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公开(公告)号：US6059968A
公开(公告)日：2000-05-09
申请号：US009479
申请日：1998-01-20
申请人： Ludwig Wolf, Jr.
发明人： Ludwig Wolf, Jr.
CPC分类号： A61M1/0209 , A61M2202/0462
摘要： Assemblies and methods process cord blood in a sterile fashion to avoid exposure to bacterial contamination. A transfer tube couples a cord blood processing container to an other container, which, in use, holds a cryopreservative solution. The transfer tube has an interior diameter that is restricted substantially along its entire length, to meter the introduction of cryopreservation solution into cord blood at a desired rate, thereby avoiding damage or trauma to the cord blood cells.
摘要翻译： 装配和方法以无菌方式处理脐带血，以避免暴露于细菌污染。 输送管将脐带血处理容器连接到另一个容器中，其在使用中保持冷冻保存溶液。 转移管具有基本上沿着其整个长度受到限制的内径，以便以所需的速率将冷冻保存溶液引入脐带血中，从而避免对脐带血细胞的损伤或创伤。
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公开(公告)号：US4251310A
公开(公告)日：1981-02-17
申请号：US854762
申请日：1977-11-25
CPC分类号： B29C65/44 , A61M25/0014 , B21G1/08 , B29C65/04 , B29C65/5057 , B29C66/5344 , B29C66/81263 , B29C66/8322 , B29C66/742 , B29K2705/00 , B29L2031/7544
摘要： There is disclosed herein an improved needle assembly or fistula set which includes a hollow metal needle, a larger plastic fluid-carrying conduit, and plastic spacers between the needle and the conduit. The conduit and spacers are heat sealed to each other so as to provide a fluid-tight junction with the needle.A method for heat sealing the fistula set is also disclosed. In that method, the needle is used as one electrode and the other electrode includes jaw-like members which engage and surround the conduit at the junction where the heat seal is to be formed. During the heat sealing operation, the conduit and needle are maintained in substantial coaxial alignment so as to assure coaxial alignment thereafter.A fixture or tooling apparatus is also disclosed for effecting heat sealing and assuring substantial coaxial alignment.
摘要翻译： 本文公开了一种改进的针组件或瘘组，其包括中空金属针，较大的塑料流体输送导管和针与导管之间的塑料间隔物。 导管和间隔件彼此热密封，以便提供与针的流体密封连接。 还公开了一种用于热封瘘组的方法。 在该方法中，针被用作一个电极，而另一个电极包括在形成热封的接合部处接合和围绕导管的颚状构件。 在热封操作期间，导管和针保持基本上同轴对准，以便此后保证同轴对齐。 还公开了用于实现热密封并确保基本上同轴对准的固定装置或模具装置。
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13.发明授权公开(公告)号：US06800432B1
公开(公告)日：2004-10-05
申请号：US09675511
申请日：2000-09-29
申请人： Ludwig Wolf, Jr. , William Bratten , John Foley
发明人： Ludwig Wolf, Jr. , William Bratten , John Foley
IPC分类号： A01N102
CPC分类号： C12M37/00 , A61L2/0011 , A61L2/0082 , A61L2/08 , C12N7/04
摘要： A method and apparatus for inactivating viruses in a body fluid. A mixture including a therapeutically effective amount of methylene blue and an amount of a body fluid is formed in a container under sterile conditions and then the container is irradiated with a light field of a suitable intensity and wavelength for activating the methylene blue for a time sufficient to inactivate viruses in the mixture. The mixture is maintained in a substantially static state within the container.
摘要翻译： 用于灭活体液中的病毒的方法和装置。 在无菌条件下在容器中形成包含治疗有效量的亚甲基蓝和体液的混合物，然后用适当强度和波长的光场照射容器以足够的时间活化亚甲基蓝 灭活混合物中的病毒。 混合物在容器内维持在基本上静止的状态。
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公开(公告)号：US06361642B1
公开(公告)日：2002-03-26
申请号：US08982758
申请日：1997-12-02
申请人： David Bellamy , Ludwig Wolf, Jr.
发明人： David Bellamy , Ludwig Wolf, Jr.
IPC分类号： B32B3104
CPC分类号： A61J1/05 , A61J1/10 , A61M1/0209 , A61M2207/00 , B29C49/0047 , B29C51/00 , B29C65/18 , B29C66/1122 , B29C66/133 , B29C66/242 , B29C66/53262 , B29C66/63 , B29C66/71 , B29C66/712 , B29C66/81423 , B29C66/81427 , B29C66/81431 , B29C66/81811 , B29C66/8322 , B29C66/843 , B29K2023/083 , B29K2023/086 , B29K2027/06 , B29L2031/7148 , B29C65/00 , B29K2027/12 , B29K2023/12 , B29K2023/06
摘要： A flexible container comprises first and second flexible sheets of plastic material having peripheral edges, which have been sealed together along a plane to create an interior chamber in the container. At least one of the first and second flexible sheets includes a preformed, stress-relieved region, which is extended outside the plane and overlies at least a portion of the interior chamber.
摘要翻译： 柔性容器包括具有外围边缘的塑料材料的第一和第二柔性片材，其沿着平面密封在一起以在容器中形成内部腔室。 第一和第二柔性片材中的至少一个包括预成型的应力释放区域，其延伸到平面外部并且覆盖在内部室的至少一部分上。
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公开(公告)号：US4439188A
公开(公告)日：1984-03-27
申请号：US378029
申请日：1982-05-13
摘要： Equipment for continuous ambulatory peritoneal dialysis in which a solution container is coupled via flexible tubing to a patient's tube that communicates with the patient's peritoneal cavity by means of a catheter, usually a surgically implanted catheter. The equipment includes a flexible, foldable plastic dialysis solution container having a transfer port. A flexible tube having a luer connector at its distal end extends from the transfer port, for connecting to a luer connector carried by the patient's tube. The flexible tube carries a frangible member which normally blocks fluid flow but permits fluid flow after the frangible member is broken. A particulate filter and a manually-operable clamp are in series with the flexible tube.Peritoneal dialysis is accomplished by connecting the luer connector from a fresh dialysis solution bag to the patient's tube luer connector, breaking the frangible member, and opening the clamp on the flexible tubing. After the dialysis solution is introduced into the patient's peritoneal cavity and remains there for a predetermined time, the solution is drained back into the flexible bag, the luer connectors are disconnected and the foregoing steps are repeated. If desired, once the dialysis solution has been introduced into the patient's peritoneal cavity, the luer connections may be disconnected and the patient's tube luer connector may be capped.
摘要翻译： 用于连续不卧床腹膜透析的设备，其中溶液容器通过柔性管连接到通过导管（通常是手术植入的导管）与患者的腹膜腔连通的患者管。 该设备包括具有转移口的柔性可折叠塑料透析溶液容器。 在其远端处具有鲁尔连接器的柔性管从传送端口延伸，用于连接到患者管所承载的鲁尔连接器。 柔性管带有易碎构件，其通常阻挡流体流动，但在易碎构件破裂之后允许流体流动。 微粒过滤器和可手动操作的夹具与柔性管串联。 腹膜透析是通过将鲁尔连接器从新鲜透析溶液袋连接到患者管路鲁尔连接器，破坏易碎构件，以及将柔性管上的夹子打开来实现的。 将透析溶液引入患者的腹膜腔内并保持在预定时间之后，将溶液排回到柔性袋中，将鲁尔连接器断开并重复上述步骤。 如果需要，一旦透析溶液已经被引入到患者的腹膜腔中，则路厄氏连接可能被断开并且患者的管路鲁尔连接器可能被封盖。
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公开(公告)号：US4242310A
公开(公告)日：1980-12-30
申请号：US959610
申请日：1978-11-13
申请人： Richard Greff , Ludwig Wolf, Jr. , John Munsch , Layton C. Kinney
发明人： Richard Greff , Ludwig Wolf, Jr. , John Munsch , Layton C. Kinney
摘要： A sterile connection apparatus is provided for enabling the connection of a first tube to a transfer tube of a medical solution container. The apparatus includes a housing having a cover portion which is adapted for interfitting with a base portion to provide a substantially closed interior volume. The first tube and the transfer tube of the medical solution container are introduced within the interior volume and the housing carries means located therewithin and operable from the outside of the housing for enabling manipulation of one of the tubes. In this manner, the first tube may be disconnected from and/or connected to the transfer tube. Means are provided for sterilizing the tubes within the substantially closed interior volume.
摘要翻译： 提供了一种无菌连接装置，用于使第一管与医用溶液容器的输送管连接。 该装置包括具有覆盖部分的壳体，该盖部分适于与基部相配合以提供基本封闭的内部容积。 医用溶液容器的第一管和输送管被引入内部容积中，并且壳体承载位于其中并且可从外壳的外部操作的装置，以使得能够操纵其中一个管。 以这种方式，第一管可以与传送管断开和/或连接到传送管。 提供了用于在基本上封闭的内部容积内对管进行灭菌的装置。
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公开(公告)号：US4009107A
公开(公告)日：1977-02-22
申请号：US620541
申请日：1975-10-08
IPC分类号： A61M20060101 , B01D20060101 , B01D63/10 , B01D13/00
CPC分类号： B01D63/10 , B01D61/28 , B01D2313/02
摘要： A support member for use in a coil dialyzer to support an elongated, tubularly-shaped, semipermeable membrane is disclosed herein. The member is embossed and has generally angularly-extending parallel ribs on both sides of the web. The ribs are arranged so that on each side there are high ribs and low ribs positioned between said high ribs. The ribs are arranged in a pattern whereby the lower ribs are at least of two different heights so that on each side of the support membrane there are ribs of at least three different heights.
摘要翻译： 本文公开了用于线圈透析器中用于支撑细长的，管状的半透膜的支撑构件。 该构件被压花并且在幅材的两侧上具有大致角度延伸的平行肋。 肋被布置成使得在每一侧上都有高肋和位于所述高肋之间的低肋。 肋以图案布置，由此下肋至少具有两个不同的高度，使得在支撑膜的每一侧上具有至少三个不同高度的肋。
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公开(公告)号：US4583975A
公开(公告)日：1986-04-22
申请号：US717487
申请日：1985-03-29
CPC分类号： A61M5/1689 , Y10S128/13
摘要： The present invention provides an accurate method and apparatus for monitoring the drop flow rate from a fluid source. The drops are indirectly sensed by piezoelectric means mounted on a drip chamber when the drops impinge on a fluid surface in the chamber. The chamber can include a second differential piezoelectric sensing element, which provides a noise reference signal which can be subtracted from the drop sensing signal. The volume of the fluid drops sensed can be determined. The sensing element can be incorporated in open and closed loop disposable chamber modules which can include both monitoring and occlusion valving functions integral therewith.
摘要翻译： 本发明提供了一种用于监测来自流体源的液滴流速的精确方法和装置。 当液滴撞击在腔室中的流体表面上时，通过安装在滴水室上的压电装置间接感测液滴。 腔室可以包括第二差分压电感测元件，其提供可以从液滴感测信号中减去的噪声参考信号。 可以确定感测到的液滴的体积。 感测元件可以结合在开放和闭环一次性室模块中，其可以包括与其一体的监测和闭塞阀功能。
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公开(公告)号：US4346703A
公开(公告)日：1982-08-31
申请号：US187008
申请日：1980-09-15
CPC分类号： A61M39/221 , A61M39/10 , A61M5/14 , A61J1/14 , A61M1/28 , A61M2039/1033 , Y10S604/905
摘要： Equipment for continuous ambulatory peritoneal dialysis in which a solution container is coupled via flexible tubing to a patient's tube that communicates with the patient's peritoneal cavity by means of a catheter, usually a surgically implanted catheter. The equipment includes a flexible, foldable plastic dialysis solution container having a transfer port. A flexible tube having a luer connector at its distal end extends from the transfer port, for connecting to a luer connector carried by the patient's tube. The flexible tube carries a frangible member which normally blocks fluid flow but permits fluid flow after the frangible member is broken. A particulate filter and a manually-operable clamp are in series with the flexible tube.Peritoneal dialysis is accomplished by connecting the luer connector from a fresh dialysis solution bag to the patient's tube luer connector, breaking the frangible member, and opening the clamp on the flexible tubing. After the dialysis solution is introduced into the patient's peritoneal cavity and remains there for a predetermined time, the solution is drained back into the flexible bag, the luer connectors are disconnected and the foregoing steps are repeated. If desired, once the dialysis solution has been introduced into the patient's peritoneal cavity, the luer connections may be disconnected and the patient's tube luer connector may be capped.
摘要翻译： 用于连续不卧床腹膜透析的设备，其中溶液容器通过柔性管连接到通过导管（通常是手术植入的导管）与患者的腹膜腔连通的患者管。 该设备包括具有转移口的柔性可折叠塑料透析溶液容器。 在其远端处具有鲁尔连接器的柔性管从传送端口延伸，用于连接到患者管所承载的鲁尔连接器。 柔性管带有易碎构件，其通常阻挡流体流动，但在易碎构件破裂之后允许流体流动。 微粒过滤器和可手动操作的夹具与柔性管串联。 腹膜透析是通过将鲁尔连接器从新鲜透析溶液袋连接到患者管路鲁尔连接器，破坏易碎构件，以及将柔性管上的夹子打开来实现的。 将透析溶液引入患者的腹膜腔内并保持在预定时间之后，将溶液排回到柔性袋中，将鲁尔连接器断开并重复上述步骤。 如果需要，一旦透析溶液已经被引入到患者的腹膜腔中，则路厄氏连接可能被断开并且患者的管路鲁尔连接器可能被封盖。
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公开(公告)号：US4201406A
公开(公告)日：1980-05-06
申请号：US960157
申请日：1978-11-13
CPC分类号： A61M39/14 , A61J1/10 , A61J1/1475 , A61M2039/1027
摘要： A touch-contamination protected spike connector is provided for coupling a plastic fluid conduit to a port extending from a medical solution container. The spike defines a longitudinal bore and has an angled tip, and carries a flange which extends outwardly from the spike. A tube surrounds and is concentric with a major portion of the spike, with the tube having a dimension suited for coupling to the port with a snug pressure fit. A spacer is interposed between the spike and the tube. The flange and surrounding tube cooperate to enable the spike to be connected to the port with the chance of bacterial contamination caused by accidental touching of the spike being minimized.
摘要翻译： 提供接触污染保护的尖钉连接器，用于将塑料流体导管连接到从医用溶液容器延伸的端口。 尖钉限定纵向孔并且具有倾斜的尖端，并且承载从尖峰向外延伸的凸缘。 管围绕并且与钉的主要部分同心，其中管具有适于以贴合压力配合连接到端口的尺寸。 间隔件插入在钉和管之间。 法兰和周围管配合使得尖峰连接到端口，由于尖峰的意外触摸而导致细菌污染的可能性最小化。
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