公开(公告)号：US06437002B1

公开(公告)日：2002-08-20

申请号：US09418317

申请日：1999-10-14

申请人： Shinobu Ito ,  Eiji Ogata ,  Hiroshi Ikeno

发明人： Shinobu Ito ,  Eiji Ogata ,  Hiroshi Ikeno

IPC分类号： A61K3100

CPC分类号： C07F9/65515 ,  A61K8/11 ,  A61K8/14 ,  A61K8/676 ,  A61K9/127 ,  A61K31/7048 ,  A61K2800/412 ,  A61K2800/522 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/10 ,  C07D307/62

摘要： The present invention relates to an agent for preventing and treating skin diseases comprising as an active ingredient an ascorbic acid derivative which is a compound represented by the following formula (1) or a salt thereof and which per se exhibits no anti-oxidation activity but is capable of transforming in vivo into a compound having an anti-oxidation activity; wherein R1 represents a group capable of bonding to the carbon at the 2-position of the ascorbic acid skeleton through an ether or ester bond and transformable in vivo into a hydroxyl group, and R2 to R4 may be the same or different and each represents a hydroxyl group or a group derived therefrom.

摘要翻译： 本发明涉及一种用于预防和治疗皮肤疾病的药剂，其包含作为活性成分的作为下式（1）表示的化合物的抗坏血酸衍生物或其盐，本身不具有抗氧化活性， 能够在体内转化成具有抗氧化活性的化合物;其中R1表示能够通过醚或酯键与抗坏血酸骨架的2-位上的碳键合并在体内可转化为羟基的基团 ，R 2〜R 4可以相同或不同，表示羟基或由其衍生的基团。

公开(公告)号：US06420419B1

公开(公告)日：2002-07-16

申请号：US09095895

申请日：1998-06-11

申请人： Masahiro Suzuki ,  Toshi Tsuzuki ,  Shinobu Ito ,  Eiji Ogata

发明人： Masahiro Suzuki ,  Toshi Tsuzuki ,  Shinobu Ito ,  Eiji Ogata

IPC分类号： A61K31341

CPC分类号： A61K31/665 ,  C07D307/62

摘要： L-Ascorbic acid 2-phosphate zinc salt and a salt hydrate thereof having excellent solubility and exhibiting good stability even under weakly acidic conditions. Also disclosed is a process of manufacturing L-ascorbic acid 2-phosphate zinc salt by displacing a cation of a salt of an L-ascorbic acid 2-phosphate other than a zinc salt with a zinc cation. Further disclosed is a composition containing L-ascorbic acid 2-phosphate zinc salt or a salt hydrate thereof as an active ingredient.

摘要翻译： L-抗坏血酸2-磷酸锌盐及其盐水合物，即使在弱酸性条件下也具有优异的溶解性和良好的稳定性。 还公开了通过用锌阳离子置换除了锌盐之外的L-抗坏血酸2-磷酸盐的阳离子来制造L-抗坏血酸2-磷酸锌盐的方法。 进一步公开了含有L-抗坏血酸2-磷酸锌盐或其盐水合物作为活性成分的组合物。

公开(公告)号：US6046181A

公开(公告)日：2000-04-04

申请号：US342228

申请日：1999-06-29

申请人： Yutaka Oonishi ,  Tsutomu Nozawa ,  Takami Ooe ,  Keisuke Mano ,  Naoaki Misu ,  Yohei Kurata ,  Shinobu Ito ,  Eiji Ogata

发明人： Yutaka Oonishi ,  Tsutomu Nozawa ,  Takami Ooe ,  Keisuke Mano ,  Naoaki Misu ,  Yohei Kurata ,  Shinobu Ito ,  Eiji Ogata

IPC分类号： A61K8/02 ,  A61K8/67 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/10 ,  C07F9/655 ,  G01N30/02 ,  G01N30/88 ,  G01N33/82 ,  A61K7/035 ,  A61K7/00 ,  A61K7/02 ,  A61K7/021 ,  A61K7/027

CPC分类号： G01N33/82 ,  A61K8/0212 ,  A61K8/678 ,  A61Q19/00 ,  C07F9/65522 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q11/00 ,  A61Q19/10 ,  A61Q5/02 ,  A61Q7/00 ,  G01N2030/884 ,  G01N30/02 ,  Y10S514/846

摘要： Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and/or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P'-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P'-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P'-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.

摘要翻译： 本文公开了高纯度的生育磷酸酯和/或其盐（生育磷酸酯），其中P，P'-二生育酚低磷酸盐和/或其盐（P，P'-二生育基二磷酸酯）的含量不高于 超过3％重量; 一种生产高纯度生育磷酸酯和/或其盐的方法，其包括使生育酚与三卤氧磷反应，然后用酸或碱性水溶液处理，从而形成生育磷酸酯（i），其中P， 含有作为副产物形成的P'-二生育基二磷酸酯（ⅱ），在酸性条件下水解P，P'-二生育基二磷酸酯（ⅱ），任选地在碱性条件下使水解产物中性或碱性。 以及分析生育磷酸酯的方法，包括使用填充有与其键合的聚甲基丙烯酸酯的凝胶的高效液相色谱柱分析含有成分（i）和（ii）的样品的长链烷基。 高纯度的生育磷酸酯中没有或仅有非常少量的P，P'-二生育基二磷酸酯，因此高纯度的生育磷酸酯表现出抗氧化和促进血液循环的作用，具有优异的水溶性，是粉末状的， 它非常容易，没有皮肤刺激和过敏原，并确保皮肤安全。 因此，高纯度的生育磷酸酯可用作化妆品成分。 组分（i）和（ii）的量可以通过上述方法以高精度简单地测量。

公开(公告)号：US6022867A

公开(公告)日：2000-02-08

申请号：US980371

申请日：1997-11-28

申请人： Shinobu Ito ,  Eiji Ogata

发明人： Shinobu Ito ,  Eiji Ogata

IPC分类号： A23K1/16 ,  A23L1/32 ,  A61K31/665 ,  G01N33/82 ,  A61K31/355

CPC分类号： A61K31/665 ,  A23K20/174 ,  A23L15/00 ,  G01N33/82

摘要： A vitamin E source composition for administration to animals, which comprises a tocopheryl phosphate, a salt thereof or a composition containing a tocopheryl phosphate or a salt thereof. Also, disclosed is a method of supplying vitamin E to animals which comprises administering to animals the above vitamin E source composition. The tocopheryl phosphoric acid and a salt thereof can be formed into a composition and also can contain an antioxidant or the like.

摘要翻译： 一种用于给予动物的维生素E源组合物，其包含生育磷酸酯，其盐或含有生育磷酸酯或其盐的组合物。 此外，还公开了向动物提供维生素E的方法，其包括向动物施用上述维生素E源组合物。 生育磷酸及其盐可以形成为组合物，也可以含有抗氧化剂等。

公开(公告)号：US5189223A

公开(公告)日：1993-02-23

申请号：US678332

申请日：1991-05-01

申请人： Eiji Ogata ,  Nobuyuki Nate

发明人： Eiji Ogata ,  Nobuyuki Nate

IPC分类号： C07C315/00 ,  C07C315/04 ,  C07C317/22

CPC分类号： C07C315/04 ,  C07C315/00

摘要： The present invention provides a process for preparing 4,4'-dihydroxydiphenylsulfone which comprises subjecting a phenol and a sulfonating agent to dehydration reaction in the presence of mesitylene as a reaction medium while the produced 4,4'-dihydroxydiphenylsulfone is suspended in the mesitylene, and a process for preparing 4,4'-dihydroxydiphenylsulfone, characterized in that after the foregoing dehydration reaction, the 4,4'-dihydroxydiphenysulfone obtained as suspended in the mesitylene and/or retained in a liquid-free solid form is subjected to reaction for isomerization of 2,4'-dihydroxydiphenylsulfone produced as a by-product into 4,4'-dihydroxydiphenylsulfone with heating at a temperature of not lower than that for isomerization of 2,4'-dihydroxydiphenylsulfone into 4,4'-dihydroxydiphenylsulfone.

摘要翻译： PCT No.PCT / JP90 / 01179 Sec。 371日期1991年5月1日 102（e）1991年5月1日PCT PCT 1990年9月14日PCT公布。 公开号WO91 / 04245 日本1991年4月4日。本发明提供一种4,4'-二羟基二苯砜的制备方法，其包括在作为反应介质的均三甲苯存在下使苯酚和磺化剂进行脱水反应， 二羟基二苯基砜悬浮在均三甲苯中，制备4,4'-二羟基二苯砜的方法，其特征在于，在上述脱水反应后，获得悬浮在均三甲苯中和/或保留在无液体中的4,4'-二羟基二苯砜 使2,4-二羟基二苯基砜的2,4'-二羟基二苯基砜的异构化反应为4,4'-二羟基二苯基砜的2,4'-二羟基二苯砜异构化，在不低于2,4'-二羟基二苯基砜异构化的温度下加热至4， 4'-二羟基二苯砜。

公开(公告)号：US07575442B2

公开(公告)日：2009-08-18

申请号：US12076014

申请日：2008-03-12

申请人： Eiji Ogata ,  Kazunori Omori ,  Koichi Namimatsu ,  Kazunari Fukagawa

发明人： Eiji Ogata ,  Kazunori Omori ,  Koichi Namimatsu ,  Kazunari Fukagawa

IPC分类号： H01R12/06

CPC分类号： H05K3/4046 ,  H05K3/3447 ,  H05K2201/0133 ,  H05K2201/09645 ,  H05K2201/1059

摘要： A first wiring pattern formed on a first layer of a multilayer wiring substrate, a second wiring pattern formed on a layer different from the first layer on which the first wiring pattern is formed, a penetration hole penetrating the front surface and the back surface of the substrate, and a penetration hole penetrating a front surface and a back surface of the substrate; and a fitting connector having a conductor part on a side surface inscribed in the penetration hole and fitting into the penetration hole are provided. The first wiring pattern and the second wiring pattern are exposed from the internal surface of the penetration hole, and the fitting connector connects a first end part of the conductor part and a second end part with an exposed part of the first wiring pattern and an exposed part of the second wiring pattern, respectively.

摘要翻译： 形成在多层布线基板的第一层上的第一布线图案，形成在与形成有第一布线图案的第一层不同的层上的第二布线图案，穿透第一布线图案的前表面和后表面的穿透孔 基板和穿透基板的前表面和后表面的穿透孔; 以及配合连接器，其具有位于贯通孔内侧的嵌合于贯通孔的侧面的导体部。 第一布线图案和第二布线图案从穿孔的内表面露出，并且嵌合连接器将导体部分的第一端部和第二端部与第一布线图案的露出部分连接， 分别是第二布线图案的一部分。

公开(公告)号：US07290276B2

公开(公告)日：2007-10-30

申请号：US10735993

申请日：2003-12-15

申请人： Eiji Ogata

发明人： Eiji Ogata

IPC分类号： G06F17/30

CPC分类号： G06F21/79 ,  G06F21/575

摘要： In an information processing apparatus for performing user certification when an OS starts based on security key information of security hardware, a need has arisen to restore the security key information before replacement of the security hardware replaced for troubleshooting. A cancellation means is generated in a second system status generated by a functionally restricted second type OS start such as a safe mode. Although the user certification based on the security key information of the security hardware is usually performed in a first type OS start, the cancellation means cancels it. Thus, it is possible to put the information processing apparatus in a first system status without undergoing the user certification so as to restore the security key information. A cancel release means releases cancellation of the user certification so that the user certification on the first type OS start is restored after the restoration of the security key information.

摘要翻译： 在OS基于安全硬件的安全密钥信息开始的情况下执行用户认证的信息处理装置中，出现了替换为故障排除替换的安全性硬件之前恢复安全密钥信息的需要。 在由诸如安全模式的功能受限的第二类型OS启动产生的第二系统状态中产生消除装置。 虽然基于安全硬件的安全密钥信息的用户认证通常在第一类型OS开始中执行，但取消装置取消它。 因此，可以将信息处理装置置于第一系统状态而不进行用户认证，以恢复安全密钥信息。 取消发布装置释放用户认证的取消，使得在恢复安全密钥信息之后恢复第一类型OS开始的用户认证。

公开(公告)号：US6127409A

公开(公告)日：2000-10-03

申请号：US70012

申请日：1998-04-30

申请人： Masahiro Suzuki ,  Toshi Tsuzuki ,  Shinobu Ito ,  Eiji Ogata

发明人： Masahiro Suzuki ,  Toshi Tsuzuki ,  Shinobu Ito ,  Eiji Ogata

IPC分类号： A61K8/67 ,  A61Q19/00 ,  C07F9/655 ,  A01N43/08 ,  C07D307/02

CPC分类号： C07F9/65515 ,  A61K8/676 ,  A61Q19/00 ,  A61K2800/52

摘要： A novel ascorbic acid derivative having both sufficiently improved stability and liposolubility, and facilitated cellular uptake. Also disclosed is a process for producing the derivative and a composition capable of effectively providing the action of vitamin C, for use in medical preparations, agricultural chemicals, animal drugs, foods, feeds or cosmetic preparations. The ascorbic acid derivative is a compound represented by the following formula (1) or a salt thereof: ##STR1## wherein R represents an acyl group having eleven or more carbon atoms and n is 0, 1 or 2.

摘要翻译： 具有足够改善的稳定性和脂溶性的新型抗坏血酸衍生物，促进细胞摄取。 还公开了一种生产该衍生物的方法和能够有效提供维生素C作用的组合物，用于医疗制剂，农药，动物药物，食品，饲料或化妆品制剂。 抗坏血酸衍生物是由下式（1）表示的化合物或其盐：其中R表示具有11个或更多个碳原子且n为0,1或2的酰基。

公开(公告)号：US5869525A

公开(公告)日：1999-02-09

申请号：US647767

申请日：1996-05-15

申请人： Shinobu Ito ,  Eiji Ogata ,  Nobuhiko Miwa

发明人： Shinobu Ito ,  Eiji Ogata ,  Nobuhiko Miwa

IPC分类号： A61K31/375 ,  A61K31/34 ,  A61K31/70 ,  A61K31/715

CPC分类号： A61K31/375

摘要： An L-ascorbic acid drug for intracerebral administration comprising one or more stable activity L-ascorbic acid compounds and one or more blood brainbarrier deobstruents. Also disclosed is a method for increasing intracerebral concentration of L-ascorbic acid in a human being comprising administering by injection an L-ascorbic acid drug comprising one or more stable activity L-ascorbic acid compounds. Additionally disclosed is a method for increasing intracerebral concentration of L-ascorbic acid in a human being comprising administering by injection an L-ascorbic acid drug comprising one or more stable activity L-ascorbic acid compounds and one or more blood brainbarrier deobstruents. Also disclosed is a method for treating diseases or disorders that result from intracerebral bloodstream inhibition or intracerebral bloodstream lowering comprising administering by injection to a person in need of such treatment, a dosage effective amount of an L-ascorbic acid drug comprising one or more stable activity L-ascorbic acid compounds. Additionally disclosed is a method for treating diseases or disorders that result from intracerebral bloodstream inhibition or intracerebral bloodstream lowering comprising administering by injection to a person in need of such treatment, a dosage effective amount of an L-ascorbic acid drug comprising one or more stable activity L-ascorbic acid compounds and one or more blood brainbarrier deobstruents.

摘要翻译： 一种用于脑内给药的L-抗坏血酸药物，其包含一种或多种稳定的活性L-抗坏血酸化合物和一种或多种血液脑阻滞剂。 还公开了增加人体中L-抗坏血酸的脑内浓度的方法，包括通过注射施用包含一种或多种稳定活性L-抗坏血酸化合物的L-抗坏血酸药物。 另外公开了一种增加人抗坏血酸的脑内浓度的方法，包括通过注射施用包含一种或多种稳定的活性L-抗坏血酸化合物和一种或多种血脑屏障去除剂的L-抗坏血酸药物。 还公开了一种用于治疗由脑内血流抑制或脑内血流降低引起的疾病或病症的方法，其包括通过注射给予需要这种治疗的人，剂量有效量的包含一种或多种稳定活性的L-抗坏血酸药物 L-抗坏血酸化合物。 另外公开了一种治疗由脑内血流抑制或脑内血流降低引起的疾病或病症的方法，其包括通过注射给予需要这种治疗的人，剂量有效量的包含一种或多种稳定活性的L-抗坏血酸药物 L-抗坏血酸化合物和一种或多种血脑屏障阻断剂。

公开(公告)号：US5419865A

公开(公告)日：1995-05-30

申请号：US241670

申请日：1994-05-12

申请人： Eiji Ogata ,  Shokichi Seki

发明人： Eiji Ogata ,  Shokichi Seki

IPC分类号： B29C33/10 ,  B29C33/42 ,  B29C45/26 ,  B29C45/34 ,  B29C45/37 ,  B29C45/56 ,  B29D99/00 ,  B29L31/34 ,  H04R1/02 ,  B29C39/36

CPC分类号： H04R1/023 ,  B29C45/2628

摘要： A method of making plastic molding consists of a boxlike body having an field of multiple fine conical holes. The internal diameter of the fine conical holes gradually decreases from the inner surface of the plastic molding toward the outer surface of the plastic molding, and is in the range 0.1-0.5 mm at the outer surface. The fine conical holes are hardly visible when the outer surface of the box is viewed; ventilation is provided without detriment to the aesthetic appearance of the exterior of the box, and it is not necessary to cover the ventilation holes in the box to keep them out of sight. Conical projection on a male mold are withdrawn before the plastic molding hardens completely and the male mold is separated from a female mold after the plastic material has hardened completely.

摘要翻译： 制造塑料成型的方法由具有多个细圆锥孔的场的盒状体构成。 细圆锥孔的内径从塑料模制品的内表面朝向塑料模制件的外表面逐渐减小，并且在外表面处于0.1-0.5mm的范围内。 当观察箱的外表面时，细小的锥形孔几乎看不到; 提供通风而不损害箱体外观的美观外观，并且不需要覆盖盒中的通风孔以使其不在视线之内。 在塑料模制完全硬化之前，取出阳模上的锥形突出物，并且在塑料材料完全硬化后，阳模与阴模分离。