公开(公告)号：US08809330B2

公开(公告)日：2014-08-19

申请号：US14069685

申请日：2013-11-01

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Constantine G. Boojamra ,  Eugene J. Eisenberg ,  Hon Chung Hui ,  Richard L. Mackman ,  Jay P. Parrish ,  Michael Sangi ,  Oliver L. Saunders ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: A61P31/14

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K31/675 ,  A61K45/06 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07F9/65616

Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Abstract translation: 本发明提供了本文所述的式I或式II化合物或其药学上可接受的盐或酯。 其化合物及其组合物可用于治疗肺炎链球菌病毒感染。 提供的化合物，组合物和方法特别可用于治疗人呼吸道合胞病毒感染。

公开(公告)号：US20250122219A1

公开(公告)日：2025-04-17

申请号：US18911404

申请日：2024-10-10

Applicant: Gilead Sciences, Inc.

Inventor： Megan K. Armstrong ,  Chienhung Chou ,  Ana Z. Gonzalez Buenrostro ,  Xiaochun Han ,  Lan Jiang ,  Jiayao Li ,  Gregg M. Schwarzwalder ,  Qiaoyin Wu ,  Hai Yang

IPC: C07D498/22 ,  A61K31/55 ,  A61K45/06

Abstract: The present disclosure relates generally to compounds, of Formula I: Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

公开(公告)号：US20240279186A1

公开(公告)日：2024-08-22

申请号：US18428316

申请日：2024-01-31

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:






or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20240174704A1

公开(公告)日：2024-05-30

申请号：US18354362

申请日：2023-07-18

Applicant: GILEAD SCIENCES, INC.

Inventor： Gregory F. Chin ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Dustin S. Siegel ,  Hai Yang

IPC: C07F9/6561 ,  A61P31/14

CPC classification number: C07F9/6561 ,  A61P31/14

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US11919869B2

公开(公告)日：2024-03-05

申请号：US18050404

申请日：2022-10-27

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:




or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20230183189A1

公开(公告)日：2023-06-15

申请号：US18050404

申请日：2022-10-27

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:




or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20220356196A1

公开(公告)日：2022-11-10

申请号：US17176497

申请日：2021-02-16

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Byoung-kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  David Sperandio ,  Hai Yang ,  Lijun Zhang

IPC: C07F9/6561

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US20220241281A1

公开(公告)日：2022-08-04

申请号：US17496962

申请日：2021-10-08

Applicant: Gilead Sciences, Inc.

Inventor： Gregory Chin ,  Michael O`Neil Hanrahan Clarke ,  Xiaochun Han ,  Tim Hansen ,  Yunfeng Eric Hu ,  Dmitry Koltun ,  Ryan McFadden ,  Michael R. Mish ,  Eric Q. Parkhill ,  David Sperandio ,  Lianhong Xu ,  Hai Yang

IPC: A61K31/519 ,  A61K45/06 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D519/00

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.

公开(公告)号：US11179397B2

公开(公告)日：2021-11-23

申请号：US16591092

申请日：2019-10-02

Applicant: Gilead Sciences, Inc.

Inventor： Gregory Chin ,  Michael O' Neil Hanrahan Clarke ,  Xiaochun Han ,  Tim Hansen ,  Yunfeng Eric Hu ,  Dmitry Koltun ,  Ryan McFadden ,  Michael R. Mish ,  Eric Q. Parkhill ,  David Sperandio ,  Lianhong Xu ,  Hai Yang

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  C07D471/04 ,  C07D471/10 ,  C07D519/00

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.

公开(公告)号：US10017501B2

公开(公告)日：2018-07-10

申请号：US15239422

申请日：2016-08-17

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Gregory Chin ,  Britton Kenneth Corkey ,  Jinfa Du ,  Kristyna Elbel ,  Robert H. Jiang ,  Tetsuya Kobayashi ,  Rick Lee ,  Ruben Martinez ,  Samuel E. Metobo ,  Michael Mish ,  Manuel Munoz ,  Sophie Shevick ,  David Sperandio ,  Hai Yang ,  Jeff Zablocki

IPC: C07D413/04 ,  C07D453/02 ,  C07D417/04 ,  C07D413/14 ,  C07D471/04 ,  C07D417/14

CPC classification number: C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.