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公开(公告)号：US09724360B2
公开(公告)日：2017-08-08
申请号：US14926062
申请日：2015-10-29
Applicant: Gilead Sciences, Inc.
Inventor： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC: C07H15/18 , C07H7/06 , A61K31/685 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00
CPC classification number: A61K31/685 , A61K31/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/675 , A61K31/683 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/2429 , C07F9/65616 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K2300/00
Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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![PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT](/abs-image/US/2017/07/06/US20170190708A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170190708A1
公开(公告)日：2017-07-06
申请号：US15347494
申请日：2016-11-09
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC: C07D487/04
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616
Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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公开(公告)号：US08809527B2
公开(公告)日：2014-08-19
申请号：US14089633
申请日：2013-11-25
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
Abstract translation: 提供了式II的TLR的调节剂：其药学上可接受的盐，含有这些化合物的组合物和包括施用这些化合物的治疗方法。
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![PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS](/abs-image/US/2013/06/27/US20130164280A1/abs.jpg.150x150.jpg)
公开(公告)号：US20130164280A1
公开(公告)日：2013-06-27
申请号：US13722962
申请日：2012-12-20
Applicant: Gilead Sciences, Inc.
Inventor： Constantine G. Boojamra , Hon Chung Hui , Petr Jansa , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Dustin Siegel , David Sperandio , Hai Yang
IPC: A61K45/06 , A61K31/519 , A61K31/675 , A61K31/538 , C07F9/6561 , C07D487/04 , C07D487/08
CPC classification number: A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/675 , A61K45/06 , C07D487/04 , C07D487/08 , C07D519/00 , C07F9/6561
Abstract: The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.
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公开(公告)号：US11110091B2
公开(公告)日：2021-09-07
申请号：US16201221
申请日：2018-11-27
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D243/00 , C07D403/10 , C07D403/12 , C07D487/22 , A61K31/519 , C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04 , A61K31/5377 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , C07D475/10 , A61K31/527 , A61K31/551 , A61K45/06
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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Patent Agency Ranking
![PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT](/abs-image/US/2017/12/21/US20170362244A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170362244A1
公开(公告)日：2017-12-21
申请号：US15639970
申请日：2017-06-30
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC: C07D487/04 , C07D519/00 , C07D513/04 , C07D495/04 , A61K45/06 , A61K31/675 , A61K31/551 , A61K31/55 , A61K31/5377 , C07F9/6561 , A61K31/519
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616
Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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公开(公告)号：US09127006B2
公开(公告)日：2015-09-08
申请号：US14321689
申请日：2014-07-01
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04 , C07D475/10 , A61K31/519 , A61K31/5377 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , C07D403/12
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
Abstract translation: 提供了式II的TLR的调节剂：其药学上可接受的盐，含有这些化合物的组合物和包括施用这些化合物的治疗方法。
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![PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS](/abs-image/US/2015/06/18/US20150166546A1/abs.jpg.150x150.jpg)
公开(公告)号：US20150166546A1
公开(公告)日：2015-06-18
申请号：US14566340
申请日：2014-12-10
Applicant: Gilead Sciences, Inc.
Inventor： Constantine G. Boojamra , Hon Chung Hui , Petr Jansa , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Dustin Siegel , David Sperandio , Hai Yang
IPC: C07D487/04
CPC classification number: A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/675 , A61K45/06 , C07D487/04 , C07D487/08 , C07D519/00 , C07F9/6561
Abstract: The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.
Abstract translation: 本发明提供了用于治疗病毒感染的化合物及其药学上可接受的盐和酯及其组合物。 化合物和组合物可用于治疗肺炎链球菌病毒感染，包括人呼吸道合胞病毒感染。
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公开(公告)号：US20130273037A1
公开(公告)日：2013-10-17
申请号：US13865069
申请日：2013-04-17
Applicant: GILEAD SCIENCES, INC.
Inventor： Dustin Siegel , David Sperandio , Hai Yang , Michael Sangi , Jay P. Parrish , Hon Chung Hui
IPC: C07D487/04 , C07D471/04 , A61K45/06 , C07D519/00
CPC classification number: C07D487/04 , A61K31/4545 , A61K31/5025 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D519/00
Abstract: Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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公开(公告)号：US11266666B2
公开(公告)日：2022-03-08
申请号：US16881419
申请日：2020-05-22
Applicant: GILEAD SCIENCES, INC.
Inventor： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC: A61K31/706 , A61K31/7056 , A61K31/685 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00
Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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