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公开(公告)号:US06942837B2
公开(公告)日:2005-09-13
申请号:US09848270
申请日:2001-05-04
IPC分类号: G01N31/20 , B01J4/00 , B01L3/00 , B01L3/02 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N1/00 , G01N35/00 , G01N35/02 , G01N35/10 , G01N37/00 , C12M1/34
CPC分类号: B01L3/50853 , B01L3/0203 , B01L2200/025 , B01L2200/0642 , B01L2200/141 , B01L2300/046 , B01L2300/047 , B01L2300/049 , B01L2300/0829 , B01L2300/0864 , B01L2400/049 , B01L2400/0633 , G01N1/14 , G01N35/00 , G01N35/028 , G01N35/1097 , G01N2035/00148 , G01N2035/1037
摘要: A system for filling a substrate having at least one chamber with a liquid sample is provided. The system in one embodiment includes a substrate defining a network of passageways including at least one chamber for the liquid sample, and an adapter. The adapter includes a fill reservoir for the liquid sample, a vacuum port for attachment to a vacuum source, and at least two channels. One channel allows a vacuum to be imparted to the network, and the other channel allows the liquid sample to be introduced into the network. The system also includes a mechanism that sequentially closes and opens at least one of the channels so that a vacuum can first be introduced to the substrate and thereafter the liquid sample introduced to the substrate for permitting the vacuum to urge the liquid sample to flow from the fill reservoir into the substrate. An apparatus for positioning a substrate with a plurality of sample detection chambers in a detection unit is also provided.
摘要翻译: 提供了一种用于用液体样品填充具有至少一个室的基板的系统。 在一个实施例中的系统包括限定通道网络的基板,包括用于液体样品的至少一个室和适配器。 适配器包括用于液体样品的填充容器,用于附接到真空源的真空端口和至少两个通道。 一个通道允许将真空赋予网络,另一个通道允许将液体样品引入网络。 该系统还包括依次关闭和打开至少一个通道的机构,使得可以首先将真空引入衬底,然后将引入到衬底中的液体样品引入真空以迫使液体样品从 将储存器填充到基板中。 还提供了一种用于将具有多个样本检测室的基板定位在检测单元中的装置。
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公开(公告)号:US20130052723A1
公开(公告)日:2013-02-28
申请号:US13468964
申请日:2012-05-10
申请人: Donald Sandell , Eugene Young , Steven Boege
发明人: Donald Sandell , Eugene Young , Steven Boege
IPC分类号: C12M1/42
CPC分类号: G01N21/6452 , B01L7/52 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , G01N21/253 , G02B3/0056 , G02B3/08
摘要: The invention relates to an optical detection system for a thermal cycling device including at least one light source, a light detection device for detecting light received from a plurality of biological samples, and a lens having first and second surfaces formed on the lens, the second surface substantially opposed to the first surface. The first surface may be configured to collimate light and the second surface may be configured to direct light into each of the plurality of biological samples.
摘要翻译: 本发明涉及一种用于热循环装置的光学检测系统,其包括至少一个光源,用于检测从多个生物样品接收的光的光检测装置,以及具有形成在透镜上的第一和第二表面的透镜,第二 表面基本上与第一表面相对。 第一表面可以被配置为准直光,并且第二表面可以被配置为将光引导到多个生物样品中的每一个中。
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公开(公告)号:US20120035709A1
公开(公告)日:2012-02-09
申请号:US13251929
申请日:2011-10-03
申请人: Eugene Young , Russ Borg , David Trask , Travis Richard Yribarren , Erik Eli
发明人: Eugene Young , Russ Borg , David Trask , Travis Richard Yribarren , Erik Eli
IPC分类号: A61F2/82
CPC分类号: A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2002/91591 , A61F2220/0041 , A61F2230/0054 , A61F2250/0098
摘要: Endoprosthesis for delivery in a body lumen is provided. The endoprosthesis includes an annular element defined by a set of interconnected strut members, each strut member including a first end and a second end. The first end of selected pairs of circumferentially-adjacent strut members of the annular element are interconnected to define apices proximate a first longitudinal side of the annular element and the second end of selected pairs circumferentially-adjacent strut members are interconnected to define apices proximate a second longitudinal side of the annular element. At least one of the selected pairs of circumferentially-adjacent strut members has a modulator disposed proximate the apex defined there between, the modulator having a first mode to allow expansion of the annular element from an unexpanded configuration toward an expanded configuration and a second mode to resist contraction of the annular element from the expanded configuration toward the unexpanded configuration.
摘要翻译: 提供用于在体腔内输送的内用假体。 内假体包括由一组相互连接的支柱构件限定的环形元件,每个支柱构件包括第一端和第二端。 环形元件的选定对的周向相邻的支柱构件的第一端互连以限定靠近环形元件的第一纵向侧面的顶点,并且所选择的对周向相邻的支柱构件的第二端互连以限定靠近第二 环形元件的纵向侧。 所选择的一对周向相邻的支柱构件中的至少一个具有设置在其间限定的顶点附近的调制器,调制器具有第一模式以允许环形元件从未膨胀构型朝向扩张构型膨胀,第二模式 防止环形元件从膨胀构型向未膨胀构型的收缩。
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公开(公告)号:US08048146B2
公开(公告)日:2011-11-01
申请号:US11479643
申请日:2006-06-30
申请人: Eugene Young , Russ Borg , David Trask , Travis Richard Yribarren , Erik Eli
发明人: Eugene Young , Russ Borg , David Trask , Travis Richard Yribarren , Erik Eli
IPC分类号: A61F2/06
CPC分类号: A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2002/91591 , A61F2220/0041 , A61F2230/0054 , A61F2250/0098
摘要: Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration. The annular elements are longitudinally aligned and connected at connection locations with connectors, wherein at least one of the connectors is constructed of a bio-absorbable material.
摘要翻译: 内置假体,例如支架,包括至少一个环形元件,所述至少一个环形元件由第一组支柱构件限定,所述第一组撑杆构件互相连接以限定靠近所述环形元件相对侧的顶点。 环形元件还包括在至少一对周向相邻的支柱构件之间延伸的脚延伸部。 脚部延伸部具有从周向相邻的支柱构件的对应端部周向延伸的第一和第二脚部,并且具有轮廓以提供至少两个弯曲区域。 第一和第二脚部在脚延伸部的脚趾部分处连接,并且在一对周向相邻的支柱构件之间限定圆周方向的顶点。 优选地,提供至少一个或多个另外的环形元件,每个环形元件由互连的支柱构件限定。 环形元件通常在输送配置和展开配置之间可扩展。 环形元件在与连接器的连接位置处纵向对准并连接,其中至少一个连接器由生物吸收材料构成。
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公开(公告)号:US07625398B2
公开(公告)日:2009-12-01
申请号:US10992976
申请日:2004-11-19
申请人: Anton Clifford , Kevin Kang , David Lowe , Jeff Pappas , Erik Eli , Howard Huang , Lisa Weldon , Ketan Muni , Eugene Young
发明人: Anton Clifford , Kevin Kang , David Lowe , Jeff Pappas , Erik Eli , Howard Huang , Lisa Weldon , Ketan Muni , Eugene Young
IPC分类号: A61F2/06
CPC分类号: A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2230/0054 , A61F2250/0098 , Y10T29/49826 , Y10T29/49908
摘要: Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration. The annular elements are longitudinally aligned and connected at connection locations. Preferably, each connection location includes a foot extension, such as by an overlapping pattern between the longitudinally-adjacent annular elements or by a connector extending therebetween.
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公开(公告)号:US06272939B1
公开(公告)日:2001-08-14
申请号:US09549382
申请日:2000-04-13
IPC分类号: G01N100
CPC分类号: B01L3/50853 , B01L3/0203 , B01L2200/025 , B01L2200/0642 , B01L2200/141 , B01L2300/046 , B01L2300/047 , B01L2300/049 , B01L2300/0829 , B01L2300/0864 , B01L2400/049 , B01L2400/0633 , G01N1/14 , G01N35/00 , G01N35/028 , G01N35/1097 , G01N2035/00148 , G01N2035/1037
摘要: A system for filling a substrate having at least one chamber with a liquid sample is provided. The system in one embodiment includes a substrate defining a network of passageways including at least one chamber for the liquid sample, and an adapter. The adapter includes a fill reservoir for the liquid sample, a vacuum port for attachment to a vacuum source, and at least two channels. One channel allows a vacuum to be imparted to the network, and the other channel allows the liquid sample to be introduced into the network. The system also includes a mechanism that sequentially closes and opens at least one of the channels so that a vacuum can first be introduced to the substrate and thereafter the liquid sample introduced to the substrate for permitting the vacuum to urge the liquid sample to flow from the fill reservoir into the substrate. An apparatus for positioning a substrate with a plurality of sample detection chambers in a detection unit is also provided.
摘要翻译: 提供了一种用于用液体样品填充具有至少一个室的基板的系统。 在一个实施例中的系统包括限定通道网络的基板,包括用于液体样品的至少一个室和适配器。 适配器包括用于液体样品的填充容器,用于附接到真空源的真空端口和至少两个通道。 一个通道允许将真空赋予网络,另一个通道允许将液体样品引入网络。 该系统还包括依次关闭和打开至少一个通道的机构,使得可以首先将真空引入衬底,然后将引入到衬底的液体样品引入真空以迫使液体样品从 将储存器填充到基板中。 还提供了一种用于将具有多个样本检测室的基板定位在检测单元中的装置。
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公开(公告)号:US08915954B2
公开(公告)日:2014-12-23
申请号:US13251929
申请日:2011-10-03
申请人: Eugene Young , Russ Borg , David Trask , Travis Richard Yribarren , Erik Eli
发明人: Eugene Young , Russ Borg , David Trask , Travis Richard Yribarren , Erik Eli
CPC分类号: A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2002/91591 , A61F2220/0041 , A61F2230/0054 , A61F2250/0098
摘要: Endoprosthesis for delivery in a body lumen is provided. The endoprosthesis includes an annular element defined by a set of interconnected strut members, each strut member including a first end and a second end. The first end of selected pairs of circumferentially-adjacent strut members of the annular element are interconnected to define apices proximate a first longitudinal side of the annular element and the second end of selected pairs circumferentially-adjacent strut members are interconnected to define apices proximate a second longitudinal side of the annular element. At least one of the selected pairs of circumferentially-adjacent strut members has a modulator disposed proximate the apex defined there between, the modulator having a first mode to allow expansion of the annular element from an unexpanded configuration toward an expanded configuration and a second mode to resist contraction of the annular element from the expanded configuration toward the unexpanded configuration.
摘要翻译: 提供用于在体腔内输送的内用假体。 内假体包括由一组相互连接的支柱构件限定的环形元件,每个支柱构件包括第一端和第二端。 环形元件的选定对的周向相邻的支柱构件的第一端互连以限定靠近环形元件的第一纵向侧面的顶点,并且所选择的对周向相邻的支柱构件的第二端互连以限定靠近第二 环形元件的纵向侧。 所选择的一对周向相邻的支柱构件中的至少一个具有设置在其间限定的顶点附近的调制器,调制器具有第一模式以允许环形元件从未膨胀构型朝向扩张构型膨胀,第二模式 防止环形元件从膨胀构型向未膨胀构型的收缩。
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公开(公告)号:US20070134579A1
公开(公告)日:2007-06-14
申请号:US11651738
申请日:2007-01-09
申请人: Steven Malachowski , Amy Grillo , Eugene Young
发明人: Steven Malachowski , Amy Grillo , Eugene Young
IPC分类号: G03G9/08
CPC分类号: G03G9/0806 , G03G9/0804 , G03G9/08711 , G03G9/08775 , G03G9/08777 , G03G9/08782 , G03G9/08795 , G03G9/08797 , G03G9/09725 , G03G9/09733
摘要: Herein is disclosed a process for producing emulsion aggregation toner including (i) adding a base to an emulsion aggregation toner to increase the pH of the toner to from about 7 to about 12; (ii) sieving and filtering the toner; (iii) washing the toner with an enzyme selected from the group consisting of carboxylic ester hydrolase and sulfuric ester hydrolase; (iv) filtering the toner; (v) washing the toner with reverse osmosis or deionized water; and (vi) adding an acid to reduce the pH of the toner to from about 3 to about 8.
摘要翻译: 本文公开了一种生产乳液聚集调色剂的方法,其包括(i)向乳液聚集调色剂中加入碱以将调色剂的pH提高至约7至约12; (ii)筛分和过滤调色剂; (iii)用选自羧酸酯水解酶和硫酸酯水解酶的酶洗涤调色剂; (iv)过滤调色剂; (v)用反渗透或去离子水洗涤调色剂; 和(vi)加入酸以将调色剂的pH降低至约3至约8。
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公开(公告)号:US20070134576A1
公开(公告)日:2007-06-14
申请号:US11301481
申请日:2005-12-13
申请人: Maura Sweeney , Eugene Young
发明人: Maura Sweeney , Eugene Young
IPC分类号: G03G9/08
CPC分类号: G03G9/0806 , G03G9/08775 , G03G9/08777 , G03G9/08795 , G03G9/08797 , G03G9/09733
摘要: Toner compositions having reduced odor are provided.
摘要翻译: 提供了具有降低气味的调色剂组合物。
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公开(公告)号:US20070021834A1
公开(公告)日:2007-01-25
申请号:US11479643
申请日:2006-06-30
申请人: Eugene Young , Russ Borg , David Trask , Travis Yribarren , Erik Eli
发明人: Eugene Young , Russ Borg , David Trask , Travis Yribarren , Erik Eli
IPC分类号: A61F2/28
CPC分类号: A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2002/91591 , A61F2220/0041 , A61F2230/0054 , A61F2250/0098
摘要: Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration. The annular elements are longitudinally aligned and connected at connection locations with connectors, wherein at least one of the connectors is constructed of a bio-absorbable material.
摘要翻译: 内置假体,例如支架,包括至少一个环形元件,所述至少一个环形元件由第一组支柱构件限定,所述第一组撑杆构件互相连接以限定靠近所述环形元件相对侧的顶点。 环形元件还包括在至少一对周向相邻的支柱构件之间延伸的脚延伸部。 脚部延伸部具有从周向相邻的支柱构件的对应端部周向延伸的第一和第二脚部,并且具有轮廓以提供至少两个弯曲区域。 第一和第二脚部在脚延伸部的脚趾部分处连接,并且在一对周向相邻的支柱构件之间限定圆周方向的顶点。 优选地,提供至少一个或多个另外的环形元件,每个环形元件由互连的支柱构件限定。 环形元件通常在输送配置和展开配置之间可扩展。 环形元件在与连接器的连接位置处纵向对准并连接,其中至少一个连接器由生物吸收材料构成。
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