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    Connector for aseptic connection
    11.
    发明授权
    Connector for aseptic connection 有权

    公开(公告)号：US10449350B2

    公开(公告)日：2019-10-22

    申请号：US15032249

    申请日：2014-11-05

    Applicant: GE Healthcare Bio-Sciences AB

    Inventor： Klaus Gebauer

    IPC: F16L55/24 ,  A61M39/10 ,  A61M39/18 ,  A61M39/16 ,  C12M1/12

    Abstract: Provided is a connector for substantially aseptic connection of tubing, that includes a central tubular stem member with a line connection end and a coupling end having an annular gasket arranged to engage a similar annular gasket on a similar second connector in sealing abutment and a tubular socket member, concentrically arranged outside the stem member, having a flange concentrically arranged outside the coupling end and a cover film releasably bonded to the flange and covering the coupling end of the stem member, the annular gasket and at least a portion of the flange. The socket member is rotatable around the stem member and the connector also has an annular seal member in sealing abutment between an inside of the socket member and an outside of the stem member.

    Apparatus and method for making a sterile connection of flexible tubing
    13.
    发明授权
    Apparatus and method for making a sterile connection of flexible tubing 有权

    公开(公告)号：US10195416B2

    公开(公告)日：2019-02-05

    申请号：US14892649

    申请日：2014-05-19

    Applicant: GE Healthcare Bio-Sciences AB

    Inventor： Klaus Gebauer ,  Eric Faldt ,  Nachiket Karmarkar

    IPC: A61M39/18 ,  F16L33/30

    Abstract: An apparatus for substantially sterile connection of flexible tubing, including at least one tubing holder, which is adapted to receive one or more lengths of flexible tubing and which is also equipped with one or more sterilant applicators. The sterilant applicator is adapted to apply a sterilant to the length of tubing when the tubing length is received in the tubing holder. At least one cutter, which is movable in relation to the tubing holder and adapted to cut the length of tubing. A connector holder, which includes a compartment housing and a substantially sterile tubing connector. The connector holder is movable in relation to the tubing holder to a position where the length of tubing and the sterile tubing connector are aligned and can be urged together.

    Valve Manifolds for Simulated Moving Bed Chromatography
    15.
    发明申请
    Valve Manifolds for Simulated Moving Bed Chromatography 审中-公开

    公开(公告)号：US20170361245A1

    公开(公告)日：2017-12-21

    申请号：US15534540

    申请日：2015-12-23

    Applicant: GE HEALTHCARE BIO-SCIENCES AB

    Inventor： Klaus Gebauer ,  Bjorn Markus Olovsson

    IPC: B01D15/18 ,  G01N30/20 ,  G01N30/88

    CPC classification number: B01D15/1842 ,  G01N30/20 ,  G01N30/42 ,  G01N30/88 ,  G01N2030/205 ,  G01N2030/8881

    Abstract: Disclosed is a device for chromatographic separations comprising: a manifold comprising a manifold body defining an elongate central duct, the central duct comprising a centrally-located closable duct valve providing selective fluid communicationGo between a first portion of the central duct and an opposed second portion of the central duct, a first plurality of connectors, each connector of the first plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; a second plurality of connectors, each connector of the second plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; wherein said manifold body further defines: a first plurality of branch ducts, each branch duct of which extending from the first portion of the central duct to an individual one of the first plurality of connectors, each of the branch ducts of the first plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the first portion of the central duct, a second plurality of branch ducts, each branch duct of which extending from the second portion of the central duct to an individual one of the second plurality of connectors, each of the branch ducts of the second plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the second portion of the central duct; first and second ports in fluid communication with the centrally-located closable duct valve wherein said first port communicates with said first portion of the central duct and said second port communicates with said second portion of said central duct, wherein one of said first and second ports is further positioned to communicate with said central duct at a location between the centrally-located closable duct valve and the first and second plurality of branch ducts, respectively.

    Distribution plate for crossflow filtration cassettes
    16.
    发明授权
    Distribution plate for crossflow filtration cassettes 有权

    公开(公告)号：US09718028B2

    公开(公告)日：2017-08-01

    申请号：US14359328

    申请日：2012-12-17

    Applicant: GE HEALTHCARE BIO-SCIENCES AB

    Inventor： Karl Ekstrom ,  Klaus Gebauer ,  Hakan Lundstrom ,  Patrik Akerstrom

    IPC: B01D63/08

    CPC classification number: B01D63/08 ,  B01D63/081 ,  B01D63/082 ,  B01D2313/10 ,  B01D2313/105 ,  B01D2313/12 ,  B01D2313/125 ,  B01D2313/13 ,  B01D2313/21 ,  B01D2313/54 ,  B01D2317/04 ,  Y10T408/03

    Abstract: The invention discloses a distribution plate for supplying crossflow filtration cassettes, which comprises a surface, two opposite end walls, two opposite side walls, a feed channel in fluid communication with a feed inlet port and with a plurality of feed apertures; a retentate channel in fluid communication with a retentate outlet port, and with a plurality of retentate apertures; and a permeate channel in fluid communication with two permeate outlet ports and with a plurality of permeate apertures;wherein the feed channel, the retentate channel and the permeate channel extend in a direction essentially parallel with one or both side walls;wherein the feed apertures are grouped at a first area on the surface, the retentate apertures are grouped at a second area on the surface;wherein the permeate apertures are located at the first and/or the second area; andwherein a plurality of permeate connector channels extend inside the plate from at least one region of the permeate channel, adjacent the permeate outlet ports and the permeate connector channels provide fluidic communication between the permeate apertures and the permeate channel.

    SYSTEMS AND METHODS FOR STATUS INDICATION IN A SINGLE-USE BIOMEDICAL AND BIOPROCESS SYSTEM
    17.
    发明申请
    SYSTEMS AND METHODS FOR STATUS INDICATION IN A SINGLE-USE BIOMEDICAL AND BIOPROCESS SYSTEM 有权
    在单一生物医学和生物系统系统中用于状态指示的系统和方法

    公开(公告)号：US20150137992A1

    公开(公告)日：2015-05-21

    申请号：US14086117

    申请日：2013-11-21

    Applicant: GE HEALTHCARE BIO-SCIENCES AB

    Inventor： Radislav A. Potyrailo ,  Klaus Gebauer ,  Kajsa Stridsberg-Friden ,  Timothy A. Wortley

    IPC: H04Q9/00

    CPC classification number: G08B21/18 ,  A61L2/24 ,  C12M41/48 ,  G01N27/3272 ,  G06K19/0702 ,  G06K19/0707 ,  G06K19/07745 ,  H04Q9/00 ,  H04Q2209/30 ,  H04Q2209/47

    Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioproces sing platform including the component.

    Abstract translation: 公开和描述了在生物处理环境中监测组件状态的方法，系统和装置。 某些实例提供了用于一次性生物处理组件的传感器装置。 示例性传感器设备包括附接到部件的第一部分，第一部分被配置为提供与部件相关联的标识符。 示例性传感器设备还包括被配置为基于组件的状态提供状态指示的第二部分。 示例性传感器设备被配置为将标识符和状态指示发送到与包括该组件的生物处理平台相关联的控制计算机。

    PACKING SYSTEM AND METHOD FOR CHROMATOGRAPHY COLUMNS
    18.
    发明申请
    PACKING SYSTEM AND METHOD FOR CHROMATOGRAPHY COLUMNS 有权
    色谱柱的包装系统和方法

    公开(公告)号：US20130062267A1

    公开(公告)日：2013-03-14

    申请号：US13672832

    申请日：2012-11-09

    Applicant: GE HEALTHCARE BIO-SCIENCES AB

    Inventor： Klaus Gebauer

    IPC: B01D15/20

    CPC classification number: B01D15/206 ,  B01D15/14 ,  B01D15/22 ,  G01N30/56 ,  G01N30/6021 ,  G01N30/603 ,  G01N30/606 ,  G01N2030/565

    Abstract: The invention relates to a method for providing an aseptic chromatography column, said method comprising the steps of: pre-sterilize an empty chromatography column; pre-sterilize a chromatography medium; introducing the pre-sterilized chromatography medium into the pre-sterilized chromatography column using aseptic equipment, thereby providing an aseptic chromatography column comprising chromatography medium.

    Abstract translation: 本发明涉及一种提供无菌色谱柱的方法，所述方法包括以下步骤：对空色谱柱进行预消毒; 对色谱介质进行预灭菌; 使用无菌设备将预灭菌色谱介质引入预灭菌色谱柱，从而提供包含色谱介质的无菌色谱柱。

    Method for Pressure Control in Crossflow Filtration
    19.
    发明申请
    Method for Pressure Control in Crossflow Filtration 审中-公开

    公开(公告)号：US20200282361A1

    公开(公告)日：2020-09-10

    申请号：US16077779

    申请日：2017-02-21

    Applicant: GE HEALTHCARE BIO-SCIENCES AB

    Inventor： Klaus Gebauer ,  Sudheer Mygapula ,  Nachiket Karmarkar ,  Sasikumar Arumugam ,  Bashkar HV ,  Ajit S. Vernekar ,  Nityananda Maiya ,  Prashanth Hosabettu Mohan ,  Sasi Kumar Nutalapati ,  Sameera Simha Hindupur ,  Shashidhar Hedge

    IPC: B01D61/12 ,  B01D61/22 ,  F16K7/06 ,  F16K7/07 ,  G05D16/20

    Abstract: The invention discloses embodiments of different high precision pinch control valves having an accuracy in the micron range and a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump (21) fluidically connected via a retentate compartment (33) of a crossflow filter (32) and a length of flexible tubing to Sa regulator valve (1;101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve. The apparatus further comprises a first pressure transducer (22) adapted to measure a pressure between the retentate compartment and the regulator valve, a second pressure transducer (39) adapted to measure a pressure between the pump and the retentate compartment and a third pressure transducer (40) adapted to measure a pressure at a permeate outlet (36) of the crossflow filter, and a control unit (23) electrically or electromagnetically connected to said regulator valve, the first, second and third pressure transducers and optionally to the pump; b) pumping a liquid with the pump via the second pressure transducer, through the retentate compartment via the length of flexible tubing, the first pressure transducer and the regulator valve; c) controlling the regulator valve with the control unit, such that a TMP calculated by formula (I) TMP=(Pinlet+Poutlet/2−Pperm  (I)

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