公开(公告)号：US20060036373A1

公开(公告)日：2006-02-16

申请号：US10915849

申请日：2004-08-11

申请人： Srinka Ghosh ,  Peter Webb

发明人： Srinka Ghosh ,  Peter Webb

IPC分类号： G06F19/00 ,  G06K9/00 ,  G01N33/48 ,  G01N33/50

CPC分类号： G06K9/00 ,  G06T7/12 ,  G06T7/70 ,  G06T2207/20056 ,  G06T2207/20068 ,  G06T2207/30072

摘要： A method and system for cropping a digital image of multiple individual microarrays. Various embodiments of the present invention include, a digital image of multiple individual microarrays projected along a first coordinate axis by summing columns of pixel intensity values. A transformation maps the projected pixel intensity values to a transform in a frequency domain. A filter function is constructed from a power spectrum of the transform and multiplied by the transform to obtain a filtered transform. The filtered transform is mapped back to the spatial domain to give the filtered, spatial-domain image. The filtered, spatial-domain image is used to determine the coordinates of boundaries separating the individual microarrays along the first coordinate axis. The multi-pack of microarrays is rotated, and the method may be repeated for a second coordinate axis that is perpendicular to the first coordinate axis. The boundaries are used to identify the boundaries separating individual microarrays.

摘要翻译： 用于裁剪多个单个微阵列的数字图像的方法和系统。 本发明的各种实施例包括通过对像素强度值的列求和来沿着第一坐标轴投影的多个单独的微阵列的数字图像。 A变换将投影像素强度值映射到频域中的变换。 滤波函数由变换的功率谱构成，并与变换相乘以获得滤波变换。 滤波后的变换映射回空间域，以给出过滤的空间域图像。 滤波后的空间域图像用于确定沿着第一坐标轴分开各个微阵列的边界的坐标。 旋转多组微阵列，并且对于垂直于第一坐标轴的第二坐标轴可以重复该方法。 边界用于识别分离各个微阵列的边界。

公开(公告)号：US20050026154A1

公开(公告)日：2005-02-03

申请号：US10633609

申请日：2003-07-31

申请人： Laurakay Bruhn ,  Douglas Amorese ,  Michael Caren ,  Leslie Leonard ,  Richard Pittaro ,  Carol Schembri ,  Peter Webb ,  Paul Wolber

发明人： Laurakay Bruhn ,  Douglas Amorese ,  Michael Caren ,  Leslie Leonard ,  Richard Pittaro ,  Carol Schembri ,  Peter Webb ,  Paul Wolber

IPC分类号： B01J19/00 ,  B01L3/00 ,  C12Q1/68 ,  C40B40/06 ,  G01N21/25 ,  G01N33/48 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  G01N33/58 ,  G06F19/00

CPC分类号： B01L3/545 ,  B01J2219/00662 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01L3/5088 ,  B01L2200/025 ,  B01L2300/024 ,  B01L2300/0819 ,  C40B40/06 ,  G01N21/253

摘要： A method of using a chemical array unit having a chemical array with probes at multiple feature locations. A request for test may be read, which test uses a sub-array of the array. A pattern of the sub-array may be retrieved from a memory using the test request, which memory carries a pattern for the sub-array which is retrievable with the different test request. Also, a method of reading a chemical array unit which has been exposed to a sample, and feature locations of which have been rendered incapable of providing signal data representative of binding of a sample component. Further methods, apparatus, and computer program products are provided.

摘要翻译： 一种在多个特征位置使用具有化学阵列的化学阵列单元和探针的方法。 可以读取测试请求，哪个测试使用数组的子阵列。 可以使用测试请求从存储器检索子阵列的模式，该存储器携带用于使用不同测试请求可检索的子阵列的模式。 此外，读取已经暴露于样品的化学阵列单元的方法，其特征位置已经不能提供表示样品组分的结合的信号数据。 提供其他方法，装置和计算机程序产品。

公开(公告)号：US20080052730A1

公开(公告)日：2008-02-28

申请号：US11880408

申请日：2007-07-20

申请人： Peter Webb ,  Barry Simon ,  Charles Nylander ,  John Micco ,  Marc Ullman

发明人： Peter Webb ,  Barry Simon ,  Charles Nylander ,  John Micco ,  Marc Ullman

IPC分类号： G06F9/44

CPC分类号： G06F8/433 ,  G06F8/30 ,  G06F9/44521

摘要： The present invention is directed toward automatically integrating a late bound program language into an external environment. The external environment may be an early bound environment, a late bound environment or some combination thereof. Associated with the late bound program environment is a modular execution engine and an interface mechanism, wherein the interface mechanism is capable of expressing late bound semantics in a format compatible with the external environment.

摘要翻译： 本发明旨在将后期绑定程序语言自动地集成到外部环境中。 外部环境可能是早期约束环境，后期环境或其某些组合。 与后期程序环境相关联的是模块化执行引擎和接口机制，其中接口机制能够以与外部环境兼容的格式表达后期绑定语义。

公开(公告)号：US20070219727A1

公开(公告)日：2007-09-20

申请号：US11378661

申请日：2006-03-17

申请人： Stephanie Fulmer-Smentek ,  Peter Webb

发明人： Stephanie Fulmer-Smentek ,  Peter Webb

IPC分类号： G06F19/00

CPC分类号： G16B45/00 ,  G16B25/00

摘要： Comparative genomic hybridization is a tool that compares DNA samples from suspect cells of an organism with DNA samples from normal cells. Cross-species comparative genomic hybridization visualization allows genomic data from model organisms to be mapped and presented in accordance with the (for example) human genome to suggest possible common biological effects between two or more species.

摘要翻译： 比较基因组杂交是将生物体的可疑细胞的DNA样品与来自正常细胞的DNA样品进行比较的工具。 跨物种比较基因组杂交可视化允许来自模型生物体的基因组数据根据（例如）人类基因组进行绘制和呈现，以提出两种或多种物种之间可能的常见生物学效应。

公开(公告)号：US20070025412A1

公开(公告)日：2007-02-01

申请号：US11481092

申请日：2006-07-06

申请人： Peter Webb

发明人： Peter Webb

IPC分类号： G01K7/00

CPC分类号： G01K7/026

摘要： There are a number of sensors (2, 22) such as thermocouples which can provide a putative measurand signal which is within a predicted range for such signals whilst the sensor is incorrectly operating, such as as due to an open circuit. Techniques and processes are available to determine by interrogation sensor operational validity, but these can distort the measurand signal if correct. By time division multiplex techniques the present arrangement takes a putative measurand signal from a sensor (2, 22) in order that either within the same time division or more normally a separate time division, an interrogation of the sensor is performed in order to determine accuracy and therefore validity of the sensor 22. In such circumstances, the putative measurand signal from the sensor 22 is dynamically verified by the interrogator 23 to allow greater confidence with respect to interpretation, if an invalid sensor operation is determined, then a pre-defined value for that sensor failure can be output for the data signal.

摘要翻译： 存在许多传感器（2,22），例如热电偶，其可以提供推测的被测量信号，该信号在传感器不正确地操作时，例如由于开路而在预定范围内。 技术和过程可以通过询问传感器的操作有效性来确定，但是如果正确，这些技术和过程可能会使被测信号失真。 通过时分复用技术，本发明的装置从传感器（2,22）中获取推定的被测量信号，以便在相同的时间分割或更多的时间内通常是单独的时分，执行传感器的询问以确定精度 因此传感器22的有效性。 在这种情况下，来自传感器22的推定的被测量信号由询问器23动态地验证，以便在解释方面有更大的置信度，如果确定了无效的传感器操作，则可以输出该传感器故障的预定义值 数据信号。

公开(公告)号：US20060122240A1

公开(公告)日：2006-06-08

申请号：US10533799

申请日：2003-11-04

申请人： Graeme Semple ,  Philip Skinner ,  Martin Cherrier ,  Peter Webb ,  Susan Tamura

发明人： Graeme Semple ,  Philip Skinner ,  Martin Cherrier ,  Peter Webb ,  Susan Tamura

IPC分类号： C07D249/16 ,  A61K31/4192

CPC分类号： C07D405/06 ,  A61K31/4192 ,  C07D249/18

摘要： The present invention relates to certain benzotriazole carboxylic acid or ester derivatives of Formula (I), pharmaceutically acceptable salts and solvates thereof, which exhibit useful pharmaceutical properties, for example, as agonists for the GPCR referred to as hRUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.

摘要翻译： 本发明涉及一些表现出有用的药物性质的式（I）的苯并三唑羧酸或酯衍生物，其药学上可接受的盐和溶剂化物，例如被称为hRUP38的GPCR的激动剂。 本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物预防或治疗代谢相关疾病（包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，类型 2型糖尿病，综合征X等。 此外，本发明还提供本发明化合物与其它活性剂如属于葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成抑制剂 ，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等。

公开(公告)号：US20050100480A1

公开(公告)日：2005-05-12

申请号：US10649105

申请日：2003-08-26

申请人： Peter Webb

发明人： Peter Webb

IPC分类号： B01J19/00 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00 ,  G01N35/00 ,  G01N35/10 ,  G01N1/10

CPC分类号： G01N35/1074 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00 ,  G01N35/1011 ,  G01N2035/00158 ,  G01N2035/1041 ,  Y10T436/2575

摘要： A method, apparatus, and computer program, for fabricating multiple arrays arranged successively in a first direction on a substrate and each having multiple feature sets arranged successively in the first direction within the array. The method uses a head system having multiple successive sets of dispensers. In the method, the head system is advanced in the first direction over the substrate while dispensing drop sets for each array from dispenser sets so as to form the arrays. In one aspect, drop sets are dispensed in an order the reverse of that from which the dispenser sets pass over a given location on the substrate as the head system advances in the first direction. In this case, each dispenser set deposits a drop set at a distance ahead of a drop set deposited by a preceding dispenser set which is less than the distance to the successive drop dispenser set which deposits the next drop set, .

摘要翻译： 一种方法，装置和计算机程序，用于制造在基板上沿第一方向连续布置的多个阵列，并且每个具有在阵列内的第一方向上连续布置的多个特征集。 该方法使用具有多个连续的分配器组的头系统。 在该方法中，头系统在衬底上沿第一方向前进，同时从分配器组分配每个阵列的滴组，以形成阵列。 在一个方面，当头系统沿着第一方向前进时，滴套以与分配器组在基板上的给定位置通过的顺序相反地分配。 在这种情况下，每个分配器装置将在前面的分配器组所沉积的液滴组件前面的距离处设置一个液滴，该液滴组件小于与沉积下一个液滴组的连续滴液分离器组件的距离，。

公开(公告)号：US6019726A

公开(公告)日：2000-02-01

申请号：US96016

申请日：1998-06-10

申请人： Peter Webb

发明人： Peter Webb

IPC分类号： A61B8/12 ,  A61B8/14

CPC分类号： A61B8/12 ,  A61B8/4245 ,  A61B8/4254 ,  A61B8/4461

摘要： A catheter for imaging a cavity. The catheter includes a sheath having a distal end that is introduced into a cavity to be imaged and a proximal end that resides outside of the cavity. The sheath includes a tubular member with a first fixed probe located proximate to the distal end and fixed in relation to the tubular member while the cavity is being imaged. The catheter also includes a transducer for delivering an energy pulse in a predetermined direction relative to the transducer and collecting echoes generated by the pulse. The transducer is located within the sheath proximate to the distal end of the sheath and includes a transducer probe affixed to the transducer. A drive cable in the catheter causes the transducer and the transducer probe to rotate relative to the sheath. The drive cable connects the transducer to a mechanical drive mechanism located at the proximate end of the sheath. A tracking circuit measures the electrical coupling between the transducer probe and the first fixed probe to determine the location of the transducer relative to the sheath.

摘要翻译： 用于成像腔的导管。 导管包括具有远端的护套，该远端被引入待成像的空腔中并且位于腔的外侧的近端。 护套包括管状构件，其具有靠近远端定位的第一固定探头，并且在腔被成像时相对于管状构件固定。 导管还包括用于相对于换能器在预定方向传送能量脉冲并收集脉冲产生的回波的换能器。 传感器位于鞘内，靠近护套的远端，并包括固定在换能器上的换能器探头。 导管中的驱动电缆使换能器和换能器探头相对于护套旋转。 驱动电缆将传感器连接到位于护套近端的机械驱动机构。 跟踪电路测量换能器探头与第一固定探针之间的电耦合，以确定换能器相对于护套的位置。

公开(公告)号：US08238030B2

公开(公告)日：2012-08-07

申请号：US12729187

申请日：2010-03-22

申请人： Peter Webb ,  David Lande

发明人： Peter Webb ,  David Lande

IPC分类号： G02B27/30

CPC分类号： G02B27/30 ,  G02B6/327

摘要： An apparatus for providing multiple collimated light beams from optical fibers and the method for producing such beams. The apparatus includes first and second optical fibers that carry light of first and second wavelengths, respectively, a fixture that maintains the fibers in a fixed relationship to one another, and a collimating lens. Light from each of the first and second optical fibers diverges from a face of the fixture. The collimating lens produces first and second collimated light beams that are displaced relative to one another from the light leaving the face. The face of the fixture is positioned to correct for chromatic aberration in the lens.

摘要翻译： 一种用于从光纤提供多个准直光束的装置以及用于产生这种光束的方法。 该装置包括分别承载第一和第二波长的光的第一和第二光纤，将光纤保持彼此固定关系的固定装置和准直透镜。 来自第一和第二光纤中的每一个的光从夹具的表面发散。 准直透镜产生第一和第二准直光束，其相对于彼此离开离开面部的光而相对移动。 固定装置的表面被定位以校正透镜中的色差。

公开(公告)号：US20070233398A1

公开(公告)日：2007-10-04

申请号：US11390797

申请日：2006-03-28

申请人： Svetlana Shchegrova ,  Peter Webb ,  Douglas Roberts ,  B. Giles

发明人： Svetlana Shchegrova ,  Peter Webb ,  Douglas Roberts ,  B. Giles

IPC分类号： G06F19/00

CPC分类号： G16B40/00 ,  G16B25/00

摘要： Methods are disclosed for predicting the performance of oligonucleotide probes by identifying the sequence of a candidate probe, generating experimental data for the probe and using the data to train a statistical regression model. Nucleic acid arrays containing probes with performance predicted by the described using methods are provided. Also included are algorithms for performing the subject methods recorded on computer-readable media, and computational systems for analysis.

摘要翻译： 公开了通过识别候选探针的序列，产生探针的实验数据并使用数据来训练统计回归模型来预测寡核苷酸探针的性能的方法。 提供了含有通过所述使用方法预测的性能的探针的核酸阵列。 还包括用于执行记录在计算机可读介质上的主题方法的算法和用于分析的计算系统。