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公开(公告)号：US20080175882A1
公开(公告)日：2008-07-24
申请号：US11657433
申请日：2007-01-23
申请人： Mikael O. Trollsas , Nam D. Pham , Michael H. Ngo
发明人： Mikael O. Trollsas , Nam D. Pham , Michael H. Ngo
IPC分类号： A61K31/4745 , A61F2/02
CPC分类号： A61L27/34 , A61K47/6957 , A61L31/10 , C08G75/26 , C09D181/00 , C08L81/00
摘要： A coating comprising a polymer that comprises units derived from an aliphatic thioester on a medical device is provided.
摘要翻译： 提供了包含在医疗装置上包含衍生自脂肪族硫酯的单元的聚合物的涂层。
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公开(公告)号：US09737638B2
公开(公告)日：2017-08-22
申请号：US11820833
申请日：2007-06-20
申请人： Nam D. Pham , Michael H. Ngo , Mikael O. Trollsas
发明人： Nam D. Pham , Michael H. Ngo , Mikael O. Trollsas
CPC分类号： A61L29/085 , A61L27/34 , A61L31/10 , C08L77/12
摘要： A poly(ester amide) polymer having free carboxylic acid pendant groups and method of making and using the same are disclosed.
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公开(公告)号：US07927621B2
公开(公告)日：2011-04-19
申请号：US11821995
申请日：2007-06-25
IPC分类号： A61K31/436 , A61K31/506 , A61K38/44 , A61K31/56 , A61K31/337 , A61F2/04 , C08G75/02 , A61P9/00
CPC分类号： C08G69/44 , C08G75/26 , C08L2205/05 , C09D181/00
摘要： A poly(thioester ester amide) copolymer and method of making and using the same are disclosed.
摘要翻译： 公开了一种聚（硫酯酯酰胺）共聚物及其制备和使用方法。
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公开(公告)号：US20080314289A1
公开(公告)日：2008-12-25
申请号：US11820833
申请日：2007-06-20
申请人： Nam D. Pham , Michael H. Ngo , Mikael O. Trollsas
发明人： Nam D. Pham , Michael H. Ngo , Mikael O. Trollsas
CPC分类号： A61L29/085 , A61L27/34 , A61L31/10 , C08L77/12
摘要： A poly(ester amide) polymer having free carboxylic acid pendant groups and method of making and using the same are disclosed.
摘要翻译： 公开了具有游离羧酸侧基的聚（酯酰胺）聚合物及其制备和使用方法。
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公开(公告)号：US09345602B2
公开(公告)日：2016-05-24
申请号：US13090164
申请日：2011-04-19
申请人： Michael H. Ngo , Mikael Trollsas , John E. Papp , Hung T. Nguyen , Dudley Jayasinghe , Ron Farnbach , Gregory C. Orr , Joshua Takeshi Smith , Yongjin Xie , Yu-Chun Ku
发明人： Michael H. Ngo , Mikael Trollsas , John E. Papp , Hung T. Nguyen , Dudley Jayasinghe , Ron Farnbach , Gregory C. Orr , Joshua Takeshi Smith , Yongjin Xie , Yu-Chun Ku
CPC分类号： A61F2/844 , A61F2/89 , A61F2/915 , A61F2/958 , A61F2002/91566 , A61F2002/91575 , A61F2002/91583 , A61F2002/9522 , A61F2002/9583 , A61F2210/0071 , A61F2230/0054 , A61F2230/0056 , B23K26/361 , B23K26/362 , B23K26/402 , B23K2103/42 , B23K2103/50 , B29C49/0073 , B29C49/08 , B29C55/26 , B29C2049/0089 , B29C2793/0009 , B29K2067/046 , B29L2031/753 , B29L2031/7534 , Y10T156/1002
摘要： Methods for making scaffolds for delivery via a balloon catheter are described. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold structure has patterns that include an asymmetric or symmetric closed cell, and links connecting such closed cells.
摘要翻译： 描述了通过球囊导管进行支架制备的方法。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架结构具有包括不对称或对称闭孔的图案，以及连接这种闭孔的连接。
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公开(公告)号：US20140025161A1
公开(公告)日：2014-01-23
申请号：US13555903
申请日：2012-07-23
申请人： John S. Stankus , Hugh Zhao , Mikael Trollsas , Syed Faiyaz Ahmed Hossainy , Michael H. Ngo , Yunbing Wang , Benny Serna
发明人： John S. Stankus , Hugh Zhao , Mikael Trollsas , Syed Faiyaz Ahmed Hossainy , Michael H. Ngo , Yunbing Wang , Benny Serna
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/915 , A61F2002/91508 , A61F2002/91541 , A61F2002/91558 , A61F2210/0019 , A61F2230/0054 , A61F2230/0056 , A61F2230/006 , A61F2250/001 , A61L31/041 , A61L31/06 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2400/16 , C08L67/04
摘要： Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed. The scaffolds are made from a random copolymer of PLLA and a rubbery polymer such as polycaprolactone.
摘要翻译： 公开了具有高压碎可恢复性，高抗断裂性和由于在生理条件下的自膨胀性能而减少或无反冲的生物可吸收支架。 支架由PLLA和橡胶状聚合物如聚己内酯的无规共聚物制成。
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公开(公告)号：US08568471B2
公开(公告)日：2013-10-29
申请号：US13015488
申请日：2011-01-27
申请人： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
发明人： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
IPC分类号： A61F2/82
CPC分类号： A61F2/958 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/9522 , A61F2210/0004 , A61F2210/0014 , A61F2210/0019 , A61F2210/0076 , A61F2230/0006 , A61F2230/0008 , A61F2250/0067 , A61F2250/0096 , A61F2250/0098 , A61L27/00 , A61L31/06 , A61L31/14 , B21D39/046 , B29C35/08 , B29C2035/0838 , B29K2067/046 , B29L2023/00 , B29L2031/7543 , Y10T29/49826 , Y10T29/4987 , Y10T29/49908 , Y10T29/49925 , Y10T29/49927 , C08L67/04 , C08L71/02
摘要： A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells.
摘要翻译： 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架具有图案，其包括连接连接封闭单元的链接的非对称封闭单元。
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公开(公告)号：US20110190872A1
公开(公告)日：2011-08-04
申请号：US13015474
申请日：2011-01-27
申请人： Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John Papp
发明人： Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John Papp
CPC分类号： A61F2/89 , A61F2/82 , A61F2/915 , A61F2002/91508 , A61F2002/91575 , A61F2240/002 , A61M25/1034 , B23P11/005 , B29C55/24 , B29C69/00 , Y10T29/49908
摘要： A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile.
摘要翻译： 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架还具有减小的卷边轮廓和在冠部处的支架环形结构的改进，其有助于减小卷曲轮廓。
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公开(公告)号：US09180228B2
公开(公告)日：2015-11-10
申请号：US13252120
申请日：2011-10-03
申请人： John Stankus , Yunbing Wang , Mikael Trollsas , Syed Faiyaz Ahmed Hossainy , Michael H. Ngo , Dariush Davalian
发明人： John Stankus , Yunbing Wang , Mikael Trollsas , Syed Faiyaz Ahmed Hossainy , Michael H. Ngo , Dariush Davalian
CPC分类号： A61F2/915 , A61F2210/0004 , A61F2210/0057 , A61F2230/0013 , A61F2230/0054 , A61L31/041 , A61L31/129 , A61L31/141 , A61L31/148
摘要： Bioabsorbable scaffolds are disclosed with a rigid polymer component and a rubbery polymer component. The rubbery polymer component is miscible, partially miscible, or immiscible with the rigid polymer component.
摘要翻译： 公开了具有刚性聚合物组分和橡胶状聚合物组分的生物可吸收支架。 橡胶状聚合物组分是可混溶的，部分混溶的或与刚性聚合物组分不混溶的。
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公开(公告)号：US20130085563A1
公开(公告)日：2013-04-04
申请号：US13252120
申请日：2011-10-03
申请人： John Stankus , Yunbing Wang , Mikael Trollsas , Syed Faiyaz Ahmed Hossainy , Michael H. Ngo , Dariush Davalian
发明人： John Stankus , Yunbing Wang , Mikael Trollsas , Syed Faiyaz Ahmed Hossainy , Michael H. Ngo , Dariush Davalian
CPC分类号： A61F2/915 , A61F2210/0004 , A61F2210/0057 , A61F2230/0013 , A61F2230/0054 , A61L31/041 , A61L31/129 , A61L31/141 , A61L31/148
摘要： Bioabsorbable scaffolds are disclosed with a rigid polymer component and a rubbery polymer component. The rubbery polymer component is miscible, partially miscible, or immiscible with the rigid polymer component.
摘要翻译： 公开了具有刚性聚合物组分和橡胶状聚合物组分的生物可吸收支架。 橡胶状聚合物组分是可混溶的，部分混溶的或与刚性聚合物组分不混溶的。
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