
    BIOERODIBLE CROSSLINKING HYDROGEL BASED ON MULTI-ARM POLYOXAZOLINES WITH CAGE-LIKE SILICON-OXYGEN CORES 审中-公开

    公开(公告)号：US20240076454A1

    公开(公告)日：2024-03-07

    申请号：US18450122

    申请日：2023-08-15

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Joseph Thomas Delaney, JR. ,  Yen-Hao Hsu

    IPC: C08G83/00 ,  A61L27/18 ,  A61L27/52 ,  A61L27/58

    CPC classification number: C08G83/006 ,  A61L27/18 ,  A61L27/52 ,  A61L27/58 ,  C08G83/005 ,  A61L2400/06

    Abstract: In some aspects, the present disclosure pertains to reactive multi-arm polymers having a cage-like silicon-oxygen core and a plurality of polyoxazoline-containing arms extending from the core, in which the polyoxazoline-containing arms comprise a first end that is covalently attached to the cage-like silicon-oxygen core and a second end comprising a moiety that comprises a reactive end group. In other aspects, the present disclosure pertains to systems that comprise such reactive multi-arm polymers and multifunctional compounds that comprise functional groups that are reactive with the reactive end groups of the reactive multi-arm polymers. Other aspects pertain to medical hydrogels formed by crosslinking such reactive multi-arm polymers with such multifunctional compounds and methods of treatment that comprise administering to a subject a mixture that comprises and such reactive multi-arm polymers with such multifunctional compounds.

    IODINE LABELED HYDROGELS AND PRECURSORS THEREOF WITH IMPROVED PROPERTIES
    14.
    发明公开
    IODINE LABELED HYDROGELS AND PRECURSORS THEREOF WITH IMPROVED PROPERTIES 审中-公开

    公开(公告)号：US20240076266A1

    公开(公告)日：2024-03-07

    申请号：US18451579

    申请日：2023-08-17

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Joseph Thomas Delaney, JR. ,  Yen-Hao Hsu ,  Tatyana Dyndikova

    IPC: C07C273/18

    CPC classification number: C07C273/1872

    Abstract: In various aspects, the present disclosure pertains to systems for forming hydrogels that comprise an iodinated polyamino compound and a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with amino groups of the iodinated polyamino compound. Other aspects of the present disclosure pertain to medical hydrogels that are formed by crosslinking the iodinated polyamino compound and the reactive multi-arm polymer of such systems. Further aspects of the present disclosure pertain to medical procedures that can be performed using such systems. Still other aspects of the present disclosure pertain to methods of making iodinated polyamino compounds.

    IODINATED COMPOUNDS AND HYDROGELS FORMED FROM SAME
    15.
    发明公开
    IODINATED COMPOUNDS AND HYDROGELS FORMED FROM SAME 审中-公开

    公开(公告)号：US20230241295A1

    公开(公告)日：2023-08-03

    申请号：US18103932

    申请日：2023-01-31

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Joseph Thomas Delaney, JR. ,  Yen-Hao Hsu ,  Tatyana Dyndikova

    IPC: A61L31/14 ,  A61L31/04 ,  A61M5/19 ,  C07C233/66

    CPC classification number: A61L31/145 ,  A61L31/041 ,  A61M5/19 ,  C07C233/66

    Abstract: In some aspects, the present disclosure pertains to systems for forming hydrogels that comprise (a) a first composition that comprises a polyiodinated polyamino compound that comprises a polyamino moiety linked to a polyiodinated aromatic moiety by an amide group or ester group and (b) a second composition that comprises a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with amino groups of the polyiodinated polyamino compound. Other aspects of the present disclosure pertain to medical hydrogels and methods of making medical hydrogels that are based on such compositions. Further aspects of the present disclosure pertain to methods of making polyiodinated polyamino compounds.

    INJECTABLE SHEAR-THINNING AND SELF-ASSEMBLING HYDROGELS
    17.
    发明申请
    INJECTABLE SHEAR-THINNING AND SELF-ASSEMBLING HYDROGELS 有权

    公开(公告)号：US20250049964A1

    公开(公告)日：2025-02-13

    申请号：US18796777

    申请日：2024-08-07

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Yen-Hao Hsu ,  Nicolas Ball-Jones ,  Sasha Viola Rios ,  Joseph Thomas Delaney, JR. ,  Cristian Parisi

    IPC: A61K49/04

    Abstract: In some aspects, the present disclosure pertains to an injectable hydrogel that comprises (a) one or more types of polymeric hydrogen bond donors, (b) one or more types of polymeric hydrogen bond acceptors and (c) water. Other aspects of the present disclosure pertain to kits that comprise a delivery device and one or more containers that contain an injectable hydrogel that comprises one or more types of polymeric hydrogen bond donors, one or more types of polymeric hydrogen bond acceptors, and water. Further aspects of the present disclosure pertain to medical procedures that comprise administering to a subject an injectable hydrogel that comprises one or more types of polymeric hydrogen bond donors, one or more types of polymeric hydrogen bond acceptors, and water.

    CROSSLINKED HYDROGELS WITH ENHANCED RADIOPACITY FOR MEDICAL APPLICATIONS
    18.
    发明申请
    CROSSLINKED HYDROGELS WITH ENHANCED RADIOPACITY FOR MEDICAL APPLICATIONS 有权

    公开(公告)号：US20250019500A1

    公开(公告)日：2025-01-16

    申请号：US18763649

    申请日：2024-07-03

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Rick Dorn ,  Joseph Thomas Delaney, JR.

    IPC: C08J3/075 ,  A61L27/18 ,  A61L27/52 ,  A61L27/58 ,  C08K3/08

    Abstract: The present disclosure pertains to systems for forming hydrogel compositions that comprise a reactive polymer comprising a plurality of hydrophilic polymer segments and a plurality of first reactive moieties and gold nanoparticles, wherein the system is configured to deliver the reactive polymer and the gold nanoparticles under conditions such that covalent crosslinks are formed between the reactive polymer and the gold nanoparticles. The present disclosure also pertains to methods of treatment that comprise administering to a subject a mixture that comprises a reactive polymer comprising a plurality of hydrophilic polymer segments and a plurality of first reactive moieties and gold nanoparticles, under conditions such that the reactive polymer and the gold nanoparticles crosslink after administration, and to radiopaque crosslinked hydrogel compositions that comprise a crosslinked reaction product of a reactive polymer comprising a plurality of hydrophilic polymer segments and a plurality of first reactive moieties and gold nanoparticles.

    CROSSLINKED HYDROGELS WITH TUNABLE RADIOPACITY FOR MEDICAL APPLICATIONS
    19.
    发明申请
    CROSSLINKED HYDROGELS WITH TUNABLE RADIOPACITY FOR MEDICAL APPLICATIONS 有权

    公开(公告)号：US20240390527A1

    公开(公告)日：2024-11-28

    申请号：US18670474

    申请日：2024-05-21

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Yen-Hao Hsu ,  Sasha Viola Rios ,  Nicolas Ball-Jones ,  Joseph Thomas Delaney, JR. ,  Cristian Parisi

    IPC: A61K49/04

    Abstract: In some aspects the present disclosure provides a radiopaque, reactive copolymer comprising at least one hydrophilic polymer segment having a plurality of hydrophilic polymer segment ends, a plurality of iodinated polymer segments covalently linked to the plurality of hydrophilic polymer segment ends, and a plurality of reactive moieties covalently linked to the iodinated polymer segments. In other aspects, the present disclosure pertains to a system for forming a hydrogel composition that comprises (a) such a radiopaque, reactive copolymer and (b) a nucleophilic compound, as well as to a crosslinked reaction product of the same. In further aspects, the present disclosure pertains to a method of treatment comprising administering to a subject a mixture that comprises (a) such a radiopaque, reactive copolymer and (b) a nucleophilic compound, under conditions such that the nucleophilic compound and the radiopaque, reactive copolymer crosslink after administration.

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