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公开(公告)号：US08193352B2
公开(公告)日：2012-06-05
申请号：US12552430
申请日：2009-09-02
申请人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
发明人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61K31/4439
CPC分类号： C07D401/14 , C07D403/14
摘要： The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译： 本发明涉及抑制细菌回旋酶和/或Topo IV的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号：US07727992B2
公开(公告)日：2010-06-01
申请号：US10459420
申请日：2003-06-11
申请人： Paul S. Charifson , David D. Deininger , Joseph Drumm , Anne-Laure Grillot , Yusheng Liao , Patricia Oliver-Shaffer , Dean Stamos
发明人： Paul S. Charifson , David D. Deininger , Joseph Drumm , Anne-Laure Grillot , Yusheng Liao , Patricia Oliver-Shaffer , Dean Stamos
IPC分类号： C07D239/42 , A61K31/505 , A61K31/44 , C07D239/00 , C07D401/00
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , C07C275/06 , C07D401/14 , C07D403/04 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要： The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to a method for preparing these compounds.
摘要翻译： 本发明涉及抑制细菌促旋酶的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。 本发明还涉及一种制备这些化合物的方法。
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公开(公告)号：US20090176771A1
公开(公告)日：2009-07-09
申请号：US12246778
申请日：2008-10-07
申请人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号： A61K31/55 , C07D243/12 , A61P31/04
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译： 本发明涉及抑制细菌促旋酶和/或Topo IV的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号：US07495014B2
公开(公告)日：2009-02-24
申请号：US10767638
申请日：2004-01-29
申请人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiensheng Wang , Arnaud LeTiran , Joseph Drumm
发明人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiensheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号： A61K31/44 , C07D401/04 , C07D401/14
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译： 本发明涉及抑制细菌促旋酶和/或Topo IV的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号：US20130023525A1
公开(公告)日：2013-01-24
申请号：US13454510
申请日：2012-04-24
申请人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号： A61K31/4184 , C07D401/14 , A61K31/4439 , A61K31/506 , C07D405/14 , A61P31/04 , A61K31/4545 , C07D491/056 , A61K31/4355 , C07D413/14 , A61K31/5377 , A61K31/5513 , C07D403/14 , C07D403/10
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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公开(公告)号：US20120202784A1
公开(公告)日：2012-08-09
申请号：US13349868
申请日：2012-01-13
申请人： Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
发明人： Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
IPC分类号： A61K31/437 , A61K31/5377 , C12N9/99 , A61K31/496 , A61K31/551 , C07D471/20 , C07D471/04 , C07D491/20
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20120010222A1
公开(公告)日：2012-01-12
申请号：US13234634
申请日：2011-09-16
申请人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号： A61K31/506 , A61K31/4184 , A61P31/04 , A61K31/4439
CPC分类号： C07D413/14 , A61K31/4439 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
摘要翻译： 本发明涉及使用式I或式VII化合物或其药学上可接受的方法治疗，预防或减轻哺乳动物中抗性细菌感染的严重性。 本发明还涉及使用式I或式VII化合物与一种或多种另外的抗菌剂和/或一种或多种增加细菌生物体对抗生素敏感性的其它治疗剂的组合的方法。
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公开(公告)号：US07569591B2
公开(公告)日：2009-08-04
申请号：US10901928
申请日：2004-07-29
申请人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
发明人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号： A61K31/4439 , C07D401/00
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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公开(公告)号：US20090176769A1
公开(公告)日：2009-07-09
申请号：US11955874
申请日：2007-12-13
申请人： Corey Anderson , Andreas Termin , Sara Hadida-Ruah , Pramod Joshi , Sanghee Yoo , Daniele Bergeron , Hayley Binch , Jon Come , Jingrong Cao , Suganthi Nanthakumar , Elaine Krueger , John Maxwell , Arnaud Le Tiran , Yusheng Liao
发明人： Corey Anderson , Andreas Termin , Sara Hadida-Ruah , Pramod Joshi , Sanghee Yoo , Daniele Bergeron , Hayley Binch , Jon Come , Jingrong Cao , Suganthi Nanthakumar , Elaine Krueger , John Maxwell , Arnaud Le Tiran , Yusheng Liao
IPC分类号： A61K31/551 , C07D417/14 , C07D471/04 , A61K31/496 , A61K31/437 , A61P25/06 , A61P19/02
CPC分类号： C07D277/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/10 , C07D498/10 , C07D513/10
摘要： The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.
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20.发明授权公开(公告)号：US08524906B2
公开(公告)日：2013-09-03
申请号：US13211502
申请日：2011-08-17
申请人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
发明人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
IPC分类号： A61K31/4365 , C07D513/04
CPC分类号： C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kgamma的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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