公开(公告)号：US20210395656A1

公开(公告)日：2021-12-23

申请号：US17462025

申请日：2021-08-31

Applicant: FUJIFILM CORPORATION

Inventor： Hidetoshi TAKAYAMA ,  Koju ITO ,  Takahiro OBA ,  Keisuke OKU

IPC: C12M1/00

Abstract: There is provided an incubator including an accommodation space that is shielded from an external environment, an environmental control unit that controls an environment of the inside of the accommodation space, a power supply unit that is provided in the accommodation space and transmits electric power to a power supply target in a noncontact state, and a partition wall that is provided in the accommodation space and shields electromagnetic waves radiated from the power supply unit.

公开(公告)号：US20200095527A1

公开(公告)日：2020-03-26

申请号：US16695063

申请日：2019-11-25

Applicant: FUJIFILM CORPORATION

Inventor： Takahiro OBA ,  Akira WAKABAYASHI ,  Koju ITO

IPC: C12M3/06 ,  C12M1/12 ,  B81B3/00

Abstract: A microchannel device includes: a channel unit which is configured of a plurality of channel members which are laminated in a thickness direction to define a microchannel, at least one of the channel members being made of a material having elasticity; and a holding member which is provided separately from or integrally with the channel unit and holds the channel unit in a state of being compressed in the thickness direction.

公开(公告)号：US20160046828A1

公开(公告)日：2016-02-18

申请号：US14840648

申请日：2015-08-31

Applicant: FUJIFILM CORPORATION

Inventor： Koju ITO ,  Hiroshi YABU ,  Yuta SAITO

IPC: C09D133/26 ,  B05D5/00 ,  B05D1/30

CPC classification number: C09D133/26 ,  B05D1/30 ,  B05D5/00 ,  B29C41/24 ,  B29C59/005 ,  B29C70/64 ,  B29D7/00 ,  C08K3/22 ,  C08K2003/2241

Abstract: A protrusion/recess structure in which fine particles will not drop easily and which will not be deformed easily is provided, and a producing method for the same is provided. In the protrusion/recess structure (porous film), protrusions or recesses (fine corrugations) are formed in a surface. The protrusion/recess structure is formed from plural fine particles and an amphipathic high molecular compound having a catechol group. The high molecular compound at least partially coats a surface of the fine particles, to adhere the fine particles to one another. A diameter of the recesses is larger than a diameter of the fine particles. Cast film is formed from solution containing the fine particles and the high molecular compound having the catechol group. Condensation on the cast film is performed, and organic solvent and water droplets created by the condensation are evaporated to produce the protrusion/recess structure.

Abstract translation: 提供了一种突起/凹陷结构，其中细颗粒不会容易地下落并且不容易变形，并且提供了其制造方法。 在突出/凹陷结构（多孔膜）中，在表面上形成突起或凹陷（细微波纹）。 突起/凹部结构由多个细小颗粒和具有儿茶酚基的两亲性高分子化合物形成。 高分子化合物至少部分地涂覆细颗粒的表面，以将细颗粒彼此粘附。 凹部的直径大于微粒的直径。 流延膜由含有微粒和具有儿茶酚基的高分子化合物的溶液形成。 进行流延薄膜上的冷凝，通过冷凝产生的有机溶剂和水滴蒸发以产生突出/凹陷结构。

公开(公告)号：US20140065202A1

公开(公告)日：2014-03-06

申请号：US14075614

申请日：2013-11-08

Applicant: FUJIFILM Corporation

Inventor： Koju ITO

IPC: A61K9/70

CPC classification number: A61K9/7007 ,  A61K9/7084 ,  A61K45/06 ,  B32B7/12 ,  B32B27/08 ,  B32B2307/7163 ,  B32B2535/00

Abstract: A composite film comprises a drug sustained-release portion and an adhesive portion which are layered on each other. The drug sustained-release portion has film-like drug layers and a film-like biodegradable polymer layer. The drug sustained-release portion has the drug layer, the biodegradable polymer layer, and the drug layer in this order from the adhesive portion side. Each drug layer is a drug form containing a drug of a predetermined concentration or more. The drug is released from the drug layer exposed. When the drug layer disappears, a biodegradable polymer of the biodegradable polymer layer starts to degrade and/or dissolve. When the biodegradable polymer layer disappears, the drug is released from the drug layer adjoining the adhesive portion. A plurality of pores are formed in the adhesive portion. The pores retain water due to capillary force.

Abstract translation: 复合膜包括彼此层叠的药物缓释部和粘合部。 药物缓释部分具有膜状药物层和膜状可生物降解聚合物层。 药物缓释部从粘合部侧依次具有药物层，生物降解性聚合物层和药物层。 每个药物层是含有预定浓度或更多浓度的药物的药物形式。 药物从暴露的药物层释放出来。 当药物层消失时，可生物降解的聚合物层的可生物降解的聚合物开始降解和/或溶解。 当可生物降解聚合物层消失时，药物从邻接粘合剂部分的药物层释放。 在粘合剂部分中形成多个孔。 由于毛细管力，孔隙保持水分。

公开(公告)号：US20220119763A1

公开(公告)日：2022-04-21

申请号：US17556880

申请日：2021-12-20

Applicant: FUJIFILM CORPORATION

Inventor： Keisuke OKU ,  Koju ITO ,  Koji NAKAZAWA

IPC: C12N5/071 ,  C12M1/12

Abstract: Provided are a method for producing a hepatocyte culture and a method for improving or maintaining a function of a hepatocyte or a hepatic progenitor cell, each method including a culturing step of culturing a hepatocyte or a hepatic progenitor cell inside at least a part of a plurality of opening pores and communication pores of a porous film having the plurality of opening pores provided on a surface thereof and the communication pores for communicating the opening pores adjacent to each other; and a cell-containing porous film.

公开(公告)号：US20200369998A1

公开(公告)日：2020-11-26

申请号：US16986259

申请日：2020-08-06

Applicant: FUJIFILM CORPORATION

Inventor： Hayato MIYOSHI ,  Koju ITO ,  Takahiro OBA ,  Akira WAKABAYASHI

IPC: C12M3/06 ,  C12M1/12 ,  B81B1/00

Abstract: Provided is a microchannel device including a first microchannel that is formed in a first channel member, a second microchannel that is formed in a second channel member and at least a portion of which overlaps the first microchannel in plan view with a step portion formed between the first microchannel and the second microchannel, a porous membrane that has a plurality of holes penetrating the porous membrane in a thickness direction and is disposed between the first channel member and the second channel member to partition the first microchannel and the second microchannel, and a reinforcing member that is provided between the first channel member or the second channel member and the porous membrane, is higher in stiffness than the porous membrane, and reinforces at least a portion of the porous membrane that faces the step portion.

公开(公告)号：US20180356398A1

公开(公告)日：2018-12-13

申请号：US15618150

申请日：2017-06-09

Applicant: FUJIFILM Corporation ,  The General Hospital Corporation

Inventor： Koju ITO ,  Chihaya KAKINUMA ,  Masafumi NISHINO ,  Shinji MIMA ,  Craig M Neville ,  Cathryn A Sundback

IPC: G01N33/50

CPC classification number: G01N33/5088 ,  G01N33/5023 ,  G01N33/5044 ,  G01N33/5061 ,  G01N33/5064

Abstract: A living tissue model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a cell layered body disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. A vascular wall model includes: a porous membrane having a honeycomb structure; a vascular endothelial cell layer disposed on one face of the porous membrane; and a smooth muscle cell layer, or a mesenchymal stem cell layer, disposed on another face of the porous membrane. A vascular wall model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a vascular wall model disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. Applications of these models or model devices are also provided.

公开(公告)号：US20180216075A1

公开(公告)日：2018-08-02

申请号：US15939300

申请日：2018-03-29

Applicant: FUJIFILM Corporation

Inventor： Koju ITO ,  Shun GOTO ,  Souichi KOHASHI

IPC: C12N5/071 ,  C12M3/00 ,  C12M1/12

CPC classification number: C12N5/0671 ,  C12M21/08 ,  C12M23/34 ,  C12M25/02 ,  C12M25/14 ,  C12M33/00 ,  C12N1/04 ,  C12N5/0068 ,  C12N2533/40

Abstract: Provided is a composite binder material, a cell aggregate, a cell accumulation method, a cell preservation method, and a method of manufacturing a composite binder that can supply oxygen and nutrients to cells.A composite binder material comprises a binder material and a cell non-adhesive portion. A binder material formed in a membrane shape is provided between a first cell sheet and a second cell sheet. The cell non-adhesive portion formed at least in a portion of one membrane surface and/or other membrane surface of the binder material. A plurality of pores are formed in the binder material, and the pores open to the one membrane surface coming into contact with one sheet surface of the first cell sheet. The pores penetrate in a thickness direction and a surface direction along the one membrane surface. The porosity of the binder material is set to be at least 50%.

公开(公告)号：US20160257903A1

公开(公告)日：2016-09-08

申请号：US15057583

申请日：2016-03-01

Applicant: FUJIFILM Corporation

Inventor： Koju ITO ,  Hiroshi YABU ,  Jun KAMEI

IPC: C10M169/04 ,  C10M147/02 ,  B05D3/12 ,  C10M107/02 ,  B29D99/00 ,  B05D5/08

CPC classification number: C10M169/041 ,  B05D3/12 ,  B05D5/083 ,  B29D99/0089 ,  B29K2023/18 ,  B29K2105/045 ,  B29K2995/0093 ,  C10M107/02 ,  C10M107/14 ,  C10M107/38 ,  C10M107/46 ,  C10M109/02 ,  C10M147/02 ,  C10M177/00 ,  C10M2205/063 ,  C10N2250/141

Abstract: Provided are a lubricating material which is made of a non-fluorine-based compound and thus has a surface that is slippery enough for liquid such as water or oil, a lubricant-holding base material which holds a fluorine-based lubricant and thus can be used as a lubricating material, and methods for producing the same. A slippery film has a holding base and a lubricant. The holding base has pillar structure portions and fluorine-containing portions, and the fluorine-containing portions are provided on outer surfaces of a plurality of pillar portions in the pillar structure portion. The lubricant is a fluorine-based liquid, and the fluorine-containing portion has a C—F bond. The lubricant is loaded into a region surrounded by a plurality of the pillar portions and is held in this region.

Abstract translation: 本发明提供一种由非氟系化合物制成的润滑材料，具有对水，油等液体的光滑的表面，保持氟系润滑剂的润滑剂保持基材，因此可以 用作润滑材料，及其制造方法。 滑溜膜具有保持底座和润滑剂。 保持基部具有支柱结构部分和含氟部分，并且氟化物部分设置在柱状结构部分中的多个柱部分的外表面上。 润滑剂为氟系液体，含氟部分为C-F键。 润滑剂被装载到由多个柱部包围的区域中并保持在该区域中。

公开(公告)号：US20160082148A1

公开(公告)日：2016-03-24

申请号：US14851467

申请日：2015-09-11

Applicant: FUJIFILM CORPORATION

Inventor： Koju ITO ,  Souichi KOHASHI ,  Hidekazu YAMAZAKI ,  Kenichiro HATA ,  Katsura SUGAWARA ,  Eiko GOTO ,  Masatsugu SHIMOMURA ,  Hiroshi YABU ,  Takahito KAWANO

IPC: A61L27/18 ,  A61L27/56

CPC classification number: A61L31/06 ,  A61L15/425 ,  A61L15/58 ,  A61L15/64 ,  C08L67/04

Abstract: Disclosed is a film which is able to suppress agglutination by being continuously adhered to an adhesion target portion in a biological body while suppressing a position shift. A film includes an adhesive and an adhesion inhibiting layer. The adhesive layer absorbs and maintains a liquid in a plurality of pores which are opened in one film surface and has a capillary force for adhering the adhesive layer to a first-cell group. The adhesive layer is formed of a biodegradable polymer. The adhesion inhibiting layer configures the other film surface, and inhibits adhesion between a second-cell group which is different from the first-cell group and the adhesive layer. In the adhesive layer, the pore is formed not to be penetrated in a thickness direction of the film, and thus the first-cell group and the second-cell group are separated into the one film surface side and the other film surface side.

Abstract translation: 公开了一种能够通过在抑制位置偏移的同时在生物体中连续粘附到粘合目标部分来抑制凝集的膜。 膜包括粘合剂和粘附抑制层。 粘合剂层吸收并保持在一个膜表面中打开的多个孔中的液体，并且具有用于将粘合剂层粘合到第一电池组的毛细管力。 粘合剂层由可生物降解的聚合物形成。 粘合抑制层构成另一个膜表面，并且抑制不同于第一电池组的第二电池组与粘合剂层之间的粘合。 在粘合剂层中，形成不在膜的厚度方向上穿透的孔，因此第一电池组和第二电池组分离成一个膜表面侧和另一个膜表面侧。