公开(公告)号：US20150202344A1

公开(公告)日：2015-07-23

申请号：US14677592

申请日：2015-04-02

Applicant: FUJIFILM Corporation

Inventor： Reiko IWAZAWA ,  Kentaro NAKAMURA

IPC: A61L27/22 ,  A61L27/36

CPC classification number: A61K9/7007 ,  A61L27/14 ,  A61L27/22 ,  A61L27/222 ,  A61L27/227 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3625 ,  A61L27/38 ,  A61L27/3808 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/40 ,  A61L2300/64 ,  A61L2300/80 ,  A61L2400/06 ,  A61L2430/22 ,  C07K14/78

Abstract: An object of the present invention is to provide a cell construct for cell transplantation capable of having a thickness suitable for cell transplantation, preventing the necrosis of transplanted cells, and forming blood vessels in the transplantation site after transplantation. The present invention provides a cell construct for cell transplantation which comprises polymer blocks having biocompatibility and cells of at least one type, wherein the plural polymer blocks are arranged in spaces between the plural cells.

Abstract translation: 本发明的目的是提供一种能够具有适合细胞移植的厚度的细胞移植用细胞构建体，能够防止移植细胞的坏死，移植后的移植部位形成血管。 本发明提供一种用于细胞移植的细胞构建体，其包含具有生物相容性的聚合物嵌段和至少一种类型的细胞，其中所述多个聚合物嵌段排列在所述多个细胞之间的空间中。

公开(公告)号：US20150175969A1

公开(公告)日：2015-06-25

申请号：US14640218

申请日：2015-03-06

Applicant: FUJIFILM Corporation

Inventor： Yuichi YOSHINO ,  Rie IWATA ,  Kentaro NAKAMURA

IPC: C12N5/077 ,  C07K14/78

CPC classification number: C12N5/0655 ,  A61K38/00 ,  A61L27/227 ,  A61L2300/252 ,  A61L2430/06 ,  C07K14/78 ,  C12N2501/998

Abstract: A polypeptide having an amino acid sequence in which the number of RGD sequences contained per molecular weight of 10 kDa is not less than 0.30; the number of GFPGER sequences contained per molecular weight of 10 kDa is not less than 0.15; and the number of GVMGFP sequences contained per molecular weight of 10 kDa is less than 0.30; is provided. A scaffold composition, a composition for repairing a cartilage tissue, a composition for culturing cartilage cells, and a composition for promoting glycosaminoglycan production, which compositions contain the above polypeptide, are also provided.

Abstract translation: 具有每分子量为10kDa的RGD序列数不少于0.30的氨基酸序列的多肽; 每分子量为10kDa的GFPGER序列数不低于0.15; 每分子量为10kDa的GVMGFP序列数小于0.30; 被提供。 还提供了一种支架组合物，用于修复软骨组织的组合物，用于培养软骨细胞的组合物和用于促进糖胺聚糖生产的组合物，该组合物含有上述多肽。

公开(公告)号：US20140371145A1

公开(公告)日：2014-12-18

申请号：US14340942

申请日：2014-07-25

Applicant: FUJIFILM Corporation

Inventor： Reiko IWAZAWA ,  Kentaro NAKAMURA

IPC: A61K47/42 ,  A61K38/18

CPC classification number: A61K47/42 ,  A61K38/1825 ,  A61L27/222 ,  A61L27/3808 ,  A61L27/507

Abstract: A scaffold for vascular endothelial cell migration includes a recombinant gelatin having an amino acid sequence derived from a partial amino acid sequence of collagen. A method for producing a blood vessel uses this scaffold.

Abstract translation: 用于血管内皮细胞迁移的支架包括具有衍生自胶原的部分氨基酸序列的氨基酸序列的重组明胶。 血管的制造方法使用该支架。

公开(公告)号：US20240299459A1

公开(公告)日：2024-09-12

申请号：US18590366

申请日：2024-02-28

Applicant: FUJIFILM Corporation ,  National University Corporation Tokyo Medical and Dental University

Inventor： Tsukasa KITAHASHI ,  Ryo KOGAWA ,  Kentaro NAKAMURA ,  Ichiro SEKIYA

IPC: A61K35/28 ,  A61P19/02 ,  C12N5/0775

CPC classification number: A61K35/28 ,  A61P19/02 ,  C12N5/0668

Abstract: An object of the present invention is to provide a therapeutic agent for arthrosis, which contains synovium-derived mesenchymal stem cells having a molecule essential for joint medical treatment, and a production method for the therapeutic agent for arthrosis. According to the present invention, there is provided a therapeutic agent for arthrosis, which contains synovium-derived mesenchymal stem cells having any one or more kinds of surface antigens of integrin β1 or platelet-derived growth factor receptor β.

公开(公告)号：US20240233867A1

公开(公告)日：2024-07-11

申请号：US18412092

申请日：2024-01-12

Applicant: FUJIFILM Corporation

Inventor： Kentaro NAKAMURA ,  Yuichi YOSHINO ,  Rie HANDO

IPC: G16B25/10 ,  A61K35/28 ,  C12N5/0775

CPC classification number: G16B25/10 ,  A61K35/28 ,  C12N5/0662

Abstract: An object of the present invention is to provide such a quality management method for a cell that enables the sorting-out of a cell having drug efficacy, and a method of producing a cell using the quality management method. According to the present invention, there is provided a method that is a quality management method for a specific cell, where the method includes evaluating a correlation relationship between an expression pattern of a gene group obtained by measuring an expression state of a related gene group that is characteristic of the specific cell and an expression pattern that serves as a reference and determining the cell to be usable in a case where the correlation relationship is equal to or higher than a certain level.

公开(公告)号：US20200246760A1

公开(公告)日：2020-08-06

申请号：US16805075

申请日：2020-02-28

Applicant: FUJIFILM Corporation

Inventor： Kentaro NAKAMURA ,  Ryo KOGAWA ,  Yusuke MOCHIZUKI ,  Ryuta TAKEGAMI

IPC: B01D71/68 ,  B01D71/44 ,  B01D69/02

Abstract: An object of the present invention is to provide a cell transplant device having an ability to induce angiogenesis around the cell transplant device, and a method for manufacturing the same. According to the present invention, a cell transplant device including a cell structure (A) that includes a plurality of biocompatible polymer blocks and a plurality of cells of at least one type, and in which at least one of the biocompatible polymer blocks is disposed in gaps between the plurality of cells; and an immunoisolation membrane (B) that encloses the cell structure is provided.

公开(公告)号：US20190008791A1

公开(公告)日：2019-01-10

申请号：US16139814

申请日：2018-09-24

Applicant: FUJIFILM Corporation ,  TERUMO KABUSHIKI KAISHA

Inventor： Kentaro NAKAMURA ,  Shinya SANO ,  Yosuke KURUMA ,  Tadashi SAMESHIMA

IPC: A61K9/70 ,  A61K35/34 ,  A61K47/42 ,  A61P9/00 ,  C08L89/00

Abstract: An object of the present invention is to provide a laminate containing a cell sheet which has hardness and is easy to handle at the time of transplantation or transport, an agent for treating cardiac diseases using the laminate, and a film for being laminated on a cell sheet. According to the present invention there are provided a laminate including a biocompatible polymer film having a density of 500 μg/cm2 to 10 mg/cm2 and a cell sheet disposed on at least one surface of the biocompatible polymer film, an agent for treating cardiac diseases using the laminate, and a film for being laminated on a cell sheet.

公开(公告)号：US20180064849A1

公开(公告)日：2018-03-08

申请号：US15705826

申请日：2017-09-15

Applicant: FUJIFILM Corporation ,  JAPAN TISSUE ENGINEERING CO., LTD.

Inventor： Kentaro NAKAMURA ,  Hayato MIYOSHI ,  Satoko HADA ,  Masatoki WATANABE

IPC: A61L27/36 ,  A61L27/56 ,  A61L27/54 ,  A61K35/32 ,  A61L27/38

CPC classification number: A61L27/3654 ,  A61F2002/30766 ,  A61K35/28 ,  A61K35/32 ,  A61K38/17 ,  A61K38/39 ,  A61L27/222 ,  A61L27/3834 ,  A61L27/3852 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2430/06

Abstract: An object of the invention is to provide a cartilage regenerative material that is capable of regenerating bone and cartilage using cells. Provided is a cartilage regenerative material including a cell construct, which includes biocompatible polymer blocks and stem cells, in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the stem cells.

公开(公告)号：US20240287465A1

公开(公告)日：2024-08-29

申请号：US18662797

申请日：2024-05-13

Applicant: FUJIFILM Corporation ,  Tokushima University

Inventor： Kentaro NAKAMURA ,  Mitsuo SHIMADA ,  Tetsuya IKEMOTO

IPC: C12N5/071

CPC classification number: C12N5/0676 ,  C12N2500/38 ,  C12N2501/12 ,  C12N2501/16 ,  C12N2501/335 ,  C12N2506/1384

Abstract: An object of the present invention is to provide a method for producing insulin-producing cells having sufficient glucose responsiveness from mesenchymal stem cells, an insulin-producing cell having sufficient glucose responsiveness, a cell structure containing the insulin-producing cell, and a pharmaceutical composition. According to the present invention, there is provided a method for producing an insulin-producing cell from a mesenchymal stem cell, including (a) a step of producing a cell structure by incubating a plurality of biocompatible macromolecular blocks and a plurality of mesenchymal stem cells, and (b) a step of culturing one or more of the mesenchymal stem cells before the incubation in the step (a), the mesenchymal stem cell in the incubation in the step (a), or the cell structure produced in the step (a) in a medium containing the GLP-1 receptor agonist, and (c) a step of culturing the cell structure obtained in the step (a) or the step (b) in a medium containing the water-soluble vitamin and the hepatocyte growth factor.

公开(公告)号：US20240191294A1

公开(公告)日：2024-06-13

申请号：US18410502

申请日：2024-01-11

Applicant: FUJIFILM Corporation

Inventor： Kentaro NAKAMURA ,  Tsukasa KITAHASHI ,  Yuichi YOSHINO ,  Ryo KOGAWA

IPC: C12Q1/6876 ,  A61K35/28 ,  A61P19/02

CPC classification number: C12Q1/6876 ,  A61K35/28 ,  A61P19/02 ,  C12Q2600/158

Abstract: An object of the present invention is to provide such a quality management method for a cell that enables the sorting-out of a cell having drug efficacy, and a method of producing a cell using the quality management method. According to the present invention, there is provided a method that is a quality management method for a cell for a medical treatment or drug discovery, the method including managing a behavior of one or more specific protein molecules, which is essential for exhibiting a therapeutic effect due to a cell and managing an expression behavior of a related gene group that is characteristic of the cell.