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11.发明授权Polynucleotides encoding the human citron kinase polypeptide, BMSNKC—0020/0021 有权编码人柚子激酶多肽的多核苷酸BMSNKC-0020/0021公开(公告)号：US07326781B2
公开(公告)日：2008-02-05
申请号：US10412897
申请日：2003-04-11
申请人： Daniel B. Davison , John N. Feder , Liana M. Lee , Karl-Heinz Ott
发明人： Daniel B. Davison , John N. Feder , Liana M. Lee , Karl-Heinz Ott
IPC分类号： C07H21/04
CPC分类号： C12N9/1205
摘要： The present invention describes a novel human protein kinase related to citron kinase, and its encoding polynucleotide. Also described are expression vectors, host cells, antisense molecules, and antibodies associated with the protein kinase polynucleotide and/or polypeptide of this invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders or diseases associated with abnormal biological activity of the protein kinase are described, as are methods for screening for modulators, e.g., agonists or antagonists, of the protein kinase activity and/or function.
摘要翻译： 本发明描述了与柚子激酶相关的新型人蛋白激酶及其编码多核苷酸。 还描述了与本发明的蛋白激酶多核苷酸和/或多肽相关的表达载体，宿主细胞，反义分子和抗体。 此外，描述了用于治疗，诊断，预防和筛选与蛋白激酶的异常生物活性相关的疾病或疾病的方法，以及用于筛选蛋白激酶活性的调节剂例如激动剂或拮抗剂的方法和/ 或功能。
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12.发明授权Polynucleotides encoding a human cell surface protein with immunoglobulin folds, BGS-19 有权编码具有免疫球蛋白折叠的人细胞表面蛋白的多核苷酸，BGS-19公开(公告)号：US07202056B2
公开(公告)日：2007-04-10
申请号：US10403938
申请日：2003-03-28
申请人： Liana M. Lee , John N. Feder , Shujian Wu , Jian Chen
发明人： Liana M. Lee , John N. Feder , Shujian Wu , Jian Chen
CPC分类号： C07K14/705 , A61K38/00 , C07K14/70503
摘要： The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-19多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将新型BGS-19多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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13.发明授权Polynucleotides encoding the novel human phosphatase, RET31, and variants thereof 有权编码新型人磷酸酶RET31的多核苷酸及其变体公开(公告)号：US07153678B2
公开(公告)日：2006-12-26
申请号：US10029345
申请日：2001-12-20
申请人： Donald G. Jackson , Chandra S. Ramanathan , John N. Feder , Liana Lee , Thomas C. Nelson , Nathan Siemers , Suzanne J. Suchard , Joshua Finger , C. Gordon Todderud , Dana Banas
发明人： Donald G. Jackson , Chandra S. Ramanathan , John N. Feder , Liana Lee , Thomas C. Nelson , Nathan Siemers , Suzanne J. Suchard , Joshua Finger , C. Gordon Todderud , Dana Banas
CPC分类号： G06F19/16 , A61K38/00 , C07K2319/00 , C07K2319/30 , C12N9/16 , C12Q1/6883 , C12Q2600/158 , C12Y301/03048 , G01N33/573 , G01N33/6893 , G01N2333/916 , G01N2500/00 , G01N2500/04 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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14.发明授权Determining genotype of a polymorphic site in the hereditary hemochromatosis gene 有权确定遗传性血色素沉着症基因多态位点的基因型公开(公告)号：US07998680B2
公开(公告)日：2011-08-16
申请号：US12389324
申请日：2009-02-19
申请人： Winston J. Thomas , Dennis T. Drayna , John N. Feder , Andreas Gnirke , David Ruddy , Zenta Tsuchihashi , Roger K. Wolff
发明人： Winston J. Thomas , Dennis T. Drayna , John N. Feder , Andreas Gnirke , David Ruddy , Zenta Tsuchihashi , Roger K. Wolff
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/70539 , C12Q1/6883
摘要： The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
摘要翻译： 本发明一般涉及导致疾病遗传性血色素沉着症（HH）的基因及其突变。 更具体地，本发明涉及对应于正常和突变HH基因的DNA序列的鉴定，分离和克隆，以及它们的转录物和基因产物的表征。 本发明还涉及用于筛选HH纯合子的方法等，还涉及HH诊断，产前筛查和诊断以及HH疾病的治疗，包括基因治疗剂，基于蛋白质和基于抗体的治疗剂和小分子治疗剂。
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15.发明授权Methods of diagnosing colon adenocarcinoma using mRNA encoding the human g-protein coupled receptor, HGPRBMY23 有权使用编码人g-蛋白偶联受体HGPRBMY23的mRNA诊断结肠腺癌的方法公开(公告)号：US07713699B2
公开(公告)日：2010-05-11
申请号：US11897997
申请日：2007-08-31
申请人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Kornacker
发明人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Kornacker
IPC分类号： C12N1/68 , G01N33/48 , C07K14/705
CPC分类号： G01N33/5008 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2319/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5091 , G01N33/566 , G01N33/57415 , G01N33/57419 , G01N33/6893 , G01N2333/726 , G01N2500/04 , G01N2510/00 , G01N2800/347 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法 以及与异常NFκB调节相关的疾病和病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07579169B2
公开(公告)日：2009-08-25
申请号：US11327689
申请日：2006-01-05
申请人： Winston J. Thomas , Dennis T. Drayna , John N. Feder , Andreas Gnirke , David Ruddy , Zenta Tsuchihashi , Roger K. Wolff
发明人： Winston J. Thomas , Dennis T. Drayna , John N. Feder , Andreas Gnirke , David Ruddy , Zenta Tsuchihashi , Roger K. Wolff
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/70539 , C12Q1/6883
摘要： The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
摘要翻译： 本发明一般涉及导致疾病遗传性血色素沉着症（HH）的基因及其突变。 更具体地，本发明涉及对应于正常和突变HH基因的DNA序列的鉴定，分离和克隆，以及它们的转录物和基因产物的表征。 本发明还涉及用于筛选HH纯合子的方法等，还涉及HH诊断，产前筛查和诊断以及HH疾病的治疗，包括基因治疗剂，基于蛋白质和基于抗体的治疗剂和小分子治疗剂。
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17.发明申请公开(公告)号：US20080213918A1
公开(公告)日：2008-09-04
申请号：US11891836
申请日：2007-08-13
IPC分类号： G01N33/566 , C07K16/18
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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18.发明授权Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases 失效由HFE蛋白设计的肽和肽类似物及其在治疗铁超负荷疾病中的应用公开(公告)号：US07329650B2
公开(公告)日：2008-02-12
申请号：US11184459
申请日：2005-07-18
IPC分类号： A01N43/04
CPC分类号： C07K14/70539 , A61K38/00
摘要： The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein which lowers the binding affinity of transferrin receptor for transferrin. Such compounds mimic HFE protein function, and reduce iron uptake and/or accumulation by a cell.
摘要翻译： 本发明涉及由HFE蛋白设计的肽和肽类似物。 特别地，它涉及由HFE蛋白的α-1区设计的肽和肽类似物，其降低转铁蛋白受体对转铁蛋白的结合亲和力。 这种化合物模拟HFE蛋白功能，并减少细胞吸收铁和/或积累。
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公开(公告)号：US07189539B2
公开(公告)日：2007-03-13
申请号：US10994987
申请日：2004-11-22
CPC分类号： C07K14/723
摘要： The present invention provides novel polynucleotides encoding HGPRBMY5v1 and HGPRBMY5v2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY5v1 and HGPRBMY5v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码HGPRBMY5v1和HGPRBMY5v2多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY5v1和HGPRBMY5v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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20.发明授权公开(公告)号：US07119170B2
公开(公告)日：2006-10-10
申请号：US10092404
申请日：2002-03-04
IPC分类号： A61K38/17 , C07K14/435 , C07K14/705 , C07K14/74
CPC分类号： C07K14/70539 , A61K38/00
摘要： Methods and compositions are provided for the diagnosis and treatment of iron overload diseases and iron deficiency diseases.
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