公开(公告)号：US12203926B2

公开(公告)日：2025-01-21

申请号：US17309896

申请日：2019-12-17

Applicant: Colgate-Palmolive Company

Inventor： Camille Zenobia ,  Harsh Mahendra Trivedi ,  Ying Yang ,  Carlo Daep ,  James Masters

IPC: G01N33/50 ,  C12N1/20 ,  G09B23/30 ,  A61K8/27 ,  A61Q11/00 ,  C12R1/04 ,  C12R1/46

Abstract: An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.

公开(公告)号：US11957778B2

公开(公告)日：2024-04-16

申请号：US16406069

申请日：2019-05-08

Applicant: Colgate-Palmolive Company

Inventor： Shamim Ansari ,  Harsh Mahendra Trivedi ,  James Masters

IPC: A61K8/73 ,  A61K8/34 ,  A61K8/92 ,  A61K8/9794 ,  A61Q11/00

CPC classification number: A61K8/735 ,  A61K8/345 ,  A61K8/922 ,  A61K8/9794 ,  A61Q11/00

Abstract: Disclosed herein are oral care compositions comprising hemp seed oil and caprylyl glycol. In certain embodiments, the oral care composition optionally further comprises one or more ingredients selected from hyaluronic acid and aloe vera. Methods of making and using the compositions are also provided.

公开(公告)号：US11490623B2

公开(公告)日：2022-11-08

申请号：US16846770

申请日：2020-04-13

Applicant: Colgate-Palmolive Company ,  The Trustees of the University of Pennsylvania

Inventor： Carl Myers ,  Carlo Daep ,  Lynette Zaidel ,  James Masters ,  Russell Composto ,  Hyun-Su Lee

IPC: A01N47/44 ,  C11D3/37 ,  A61K31/785 ,  A61Q17/00 ,  C11D3/48 ,  A61Q11/00 ,  C08F126/02 ,  A61K8/91 ,  A01N25/08 ,  A61K8/81 ,  C08F8/30 ,  C09D5/14 ,  C09D139/00

Abstract: Antimicrobial compositions and methods for depositing or coating the antimicrobial or antibacterial compositions on a substrate to prevent microbial adhesion are provided. The antimicrobial composition may include a cationic polymer having a poly-allylamine backbone. A portion of the poly-allylamine backbone may be functionalized with at least one of a guanidine functional group and a biguanide functional group.

公开(公告)号：US20210318306A1

公开(公告)日：2021-10-14

申请号：US17301428

申请日：2021-04-02

Applicant: Colgate-Palmolive Company

Inventor： Dandan Chen ,  Harsh Mahendra Trivedi ,  James Masters

IPC: G01N33/566 ,  G01N33/543 ,  A61K33/30 ,  A61K33/16 ,  G01N33/50 ,  A61P31/04

Abstract: Methods for identifying a composition that neutralizes toxicity of a lipopolysaccharide are disclosed. The methods comprise comparing the amount of cytokine and/or prostaglandin E2 secreted by cells that have Toll-like receptors activated by a lipopolysaccharide in the presence or absence of a test composition. Methods of neutralizing toxicity of a lipopolysaccharide in an individual's oral cavity using compositions identified neutralizing toxicity of a lipopolysaccharide are also disclosed. Method of neutralizing toxicity of a lipopolysaccharide in an individual's oral cavity using oral care compositions that comprise combinations of zinc oxide and zinc citrate are also disclosed.

公开(公告)号：US20210308028A1

公开(公告)日：2021-10-07

申请号：US17301257

申请日：2021-03-30

Applicant: Colgate-Palmolive Company

Inventor： Ying Yang ,  James Masters ,  Harsh Mahendra Trivedi ,  Tulika Sarma

IPC: A61K8/58 ,  A61K8/44 ,  A61K8/21 ,  A61K8/27 ,  A61Q11/00

Abstract: Method of improving tissue integrity of tissue that functions as a barrier are provided. Method of protecting and maintaining tissue integrity of tissue that functions as a barrier are provided. Method of repairing damage to tissue that functions as a barrier, and to restoring and improving function of such damaged tissue are provided. Methods of improving, maintaining, protecting, repairing and/or restoring the integrity of tissue which functions as a barrier and repair of damage to and healing of wounds to such tissue improves, maintains, protects, repairs and restores immunity. The methods comprising contacting the tissue with an effective amount of a composition comprising one or more sources of zinc ions such as zinc oxide, zinc citrate, or combination thereof zinc oxide and zinc citrate, and optionally further comprising arginine and/or one or more neutral amino acids.

公开(公告)号：US10588841B2

公开(公告)日：2020-03-17

申请号：US16135136

申请日：2018-09-19

Applicant: Colgate-Palmolive Company

Inventor： Long Pan ,  Shaotang Yuan ,  Shira Pilch ,  James Masters ,  Zhiqiang Liu

IPC: A61K8/58 ,  A61K8/20 ,  A61K8/27 ,  A61K8/21 ,  A61K8/44 ,  A61Q11/00

Abstract: Disclosed herein are oral care compositions comprising a zinc amino acid halide. Methods of making and using the compositions are also provided.

公开(公告)号：US10335615B2

公开(公告)日：2019-07-02

申请号：US15629190

申请日：2017-06-21

Applicant: Colgate-Palmolive Company

Inventor： Ying Yang ,  Dandan Chen ,  Robert D'Ambrogio ,  Paul Thomson ,  Harsh Mahendra Trivedi ,  Michael Prencipe ,  James Masters ,  Stanislav Jaracz

IPC: A61K8/21 ,  A61K8/22 ,  A61K8/27 ,  A61K8/34 ,  A61K8/35 ,  A61K8/97 ,  A61K45/06 ,  A61K8/365 ,  A61Q11/00 ,  A61Q17/00 ,  A61K36/9068

Abstract: This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.

公开(公告)号：US10245222B2

公开(公告)日：2019-04-02

申请号：US15674557

申请日：2017-08-11

Applicant: Colgate-Palmolive Company

Inventor： Long Pan ,  Shaotang Yuan ,  Shira Pilch ,  James Masters ,  Zhiqiang Liu ,  Vyoma Patel

IPC: A61K8/44 ,  A61K8/20 ,  A61K8/04 ,  A61K8/27 ,  A61K8/73 ,  A61Q11/00 ,  A61K8/21

Abstract: Disclosed herein are dentifrices comprising a zinc amino acid halide, which provide a precipitate of zinc oxide upon use with dilution with water and/or saliva. Methods of making and using the dentifrices are also provided.

公开(公告)号：US10213374B2

公开(公告)日：2019-02-26

申请号：US15791812

申请日：2017-10-24

Applicant: Colgate-Palmolive Company

Inventor： Jane Ong ,  James Masters ,  Tatiana Brinzari ,  Chi-Yuan Cheng ,  Donghui Wu ,  Long Pan

IPC: A61K8/27 ,  A61K8/60 ,  A61Q11/00 ,  A61K8/49

Abstract: Disclosed herein are oral care compositions comprising naringin:Zinc complexes having a 2:1 naringin to zinc molar ratio. Methods of making and using the compositions are also provided.

公开(公告)号：US12077824B2

公开(公告)日：2024-09-03

申请号：US17471876

申请日：2021-09-10

Applicant: Colgate-Palmolive Company ,  The Regents of the University of California

Inventor： David T. W. Wong ,  Karolina Elzbieta Kaczor-Urbanowicz ,  Harsh Mahendra Trivedi ,  James Masters

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Described herein are methods used for the detection of gingivitis and the monitoring of gingivitis in a subject.