公开(公告)号：US07662139B2

公开(公告)日：2010-02-16

申请号：US10697862

申请日：2003-10-30

申请人： Jason A. Demers ,  David W. McGill ,  Brian Tracey ,  James D. Dale ,  Larry B. Gray

发明人： Jason A. Demers ,  David W. McGill ,  Brian Tracey ,  James D. Dale ,  Larry B. Gray

IPC分类号： A61M19/00

CPC分类号： A61M5/162 ,  A61M1/0281 ,  A61M5/1626 ,  A61M2205/12

摘要： An apparatus for use in a fluid processing system having a pump. The apparatus includes a pump cassette for use with the pump. The pump cassette includes at least one pump chamber and a first port in selective fluid communication with the at least one pump chamber. A spiking assembly includes at least one hollow spike having a piercing end for piercing a first container. The at least one hollow spike includes a first spike in fluid communication with the first port of the pump cassette.

摘要翻译： 一种用于具有泵的流体处理系统的装置。 该装置包括与泵一起使用的泵盒。 所述泵盒包括至少一个泵室和与所述至少一个泵室选择性流体连通的第一端口。 尖峰组件包括至少一个具有穿刺端部以刺穿第一容器的中空尖钉。 所述至少一个中空尖钉包括与所述泵盒的所述第一端口流体连通的第一尖峰。

公开(公告)号：US08950728B2

公开(公告)日：2015-02-10

申请号：US12714056

申请日：2010-02-26

申请人： Rodney S. Kenley ,  Dean Kamen ,  Keith D. Violette ,  Kevin L. Grant ,  Larry B. Gray ,  Richard J. Lanigan ,  Jason A. Demers

发明人： Rodney S. Kenley ,  Dean Kamen ,  Keith D. Violette ,  Kevin L. Grant ,  Larry B. Gray ,  Richard J. Lanigan ,  Jason A. Demers

IPC分类号： F16K7/06 ,  A61M39/28

CPC分类号： A61M39/281 ,  F16K7/06 ,  F16K7/063

摘要： A device and method to constrict or occlude the lumen of a flexible tube may include an occluder under the influence of an elastic force, such as a spring force, that can compress a portion of the wall of the flexible tube. The occluder can be under the influence of the elastic force, but prevented from occluding the tube by a stop. The stop can be connected to a tube gripping feature, so that a pulling force on the tube near the gripping feature can disengage the stop from the occluder, releasing the occluder to compress the tube. In some embodiments, the pulling force applied to the tube causes movement of the gripping feature by taking up slack in a portion of the tube held in the device. In other embodiments, the pulling force applied to the tube causes the tube to stretch elastically near the gripping feature, causing the gripping feature to move, and disengaging the stop from the occluder.

摘要翻译： 用于收缩或闭塞柔性管的内腔的装置和方法可以包括在弹性力（例如弹簧力）的影响下的阻塞器，其能够压缩柔性管的壁的一部分。 闭塞器可能受到弹力的影响，但阻止了阻塞管堵塞。 止动件可以连接到管夹持特征，使得靠近抓握特征处的管上的拉力可以使止动件从闭塞器脱离，释放封堵器以压缩管。 在一些实施例中，施加到管的拉力通过在保持在装置中的管的一部分中卷起松弛而引起夹持特征的移动。 在其他实施例中，施加到管的拉力导致管在夹持特征附近弹性伸展，导致夹持特征移动，并使止动件从闭塞器脱离。

公开(公告)号：US20100234809A1

公开(公告)日：2010-09-16

申请号：US12714056

申请日：2010-02-26

申请人： Rodney S. Kenley ,  Dean Kamen ,  Keith D. Violette ,  Kevin L. Grant ,  Larry B. Gray ,  Richard J. Lanigan ,  Jason A. Demers

发明人： Rodney S. Kenley ,  Dean Kamen ,  Keith D. Violette ,  Kevin L. Grant ,  Larry B. Gray ,  Richard J. Lanigan ,  Jason A. Demers

IPC分类号： A61M39/00

CPC分类号： A61M39/281 ,  F16K7/06 ,  F16K7/063

摘要： A device and method to constrict or occlude the lumen of a flexible tube may include an occluder under the influence of an elastic force, such as a spring force, that can compress a portion of the wall of the flexible tube. The occluder can be under the influence of the elastic force, but prevented from occluding the tube by a stop. The stop can be connected to a tube gripping feature, so that a pulling force on the tube near the gripping feature can disengage the stop from the occluder, releasing the occluder to compress the tube. In some embodiments, the pulling force applied to the tube causes movement of the gripping feature by taking up slack in a portion of the tube held in the device. In other embodiments, the pulling force applied to the tube causes the tube to stretch elastically near the gripping feature, causing the gripping feature to move, and disengaging the stop from the occluder.

摘要翻译： 用于收缩或闭塞柔性管的内腔的装置和方法可以包括在弹性力（例如弹簧力）的影响下的阻塞器，其能够压缩柔性管的壁的一部分。 闭塞器可能受到弹力的影响，但阻止了阻塞管堵塞。 止动件可以连接到管夹持特征，使得靠近抓握特征处的管上的拉力可以使止动件从闭塞器脱离，释放封堵器以压缩管。 在一些实施例中，施加到管的拉力通过在保持在装置中的管的一部分中卷起松弛而引起夹持特征的移动。 在其他实施例中，施加到管的拉力导致管在夹持特征附近弹性伸展，导致夹持特征移动，并使止动件从闭塞器脱离。

公开(公告)号：US20100192686A1

公开(公告)日：2010-08-05

申请号：US12549285

申请日：2009-08-27

申请人： Dean Kamen ,  Michael J. Wilt ,  Jason A. Demers ,  Todd A. Ballantyne ,  Larry B. Gray ,  Scott A. Leonard

发明人： Dean Kamen ,  Michael J. Wilt ,  Jason A. Demers ,  Todd A. Ballantyne ,  Larry B. Gray ,  Scott A. Leonard

IPC分类号： G01F23/00 ,  B01D65/02 ,  B01D61/32 ,  G06F3/048

CPC分类号： A61M1/1621 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1613 ,  A61M1/1619 ,  A61M1/1635 ,  A61M1/1696 ,  A61M1/341 ,  A61M1/3427 ,  A61M1/3441 ,  A61M1/3462 ,  A61M1/3465 ,  A61M1/3609 ,  A61M1/3646 ,  A61M1/365 ,  A61M1/3652 ,  A61M1/3672 ,  A61M5/172 ,  A61M2205/12 ,  A61M2205/18 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3379 ,  A61M2205/502 ,  G06F19/00 ,  G06F19/3481

摘要： Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

摘要翻译： 公开了包括协作以执行透析功能的致动器和协作以监测透析功能的传感器的透析系统。 根据一个方面，这样的血液透析系统包括用户界面模型层，治疗层，在用户界面模型层下面，以及治疗层下方的机器层。 用户界面模型层被配置为管理图形用户界面的状态并从图形用户界面接收输入。 治疗层被配置为运行状态机，其至少部分地基于来自图形用户界面的输入来产生治疗命令。 机器层被配置为基于治疗命令为致动器提供命令。

公开(公告)号：US20080110523A1

公开(公告)日：2008-05-15

申请号：US11927101

申请日：2007-10-29

申请人： Jason D. Demers ,  James D. Dale ,  Brian Tracey ,  David W. McGill ,  Larry B. Gray

发明人： Jason D. Demers ,  James D. Dale ,  Brian Tracey ,  David W. McGill ,  Larry B. Gray

IPC分类号： B65B3/04 ,  B65D25/08

CPC分类号： B01F13/1013 ,  A61M1/0281 ,  A61M1/3687 ,  A61M2205/12 ,  B01F13/1016 ,  B01F15/0202 ,  B01F2015/0221

摘要： A system, device, and method for mixing a substance with a liquid pumps the liquid into a container of the substance to produce a solution. The container may be part of a container assembly including a port assembly for coupling with the container to produce an inlet and/or and outlet port for the container. The container assembly may be received within a receiving chamber for causing the coupling. The solution may be permitted to flow out of the outlet port when the solution rises within the container to a level of the outlet port so that the substance is partially diluted before flowing out of the outlet port.

摘要翻译： 用于将物质与液体混合的系统，装置和方法将液体泵送到物质的容器中以产生溶液。 容器可以是容器组件的一部分，其包括用于与容器联接以产生用于容器的入口和/或出口的端口组件。 容器组件可以被容纳在接收室内以引起联接。 当溶液在容器内升高到出口端口的水平面时，溶液可能被允许流出出口，使得物质在流出出口之前被部分地稀释。

公开(公告)号：US20080113331A1

公开(公告)日：2008-05-15

申请号：US11927081

申请日：2007-10-29

申请人： Jason D. Demers ,  James D. Dale ,  Brian Tracey ,  David W. McGill ,  Larry B. Gray

发明人： Jason D. Demers ,  James D. Dale ,  Brian Tracey ,  David W. McGill ,  Larry B. Gray

IPC分类号： A01N1/02

CPC分类号： B01F13/1013 ,  A61M1/0281 ,  A61M1/3687 ,  A61M2205/12 ,  B01F13/1016 ,  B01F15/0202 ,  B01F2015/0221

摘要： A system, device, and method for mixing a substance with a liquid pumps the liquid into a container of the substance to produce a solution. The container may be part of a container assembly including a port assembly for coupling with the container to produce an inlet and/or and outlet port for the container. The container assembly may be received within a receiving chamber for causing the coupling. The solution may be permitted to flow out of the outlet port when the solution rises within the container to a level of the outlet port so that the substance is partially diluted before flowing out of the outlet port.

摘要翻译： 用于将物质与液体混合的系统，装置和方法将液体泵送到物质的容器中以产生溶液。 容器可以是容器组件的一部分，其包括用于与容器联接以产生用于容器的入口和/或出口的端口组件。 容器组件可以被容纳在接收室内以引起联接。 当溶液在容器内升高到出口端口的水平面时，溶液可能被允许流出出口，使得物质在流出出口之前被部分地稀释。

公开(公告)号：US20110079220A1

公开(公告)日：2011-04-07

申请号：US12964205

申请日：2010-12-09

申请人： David E. Altobelli ,  Larry B. Gray ,  Derek G. Kane

发明人： David E. Altobelli ,  Larry B. Gray ,  Derek G. Kane

IPC分类号： A61M11/00 ,  G01N21/00

CPC分类号： G01F13/006 ,  A61B5/08 ,  A61M15/0003 ,  A61M15/0065 ,  A61M15/009 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3379 ,  G01F1/34 ,  G01N1/2202 ,  G01N15/02 ,  G01N15/0205 ,  G01N15/1456 ,  G01N21/53 ,  G01N2001/2223 ,  G01N2021/4707

摘要： An apparatus comprises a detector, a pressure sensor and a processor. The detector is operable to detect light that is scattered by an aerosol that is associated with a pressure. The pressure sensor is operable to measure the pressure. The processor is coupled to the detector and to the pressure sensor, and is configured to receive at least a signal from the detector and the pressure sensor. The processor is further configured to use the received signals to calculate a volume of the first aerosol, and to output an output signal associated with the calculated volume. The various measurements can be repeated and compared, and the output signal can be a feedback signal for metering subsequent amounts of the aerosol, based on the comparison.

摘要翻译： 一种装置包括检测器，压力传感器和处理器。 检测器可操作以检测由与压力相关联的气溶胶散射的光。 压力传感器可操作以测量压力。 处理器耦合到检测器和压力传感器，并且被配置为从检测器和压力传感器接收至少一个信号。 处理器还被配置为使用接收到的信号来计算第一气溶胶的体积，并输出与计算出的体积相关联的输出信号。 可以重复和比较各种测量，并且基于比较，输出信号可以是用于计量后续量的气溶胶的反馈信号。

公开(公告)号：US20080295826A1

公开(公告)日：2008-12-04

申请号：US11942883

申请日：2007-11-20

申请人： David E. Altobelli ,  Russell Beavis ,  Larry B. Gray ,  Derek G. Kane

发明人： David E. Altobelli ,  Russell Beavis ,  Larry B. Gray ,  Derek G. Kane

IPC分类号： A61M11/00 ,  A61M15/00

CPC分类号： A61M15/008 ,  A61M15/0003 ,  A61M15/002 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0065 ,  A61M15/0066 ,  A61M15/0068 ,  A61M15/0085 ,  A61M15/009 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2202/03 ,  A61M2205/3306 ,  A61M2205/3368 ,  A61M2205/3375 ,  A61M2205/3379 ,  A61M2205/50 ,  A61M2205/52 ,  B05B12/006 ,  B05B12/085 ,  G01F1/007 ,  G01F17/00 ,  G01F22/00 ,  G01F23/14 ,  G01H3/00 ,  G10K9/04

摘要： An apparatus for metering the delivery of an aerosol. The apparatus has a variable acoustic source and a microphone, both acoustically coupled to a volume having a fluid region and an air region. The apparatus may also include a processor to determine a volume of the air region based on signals received from the microphone and the variable acoustic source. A fluid valve is coupled to the processor, and is configured to allow an amount of fluid to exit the fluid region associated with the volume of the air region. An atomizer, coupled to the fluid region, is configured to aerosolize at least a portion of the fluid.

摘要翻译： 一种用于计量气溶胶输送的装置。 该装置具有声音耦合到具有流体区域和空气区域的体积的可变声源和麦克风。 该装置还可以包括处理器，用于基于从麦克风和可变声源接收的信号来确定空气区域的体积。 流体阀联接到处理器，并且被配置为允许一定量的流体离开与空气区域的体积相关联的流体区域。 耦合到流体区域的雾化器被配置为使至少一部分流体雾化。

公开(公告)号：US07342660B2

公开(公告)日：2008-03-11

申请号：US10675278

申请日：2003-09-30

申请人： David E. Altobelli ,  Larry B. Gray ,  Derek G. Kane

发明人： David E. Altobelli ,  Larry B. Gray ,  Derek G. Kane

IPC分类号： G01N21/00

CPC分类号： G01F13/006 ,  A61B5/08 ,  A61M15/0003 ,  A61M15/0065 ,  A61M15/009 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3379 ,  G01F1/34 ,  G01N1/2202 ,  G01N15/02 ,  G01N15/0205 ,  G01N15/1456 ,  G01N21/53 ,  G01N2001/2223 ,  G01N2021/4707

摘要： An apparatus comprises a detector, a pressure sensor and a processor. The detector is operable to detect light that is scattered by an aerosol that is associated with a pressure. The pressure sensor is operable to measure the pressure. The processor is coupled to the detector and to the pressure sensor, and is configured to receive at least a signal from the detector and the pressure sensor. The processor is further configured to use the received signals to calculate a volume of the first aerosol, and to output an output signal associated with the calculated volume. The various measurements can be repeated and compared, and the output signal can be a feedback signal for metering subsequent amounts of the aerosol, based on the comparison.

摘要翻译： 一种装置包括检测器，压力传感器和处理器。 检测器可操作以检测由与压力相关联的气溶胶散射的光。 压力传感器可操作以测量压力。 处理器耦合到检测器和压力传感器，并且被配置为从检测器和压力传感器接收至少一个信号。 处理器还被配置为使用接收到的信号来计算第一气溶胶的体积，并输出与计算出的体积相关联的输出信号。 可以重复和比较各种测量，并且基于比较，输出信号可以是用于计量后续量的气溶胶的反馈信号。

公开(公告)号：US20140209094A1

公开(公告)日：2014-07-31

申请号：US14229116

申请日：2014-03-28

申请人： David E. Altobelli ,  Larry B. Gray ,  Derek G. Kane

发明人： David E. Altobelli ,  Larry B. Gray ,  Derek G. Kane

IPC分类号： A61M15/00 ,  G01F1/34

CPC分类号： G01F13/006 ,  A61B5/08 ,  A61M15/0003 ,  A61M15/0065 ,  A61M15/009 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3379 ,  G01F1/34 ,  G01N1/2202 ,  G01N15/02 ,  G01N15/0205 ,  G01N15/1456 ,  G01N21/53 ,  G01N2001/2223 ,  G01N2021/4707

摘要： An apparatus comprises a detector, a pressure sensor and a processor. The detector is operable to detect light that is scattered by an aerosol that is associated with a pressure. The pressure sensor is operable to measure the pressure. The processor is coupled to the detector and to the pressure sensor, and is configured to receive at least a signal from the detector and the pressure sensor. The processor is further configured to use the received signals to calculate a volume of the first aerosol, and to output an output signal associated with the calculated volume. The various measurements can be repeated and compared, and the output signal can be a feedback signal for metering subsequent amounts of the aerosol, based on the comparison.

摘要翻译： 一种装置包括检测器，压力传感器和处理器。 检测器可操作以检测由与压力相关联的气溶胶散射的光。 压力传感器可操作以测量压力。 处理器耦合到检测器和压力传感器，并且被配置为从检测器和压力传感器接收至少一个信号。 处理器还被配置为使用接收到的信号来计算第一气溶胶的体积，并输出与计算出的体积相关联的输出信号。 可以重复和比较各种测量，并且基于比较，输出信号可以是用于计量后续量的气溶胶的反馈信号。