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1.发明授权Polynucleotides encoding the novel human phosphatase, RET31, and variants thereof 有权编码新型人磷酸酶RET31的多核苷酸及其变体公开(公告)号：US07153678B2
公开(公告)日：2006-12-26
申请号：US10029345
申请日：2001-12-20
申请人： Donald G. Jackson , Chandra S. Ramanathan , John N. Feder , Liana Lee , Thomas C. Nelson , Nathan Siemers , Suzanne J. Suchard , Joshua Finger , C. Gordon Todderud , Dana Banas
发明人： Donald G. Jackson , Chandra S. Ramanathan , John N. Feder , Liana Lee , Thomas C. Nelson , Nathan Siemers , Suzanne J. Suchard , Joshua Finger , C. Gordon Todderud , Dana Banas
CPC分类号： G06F19/16 , A61K38/00 , C07K2319/00 , C07K2319/30 , C12N9/16 , C12Q1/6883 , C12Q2600/158 , C12Y301/03048 , G01N33/573 , G01N33/6893 , G01N2333/916 , G01N2500/00 , G01N2500/04 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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2.发明授权Methods of diagnosing colon adenocarcinoma using mRNA encoding the human g-protein coupled receptor, HGPRBMY23 有权使用编码人g-蛋白偶联受体HGPRBMY23的mRNA诊断结肠腺癌的方法公开(公告)号：US07713699B2
公开(公告)日：2010-05-11
申请号：US11897997
申请日：2007-08-31
申请人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Kornacker
发明人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Kornacker
IPC分类号： C12N1/68 , G01N33/48 , C07K14/705
CPC分类号： G01N33/5008 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2319/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5091 , G01N33/566 , G01N33/57415 , G01N33/57419 , G01N33/6893 , G01N2333/726 , G01N2500/04 , G01N2510/00 , G01N2800/347 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法 以及与异常NFκB调节相关的疾病和病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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3.发明授权Methods of diagnosing colon adenocarcinoma using the human g-protein coupled receptor hgprbmy23 有权使用人类g-蛋白偶联受体hgprbmy23诊断结肠腺癌的方法公开(公告)号：US07312086B2
公开(公告)日：2007-12-25
申请号：US10375157
申请日：2003-02-26
申请人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Neubauer
发明人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Neubauer
IPC分类号： G01N33/48
CPC分类号： G01N33/5008 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2319/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5091 , G01N33/566 , G01N33/57415 , G01N33/57419 , G01N33/6893 , G01N2333/726 , G01N2500/04 , G01N2510/00 , G01N2800/347 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法 以及与异常NFκB调节相关的疾病和病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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4.发明授权Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1 有权人类含有亮氨酸的重复含有蛋白质主要在骨髓HLRRBM1中表达公开(公告)号：US07304141B2
公开(公告)日：2007-12-04
申请号：US11107572
申请日：2005-04-15
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/53 , C07K14/47
摘要： The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HLRRBM1多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HLRRBM1多肽应用于诊断，治疗和/或预防与这些多肽，特别是免疫疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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5.发明授权Human leucine-rich repeat containing protein expressed predominately in small intestine, HLRRSI1 有权人类富含亮氨酸的重复含有蛋白主要表达于小肠，HLRRSI1公开(公告)号：US07183379B2
公开(公告)日：2007-02-27
申请号：US10882761
申请日：2004-07-01
IPC分类号： C07K1/00
CPC分类号： G01N33/5008 , A61K38/00 , C07K14/705 , C12Q1/6883 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5052 , G01N33/5058 , G01N33/5064 , G01N33/5076 , G01N33/5091 , G01N33/68 , G01N33/6842
摘要： The present invention provides novel polynucleotides encoding HLRRSI1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRSI1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HLRRSI1多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HLRRSI1多肽应用于诊断，治疗和/或预防与这些多肽，特别是胃肠道疾病和/或病症有关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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6.发明授权Polynucleotides encoding a human leucine-rich repeat domain containing protein, HLLRCR-1 有权编码富含人类富含亮氨酸的重复结构域的多核苷酸HLLRCR-1公开(公告)号：US07129085B2
公开(公告)日：2006-10-31
申请号：US10271078
申请日：2002-10-11
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly nervous system diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HLLRCR-1多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HLLRCR-1多肽应用于诊断，治疗和/或预防与这些多肽，特别是神经系统疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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7.发明申请公开(公告)号：US20080213918A1
公开(公告)日：2008-09-04
申请号：US11891836
申请日：2007-08-13
IPC分类号： G01N33/566 , C07K16/18
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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公开(公告)号：US07189539B2
公开(公告)日：2007-03-13
申请号：US10994987
申请日：2004-11-22
CPC分类号： C07K14/723
摘要： The present invention provides novel polynucleotides encoding HGPRBMY5v1 and HGPRBMY5v2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY5v1 and HGPRBMY5v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码HGPRBMY5v1和HGPRBMY5v2多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY5v1和HGPRBMY5v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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9.发明申请SPLICE VARIANTS OF HUMAN G-PROTEIN COUPLED RECEPTOR HGPRBMY29 (HGPRMBY29SV2) 有权人G蛋白偶联受体HGPRBMY29（HGPRBMY29SV2）的差异变体公开(公告)号：US20120010385A1
公开(公告)日：2012-01-12
申请号：US11891240
申请日：2007-08-09
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07635758B2
公开(公告)日：2009-12-22
申请号：US11890963
申请日：2007-08-08
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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