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公开(公告)号：US20180209954A1
公开(公告)日：2018-07-26
申请号：US15935227
申请日：2018-03-26
Applicant: FUJIFILM Corporation
Inventor： Kenta MATSUBARA
CPC classification number: G01N33/49 , G01N21/27 , G01N21/31 , G01N21/314 , G01N21/41 , G01N21/84 , G01N33/48 , G01N33/721 , G01N33/80 , G01N2201/0221
Abstract: Provided are a robust and high throughput method for identifying a target cell and a target cell identification device. The method for identifying a target cell includes an image acquisition step of irradiating a specimen with a plurality of light rays having different wavelengths and acquiring a plurality of phase difference images of the specimen, a selection step of selecting a plurality of target cell candidates from the specimen based on a difference in absorption coefficients with respect to the plurality of light rays having different wavelengths, a brightness ratio acquisition step of acquiring brightness ratios between a central part and a peripheral part of each target cell candidate based on the plurality of phase difference images, and a sorting step of sorting a target cell and a non-target cell from the plurality of target cell candidates based on the brightness ratios.
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公开(公告)号：US20220341727A1
公开(公告)日：2022-10-27
申请号：US17860511
申请日：2022-07-08
Applicant: FUJIFILM Corporation
Inventor： Kenta MATSUBARA
Abstract: An information processing apparatus that executes processing of obtaining, from an interference fringe image that is a two-dimensional distribution of intensity of interference fringes of object light and reference light, a phase difference image that is a two-dimensional distribution of a phase difference between the object light and the reference light, and obtaining a shape of an object to be observed based on the phase difference image includes at least one processor configured to acquire object-related information regarding the object to be observed, read out, from a storage unit in which the object-related information and a shape profile indicating the shape of the object to be observed are stored in association with each other, the shape profile corresponding to the acquired object-related information, and perform phase connection with respect to the phase difference image with reference to the read-out shape profile.
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公开(公告)号：US20200278523A1
公开(公告)日：2020-09-03
申请号：US16878772
申请日：2020-05-20
Applicant: FUJIFILM Corporation
Inventor： Kenta MATSUBARA
Abstract: The observation apparatus includes an imaging unit that images an observation target accommodated in a cultivation container, a movement unit that scans the observation target by relatively moving the cultivation container with respect to the imaging unit in accordance with a scheduled trajectory, a measurement unit that acquires measured shape information of the cultivation container by measuring the cultivation container along a scanning trajectory using an observation region, a storage unit that stores reference shape information obtained by measuring a shape of the cultivation container using the measurement unit along a reference trajectory which is a reference in a case where the shape of the cultivation container is measured, a calculation unit that calculates a shift of a scanning trajectory with respect to a reference trajectory based on the reference shape information and the measured shape information, and a control unit that corrects the scheduled trajectory based on the shift and scans the imaging unit based on the corrected scheduled trajectory.
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公开(公告)号：US20190391376A1
公开(公告)日：2019-12-26
申请号：US16563094
申请日：2019-09-06
Applicant: FUJIFILM Corporation
Inventor： Kenta MATSUBARA
Abstract: An observation device includes: a stage on which a vessel in which a subject is stored is installed; an image-forming optical system that includes an objective lens forming an image of the subject stored in the vessel; a scan control unit that moves the stage with respect to the image-forming optical system to scan each observation position in the vessel by the image-forming optical system; and an acceleration-determination-information acquisition unit that acquires at least one piece of information among information about the subject, information about the vessel, information about an observation method, or information about an observation condition. The scan control unit controls an acceleration of the stage on the basis of the at least one piece of information.
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15.发明申请公开(公告)号：US20190195777A1
公开(公告)日：2019-06-27
申请号：US16291068
申请日：2019-03-04
Applicant: FUJIFILM Corporation
Inventor： Kenta MATSUBARA
CPC classification number: G01N15/1475 , G01B11/06 , G01N21/17 , G01N2015/1087 , G01N2015/1493 , G01N2015/1497 , G02B21/00 , G03B15/00 , G06T7/0012 , G06T2207/10056 , H04N5/232
Abstract: Provided are a captured image evaluation apparatus, a captured image evaluation method, and a captured image evaluation program capable of evaluating a thickness and a density of stacked cultured cells in a short imaging time. The captured image evaluation apparatus includes: an image acquisition section 52 that acquires captured images obtained by imaging a subject under a condition in which a numerical aperture of an objective lens is changed; a thickness estimation section 53 that estimates a thickness of the subject on the basis of a low NA captured image obtained under a condition in which the numerical aperture of the objective lens is relatively small; and a density estimation section 54 that estimates a density of the subject on the basis of a high NA captured image obtained under a condition in which the numerical aperture of the objective lens is relatively large.
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Patent Agency Ranking
公开(公告)号：US20180348493A1
公开(公告)日：2018-12-06
申请号：US16059580
申请日：2018-08-09
Applicant: FUJIFILM Corporation
Inventor： Kenta MATSUBARA
Abstract: A cell observation apparatus includes an image formation optical system control unit 51 which sets an initial scanning range of the focal position based on information relating to a thickness of a cell, forms an image of the cell at each of a plurality of focal positions within a set initial scanning range, subsequently acquires an image captured by an imaging unit 40 for each of the plurality of focal positions, estimates the thickness of the cell based on the image, updates the initial scanning range of the focal position based on the estimated thickness of the cell, and forms an image of the cell at each of a plurality of focal positions within the updated scanning range.
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公开(公告)号：US20170146514A1
公开(公告)日：2017-05-25
申请号：US15424101
申请日：2017-02-03
Applicant: FUJIFILM Corporation
Inventor： Kenta MATSUBARA , Shinichiro FUKUI , Yasuyuki ISHII
CPC classification number: G01N33/491 , G01N15/1434 , G01N21/27 , G01N21/59 , G01N33/48 , G01N33/483 , G01N33/49 , G01N33/4925 , G01N33/80 , G01N2015/0073 , G01N2015/1006 , G01N2015/149 , G01N2201/12
Abstract: Provided is a method for sorting nucleated red blood cells in which fetus-derived nucleated red blood cells are sorted out from maternal blood. The method includes a nucleated red blood cell specification step of specifying nucleated red blood cells to be sorted out; a reference red blood cell selection step of setting a search range including the nucleated red blood cells and selecting red blood cells having no nucleus within the search range as reference red blood cells; and a sorting step of sorting the nucleated red blood cells into mother-derived nucleated red blood cells and fetus-derived nucleated red blood cells in accordance with spectral characteristics attributable to oxygen affinity of hemoglobin of the nucleated red blood cells and the reference red blood cells.
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公开(公告)号：US20170081628A1
公开(公告)日：2017-03-23
申请号：US15363926
申请日：2016-11-29
Applicant: FUJIFILM Corporation
Inventor： Kenta MATSUBARA
CPC classification number: C12M41/36 , C12M23/44 , C12M23/50 , C12M41/08 , C12M41/10 , C12M41/12 , C12M41/32 , C12M41/34 , C12M41/46 , C12M41/48 , G01N21/75 , G01N2021/755 , G06K9/0014 , G06T7/0012 , G06T7/11 , G06T7/62 , G06T2207/10056 , G06T2207/30024 , G06T2207/30242
Abstract: Disclosed are a cell evaluation device, a cell evaluation method, and a non-transitory computer readable recording medium recorded with a cell evaluation program capable of evaluating individual cells in a cell image obtained by imaging a cell group with high accuracy. The cell evaluation device includes an image acquisition unit 30 that acquires a cell image obtained by imaging a cell group; a cell evaluation unit 32 that specifies an evaluation target cell and peripheral cells around the evaluation target cell in the cell group and evaluates the evaluation target cell based on evaluation results of the peripheral cells.
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公开(公告)号：US20200271914A1
公开(公告)日：2020-08-27
申请号：US15931596
申请日：2020-05-14
Applicant: FUJIFILM CORPORATION
Inventor： Kenta MATSUBARA
Abstract: By moving at least one of a culture container having a plurality of wells or an imaging optical system that forms an image of an observation target in each of the wells, an observation position in the culture container is scanned to observe the observation target. In a case where an auto-focus control for each observation position is performed, a start timing of the auto-focus control for each observation position is switched on the basis of a boundary portion between the adjacent wells in a scanning direction of the observation position.
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公开(公告)号：US20190339498A1
公开(公告)日：2019-11-07
申请号：US16515555
申请日：2019-07-18
Applicant: FUJIFILM Corporation
Inventor： Kenta MATSUBARA
Abstract: There are provided a microscope apparatus, an observation method, and a microscope apparatus-control program that can more efficiently perform auto-focus control and can shorten an imaging time in a case where a culture vessel is to be scanned by an image forming optical system and the auto-focus control is to be performed at each observation position. Focus information of a culture vessel is detected by a first displacement sensor and a second displacement sensor while a stage is moved to a scanning measurement position from an initial set position, and an auto-focus control unit performs auto-focus control at every observation position on the basis of the focus information in a case where the stage has been moved to the scanning measurement position.
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