公开(公告)号：US20230265443A1

公开(公告)日：2023-08-24

申请号：US18017819

申请日：2021-07-22

Applicant: DSM IP ASSETS B.V.

Inventor： Peter Louis HOUSTON ,  Valmik Kanubhai VYAS ,  René Marcel DE JONG ,  Anna SYMBOR-NAGRABSKA ,  Ethan LAM

IPC: C12N15/81 ,  C12N1/16 ,  C12P23/00 ,  C12N9/20

CPC classification number: C12N15/815 ,  C12N1/16 ,  C12P23/00 ,  C12N9/20 ,  C12N2500/36 ,  C12Y301/01003

Abstract: The present invention is related to a novel process for production of retinyl acetate in a host cell, particularly oleaginous yeast such as e.g. Yarrowia, growing on triglyceride oils, such as e.g. vegetable oil, wherein the host cell exhibits modified lipase activity in such a way that conversion of retinol into fatty acid retinyl esters (FAREs) is reduced or abolished. Such process is especially useful in a biotechnological process for production of vitamin A.

公开(公告)号：US20190010508A1

公开(公告)日：2019-01-10

申请号：US16068395

申请日：2017-01-06

Applicant: Adam G. LAWRENCE ,  Peter Louis HOUSTON ,  Jessica Leigh MCGRATH ,  Joshua TRUEHEART ,  DSM IP Assets B.V.

Inventor： Adam G. LAWRENCE ,  Peter Louis HOUSTON ,  Jessica Leigh MCGRATH ,  Joshua TRUEHEART

IPC: C12N15/81 ,  C12N1/16 ,  C12N15/10

Abstract: The present invention is directed to a process for switching the mating type of a Yarrowia fungus strain into an opposite mating type, and to the use thereof to sexually cross two individual strains resulting in new strains.

公开(公告)号：US20250109422A1

公开(公告)日：2025-04-03

申请号：US18834722

申请日：2023-02-01

Applicant: DSM IP ASSETS B.V.

Inventor： Peter Louis HOUSTON ,  Maria Elena MAYORGA ,  Valmik Kanubhai VYAS ,  Peter Scott YORGEY

IPC: C12P23/00 ,  C12N1/06 ,  C12N9/10 ,  C12N15/81

Abstract: The present invention is related to a novel process on biological production of lipophilic substances in an oleaginous host cell, particularly Yarrowia lipolytica, comprising modification in the N-glycosylation pathway, leading to higher yield and product purity with further facilitating the overall production process.

公开(公告)号：US20250032439A1

公开(公告)日：2025-01-30

申请号：US18715405

申请日：2022-12-05

Applicant: DSM IP ASSETS B.V.

Inventor： Christine MENDROK-EDINGER ,  Eileen JACKSON ,  Angela WILDERMANN ,  Peter Louis HOUSTON

IPC: A61K31/222 ,  A61K8/67 ,  A61Q19/00

Abstract: The present invention relates to novel compositions comprising a retinoid mixture of cis and trans isomers of a retinyl ester, particularly retinyl acetate, with a cis/trans ratio of less than 0.03 as well as the use thereof for the treatment, prevention and lessening of the symptoms of diseases and conditions which can be treated with 5-HT2B serotonin receptor antagonists, including but not limited to diseases or conditions selected from migraine headaches, anxiety, ocular hypotension, heart valve disease, irritable bowel syndrome, and MDMA (commonly called “ecstasy”) abuse.

公开(公告)号：US20240216321A1

公开(公告)日：2024-07-04

申请号：US18527530

申请日：2023-12-04

Applicant: DSM IP Assets B.V.

Inventor： Adriana CARVALHO DE SOUZA ,  Peter Louis HOUSTON ,  Valmik Kanubhai VYAS ,  Angela WILDERMANN

IPC: A61K31/23 ,  A61K31/01 ,  A61K31/045 ,  A61K31/07 ,  A61K31/11 ,  A61K31/231

CPC classification number: A61K31/23 ,  A61K31/01 ,  A61K31/045 ,  A61K31/07 ,  A61K31/11 ,  A61K31/231

Abstract: Compositions of matter suitable for use in food, feed, pharmaceutical, and beauty care products comprising a retinoid component and a fermentative residue thereof are disclosed herein. In an embodiment, the retinoid component is present in a ratio by weight relative to the fermentative residue of 4:1 or greater, wherein the retinoid contains cis- and trans-isomers, wherein the cis-isomers are present by weight relative to the entire mixture of isomers in an amount less than 3 wt. %. Preferably, the compositions are bio-based. Also described are biotechnological methods of producing the compositions elsewhere described, along with further methods for processing such compositions into more stabilized, more commercially acceptable forms. Finally, also disclosed are food, feed, pharmaceutical, and beauty care products incorporating the compositions herein described.

公开(公告)号：US20230407344A1

公开(公告)日：2023-12-21

申请号：US18251189

申请日：2021-11-01

Applicant: DSM IP ASSETS B.V.

Inventor： Peter Louis HOUSTON ,  Valmik Kanubhai VYAS

IPC: C12P5/00

CPC classification number: C12P5/007

Abstract: The present invention is related to fermentative production of isoprenoids, comprising cultivation of a suitable host cell, such as fungal host cell, particularly oleaginous host cell, in an improved two-phase culture system.

公开(公告)号：US20180148697A1

公开(公告)日：2018-05-31

申请号：US15567112

申请日：2016-04-21

Applicant: John ROYER ,  Peter Louis HOUSTON ,  DSM IP ASSETS B.V.

Inventor： John ROYER ,  Peter Louis HOUSTON

IPC: C12N9/10 ,  C12P19/44

CPC classification number: C12N9/1085 ,  A23L27/33 ,  A23V2002/00 ,  C07H15/24 ,  C12N9/0042 ,  C12P19/44 ,  C12Y106/02004 ,  C12Y205/01 ,  C12Y205/01001

Abstract: The present invention provides genetically engineered host organisms capable of producing terpenoids. The present invention also relates terpenoids obtained from such genetically engineered organisms. Examples of the produced terpenoids include carotenoids, ionones, abienol, and other isoprenoid derived compounds. In addition, the invention relates to a methods of for the preparation of terpenoids using such a genetically engineered organism.