公开(公告)号：US10040073B2

公开(公告)日：2018-08-07

申请号：US14764919

申请日：2014-01-29

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： Nils Norrman ,  Pierre Le Greves

IPC: B03C1/00 ,  B03C1/01 ,  B03C1/02 ,  B01D11/04 ,  B01D15/38 ,  B01J20/24 ,  B01J20/26 ,  B01J20/28 ,  B01J20/32 ,  C02F1/48 ,  C07K1/14 ,  H01F1/44 ,  C02F101/30

Abstract: A method for purifying a substance in a solution in a simple streamlined process using a magnetic porous particle. For easy small scale purification of a substance, the magnetic porous particle is coated with either a hydrophilic or hydrophobic liquid and transferred into a second liquid containing the substance under conditions which allow said substance to partition into the first liquid within said magnetic porous particle. Finally the magnetic porous particle is removed from said second liquid, wherein the first and second liquid are substantially immiscible and the partition coefficient P of the substance between the first and second liquid is greater than 1.

公开(公告)号：US09987628B2

公开(公告)日：2018-06-05

申请号：US15101337

申请日：2014-11-26

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Tobias Ingemar Solderman ,  Nils Norrman ,  Henrik Ostlin ,  Susanna Lindman ,  David Carl Martin Bergman ,  Peter Mats Oliviusson

IPC: B01L3/00 ,  G01N35/00 ,  G01N21/07 ,  B04B5/04 ,  G01N35/10 ,  G01N27/447 ,  G01N35/04

CPC classification number: B01L3/5025 ,  B01L3/502 ,  B01L3/5085 ,  B01L3/50855 ,  B01L2200/028 ,  B01L2200/0621 ,  B01L2200/0631 ,  B01L2300/0803 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0478 ,  G01N21/07 ,  G01N27/44739 ,  G01N35/00 ,  G01N35/1065 ,  G01N2035/00108 ,  G01N2035/0439

Abstract: The present invention provides methods and systems for eluting and an analyte from a solid phase. The invention further provides methods and systems for transferring liquid analyte reagent mixtures from a solid phase to a second vessel, such as a microtiter plate well. The invention is useful in the manipulation of biological molecules such as nucleic acids, carbohydrates, proteins and peptides. In particular, the invention has utility for manipulating proteins and peptides in isoelectric focusing gels.

公开(公告)号：US20160303561A1

公开(公告)日：2016-10-20

申请号：US15101234

申请日：2014-11-25

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： Nils Norrman ,  Henrik Ostlin

IPC: B01L3/00

Abstract: The present invention provides a microplate comprised of multiwell strips connected in such a way as to permit the microplate to unfold and to pass in a linear fashion past a fraction collector and then re-fold back into a microplate configuration. Furthermore, the invention provides for the use of the microplates of the invention in a variety of different laboratory methods.

Abstract translation: 本发明提供了一种微孔板，其包括多孔条，其以这样的方式连接，以允许微孔板展开并以线性方式穿过级分收集器，然后重新折回到微板构型。 此外，本发明提供了本发明微量培养板在各种不同实验室方法中的应用。

公开(公告)号：US20150151276A1

公开(公告)日：2015-06-04

申请号：US14407892

申请日：2013-06-11

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Gunnar Glad ,  Therese Graner ,  Nils Norrman

IPC: B01J20/291 ,  B01D15/38 ,  B01J20/26 ,  C12N9/10 ,  C07K1/22 ,  B01J20/28

CPC classification number: B01J20/291 ,  B01D15/3804 ,  B01D15/3885 ,  B01D2015/3838 ,  B01J20/265 ,  B01J20/28009 ,  B01J20/288 ,  B01J20/3212 ,  B01J20/3251 ,  B01J20/3274 ,  B01J2220/80 ,  C07K1/22 ,  C07K2319/23 ,  C12N9/1088

Abstract: The present invention relates to a novel non-cross linked chromatography media provided with glutathione ligands which may or may not be provided with magnetic particles. The chromatography media is used for production of an affinity media provided with gluthatione ligands for adsorption of GST-tagged proteins.

Abstract translation: 本发明涉及提供有或不具有磁性颗粒的谷胱甘肽配体的新型非交联色谱介质。 色谱介质用于生产具有用于吸附GST标记的蛋白质的凝胶配体的亲和介质。