公开(公告)号：US20050009204A1

公开(公告)日：2005-01-13

申请号：US10639718

申请日：2003-08-12

Applicant: Ye Fang ,  Yulong Hong ,  Joydeep Lahiri ,  Fang Lai ,  Jinlin Peng ,  Brian Webb ,  Ann Ferrie

Inventor： Ye Fang ,  Yulong Hong ,  Joydeep Lahiri ,  Fang Lai ,  Jinlin Peng ,  Brian Webb ,  Ann Ferrie

IPC: C40B30/04 ,  G01N33/68 ,  G01N33/74 ,  G01N33/543

CPC classification number: C40B30/04 ,  G01N33/74 ,  G01N2333/726

Abstract: A thematic microarray and methods for multiplexed binding assays using a cocktail solution of labeled ligands in the presence or absence of a target compound is provided. The methods enables researchers to screening compounds against multiple targets using a microarray format.

Abstract translation: 提供了一种专题微阵列和在存在或不存在目标化合物的情况下使用标记配体的混合溶液进行多重结合测定的方法。 这些方法使研究人员可以使用微阵列格式来筛选多个靶点的化合物。

公开(公告)号：US5515467A

公开(公告)日：1996-05-07

申请号：US366934

申请日：1994-12-30

Applicant: Brian Webb

Inventor： Brian Webb

IPC: G02B6/42 ,  G02B6/36

CPC classification number: G02B6/4292

Abstract: A connector affixed to the end of a cable of optical fibers and having alignment pins extending axially in parallel with the cable and beyond the end thereof. A substrate with alignment holes and light transmitting openings therethrough in axial alignment with the ends of the optical fibers when the alignment pins and holes are engaged. The substrate including mounting pads, electrical connection pins and electrical traces connecting the pads to the pins. A semiconductor die, with photonic devices thereon, mounted on the mounting pads of the substrate so that each photonic device is aligned with a light transmitting opening and electrically connected to the electrical connection pins. A sleeve surrounding and securing the connector to the mounting member.

Abstract translation: 固定在光纤电缆端部的连接器，并且具有与电缆平行且超出其端部的轴向延伸的对准销。 当对准销和孔接合时，具有对准孔和透光开口的基板与光纤的端部轴向对准。 基板包括安装焊盘，电连接引脚和将焊盘连接到引脚的电迹线。 半导体管芯，其上具有光子器件，安装在衬底的安装焊盘上，使得每个光子器件与光传输开口对准并电连接到电连接引脚。 围绕并将连接器固定到安装构件的套筒。

公开(公告)号：US10309577B1

公开(公告)日：2019-06-04

申请号：US14979136

申请日：2015-12-22

Applicant: Brian Webb

Inventor： Brian Webb

IPC: F16L55/00 ,  F16L55/26 ,  F16L41/02

Abstract: An extended switch arm for a piggable pipeline connector for directing a pig to a particular pipeline and a method of manufacturing the same. The extended switch arm may comprise a switch arm, an upper plate attached to the top of one end of the switch arm, and a lower plate attached to the bottom of the end of the switch arm and aligned with the upper plate. A switch arm extension may pivotally attach between the upper and lower plates via a pin, allowing the switch arm extension to pivot from side to side relative to the switch arm as the switch arm is moved from one side of the pipeline connector to the other, essentially blocking access by the pig to one pipeline or the other without providing any sharp angles or other surfaces upon which the pig could become caught.

公开(公告)号：US07246146B1

公开(公告)日：2007-07-17

申请号：US09442791

申请日：1999-11-18

Applicant: Steven D. Ims ,  Yongcheng Li ,  Yih-Shin Tan ,  Brian Webb

Inventor： Steven D. Ims ,  Yongcheng Li ,  Yih-Shin Tan ,  Brian Webb

IPC: G06F15/16

CPC classification number: G06F17/30893 ,  G06F17/211 ,  G06F17/2247

Abstract: A method and apparatus for navigating screens in a legacy host system. In a preferred embodiment, requests for specific legacy host screens are received by a server. The server then navigates to the appropriate screen within the legacy host system and retrieves the host screen. Any intermediate screens navigated by the server in reaching the host screen are not displayed to the user. If variable data need be entered to access the host screen, the server sends the user a submittable form on which to enter the appropriate information, which, once entered and sent to the server, is used by the server to retrieve the host screen. Once the host screen has been retrieved, the server formats it into a web page format using a hypertext language and sends the screen to the user. Other screens within the legacy host system are accessed by user selection of selectable links displayed to the user.

Abstract translation: 用于在传统主机系统中导航屏幕的方法和装置。 在优选实施例中，服务器接收对特定传统主机屏幕的请求。 然后，服务器导航到传统主机系统中的相应屏幕，并检索主机屏幕。 任何由服务器在到达主机屏幕时导航的中间屏幕都不会显示给用户。 如果需要输入可变数据来访问主机屏幕，则服务器向用户发送一个提交表单，在其上输入适当的信息，一旦输入并发送到服务器，服务器将使用该表单来检索主机屏幕。 一旦检索到主机屏幕，服务器将使用超文本语言将其格式化为网页格式，并将该屏幕发送给用户。 传统主机系统中的其他屏幕可通过用户选择显示给用户的可选链接进行访问。

公开(公告)号：US20070114152A1

公开(公告)日：2007-05-24

申请号：US11197795

申请日：2005-08-05

Applicant: Mark Bingham ,  Brian Webb

Inventor： Mark Bingham ,  Brian Webb

IPC: B65D73/00

CPC classification number: A45C11/182 ,  A45C2001/065 ,  B42D25/00 ,  B42D25/26 ,  B42D25/28 ,  B42P2241/06 ,  G09F1/00

Abstract: The present invention relates to a hospitality type card which is provided with a series of indentations on each of its first and second longitudinally extending sides and first and second transversely extending edges that are sized and configured so as to be graspable by digits of a human hand. The card may further include indentations on each of the first and second transversely extending edges to accommodate additional graspable orientations as well as add aesthetic attributes to the card structure. The card may be provided with a card carrier which may be printed with matching or complimentary indicia as well as personalized indicia directed at a recipient of the card and carrier.

Abstract translation: 本发明涉及一种接待型卡片，其在其第一和第二纵向延伸侧面中的每一个上设置有一系列凹痕，以及第一和第二横向延伸边缘，其尺寸和构造被设计成能够通过人的手 。 该卡还可以包括在第一和第二横向延伸边缘中的每一个上的凹陷，以容纳额外的可抓取的取向，以及为卡结构增加美观属性。 卡可以设置有可以打印有匹配或补充标记的卡片载体以及针对卡和载体的接收者的个性化标记。

公开(公告)号：US20060148006A1

公开(公告)日：2006-07-06

申请号：US11312776

申请日：2005-12-21

Applicant: Ye Fang ,  Ann Ferrie ,  Yulong Hong ,  Sadashiva Pai ,  Jinlin Peng ,  Brian Webb

Inventor： Ye Fang ,  Ann Ferrie ,  Yulong Hong ,  Sadashiva Pai ,  Jinlin Peng ,  Brian Webb

IPC: G01N33/567 ,  G01N33/53

CPC classification number: G01N33/52 ,  G01N2333/726

Abstract: Buffered assay solutions for performing 1) binding or 2) functional assays on GPCR arrays, along with methods for their use are described. The buffered assay solution has an underlying composition having: a buffer reagent with a pH in the range of about 6.5 to about 7.9; an inorganic salt of either a monovalent or divalent species, at a concentration from about 1 mM to about 500 mM; and optionally a combination of: c) a blocker reagent at a concentration of about 0.01 wt. % to about 2 wt. % of the composition, or d) protease-inhibitor at a concentration of about 0.001 mM to about 100 mM. In an embodiment for functional assay uses, the composition is modified to also include a GTP-analogue, a guanosine 5′-diphosphate (GDP) salt, and/or an anti-oxidant reagent.

Abstract translation: 描述了用于执行1）GPCR阵列上的结合或2）功能测定的缓冲测定溶液及其使用方法。 缓冲测定溶液具有下列组成，其具有：pH在约6.5至约7.9范围内的缓冲试剂; 浓度为约1mM至约500mM的单价或二价物质的无机盐; 和任选的以下组合：c）浓度为约0.01wt。 ％至约2wt。 ％的组合物，或d）浓度为约0.001mM至约100mM的蛋白酶抑制剂。 在功能测定用途的实施方案中，组合物被修饰为还包括GTP类似物，鸟苷5'-二磷酸（GDP）盐和/或抗氧化试剂。

公开(公告)号：US20060147993A1

公开(公告)日：2006-07-06

申请号：US11026371

申请日：2004-12-30

Applicant: Alain Carre ,  Alexander Efrenov ,  Ye Fang ,  Yulong Hong ,  Valerie Lacarriere ,  Joydeep Lahiri ,  Fang Lai ,  John Mauro ,  Srikanth Raghavan ,  Brian Webb

Inventor： Alain Carre ,  Alexander Efrenov ,  Ye Fang ,  Yulong Hong ,  Valerie Lacarriere ,  Joydeep Lahiri ,  Fang Lai ,  John Mauro ,  Srikanth Raghavan ,  Brian Webb

IPC: G01N33/53 ,  G06F19/00 ,  C12M1/34 ,  B05D3/02

CPC classification number: G01N33/554 ,  G01N33/74 ,  G01N2333/726

Abstract: The invention relates to G protein-coupled receptor (GPCR) microarrays on porous substrates for structural or functional analyses of GPCRs, and methods of preparing porous substrate surfaces for receiving membranes that comprise GPCRs. In one embodiment, a GPCR microarray of the invention comprises a membrane adhered to an upper surface of a porous substrate, the membrane spanning across a plurality of pores on the porous substrate to form a plurality of cavities having sufficient geometry to permit entry of assay reagents into each cavity, thereby allowing access of assay reagents to both sides of GPCR in the membrane.

公开(公告)号：US20050227241A1

公开(公告)日：2005-10-13

申请号：US10822385

申请日：2004-04-12

Applicant: Ye Fang ,  Ann Ferrie ,  Yulong Hong ,  Brian Webb

Inventor： Ye Fang ,  Ann Ferrie ,  Yulong Hong ,  Brian Webb

IPC: B01L3/00 ,  C12M1/34 ,  C12Q1/68 ,  G01N33/53

CPC classification number: B01L3/5085 ,  B01L2200/12 ,  B01L2300/069 ,  B01L2300/0829 ,  Y10S435/81 ,  Y10S436/809 ,  Y10T29/49885

Abstract: A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three- dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized as having a plurality of interconnected voids defined by a matrix of contiguous solid material. A method and its variants are also described.

Abstract translation: 公开了适用于生物或化学测定的底物板或装置。 该装置可以采用具有三维多孔层的多孔板的形式，作为每个孔内的支撑表面的一部分，用于固定探针物质。 多孔层的特征在于具有由连续的固体材料的基体限定的多个相互连接的空隙。 还描述了一种方法及其变体。

公开(公告)号：US20050069953A1

公开(公告)日：2005-03-31

申请号：US10676351

申请日：2003-09-30

Applicant: Ye Fang ,  Ann Ferrie ,  Yulong Hong ,  Sadashiva Pai ,  Jinlin Peng ,  Brian Webb

Inventor： Ye Fang ,  Ann Ferrie ,  Yulong Hong ,  Sadashiva Pai ,  Jinlin Peng ,  Brian Webb

IPC: G01N33/52 ,  G01N33/53

CPC classification number: G01N33/52 ,  G01N2333/726

Abstract: Buffered assay solutions for performing 1) binding or 2) functional assays on GPCR arrays, along with methods for their use are described. The buffered assay solution has an underlying composition having: a buffer reagent with a pH in the range of about 6.5 to about 7.9; an inorganic salt of either a monovalent or divalent species, at a concentration from about 1 mM to about 500 mM; and optionally a combination of: c) a blocker reagent at a concentration of about 0.01 wt. % to about 2 wt. % of the composition, or d) protease-inhibitor at a concentration of about 0.001 mM to about 100 mM. In an embodiment for functional assay uses, the composition is modified to also include a GTP-analogue, a guanosine 5′-diphosphate (GDP) salt, and/or an anti-oxidant reagent.

Abstract translation: 描述了用于执行1）GPCR阵列上的结合或2）功能测定的缓冲测定溶液及其使用方法。 缓冲测定溶液具有下列组成，其具有：pH在约6.5至约7.9范围内的缓冲试剂; 浓度为约1mM至约500mM的单价或二价物质的无机盐; 和任选的以下组合：c）浓度为约0.01wt。 ％至约2wt。 ％的组合物，或d）浓度为约0.001mM至约100mM的蛋白酶抑制剂。 在功能测定用途的实施方案中，组合物被修饰为还包括GTP类似物，鸟苷5'-二磷酸（GDP）盐和/或抗氧化试剂。

公开(公告)号：US06643825B1

公开(公告)日：2003-11-04

申请号：US09353218

申请日：1999-07-14

Applicant: Yongcheng Li ,  Yih-Shin Tan ,  Brian Webb

Inventor： Yongcheng Li ,  Yih-Shin Tan ,  Brian Webb

IPC: G06F1721

CPC classification number: G06F17/30893 ,  G06F3/14

Abstract: Screens generated by a host application are reformatted for viewing by applying styles to the host screens in response to recognized components included therein. In particular, a style defines a desired look and layout to be applied to a respective host screen. The styles are applied to the respective host screens based on recognizing components of the host screen at run time. For example, first and second styles can be associated with respective first and second components included in host screens. The first style is applied to the host screen in which the first component is recognized and the second style is applied to the host screen in which the second component is recognized. Accordingly, the application of the first and second styles provide respective first and second reformatted screens.

Abstract translation: 由主机应用程序生成的屏幕被重新格式化以便通过将样式应用于主机屏幕以响应于其中包含的识别的组件而进行查看。 特别地，风格定义了要应用于相应主机屏幕的期望外观和布局。 基于在运行时识别主机屏幕的组件，将样式应用于相应的主机屏幕。 例如，第一和第二样式可以与主机屏幕中包括的相应的第一和第二组件相关联。 将第一种样式应用于主机屏幕，其中第一组件被识别，并且第二样式被应用于识别第二组件的主屏幕。 因此，第一和第二风格的应用提供相应的第一和第二重新格式化的屏幕。