公开(公告)号：US07200252B2

公开(公告)日：2007-04-03

申请号：US10282362

申请日：2002-10-28

申请人： James Douglass

发明人： James Douglass

IPC分类号： G06K9/00

CPC分类号： G01N15/1475 ,  G01N2015/1472 ,  G06K9/00127 ,  G06T7/0012 ,  G06T2207/30004

摘要： Two color transformations, as described herein, facilitate identification of the objects of interest in the biological specimen. One of the color transformations, a Minus Clear Plus One (MC+1) transformation, can be conceptualized as either translating and rotating axes of a three-dimensional coordinate space that defines an image of the biological specimen or calculating differences between vectors in the three dimensional coordinate space that defines the image of the biological specimen. The other of the color transformations, a Quantitative Chromatic Transformation (QCT), is a colorimetric transformation that produces three new quantitities from the original red, green, and blue pixel values for each color pixel of an image. These three new quantities, X, Y, and Z can each be related to the quantitative amount of absorbing molecules sampled by that pixel. Application of one or both of the color transformations to the image of the biological specimen results in a transformed image, in which objects of interest are more readily identifiable.

摘要翻译： 如本文所述的两种颜色变换便于识别生物样本中感兴趣的物体。 颜色变换之一，Minus Clear Plus One（MC + 1）转换，可以被概念化为三维坐标空间的平移和旋转轴，其定义生物样本的图像或计算三维矢量之间的差异 定义生物样本图像的三维坐标空间。 颜色变换中的另一个是定量色变换（QCT），是一种比色变换，从图像的每个颜色像素的原始红色，绿色和蓝色像素值产生三个新的量子。 这三个新量X，Y和Z各自可以与由该像素采样的吸收分子的定量相关。 将一种或两种颜色变换应用于生物样本的图像产生变换图像，其中感兴趣的对象更易于识别。

公开(公告)号：US20070041627A1

公开(公告)日：2007-02-22

申请号：US11528080

申请日：2006-09-26

申请人： James Douglass

发明人： James Douglass

IPC分类号： G06K9/00

CPC分类号： G01N15/1475 ,  G01N2015/1472 ,  G06K9/00127 ,  G06T7/0012 ,  G06T2207/30004

摘要： Two color transformations, as described herein, facilitate identification of the objects of interest in the biological specimen. One of the color transformations, a Minus Clear Plus One (MC+1) transformation, can be conceptualized as either translating and rotating axes of a three-dimensional coordinate space that defines an image of the biological specimen or calculating differences between vectors in the three dimensional coordinate space that defines the image of the biological specimen. The other of the color transformations, a Quantitative Chromatic Transformation (QCT), is a calorimetric transformation that produces three new quantities from the original red, green, and blue pixel values for each color pixel of an image. These three new quantities, X, Y, and Z can each be related to the quantitative amount of absorbing molecules sampled by that pixel. Application of one or both of the color transformations to the image of the biological specimen results in a transformed image, in which objects of interest are more readily identifiable.

摘要翻译： 如本文所述的两种颜色变换便于识别生物样本中感兴趣的物体。 颜色变换之一，Minus Clear Plus One（MC + 1）转换，可以被概念化为三维坐标空间的平移和旋转轴，其定义生物样本的图像或计算三维矢量之间的差异 定义生物样本图像的三维坐标空间。 颜色变换中的另一个是定量色变换（QCT），它是一种量热变换，其从图像的每个颜色像素的原始红，绿和蓝像素值产生三个新量。 这三个新量X，Y和Z各自可以与由该像素采样的吸收分子的定量相关。 将一种或两种颜色变换应用于生物样本的图像产生变换图像，其中感兴趣的对象更易于识别。

公开(公告)号：US20050130931A1

公开(公告)日：2005-06-16

申请号：US11049201

申请日：2005-02-01

申请人： Jose Boyer ,  Benjamin Yerxa ,  Robert Plourde ,  Edward Brown ,  James Douglass

发明人： Jose Boyer ,  Benjamin Yerxa ,  Robert Plourde ,  Edward Brown ,  James Douglass

IPC分类号： A61K31/7068 ,  A61K31/7072 ,  A61K31/7084 ,  C07H19/04 ,  C07H19/10 ,  C07H19/20 ,  C07H19/207 ,  C07H21/00 ,  A61K31/675

CPC分类号： A61K31/7084 ,  A61K31/7068 ,  A61K31/7072 ,  C07H19/04 ,  C07H19/10 ,  C07H19/20 ,  C07H19/207 ,  C07H21/00

摘要： The present invention is directed to a method of reducing intraocular pressure. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a nucleoside 5′-pyrophosphate pyranoside or analogue, which is defined by general Formula I. The method of the present invention is useful in the treatment or prevention of ocular hypertension, such as found in glaucoma, including primary and secondary glaucoma. The method can be used alone to reduce intraocular pressure. The method can also be used in conjunction with another therapeutic agent or adjunctive therapy commonly used to treat glaucoma to enhance the therapeutic effect of reducing the intraocular pressure. The present invention also provides a novel composition comprising a nucleoside 5′-pyrophosphate pyranoside or analogue.

摘要翻译： 本发明涉及降低眼内压的方法。 该方法包括向受试者施用包含有效量的由通式I定义的核苷5'-焦磷酸吡喃糖苷或类似物的药物组合物。本发明的方法可用于治疗或预防高眼压症， 例如在青光眼中发现，包括原发性和继发性青光眼。 该方法可单独使用以降低眼内压。 该方法还可以与通常用于治疗青光眼的另一种治疗剂或辅助治疗联合使用，以增强降低眼内压的治疗效果。 本发明还提供了包含核苷5'-焦磷酸吡喃糖苷或类似物的新型组合物。

公开(公告)号：US6151405A

公开(公告)日：2000-11-21

申请号：US827268

申请日：1997-03-28

申请人： James Douglass ,  Thomas J. Riding ,  William J. Decker

发明人： James Douglass ,  Thomas J. Riding ,  William J. Decker

IPC分类号： G01N33/48 ,  G01N15/00 ,  G01N15/14 ,  G01N33/483 ,  G06K9/00

CPC分类号： G01N15/1475 ,  G06K9/00127 ,  G01N15/1456 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1472

摘要： The system and method for evaluating the amount of marker identifying precipitate in a cellular specimen on a microscope slide is disclosed. The automated microscope system performs a low magnification and high magnification scan of a cellular specimen to identify and confirm candidate objects of interest which correspond to cells containing a marker identifying precipitate. A regularly shaped area centered about a centroid computed for a candidate object of interest is used to define the pixels to be processed. A color ratio is computed for each pixel and those color ratios indicative of being dominated by the color corresponding to the marker identified precipitate are summed and normalized. The normalized color ratio is compared to at least one predetermined threshold to assign a grade to the candidate objects of interest. The grades for a predetermined number of candidate objects of interest are summed to form an aggregate score and the aggregate score is compared to a threshold. If the aggregate score exceeds a threshold, the candidate object of interest is determined to indicate the medical condition typically associated with the marker.

摘要翻译： 公开了用于评估在显微镜载玻片上细胞样本中识别沉淀物的标记量的系统和方法。 自动显微镜系统执行细胞样本的低放大倍数和高倍数扫描，以识别和确认对应于含有识别沉淀物的标记的细胞的候选对象。 使用围绕为感兴趣的候选对象计算的质心居中的规则形状的区域来定义要处理的像素。 为每个像素计算颜色比，并且指示由对应于标记识别的沉淀物的颜色所主导的那些颜色比被相加和归一化。 将归一化颜色比与至少一个预定阈值进行比较，以将等级分配给候选对象。 将预定数量的候选对象的等级相加以形成总分，并将总分与阈值进行比较。 如果总分数超过阈值，则确定候选对象物体以指示通常与标记相关联的医疗状况。

公开(公告)号：US07292718B2

公开(公告)日：2007-11-06

申请号：US11528080

申请日：2006-09-26

申请人： James Douglass

发明人： James Douglass

IPC分类号： G06K9/00

CPC分类号： G01N15/1475 ,  G01N2015/1472 ,  G06K9/00127 ,  G06T7/0012 ,  G06T2207/30004

摘要： Two color transformations, as described herein, facilitate identification of the objects of interest in the biological specimen. One of the color transformations, a Minus Clear Plus One (MC+1) transformation, can be conceptualized as either translating and rotating axes of a three-dimensional coordinate space that defines an image of the biological specimen or calculating differences between vectors in the three dimensional coordinate space that defines the image of the biological specimen. The other of the color transformations, a Quantitative Chromatic Transformation (QCT), is a calorimetric transformation that produces three new quantities from the original red, green, and blue pixel values for each color pixel of an image. These three new quantities, X, Y, and Z can each be related to the quantitative amount of absorbing molecules sampled by that pixel. Application of one or both of the color transformations to the image of the biological specimen results in a transformed image, in which objects of interest are more readily identifiable.

公开(公告)号：US20060258614A1

公开(公告)日：2006-11-16

申请号：US11413600

申请日：2006-04-28

申请人： James Douglass ,  Paul Watson ,  Sammy Shaver ,  Krzysztof Bednarski

发明人： James Douglass ,  Paul Watson ,  Sammy Shaver ,  Krzysztof Bednarski

IPC分类号： A61K31/7072 ,  A61K31/513 ,  C07H19/12 ,  C07D405/02

CPC分类号： C07D493/04 ,  C07D405/04 ,  C07H19/12

摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide pyrimidine-based compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and Ia-Ic, or tautomers, salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and Ia-Ic.

摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸嘧啶类化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和Ia-Ic的化合物，或其互变异构体，盐，水合物和溶剂合物。 本发明还提供式I和Ia-1c的新型化合物。

公开(公告)号：US20060234976A1

公开(公告)日：2006-10-19

申请号：US11393374

申请日：2006-03-30

申请人： Paul Watson ,  James Douglass ,  Bob Suchozak ,  Subramanian Pandiaraju ,  Craig Dixon ,  Daniel Levin

发明人： Paul Watson ,  James Douglass ,  Bob Suchozak ,  Subramanian Pandiaraju ,  Craig Dixon ,  Daniel Levin

IPC分类号： A61K31/7076 ,  A61K31/7072 ,  C07F9/6512 ,  A61K31/675

CPC分类号： C07F9/6561 ,  C07F9/65616 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20

摘要： The present invention is directed to a processes for the synthesis of trans isomer of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles (Formula I). The process comprises the steps of: (a) obtaining a compound of Formula II, which is a mixture of cis and trans-diastereomers, and (b) chemically decomposing the compound of Formula II in a solution comprising a solvent and an acid that is a hydrogen donor or an electron pair acceptor, whereby the cis diastereomer is decomposed and the compound of Formula I is obtained. The compounds prepared by the present invention are useful in treating diseases or conditions associated with platelet aggregation and/or platelet activation.

摘要翻译： 本发明涉及合成4,6-二取代 - 四氢 - 呋喃，噻吩并，吡咯并环戊烷并[3,4] [1,3]二氧杂环戊烯（式I）的反式异构体的方法。 该方法包括以下步骤：（a）获得式II化合物，其是顺式和反式 - 非对映异构体的混合物，和（b）在包含溶剂和酸的溶液中化学分解式II化合物， 氢供体或电子对受体，由此使顺式非对映异构体分解并获得式I化合物。 通过本发明制备的化合物可用于治疗与血小板聚集和/或血小板活化相关的疾病或病症。

公开(公告)号：US20060122143A1

公开(公告)日：2006-06-08

申请号：US11267834

申请日：2005-11-04

申请人： Jose Boyer ,  James Douglass ,  Sammy Shaver

发明人： Jose Boyer ,  James Douglass ,  Sammy Shaver

IPC分类号： A61K31/7076 ,  A61K31/7072 ,  C07H19/04 ,  A61K31/675

CPC分类号： C07H19/04 ,  A61K31/675 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/7084 ,  C07H19/10 ,  C07H19/20 ,  C07H19/207 ,  C07H21/00

摘要： The present invention provides a P2Y12 receptor antagonist compound-eluting stent, wherein the stent is coated with one or more P2Y12 receptor antagonist compounds or a pharmaceutically acceptable salt, solvate, or hydrate thereof. When the stent is placed in a narrowed or damaged arterial vessel, a therapeutically effective amount of the P2Y12 receptor antagonist compound is eluted continuously from the stent to the local environment of the stent. The P2Y12 receptor antagonist compound-eluting stents are useful in preventing thrombosis and restenosis, and are effective in inhibiting the contraction of vascular smooth muscle cells, inhibiting cell proliferation, and reducing inflammation.

摘要翻译： 本发明提供P2Y 12受体拮抗剂化合物洗脱支架，其中支架涂覆有一种或多种P2Y 12受体拮抗剂化合物或其药学上可接受的盐，溶剂化物， 或其水合物。 当支架置于狭窄或损伤的动脉血管中时，治疗有效量的P2Y 12受体拮抗剂化合物从支架连续洗脱至支架的局部环境。 P2Y 12受体拮抗剂化合物洗脱支架可用于预防血栓形成和再狭窄，并且有效抑制血管平滑肌细胞的收缩，抑制细胞增殖和减少炎症。

公开(公告)号：US20060121086A1

公开(公告)日：2006-06-08

申请号：US11267941

申请日：2005-11-04

申请人： Jose Boyer ,  James Douglass ,  Sammy Shaver

发明人： Jose Boyer ,  James Douglass ,  Sammy Shaver

IPC分类号： A61K31/519 ,  A61K31/52 ,  A61F2/00

CPC分类号： A61K31/519 ,  A61F2/82 ,  A61F2250/0067 ,  A61K31/52 ,  A61K31/522 ,  A61K31/7076 ,  A61K31/727 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides a drug-eluting stent, wherein the stent is coated with one or more non-mucleotide P2Y12 receptor antagonist compounds or a pharmaceutically acceptable salt, solvate, or hydrate thereof. When the stent is placed in a narrowed or damaged arterial vessel, a therapeutically effective amount of the P2Y12 receptor antagonist compound is eluted continuously from the stent to the local environment of the stent. The P2Y12 receptor antagonist compound-eluting stents are useful in preventing thrombosis and restenosis, and are effective in inhibiting the contraction of vascular smooth muscle cells, inhibiting cell proliferation, and reducing inflammation.

摘要翻译： 本发明提供药物洗脱支架，其中支架涂覆有一种或多种非核苷酸P2Y 12受体拮抗剂化合物或其药学上可接受的盐，溶剂合物或水合物。 当支架置于狭窄或损伤的动脉血管中时，治疗有效量的P2Y 12受体拮抗剂化合物从支架连续洗脱至支架的局部环境。 P2Y 12受体拮抗剂化合物洗脱支架可用于预防血栓形成和再狭窄，并且有效抑制血管平滑肌细胞的收缩，抑制细胞增殖和减少炎症。

公开(公告)号：US06944333B2

公开(公告)日：2005-09-13

申请号：US10427342

申请日：2003-04-30

申请人： James Douglass

发明人： James Douglass

IPC分类号： G06K9/00 ,  G06K9/36 ,  G06K9/46 ,  H04M20060101 ,  H04N7/26 ,  H04N7/30 ,  H04N7/46

CPC分类号： G06K9/0014 ,  G06K9/4652 ,  H04N19/124 ,  H04N19/20 ,  H04N19/59 ,  H04N19/60 ,  H04N19/90

摘要： A method of compressing a color image is provided. The color image comprises color data for a plurality of pixels. The method includes the step of obtaining red, green and blue pixel values of an object of interest in the image. A calculation is made of the complement of the red, green and blue values of the object of interest. Transformation coefficients are calculated which transform the complements of red, green and blue values of the object of interest into representations in a transformation color space. The transformation coefficients are applied to all the pixels in the image to thereby obtain a transformed data set representing the image having components along three mutually orthogonal axes (A, B and C herein) in a three-dimensional transformed color space. The transformed data set is scaled in accordance with the color quantization used in the system; e.g., the A, B and C values are between 0 and 255 for an 8 bit quantization. A compression algorithm, e.g., a loss less algorithm such as WINZip or LZW is applied to at least two components of the transformed data set to thereby produce output data representing a compression of the image.

摘要翻译： 提供了一种压缩彩色图像的方法。 彩色图像包括多个像素的颜色数据。 该方法包括获得图像中感兴趣对象的红色，绿色和蓝色像素值的步骤。 计算感兴趣对象的红色，绿色和蓝色值的补数。 计算转换系数，其将感兴趣对象的红色，绿色和蓝色值的互补变换为变换颜色空间中的表示。 将变换系数应用于图像中的所有像素，从而获得表示具有沿着三维变换色空间中的三个相互正交的轴（A，B和C）的分量的图像的变换数据集。 根据系统中使用的颜色量化，对经变换的数据集进行缩放; 例如，对于8位量化，A，B和C值在0和255之间。 压缩算法，例如诸如WINZip或LZW的丢失算法算法被应用于变换数据集的至少两个分量，从而产生表示图像的压缩的输出数据。