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公开(公告)号：US11117906B2
公开(公告)日：2021-09-14
申请号：US16714903
申请日：2019-12-16
Applicant: Colgate-Palmolive Company
Inventor： Zhigang Hao , Chi-Yuan Cheng , Tatiana Brinzari , Long Pan , Ravi Subramanyam , Lauren Evans , Sergio Leite
IPC: C07F3/06 , A61K8/27 , A61K8/44 , C07C229/26
Abstract: Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
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公开(公告)号：US11116707B2
公开(公告)日：2021-09-14
申请号：US16830559
申请日：2020-03-26
Applicant: Colgate-Palmolive Company
Inventor： Zhigang Hao , Long Pan , Yu Wang
Abstract: Disclosed herein are improved methods for the synthesis of stannous pyrophosphate, as well as improved methods for the manufacture of oral care compositions comprising stannous pyrophosphate.
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公开(公告)号：US10226407B2
公开(公告)日：2019-03-12
申请号：US15393953
申请日：2016-12-29
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Shiri Nawrocki , Viktor Dubovoy , Long Pan , Zhigang Hao , Nihal Dogu
Abstract: Provided are aqueous soluble tin phosphate complexes formed from a mixture comprising tin (II) fluoride or tin (II) chloride and a tripolyphosphate salt, e.g., sodium tripolyphosphate (Na5P3O10), and oral care compositions comprising the complex and uses thereof.
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公开(公告)号：US09861563B2
公开(公告)日：2018-01-09
申请号：US14653876
申请日：2012-12-19
Applicant: Colgate-Palmolive Company
Inventor： LaTonya Kilpatrick-Liverman , Zhiqiang Liu , Long Pan , Ying Yang , Guofeng Xu , Michael A. Stranick , Zhigang Hao
CPC classification number: A61K8/27 , A61K8/21 , A61K8/416 , A61K8/44 , A61K2800/74 , A61Q11/00 , C07C229/12
Abstract: The invention provides oral care compositions comprising a mixture of tetrabasic zinc halide and trimethylglycine, in free or orally acceptable salt form. Methods of making and using the compositions are also provided.
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公开(公告)号：US20150265183A1
公开(公告)日：2015-09-24
申请号：US14441184
申请日：2012-12-21
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Zhigang Hao , Deborah A. Peru , Joe Vazquez , Jessica Monk , Harsh M. Trivedi , Paul Joseph Vincenti , Osman Khalid
IPC: A61B5/08 , A61B10/00 , G01N33/497 , A61Q11/00 , A61K8/55
CPC classification number: A61B5/08 , A61B5/082 , A61B10/00 , A61B2010/0087 , A61K8/33 , A61K8/35 , A61K8/55 , A61Q11/00 , G01N33/497 , G01N2033/4975 , Y10T436/182
Abstract: The present invention relates to a method for testing oral malodor, in particular oral malodor from onion and garlic. Described herein are methods for testing the efficacy of an oral care composition to reduce oral malodor, the method comprising the steps of: a) cleaning at least a part of the oral cavity with an oral care composition; b) testing a first sample of exhaled breath from the cleaned oral cavity to provide a first test result representing a first amount of at least one oral malodor component detected in the exhaled breath; c) exposing the oral cavity to an oral malodor material including or capable of forming the at least one oral malodor component; and d) testing a second sample of exhaled breath from the oral cavity to provide a second test result representing a second amount of the at least one oral malodor component detected in the exhaled breath.
Abstract translation: 本发明涉及一种口服恶臭的检测方法，特别是洋葱和大蒜口服恶臭。 本文描述了用于测试口腔护理组合物降低口腔恶臭的功效的方法，该方法包括以下步骤：a）用口腔护理组合物清洁至少一部分口腔; b）从清洁的口腔测试呼出呼吸的第一样本，以提供表示在呼出气中检测到的第一量的至少一种口腔恶臭成分的第一测试结果; c）将口腔暴露于包含或能够形成至少一种口腔恶臭成分的口腔恶臭物质; 以及d）从所述口腔测试第二呼出呼气样品，以提供第二测试结果，所述第二测试结果代表在所述呼出气体中检测到的所述至少一种口腔恶臭成分的第二量。
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Patent Agency Ranking
公开(公告)号：US20240199538A1
公开(公告)日：2024-06-20
申请号：US18531066
申请日：2023-12-06
Applicant: Colgate-Palmolive Company
Inventor： Viktor DUBOVOY , Dailin Chen , Zhigang Hao , Xing He , Long Pan , Chi-Yuan Cheng , Yu Wang , Jake Salerno , Tatiana Brinzari
IPC: C07C279/18 , A01N47/44 , A01P1/00 , A61K8/43 , A61Q11/00 , A61Q17/00 , C07C305/04
CPC classification number: C07C279/18 , A01N47/44 , A01P1/00 , A61K8/43 , A61Q11/00 , A61Q17/005 , C07C305/04 , C07B2200/13
Abstract: This application relates to a novel chlorhexidine lauryl sulfate salt, which provides enhanced chlorhexidine stability and enhanced anti-bacterial activity, and to formulations and methods utilizing the novel salt.
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公开(公告)号：US20220192940A1
公开(公告)日：2022-06-23
申请号：US17594639
申请日：2019-04-25
Applicant: Colgate-Palmolive Company
Inventor： Zhigang Hao , Erin LASKOWSKI , Victoria YEUNG , Mania BANKOVA , Long PAN , Yun XU , Peng YAN , Fusong SUN , Zheng YANG , Chi-Yuan CHENG , Tatiana BRINZARI
Abstract: A stabilized oral care composition comprises amino acids and traditionally incompatible flavor components. Methods of making and use are further provided.
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公开(公告)号：US11091502B2
公开(公告)日：2021-08-17
申请号：US16714884
申请日：2019-12-16
Applicant: Colgate-Palmolive Company
Inventor： Zhigang Hao , Chi-Yuan Cheng , Tatiana Brinzari , Long Pan , Ravi Subramanyam
IPC: C07F3/06 , A61K8/27 , A61K8/44 , C07C229/26
Abstract: Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc halide and amino acid free base in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
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公开(公告)号：US10952943B2
公开(公告)日：2021-03-23
申请号：US16714972
申请日：2019-12-16
Applicant: Colgate-Palmolive Company
Inventor： Zhigang Hao , Chi-Yuan Cheng , Tatiana Brinzari , Long Pan , Ravi Subramanyam
Abstract: The disclosure provides a zinc-arginine complex, methods of making the same, and methods of using the same in oral care compositions.
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公开(公告)号：US09823236B2
公开(公告)日：2017-11-21
申请号：US14441962
申请日：2012-12-21
Applicant: Colgate-Palmolive Company
Inventor： Zhigang Hao , Deborah A. Peru , Joe Vazquez , Jessica Monk , Harsh M. Trivedi , Paul Joseph Vincenti , Osman Khalid , Ariel Haskel
CPC classification number: G01N33/497 , A61K8/24 , A61K8/33 , A61K8/35 , A61K8/4913 , A61K8/4973 , A61K2800/591 , A61Q11/00
Abstract: The present invention relates to a method for testing oral malodor, in particular oral malodor from coffee. Described herein are methods for testing the efficacy of an oral care composition to reduce oral malodor, the method comprising the steps of: a) cleaning at least a part of the oral cavity with an oral care composition; b) testing a sample of exhaled breath from the cleaned oral cavity to provide a test result representing a amount of at least one oral malodor component detected in the exhaled breath; c) exposing the oral cavity to an oral malodor material including or capable of forming the at least one oral malodor component; and d) testing a sample of exhaled breath from the oral cavity to provide a test result representing an amount of the at least one oral malodor component detected in the exhaled breath.
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