公开(公告)号：US20060169891A1

公开(公告)日：2006-08-03

申请号：US11315788

申请日：2005-12-22

Applicant: Bruce Collings ,  Thomas Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bradley Schneider ,  Bruce Thomson

Inventor： Bruce Collings ,  Thomas Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bradley Schneider ,  Bruce Thomson

IPC: B01D59/44

CPC classification number: H01J49/067 ,  H01J49/063

Abstract: In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.

Abstract translation: 在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。 入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。 一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。 这有效地改善离子源和质量分析器之间的离子传递。

公开(公告)号：US20060151692A1

公开(公告)日：2006-07-13

申请号：US11032376

申请日：2005-01-10

Applicant: Bruce Collings ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bruce Thomson

Inventor： Bruce Collings ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bruce Thomson

IPC: B01D59/44

CPC classification number: H01J49/04 ,  H01J49/062

Abstract: In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.

Abstract translation: 在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。 入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。 一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。 这有效地改善离子源和质量分析器之间的离子传递。

公开(公告)号：US07858927B2

公开(公告)日：2010-12-28

申请号：US12275597

申请日：2008-11-21

Applicant: Bruce Thomson

Inventor： Bruce Thomson

IPC: H01J49/26 ,  B01D59/44

CPC classification number: H01J49/004 ,  G01N27/624

Abstract: An apparatus and method of analyzing ions is described in which a Differential Mobility Analyzer (DMA) is combined with an analysis device. The DMS can be operated in first and second modes of operation to produce a plurality of ions that are sampled and analyzed by the analysis device. In the first mode of operation the DMA is configured to enable ion mobility separation and the analysis device samples and analyzes ions having ion mobility in a certain range of ion mobility and in the second mode of operation the DMA is configured to disable ion mobility separation and the analysis device samples and analyzes ions without discrimination based on ion mobility.

Abstract translation: 描述了分析离子的装置和方法，其中差分移动分析器（DMA）与分析装置组合。 DMS可以在第一和第二操作模式下操作，以产生由分析装置采样和分析的多个离子。 在第一操作模式中，DMA被配置为启用离子迁移率分离，并且分析装置对在离子迁移率的一定范围内具有离子迁移率的离子进行采样和分析，并且在第二操作模式中，DMA被配置为禁用离子迁移率分离， 分析装置基于离子迁移率对不分离的离子进行样品和分析。

公开(公告)号：US20100301205A1

公开(公告)日：2010-12-02

申请号：US12788368

申请日：2010-05-27

Applicant: Bruce Thomson

Inventor： Bruce Thomson

IPC: H01J49/26 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/0045 ,  H01J49/0027

Abstract: A method and apparatus for acquiring time profiles of ion intensities of product ions in a mass spectrometer is provided. The mass spectrometer comprises an ion trap, a fragmentation module connected to the ion trap, and a mass analyzer module positioned to receive ions from the fragmentation module. Precursor ions, trapped in the ion trap, are ejected from the ion trap in order of m/z ratio. At least of some the precursor ions are fragmented at the fragmentation module to form product ions. Time profiles of ion intensities of the product ions are acquired, the product ions received at the mass analyzer module, by recording a plurality of product mass spectra for each respective precursor ion. The plurality of product mass spectra is processed, using the time profile intensities, to associate respective product ions with the respective precursor ions.

Abstract translation: 提供了一种用于获取质谱仪中产物离子的离子强度的时间曲线的方法和装置。 质谱仪包括离子阱，连接到离子阱的碎裂模块和定位成接收来自碎裂模块的离子的质量分析器模块。 捕获在离子阱中的前体离子以离子阱的顺序从m / z比排出。 至少一些前体离子在碎裂模块处被碎裂以形成产物离子。 通过记录每个各自的前体离子的多个产物质谱，获得产物离子的离子强度的时间曲线，产物离子在质量分析器模块处接收。 使用时间分布强度处理多个产品质谱，以将各个产物离子与相应的前体离子相关联。

公开(公告)号：US07759637B2

公开(公告)日：2010-07-20

申请号：US11769254

申请日：2007-06-27

Applicant: Bruce Thomson

Inventor： Bruce Thomson

IPC: H01J49/40

CPC classification number: H01J49/063 ,  H01J49/0072 ,  Y10T436/24

Abstract: A method of analyzing ions is provided having a first ion guide with first and second ends and introducing a first group of ions and a second group of ions of opposite polarity into the first ion guide, and applying an RF voltage potential to the first ion guide for confining the first and second groups of ions radially within the first ion guide. A first trapping barrier is provided to the first end of the first ion guide for trapping the first group of ions within the first ion guide and a second trapping barrier is provided to the second end of the first ion guide for trapping the second group of ions within the first ion guide and an axial field is provided for pushing the first group of ions toward the first trapping barrier and pushing the second group of ions toward the second trapping barrier.

Abstract translation: 提供了一种分析离子的方法，其具有第一和第二端的离子引导件，并将第一组离子和第二组相反极性的离子引入第一离子导向器中，并将RF电压电势施加到第一离子导向器 用于将第一和第二组离子径向限制在第一离子导向器内。 第一捕获屏障被提供到第一离子导向器的第一端，用于捕获第一离子引导体内的第一组离子，并且第二捕获势垒被提供到第一离子引导件的第二端以捕获第二组离子 在所述第一离子导向件内设置有轴向场，用于将所述第一组离子推向所述第一捕获阻挡层并将所述第二组离子推向所述第二捕获屏障。

公开(公告)号：US06992285B1

公开(公告)日：2006-01-31

申请号：US09592436

申请日：2000-06-12

Applicant: Lisa Cousins ,  Bruce Thomson

Inventor： Lisa Cousins ,  Bruce Thomson

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/0063

Abstract: A method of and apparatus for analyzing a substance takes a stream of ions in said substance and supplies the ions to a collision cell including a quadrupole rod set for guiding the ions and a buffer gas. An RF voltage is applied to the quadrupole rod set to guide ions. An additional alternating current signal is applied to the quadrupole rod set at a frequency selected to cause resonance excitation of the secular frequency of a desired ion, whereby said desired ions are excited and undergo collision with the buffer gas causing fragmentation. The alternating current signal is then modulated, whereby periods in which said alternating current signal is applied alternate with periods in which said alternating signal is not applied. The ion spectrum after fragmentation is collected to generate one set of data for one spectrum, representative of the ion spectrum when the alternating current signal is applied, and another set of data for another spectrum, representative of the ion spectrum when the alternating current signal is not applied. These two spectra can then be subtracted.

Abstract translation: 用于分析物质的方法和装置在所述物质中吸收离子流，并将离子提供给包括用于引导离子的四极杆组和缓冲气体的碰撞室。 将RF电压施加到四极杆组以引导离子。 附加的交流信号以选定的频率施加到四极杆组，以引起期望离子的长期频率的共振激发，由此所述期望的离子被激发并与缓冲气体发生碰撞，导致碎片化。 然后调制交流信号，由此施加所述交流信号的周期与不施加所述交替信号的周期交替。 收集碎片后的离子光谱，以产生一组光谱的一组数据，代表施加交流信号时的离子光谱，另一组数据用于另一个光谱，代表交流信号为离子光谱时的离子光谱 没有申请。 然后可以减去这两个光谱。

公开(公告)号：US06507019B2

公开(公告)日：2003-01-14

申请号：US09864872

申请日：2001-05-25

Applicant: Igor Chernushevich ,  Bruce Thomson

Inventor： Igor Chernushevich ,  Bruce Thomson

IPC: B01D5944

CPC classification number: H01J49/40 ,  H01J49/004 ,  H01J49/401 ,  H01J49/42 ,  H01J49/421 ,  H01J49/4225

Abstract: There is provided a method of effecting mass analysis on an ion stream, the method comprising passing the ion stream through a first mass resolving spectrometer, to select parent ions having a first desired mass-to-charge ratio. The parent ions are then subject to collision-induced dissociation (CID) to generate product ions, and the product Ions and any remaining parent ions are trapped the CID and trapping can be carried out together in a linear ion trap. Periodically pulses of the trapped ions are released into a time of flight (TOF) instrument to determine the mass-to-charge ratio of the ions. The delay between the release of the pulses and the initiation of the push-pull pulses of the TOF instrument are adjusted to maximize the duty cycle efficiency and hence the sensitivity for a selected ion with a desired mass-to-charge ratio. This technique can be used to optimize the performance for a parent ion scan, and MRM scan or a neutral loss scan.

公开(公告)号：US06093929A

公开(公告)日：2000-07-25

申请号：US66556

申请日：1998-04-28

Applicant: Gholamreza Javahery ,  Bruce Thomson ,  Charles Jolliffe

Inventor： Gholamreza Javahery ,  Bruce Thomson ,  Charles Jolliffe

IPC: H01J49/42

CPC classification number: H01J49/4225 ,  H01J49/004 ,  H01J49/4215 ,  H01J49/4285

Abstract: A mass spectrometer system in which ions are mass selected in an RF-only quadrupole at relatively high pressure (1 to 7 torr) using FNF or SWIFT, and are then fragmented in a following collision cell which is in the same vacuum chamber, thus reducing pumping needs. The fragments can be mass analyzed in any desired way, including by another RF-only quadrupole in the same vacuum chamber and also using FNF or SWIFT. Triple MS can be performed in the same way.

Abstract translation: 使用FNF或SWIFT在相对较高压力（1至7托）的RF仅四极杆中质量选择离子的质谱仪系统，然后在处于相同真空室中的后续碰撞池中碎裂，从而减少 抽水需要。 可以以任何所需的方式对片段进行质量分析，包括在同一真空室中使用另一个仅RF的四极杆，并使用FNF或SWIFT。 三重MS可以以相同的方式执行。

公开(公告)号：US08581176B2

公开(公告)日：2013-11-12

申请号：US12788403

申请日：2010-05-27

Applicant: Bruce Thomson ,  Suzanne Ackloo

Inventor： Bruce Thomson ,  Suzanne Ackloo

IPC: H01J49/00

CPC classification number: H01J49/004 ,  G01N30/02 ,  G01N30/7233 ,  B01D15/34

Abstract: A system and method for performing MS/MS of everything are provided. Ionisable materials separated in order of molecular weight in a plurality of mass ranges are received at a mass spectrometer system in a given order in time, each mass range comprising a respective center mass value and a respective width. The ionisable materials are ionised in the given order that each of the plurality of mass ranges are received, to form respective precursor ions in a respective given mass range. The respective precursor ions are filtered via a mass filter module, a mass scan range of the mass filter module synchronized with the given order in which each of the plurality of mass ranges are received. The respective precursor ions are fragmented, via a fragmentation module, to form respective product ions. The respective product ions are analyzed in a mass spectrometer module to produce product ion spectra.

Abstract translation: 提供了一种用于执行MS / MS的一切的系统和方法。 在质谱仪系统中按照给定的时间顺序接收在多个质量范围内以分子量分级分离的可离子化材料，每个质量范围包括相应的中心质量值和相应的宽度。 可电离材料以给定的顺序电离，以便接收多个质量范围中的每一个，以在相应的给定质量范围内形成相应的前体离子。 通过质量过滤器模块过滤各个前体离子，质量过滤器模块的质量扫描范围与其中接收多个质量范围中的每一个的给定顺序同步。 各自的前体离子通过碎片模块被分段，以形成相应的产物离子。 在质谱仪模块中分析各产物离子以产生产物离子光谱。

公开(公告)号：US08217345B2

公开(公告)日：2012-07-10

申请号：US12254244

申请日：2008-10-20

Applicant: Bruce Thomson

Inventor： Bruce Thomson

IPC: H01J49/00

CPC classification number: H01J49/0422 ,  G01N27/624

Abstract: Various embodiments are described herein for an apparatus that can be used to interface a Differential Mobility Analyzer (DMA) with a Mass Spectrometer (MS). The apparatus includes first and second plates with first and second apertures respectively, and an interface region in between the first and second plates. During use, the first aperture receives mobility separated ions from the DMA, the interface region receives a gas flow to prevent gas outflow from the DMA toward the MS, and the first and second plates are configured to receive voltages to generate an electric field there between to guide the mobility separated ions from the first aperture to the second aperture, which then provides the mobility separated ions to the MS.

Abstract translation: 本文描述了可用于将差分移动分析仪（DMA）与质谱仪（MS）接口的装置的各种实施例。 该装置包括分别具有第一和第二孔的第一和第二板以及第一和第二板之间的界面区域。 在使用期间，第一孔径从DMA接收迁移率分离的离子，界面区域接收气流以防止气体从DMA向MS流出，并且第一和第二板被配置为接收电压以在其间产生电场 以将迁移率分离的离子引导到第一孔径到第二孔径，然后将离子离子提供给MS。